ATE218554T1 - Hepatobillianische magnetische resonanz- kontrastmittel - Google Patents

Hepatobillianische magnetische resonanz- kontrastmittel

Info

Publication number: ATE218554T1
Authority: AT; Austria
Prior art keywords: alkyl; branched; straight; hepatobillian; magnetic resonance
Prior art date: 1993-09-30

Application number

AT94926365T

Other languages

English (en)

Inventor

Jean-Francois Desreux

Michael F Tweedle

Peter C Ratsep

Thomas R Wagler

Edmund R Marinelli

Original Assignee

Bracco Int Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-30

Filing date

1994-09-29

Publication date

2002-06-15

1994-09-29 Application filed by Bracco Int Bv filed Critical Bracco Int Bv

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218554T1 publication Critical patent/ATE218554T1/de

Links

239000002405 nuclear magnetic resonance imaging agent Substances 0.000 title 1
125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052688 Gadolinium Inorganic materials 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
LGAILEFNHXWAJP-BMEPFDOTSA-N macrocycle Chemical group N([C@H]1[C@@H](C)CC)C(=O)C(N=2)=CSC=2CNC(=O)C(=C(O2)C)N=C2[C@H]([C@@H](C)CC)NC(=O)C2=CSC1=N2 LGAILEFNHXWAJP-BMEPFDOTSA-N 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/10—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Soft Magnetic Materials (AREA)
Magnetic Resonance Imaging Apparatus (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT94926365T 1993-09-30 1994-09-29 Hepatobillianische magnetische resonanz- kontrastmittel ATE218554T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/129,870 US5358704A (en)	1993-09-30	1993-09-30	Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
PCT/IB1994/000298 WO1995009161A1 (en)	1993-09-30	1994-09-29	Hepatobiliary magnetic resonance contrast agents

Publications (1)

Publication Number	Publication Date
ATE218554T1 true ATE218554T1 (de)	2002-06-15

Family

ID=22441998

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01127327T ATE288422T1 (de)	1993-09-30	1994-09-29	Hepatobillianische magnetische resonanz- kontrastmittel
AT94926365T ATE218554T1 (de)	1993-09-30	1994-09-29	Hepatobillianische magnetische resonanz- kontrastmittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT01127327T ATE288422T1 (de)	1993-09-30	1994-09-29	Hepatobillianische magnetische resonanz- kontrastmittel

Country Status (14)

Country	Link
US (1)	US5358704A (de)
EP (2)	EP0670832B1 (de)
JP (1)	JP3949714B2 (de)
KR (1)	KR960702447A (de)
CN (1)	CN1115180A (de)
AT (2)	ATE288422T1 (de)
AU (1)	AU7623494A (de)
CA (1)	CA2150452A1 (de)
CZ (1)	CZ136995A3 (de)
DE (2)	DE69434260T2 (de)
HK (1)	HK1046131A1 (de)
IL (1)	IL111083A0 (de)
NO (1)	NO300131B1 (de)
WO (1)	WO1995009161A1 (de)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4318369C1 (de) *	1993-05-28	1995-02-09	Schering Ag	Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
JPH0797340A (ja) *	1993-06-03	1995-04-11	Terumo Corp	Ｍｒｉ造影剤組成物
IT1269839B (it) *	1994-05-26	1997-04-15	Bracco Spa	Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
US6962686B2 (en) *	1994-10-12	2005-11-08	California Institute Of Technology	Cell-specific gene delivery vehicles
US5672335A (en) *	1994-11-30	1997-09-30	Schering Aktiengesellschaft	Use of metal complexes as liver and gallbladder X-ray diagnostic agents
TW319763B (de) *	1995-02-01	1997-11-11	Epix Medical Inc
US5707605A (en) *	1995-06-02	1998-01-13	Research Corporation Technologies	Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en)	1995-06-02	2004-03-30	Research Corporation Technologies, Inc.	Targeted magnetic resonance imaging agents for the detection of physiological processes
US5980862A (en) *	1995-06-02	1999-11-09	Research Corporation Technologies	Magnetic resonance imaging agents for the detection of physiological agents
US6770261B2 (en) *	1995-06-02	2004-08-03	Research Corporation Technologies	Magnetic resonance imaging agents for the detection of physiological agents
EP0846003A1 (de) *	1995-08-17	1998-06-10	Monsanto Company	Verfahren zur diagnostischen bildanalyse unter verwendung von biokonjugaten von metallkomplexen von stickstoffhaltigen makrocyclischen liganden
US5900228A (en)	1996-07-31	1999-05-04	California Institute Of Technology	Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
DE19744004C1 (de) *	1997-09-26	1999-07-22	Schering Ag	Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
US6495118B1 (en) *	1997-09-26	2002-12-17	Schering Aktiengesellschaft	Lipophilic metal complexes for necrosis and infarction imaging
US6713046B1 (en)	1997-10-27	2004-03-30	Research Corporation Technologies	Magnetic resonance imaging agents for the delivery of therapeutic agents
EP1032430A2 (de)	1997-11-17	2000-09-06	Research Corporation Technologies, Inc.	Mri-mittel zum nachweis von physiologischen mitteln
IT1297035B1 (it)	1997-12-30	1999-08-03	Bracco Spa	Derivati dell'acido 1,4,7,10-tetraazaciclododecan-1,4-diacetico
US6093382A (en)	1998-05-16	2000-07-25	Bracco Research Usa Inc.	Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
US6056939A (en) *	1998-08-28	2000-05-02	Desreux; Jean F.	Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
AU2001276956A1 (en)	2000-07-17	2002-01-30	California Institute Of Technology	Macrocyclic mri contrast agents
US7029655B2 (en)	2000-10-04	2006-04-18	California Institute Of Technology	Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US20030004236A1 (en) *	2001-04-20	2003-01-02	Meade Thomas J.	Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
US20030135108A1 (en) *	2001-05-02	2003-07-17	Silva Robin M.	High throughput screening methods using magnetic resonance imaging agents
US20020197648A1 (en) *	2001-05-02	2002-12-26	Silva Robin M.	High throughput screening methods using magnetic resonance imaging agents
US20040038303A1 (en) *	2002-04-08	2004-02-26	Unger Gretchen M.	Biologic modulations with nanoparticles
US7368100B2 (en) *	2002-09-06	2008-05-06	The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Backbone-substituted bifunctional DOTA ligands, complexes and compositions thereof, and methods of using same
CN1774267A (zh) *	2003-01-22	2006-05-17	综合医院有限公司	与淀粉样物质结合的金属螯合剂
US7012140B1 (en) *	2003-07-14	2006-03-14	Board Of Regents, The University Of Texas System	Selection of coordination geometry to adjust water exchange rates of paramagnetic metal ion-based macrocyclic contrast agents
US20060088475A1 (en) *	2004-05-10	2006-04-27	Northwestern University	Self-immolative magnetic resonance imaging contrast agents sensitive to beta-glucuronidase
US7504088B2 (en)	2004-06-09	2009-03-17	Kereos, Inc.	Lipophilic derivatives of chelate monoamides
EA011516B1 (ru)	2005-01-13	2009-04-28	Синвеншен Аг	Композиционный материал и способ его изготовления
CA2624906A1 (en) *	2005-10-18	2007-04-26	Cinvention Ag	Thermoset particles and methods for production thereof
US20090317335A1 (en) *	2006-04-20	2009-12-24	Wenbin Lin	Hybrid Nanomaterials as Multimodal Imaging Contrast Agents
WO2008070464A2 (en) *	2006-11-21	2008-06-12	Barnes-Jewish Hospital	Methods of imaging employing chelating agents
CN100459932C (zh) *	2007-01-15	2009-02-11	北京大学人民医院	一种mri分子影像探针及其制备方法
CN101646402A (zh) *	2007-01-19	2010-02-10	金文申有限公司	用粉末模塑法制成的多孔、不可降解植入物
CA2677699A1 (en) *	2007-02-28	2008-09-04	Cinvention Ag	High surface cultivation system
US20080206862A1 (en) *	2007-02-28	2008-08-28	Cinvention Ag	High surface cultivation system bag
EP2072060A1 (de)	2007-12-18	2009-06-24	Institut Curie	Verfahren und Zusammensetzungen zur Herstellung und Verwendung von Toxinkonjugaten
US20100029909A1 (en) *	2008-05-23	2010-02-04	Northwestern University	Compositions and methods comprising magnetic resonance contrast agents
US8580231B2 (en)	2008-05-23	2013-11-12	Northwestern University	Compositions and methods comprising magnetic resonance contrast agents
JP5681102B2 (ja)	2008-05-30	2015-03-04	シーメンスメディカルソリューションズユーエスエーインコーポレイテッドＳｉｅｍｅｎｓＭｅｄｉｃａｌＳｏｌｕｔｉｏｎｓＵＳＡ，Ｉｎｃ．	分子イメージング手法のための化合物
US20120093725A1 (en)	2009-04-10	2012-04-19	Inserm (Institut National De La Sante Et De La Recherche Medicale	Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies
WO2012072819A1 (en)	2010-12-03	2012-06-07	INSERM (Institut National de la Santé et de la Recherche Médicale)	Agents for the molecular imaging of serine-protease in human pathologies
WO2012089814A1 (en)	2010-12-30	2012-07-05	INSERM (Institut National de la Santé et de la Recherche Médicale)	Antigen binding formats for use in therapeutic treatments or diagnostic assays
US20150337308A1 (en)	2012-04-11	2015-11-26	Chu De Bordeaux	Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof
EP2733153A1 (de)	2012-11-15	2014-05-21	INSERM (Institut National de la Santé et de la Recherche Médicale)	Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon
CN107072963B (zh)	2014-09-03	2020-07-07	吉倪塞思公司	治疗性纳米粒子和相关的组合物、方法和系统
US10793532B2 (en)	2016-09-27	2020-10-06	Bayer Pharma Aktiengesellschaft	Method for producing the crystalline form of modification a of calcobutrol
EP3638320A4 (de)	2017-05-05	2021-01-20	Centre for Probe Development and Commercialization	Monoklonale igf-1r-antikörper und verwendungen davon
WO2018204869A1 (en)	2017-05-05	2018-11-08	Fusion Pharmaceuticals Inc.	Pharmacokinetic enhancements of bifunctional chelates and uses thereof
US10093741B1 (en)	2017-05-05	2018-10-09	Fusion Pharmaceuticals Inc.	IGF-1R monoclonal antibodies and uses thereof
US11607462B2 (en)	2017-05-16	2023-03-21	Northwestern University	Systems and methods for minimally-invasive assessment of toxicity-induced tissue injury

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0073456B1 (de) *	1981-08-24	1985-11-27	Asahi Kasei Kogyo Kabushiki Kaisha	Tetraazaannulen-Cobalt-Complexe und Verfahren zu ihrer Herstellung
EP0108181B1 (de) *	1982-11-03	1987-04-29	Ciba-Geigy Ag	Dibenzo(b,i)-1,4,8,11-tetraaza(14)annulenkobalt(III)jodid
DE3562917D1 (en) *	1984-04-18	1988-06-30	Ciba Geigy Ag	Substituted dibenzotetraaza-û14¨-annulene metal complexes, process for their preparation and their use
US4899755A (en) *	1985-05-08	1990-02-13	The General Hospital Corporation	Hepatobiliary NMR contrast agents
US4880008A (en) *	1985-05-08	1989-11-14	The General Hospital Corporation	Vivo enhancement of NMR relaxivity
GB8603537D0 (en) *	1986-02-13	1986-03-19	Parker D	Conjugate compound
DE3625417C2 (de) *	1986-07-28	1998-10-08	Schering Ag	Tetraazacyclododecan-Derivate
DE4001655A1 (de) *	1990-01-18	1991-07-25	Schering Ag	6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP3131219B2 (ja) *	1990-01-19	2001-01-31	ニユコメド・イメージング・アクシエセルカペト	キレート化合物

1993
- 1993-09-30 US US08/129,870 patent/US5358704A/en not_active Expired - Lifetime
1994
- 1994-09-29 EP EP94926365A patent/EP0670832B1/de not_active Expired - Lifetime
- 1994-09-29 EP EP01127327A patent/EP1184377B1/de not_active Expired - Lifetime
- 1994-09-29 IL IL11108394A patent/IL111083A0/xx unknown
- 1994-09-29 DE DE69434260T patent/DE69434260T2/de not_active Expired - Fee Related
- 1994-09-29 WO PCT/IB1994/000298 patent/WO1995009161A1/en not_active Ceased
- 1994-09-29 CZ CZ951369A patent/CZ136995A3/cs unknown
- 1994-09-29 AT AT01127327T patent/ATE288422T1/de not_active IP Right Cessation
- 1994-09-29 KR KR1019950702155A patent/KR960702447A/ko not_active Withdrawn
- 1994-09-29 DE DE69430730T patent/DE69430730T2/de not_active Expired - Fee Related
- 1994-09-29 JP JP51019495A patent/JP3949714B2/ja not_active Expired - Fee Related
- 1994-09-29 AU AU76234/94A patent/AU7623494A/en not_active Abandoned
- 1994-09-29 AT AT94926365T patent/ATE218554T1/de not_active IP Right Cessation
- 1994-09-29 CA CA002150452A patent/CA2150452A1/en not_active Abandoned
- 1994-09-29 CN CN94190738A patent/CN1115180A/zh active Pending
1995
- 1995-05-29 NO NO952111A patent/NO300131B1/no unknown
2002
- 2002-09-06 HK HK02106580.1A patent/HK1046131A1/en unknown

Also Published As

Publication number	Publication date
NO952111D0 (no)	1995-05-29
JP3949714B2 (ja)	2007-07-25
CA2150452A1 (en)	1995-04-06
DE69430730D1 (de)	2002-07-11
DE69434260T2 (de)	2006-01-19
CN1115180A (zh)	1996-01-17
EP1184377B1 (de)	2005-02-02
CZ136995A3 (en)	1995-12-13
KR960702447A (ko)	1996-04-27
US5358704A (en)	1994-10-25
EP1184377A1 (de)	2002-03-06
DE69434260D1 (de)	2005-03-10
ATE288422T1 (de)	2005-02-15
NO300131B1 (no)	1997-04-14
AU7623494A (en)	1995-04-18
NO952111L (no)	1995-05-29
WO1995009161A1 (en)	1995-04-06
IL111083A0 (en)	1994-11-28
HK1046131A1 (en)	2002-12-27
JPH08503967A (ja)	1996-04-30
EP0670832B1 (de)	2002-06-05
DE69430730T2 (de)	2003-02-06
EP0670832A1 (de)	1995-09-13

Legal Events

Date	Code	Title	Description
2002-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE288422T1 (de)	2005-02-15	Hepatobillianische magnetische resonanz- kontrastmittel
PH30934A (en)	1997-12-23	Alkyl phosphonate polyazamacrocyclic chelates for mri.
ATE137228T1 (de)	1996-05-15	Aminocarbonsäure und derivate
NZ227421A (en)	1990-10-26	1,4,7,10-tetraazacyclododecane derivatives and diagnosis using nmr
EP0717639A4 (de)	1998-04-01	Phosphonate- und nicht-phosphonate einheiten enthaltende polyamino-paramagnetische-chelate fuer anwendung in mri
FI915916A0 (fi)	1991-12-16	Tetra-azamakrocykler, foerfaranden foer deras framstaellning och deras anvaendning vid magnetresonans- bildformning.
ES2181372T3 (es)	2003-02-16	Derivados de dihidro- o tetrahidronaftaleno que tienen actividad (anti)-estrogena.
ATE160566T1 (de)	1997-12-15	Amphotere tricyclische verbindungen als antihistaminische und antiallergische mittel
ATE161844T1 (de)	1998-01-15	Acyl-(2'-hydroxybiphenyl-2-yl)- phosphinsäuresalze, ihre herstellung und verwendung
ES8300776A1 (es)	1982-11-01	Procedimiento para la obtencion de nuevos derivados de la tiazolo (3,2-a)pirimidina
WO1999032068A3 (de)	1999-08-26	Neue entwicklerkombinationen für oxidationsfärbemittel
IL76936A0 (en)	1986-04-29	3-amino-2,3-dihydro-1-benzoxepine compounds,their preparation and pharmaceutical compositions containing them
ES2018407A6 (es)	1991-04-01	Procedimiento para la obtencion de 1-ariloxi-3-nitroamino-2-propanoles.