ATE218580T1 - Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen - Google Patents

Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen

Info

Publication number: ATE218580T1
Authority: AT; Austria
Prior art keywords: preparation; pharmaceutical compositions; cyclosporine derivatives; derivatives; cyclosporine
Prior art date: 1996-12-24

Application number

AT97952998T

Other languages

English (en)

Inventor

Jean-Claude Barriere

Georges Bashiardes

Jean-Christophe Carry

Michel Evers

Bruno Filoche

Jean-Pierre Leconte

Serge Mignani

Original Assignee

Aventis Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-24

Filing date

1997-12-23

Publication date

2002-06-15

1997-12-23 Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE218580T1 publication Critical patent/ATE218580T1/de

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
229930105110 Cyclosporin A Natural products 0.000 abstract 1
108010036949 Cyclosporine Proteins 0.000 abstract 1
208000005074 Retroviridae Infections Diseases 0.000 abstract 1
229960001265 ciclosporin Drugs 0.000 abstract 1
229930182912 cyclosporin Natural products 0.000 abstract 1
-1 cyclosporin compound Chemical class 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT97952998T 1996-12-24 1997-12-23 Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen ATE218580T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9615956A FR2757522B1 (fr)	1996-12-24	1996-12-24	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1997/002405 WO1998028329A1 (fr)	1996-12-24	1997-12-23	Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE218580T1 true ATE218580T1 (de)	2002-06-15

Family

ID=9499089

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97952998T ATE218580T1 (de)	1996-12-24	1997-12-23	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen

Country Status (14)

Country	Link
US (1)	US5965527A (de)
EP (1)	EP0948527B1 (de)
JP (1)	JP4172822B2 (de)
AT (1)	ATE218580T1 (de)
AU (1)	AU5669298A (de)
DE (1)	DE69713148D1 (de)
DK (1)	DK0948527T3 (de)
ES (1)	ES2178037T3 (de)
FR (1)	FR2757522B1 (de)
MA (1)	MA26459A1 (de)
PT (1)	PT948527E (de)
TN (1)	TNSN97211A1 (de)
WO (1)	WO1998028329A1 (de)
ZA (1)	ZA9711606B (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
CN1205220C (zh) *	1998-06-12	2005-06-08	斯－凯穆公司	新颖的环孢菌素
AU759480B2 (en)	1998-07-01	2003-04-17	Debiopharm S.A.	Novel cyclosporin with improved activity profile
US6254860B1 (en)	1999-04-13	2001-07-03	Allergan Sales, Inc.	Ocular treatment using cyclosporin-A derivatives
MXPA04003625A (es)	2001-10-19	2004-12-02	Sotechnika Inc	Sintesis de analogos de ciclosporina.
IL160761A0 (en) *	2001-10-19	2004-08-31	Isotechnika Inc	Novel cyclosporin analog microemulsion preconcentrates
KR20040039622A (ko) *	2002-11-04	2004-05-12	주식회사 엘지생활건강	모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US6987090B2 (en) *	2002-05-09	2006-01-17	Lg Household & Health Care Ltd.	Use of 3-position cyclosporin derivatives for hair growth
US7538084B2 (en)	2003-03-17	2009-05-26	Amr Technology, Inc.	Cyclosporins
GB0320638D0 (en)	2003-09-03	2003-10-01	Novartis Ag	Organic compounds
JP2008514701A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキン類似体およびそれらの薬学的使用
JP2008514702A (ja)	2004-09-29	2008-05-08	エーエムアールテクノロジーインコーポレイテッド	新規シクロスポリン類似体およびそれらの薬学的使用
SI1802650T1 (sl) *	2004-10-01	2012-03-30	Scynexis Inc	Eter in tioeter substituirani ciklosporinski derivati za zdravljenje in preventivo pred infekcijami s hepatitisom c
US7196161B2 (en) *	2004-10-01	2007-03-27	Scynexis Inc.	3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
DK1793844T3 (da) *	2004-10-01	2011-03-21	Debiopharm Sa	Anvendelse af [D-MeAla]3-[EtVal]4-cyklosporin til behandling af hepatitis C-infektion
JP2008515886A (ja)	2004-10-06	2008-05-15	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
AU2005322241B2 (en) *	2004-12-23	2010-02-18	Novartis Ag	Compounds for flaviviridae treatment
WO2006071619A1 (en) *	2004-12-23	2006-07-06	Novartis Ag	Compositions for hcv treatment
EP1931696B1 (de)	2005-09-30	2011-02-16	Scynexis, Inc.	Arylalkyl- und heteroarylalkyl-derivate von cyclosporin a bei der behandlung und vorbeugung einer virusinfektion
JP5517454B2 (ja) *	2005-09-30	2014-06-11	スシネキスインク	Ｃ型肝炎感染の治療及び予防のための方法及び医薬組成物
US7696165B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en)	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
EP2023918B1 (de)	2006-05-19	2011-03-23	Scynexis, Inc.	Cyclosporins zur behandlung und vorbeugung von augenerkrankungen
CN101502196A (zh) *	2006-06-02	2009-08-05	克洛德·安妮·佩里西恩	激活电子的管理
CA2665415A1 (en) *	2006-10-12	2008-04-17	Novartis Ag	Use of modified cyclosporins
WO2008069917A2 (en)	2006-11-20	2008-06-12	Scynexis, Inc.	Novel cyclic peptides
WO2008127613A1 (en) *	2007-04-11	2008-10-23	Scynexis, Inc.	New pharmaceutical compositions
US8394763B2 (en)	2007-09-26	2013-03-12	Oregon Health & Science University	Cyclic undecapeptides and derivatives as multiple sclerosis therapies
CN102083852A (zh) *	2008-06-06	2011-06-01	西尼克斯公司	环孢菌素类似物及其在治疗hcv感染中的应用
US20090306033A1 (en) *	2008-06-06	2009-12-10	Keqiang Li	Novel cyclic peptides
JP5661035B2 (ja) *	2008-07-10	2015-01-28	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	眼および皮膚の疾患および症状の治療用のシクロスポリン誘導体
DE102008060549A1 (de)	2008-12-04	2010-06-10	MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V.	Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
EP2376524B1 (de)	2008-12-31	2017-03-15	Cypralis Limited	Derivate von cyclosporin a
AU2010254316A1 (en)	2009-05-27	2011-12-22	Allergan, Inc.	Cyclosporin derivatives for treating inflammatory diseases and conditions
GB0912584D0 (en) *	2009-07-20	2009-08-26	Ucl Business Plc	Cyclosporin conjugates
WO2012009715A2 (en) *	2010-07-16	2012-01-19	S&T Global Inc.	Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US9573978B2 (en)	2010-08-12	2017-02-21	S&T Global, Inc.	Cyclosporin derivatives for the treatment and prevention of a viral infection
CA2814191A1 (en) *	2010-10-12	2012-04-19	Allergan, Inc.	Cyclosporin analogs
JP5805774B2 (ja)	2010-10-12	2015-11-10	アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ	シクロスポリンアナログ
US9890198B2 (en)	2010-12-03	2018-02-13	S&T Global Inc.	Cyclosporin derivatives and uses thereof
BR112013014890B1 (pt)	2010-12-15	2023-10-24	Contravir Pharmaceuticals, Inc	Composto análogo de moléculas pertencentes à família ciclosporina, composição farmacêutica compreendendo o mesmo, uso terapêutico ou profilático do referido composto e processos para a preparação dos mesmos
EP2705856A1 (de)	2012-09-07	2014-03-12	Deutsches Zentrum für Neurodegenerative Erkrankungen e.V.	Verbindungen zur Behandlung von neurodegenerativen Erkrankungen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0194972B1 (de) *	1985-03-11	1992-07-29	Sandoz Ag	Cyclosporine
US4814323A (en) *	1986-03-25	1989-03-21	Andrieu J M	Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
FI111730B (fi) *	1990-11-02	2003-09-15	Novartis Ag	Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi
PL324531A1 (en) *	1995-07-17	1998-06-08	Chem Ag C	Derivatives of cyclosporin effective against hiv virus

1996
- 1996-12-24 FR FR9615956A patent/FR2757522B1/fr not_active Expired - Fee Related
1997
- 1997-12-19 MA MA24908A patent/MA26459A1/fr unknown
- 1997-12-23 PT PT97952998T patent/PT948527E/pt unknown
- 1997-12-23 AT AT97952998T patent/ATE218580T1/de active
- 1997-12-23 DK DK97952998T patent/DK0948527T3/da active
- 1997-12-23 US US08/996,699 patent/US5965527A/en not_active Expired - Fee Related
- 1997-12-23 JP JP52848998A patent/JP4172822B2/ja not_active Expired - Fee Related
- 1997-12-23 EP EP97952998A patent/EP0948527B1/de not_active Expired - Lifetime
- 1997-12-23 AU AU56692/98A patent/AU5669298A/en not_active Abandoned
- 1997-12-23 ZA ZA9711606A patent/ZA9711606B/xx unknown
- 1997-12-23 TN TNTNSN97211A patent/TNSN97211A1/fr unknown
- 1997-12-23 DE DE69713148T patent/DE69713148D1/de not_active Expired - Lifetime
- 1997-12-23 WO PCT/FR1997/002405 patent/WO1998028329A1/fr not_active Ceased
- 1997-12-23 ES ES97952998T patent/ES2178037T3/es not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2178037T3 (es)	2002-12-16
TNSN97211A1 (fr)	2005-03-15
US5965527A (en)	1999-10-12
DK0948527T3 (da)	2002-09-16
FR2757522A1 (fr)	1998-06-26
EP0948527A1 (de)	1999-10-13
JP2001507346A (ja)	2001-06-05
DE69713148D1 (de)	2002-07-11
MA26459A1 (fr)	2004-12-20
FR2757522B1 (fr)	1999-01-29
EP0948527B1 (de)	2002-06-05
PT948527E (pt)	2002-11-29
WO1998028329A1 (fr)	1998-07-02
JP4172822B2 (ja)	2008-10-29
ZA9711606B (en)	1998-06-25
AU5669298A (en)	1998-07-17

Publication	Publication Date	Title
ATE218580T1 (de)	2002-06-15	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
ATE218582T1 (de)	2002-06-15	Cyclosporinderivate, deren herstellung und pharmazeutische zusammensetzungen
DE69713151D1 (de)	2002-07-11	Cyclosporinderivat, dessen herstellung und pharmazeutische zusammensetzung
DE69829175D1 (de)	2005-04-07	Cyclosporinderivate, deren herstellung und pharmazeutische zubereitungen
BG103945A (bg)	2000-07-31	Производни на 4"-заместен-9-деоксо-9а-аза-9а- хомоеритромицин а
AP9801378A0 (en)	2000-04-29	9-amino-3- keto erythromycin derivatives.
ES2196331T3 (es)	2003-12-16	Derivados macrociclicos de cadena de 13 elementos de las eritromicinas a y b.
ATE165100T1 (de)	1998-05-15	Peptide mit endothelin antagonistischer aktivität, deren herstellung und pharmazeutische zusammensetzungen
RU95106362A (ru)	1996-12-27	Производные липопептида, способ их получения, содержащая их фармацевтическая композиция и способ ее получения
CA2286511A1 (en)	2000-04-09	Novel macrolide derivatives
GR3019274T3 (en)	1996-06-30	Substituted 3-piperazinylalkyl-2,3-dihydro-4H-1,3-benzoxazine-4-ones, their preparation and their therapeutical use
RU94040865A (ru)	1996-08-10	Производные пептида и их терапевтически приемлемые соли, способ их получения, фармацевтическая и косметическая композиция с антивирусной активностью
WO2001005386A3 (en)	2001-07-19	Pharmaceutical composition useful for the treatment of tinnitus and hearing loss
NO973401L (no)	1997-07-23	Kortikosteroidinneholdende sammensetninger og fremstilling derav
FI932654A0 (fi)	1993-06-10	Hydroxamsyraderivat, som hindrar lipoxigenas
BR0011845A (pt)	2002-03-05	Complexo farmacêutico
BR9902049A (pt)	2000-05-02	Derivados 9a,11b-desidro de 9-oxima-3-ceto-6-o-metileritromicina.
MX9605312A (es)	1998-02-28	Dipsipeptidos ciclicos antifungales.