ATE218580T1 - Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen - Google Patents

Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen

Info

Publication number: ATE218580T1
Authority: AT; Austria
Prior art keywords: preparation; pharmaceutical compositions; cyclosporine derivatives; derivatives; cyclosporine
Prior art date: 1996-12-24

Application number

AT97952998T

Other languages

English (en)

Inventor

Jean-Claude Barriere

Georges Bashiardes

Jean-Christophe Carry

Michel Evers

Bruno Filoche

Jean-Pierre Leconte

Serge Mignani

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-24

Filing date

1997-12-23

Publication date

2002-06-15

1997-12-23 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218580T1 publication Critical patent/ATE218580T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
-1 cyclosporin compound Chemical class 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT97952998T 1996-12-24 1997-12-23 Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen ATE218580T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9615956A FR2757522B1 (fr)	1996-12-24	1996-12-24	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1997/002405 WO1998028329A1 (fr)	1996-12-24	1997-12-23	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE218580T1 true ATE218580T1 (de)	2002-06-15

Family

ID=9499089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97952998T ATE218580T1 (de)	1996-12-24	1997-12-23	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen

Country Status (14)

Country	Link
US (1)	US5965527A (de)
EP (1)	EP0948527B1 (de)
JP (1)	JP4172822B2 (de)
AT (1)	ATE218580T1 (de)
AU (1)	AU5669298A (de)
DE (1)	DE69713148D1 (de)
DK (1)	DK0948527T3 (de)
ES (1)	ES2178037T3 (de)
FR (1)	FR2757522B1 (de)
MA (1)	MA26459A1 (de)
PT (1)	PT948527E (de)
TN (1)	TNSN97211A1 (de)
WO (1)	WO1998028329A1 (de)
ZA (1)	ZA9711606B (de)

Families Citing this family (42)

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US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
WO1999065933A1 (en) *	1998-06-12	1999-12-23	C-Chem Ag	Novel cyclosporins
USRE40987E1 (en)	1998-07-01	2009-11-17	Debiopharm S.A.	Cyclosporin with improved activity profile
US6254860B1 (en) *	1999-04-13	2001-07-03	Allergan Sales, Inc.	Ocular treatment using cyclosporin-A derivatives
DE60231570D1 (de)	2001-10-19	2009-04-23	Isotechnika Inc	Synthese von Cyclosporinanalogen
PT1435910E (pt) *	2001-10-19	2009-09-07	Isotechnika Inc	Novos pré-concentrados de microemulsão de análogos da ciclosporina
US6987090B2 (en) *	2002-05-09	2006-01-17	Lg Household & Health Care Ltd.	Use of 3-position cyclosporin derivatives for hair growth
KR20040039622A (ko) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
AU2004222306A1 (en)	2003-03-17	2004-09-30	Albany Molecular Research, Inc.	Novel cyclosporins
GB0320638D0 (en)	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
JP2008514702A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
WO2006039163A2 (en)	2004-09-29	2006-04-13	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
PT1793844E (pt)	2004-10-01	2011-03-10	Debiopharm Sa	Utilização de [d-meala]3-[etval]4-csa para o tratamento de infecção causada pelo vírus da hepatite c
SI1802650T1 (sl) *	2004-10-01	2012-03-30	Scynexis Inc	Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
WO2006041631A2 (en)	2004-10-06	2006-04-20	Amr Technology, Inc.	Novel cyclosporin alkynes and their utility as pharmaceutical agents
RU2007128098A (ru) *	2004-12-23	2009-01-27	Новартис АГ (CH)	Соединения для лечения инфекций, вызываемых вирусами семейства flaviviridae
US7897565B2 (en) *	2004-12-23	2011-03-01	Novartis Ag	Compositions for HCV treatment
CN105169369B (zh)	2005-09-30	2019-10-18	中美华世通生物医药科技（武汉）有限公司	治疗和预防丙型肝炎感染的方法和药物组合物
CA2623864C (en) *	2005-09-30	2014-12-16	Scynexis, Inc.	Arylalkyl and heteroarylalkyl derivatives of cyclosporine a for the treatment and prevention of viral infection
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
EP2023918B1 (de)	2006-05-19	2011-03-23	Scynexis, Inc.	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
KR101089112B1 (ko) *	2006-06-02	2011-12-06	피씨 제스띠옹 에스.아.에스.	활성 전자 관리
SG175621A1 (en) *	2006-10-12	2011-11-28	Novartis Ag	Use of modified cyclosporins
US7576057B2 (en)	2006-11-20	2009-08-18	Scynexis, Inc.	Cyclic peptides
WO2008127613A1 (en) *	2007-04-11	2008-10-23	Scynexis, Inc.	New pharmaceutical compositions
WO2009042892A1 (en)	2007-09-26	2009-04-02	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
JP5820722B2 (ja)	2008-06-06	2015-11-24	スシネキスインク	シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用
WO2009148615A1 (en) *	2008-06-06	2009-12-10	Scynexis, Inc.	Cyclosporin analogs and their use in the treatment of hcv infections
JP5661035B2 (ja) *	2008-07-10	2015-01-28	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	眼および皮膚の疾患および症状の治療用のシクロスポリン誘導体
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
CA2748389A1 (en) *	2008-12-31	2010-07-08	Scynexis, Inc.	Derivatives of cyclosporin a
CA2763207A1 (en)	2009-05-27	2010-12-02	Allergan, Inc.	Cyclosporin derivatives for treating inflammatory diseases and conditions
GB0912584D0 (en) *	2009-07-20	2009-08-26	Ucl Business Plc	Cyclosporin conjugates
CN107007815A (zh) *	2010-07-16	2017-08-04	美国科技环球有限公司	新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用
WO2012021796A2 (en) *	2010-08-12	2012-02-16	S&T Global, Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
MX2013004062A (es) *	2010-10-12	2013-07-22	Allergan Inc	Analogos de ciclosporina.
RU2013119869A (ru)	2010-10-12	2014-11-20	Аллерган, Инк.	Аналоги циклоспорина
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
LT2651965T (lt)	2010-12-15	2019-01-10	Contravir Pharmaceuticals, Inc.	Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (de) *	1985-03-11	1992-07-29	Sandoz Ag	Cyclosporine
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
DE69124459T3 (de) *	1990-11-02	2001-05-31	Novartis Ag, Basel	Zyklosporine
NZ315324A (en) *	1995-07-17	1999-10-28	Chem Ag C	Cyclosporin derivatives with anti-hiv effect

1996
- 1996-12-24 FR FR9615956A patent/FR2757522B1/fr not_active Expired - Fee Related
1997
- 1997-12-19 MA MA24908A patent/MA26459A1/fr unknown
- 1997-12-23 DE DE69713148T patent/DE69713148D1/de not_active Expired - Lifetime
- 1997-12-23 PT PT97952998T patent/PT948527E/pt unknown
- 1997-12-23 EP EP97952998A patent/EP0948527B1/de not_active Expired - Lifetime
- 1997-12-23 AT AT97952998T patent/ATE218580T1/de active
- 1997-12-23 DK DK97952998T patent/DK0948527T3/da active
- 1997-12-23 ZA ZA9711606A patent/ZA9711606B/xx unknown
- 1997-12-23 TN TNTNSN97211A patent/TNSN97211A1/fr unknown
- 1997-12-23 JP JP52848998A patent/JP4172822B2/ja not_active Expired - Fee Related
- 1997-12-23 AU AU56692/98A patent/AU5669298A/en not_active Abandoned
- 1997-12-23 WO PCT/FR1997/002405 patent/WO1998028329A1/fr not_active Ceased
- 1997-12-23 US US08/996,699 patent/US5965527A/en not_active Expired - Fee Related
- 1997-12-23 ES ES97952998T patent/ES2178037T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
PT948527E (pt)	2002-11-29
MA26459A1 (fr)	2004-12-20
DK0948527T3 (da)	2002-09-16
JP4172822B2 (ja)	2008-10-29
DE69713148D1 (de)	2002-07-11
US5965527A (en)	1999-10-12
TNSN97211A1 (fr)	2005-03-15
ES2178037T3 (es)	2002-12-16
EP0948527A1 (de)	1999-10-13
AU5669298A (en)	1998-07-17
EP0948527B1 (de)	2002-06-05
ZA9711606B (en)	1998-06-25
FR2757522A1 (fr)	1998-06-26
WO1998028329A1 (fr)	1998-07-02
JP2001507346A (ja)	2001-06-05
FR2757522B1 (fr)	1999-01-29

Publication	Publication Date	Title
ATE218580T1 (de)	2002-06-15	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
ATE218582T1 (de)	2002-06-15	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
DE69713151D1 (de)	2002-07-11	Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
DE69829175D1 (de)	2005-04-07	Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen
BG103945A (bg)	2000-07-31	Производни на 4"-заместен-9-деоксо-9а-аза-9а- хомоеритромицин а
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
ES2196331T3 (es)	2003-12-16	Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b.
RU95106362A (ru)	1996-12-27	Производные липопептида, способ их получения, содержащая их фармацевтическая композиция и способ ее получения
CA2286511A1 (en)	2000-04-09	Novel macrolide derivatives
GR3019274T3 (en)	1996-06-30	Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use
AP9801377A0 (en)	2000-04-29	Tricyclic erythromycin derivatives.
RU94040865A (ru)	1996-08-10	Производные пептида и их терапевтически приемлемые соли, способ их получения, фармацевтическая и косметическая композиция с антивирусной активностью
WO2001005386A3 (en)	2001-07-19	Pharmaceutical composition useful for the treatment of tinnitus and hearing loss
NO973401L (no)	1997-07-23	Kortikosteroidinneholdende sammensetninger og fremstilling derav
FI932654A0 (fi)	1993-06-10	Hydroxamsyraderivat, som hindrar lipoxigenas
BR0011845A (pt)	2002-03-05	Complexo farmacêutico
BR9902049A (pt)	2000-05-02	Derivados 9a,11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina.
MX9605312A (es)	1998-02-28	Dipsipeptidos ciclicos antifungales.