ES2178037T3 - Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen. - Google Patents
Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen.Info
- Publication number
- ES2178037T3 ES2178037T3 ES97952998T ES97952998T ES2178037T3 ES 2178037 T3 ES2178037 T3 ES 2178037T3 ES 97952998 T ES97952998 T ES 97952998T ES 97952998 T ES97952998 T ES 97952998T ES 2178037 T3 ES2178037 T3 ES 2178037T3
- Authority
- ES
- Spain
- Prior art keywords
- contain
- preparation
- pharmaceutical compositions
- cyclosporine derivatives
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 229930105110 Cyclosporin A Natural products 0.000 abstract 1
- 108010036949 Cyclosporine Proteins 0.000 abstract 1
- 208000005074 Retroviridae Infections Diseases 0.000 abstract 1
- 229960001265 ciclosporin Drugs 0.000 abstract 1
- 229930182912 cyclosporin Natural products 0.000 abstract 1
- -1 cyclosporin compound Chemical class 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
DERIVADOS DE CICLOSPORINA CARACTERIZADOS PORQUE RESPONDEN A LA FORMULA GENERAL (I) EN LA QUE ALK ES ALQUILENO 2 A 6 C EN CADENA RECTA O RAMIFICADA O CICLOALQUILENO QUE CONTIENEN ENTRE 3 Y 6 C Y R ES O BIEN: COOH O ALQUILOXICARBONILO, O BIEN NR SUB,1 R 2 PARA LE CUAL R 1 Y R 2 IDENTICOS O DIFE RENTES SON H, O ALQUILO, ALCENILO (2 A 4 C), CICLOALQUILO (3 A 6 C), FENILO OPCIONALMENTE SUSTITUIDO (POR HALOGENO, ALQUILOXI, ALQUILOXICARBONILO, AMINO, ALQUILAMINO O DIALQUILAMINO), O SON RADICALES BENCILO O HETEROCICLO SATURADO O INSATURADO QUE CONTIENEN ENTRE 5 Y 6 ESLABONES Y ENTRE 1 Y 3 HETEROATOMOS, O PARA EL CUAL R 1 Y R 2 FORMAN CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS UN HETEROCICLO QUE CONTIENE ENTRE 4 Y 6 ESLABONES QUE PUEDEN CONTENER OTRO HETEROATOMO ELEGIDO ENTRE N, O O S Y OPCIONALMENTE SUSTITUIDO POR ALQUILO, FENILO O BENCILO, O BIEN UN RADICAL DE FORMULA GENERAL (I'') PARA EL CUAL R 1 Y R 2 SE DEFINEN COMO ANTERIORMENTE, R 3 Y H O AL QUILO Y N ES UN NUMERO ENTERO DE ENTRE 2 Y 4, SIENDO LAS PARTES O RADICALES ALQUILO DEFINIDOS ANTERIORMENTE RECTOS O RAMIFICADOS Y CONTENIENDO ENTRE 1 Y 4 C, ASI COMO SUS SALES FARMACEUTICAMENTE ACEPTABLES CUANDO EXISTEN. ESTOS NUEVOS PRODUCTOS SON DE UTILIDAD, SOBRE TODO, PARA EL TRATAMIENTO Y/O LA PROFILAXIS DE LAS INFECCIONES CON RETROVIRUS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9615956A FR2757522B1 (fr) | 1996-12-24 | 1996-12-24 | Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2178037T3 true ES2178037T3 (es) | 2002-12-16 |
Family
ID=9499089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97952998T Expired - Lifetime ES2178037T3 (es) | 1996-12-24 | 1997-12-23 | Derivados de ciclosporina, su preparacion y las composiciones farmaceuticas que los contienen. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5965527A (es) |
| EP (1) | EP0948527B1 (es) |
| JP (1) | JP4172822B2 (es) |
| AT (1) | ATE218580T1 (es) |
| AU (1) | AU5669298A (es) |
| DE (1) | DE69713148D1 (es) |
| DK (1) | DK0948527T3 (es) |
| ES (1) | ES2178037T3 (es) |
| FR (1) | FR2757522B1 (es) |
| MA (1) | MA26459A1 (es) |
| PT (1) | PT948527E (es) |
| TN (1) | TNSN97211A1 (es) |
| WO (1) | WO1998028329A1 (es) |
| ZA (1) | ZA9711606B (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| ATE254630T1 (de) * | 1998-06-12 | 2003-12-15 | Chem Ag C | Cyclosporine |
| PT1091975E (pt) | 1998-07-01 | 2006-05-31 | Debiopharm Sa | Nova ciclosporina com um perfil de actividade melhorado |
| US6254860B1 (en) * | 1999-04-13 | 2001-07-03 | Allergan Sales, Inc. | Ocular treatment using cyclosporin-A derivatives |
| HRP20070058B1 (hr) | 2001-10-19 | 2014-05-23 | Isotechnika Inc. | Sinteza ciklosporinskih analoga |
| EP1435910B9 (en) * | 2001-10-19 | 2010-02-03 | Isotechnika Inc. | Novel cyclosporin analog microemulsion preconcentrates |
| US6987090B2 (en) * | 2002-05-09 | 2006-01-17 | Lg Household & Health Care Ltd. | Use of 3-position cyclosporin derivatives for hair growth |
| KR20040039622A (ko) * | 2002-11-04 | 2004-05-12 | 주식회사 엘지생활건강 | 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제 |
| CA2518265A1 (en) | 2003-03-17 | 2004-09-30 | Albany Molecular Research, Inc. | Novel cyclosporins |
| GB0320638D0 (en) | 2003-09-03 | 2003-10-01 | Novartis Ag | Organic compounds |
| US7378391B2 (en) | 2004-09-29 | 2008-05-27 | Amr Technology, Inc. | Cyclosporin alkyne analogues and their pharmaceutical uses |
| JP2008514702A (ja) | 2004-09-29 | 2008-05-08 | エーエムアール テクノロジー インコーポレイテッド | 新規シクロスポリン類似体およびそれらの薬学的使用 |
| PT1802650E (pt) * | 2004-10-01 | 2011-12-30 | Scynexis Inc | Derivados da ciclosporina 3-éter e 3-tioéter substituída para o tratamento e prevenção da infecção de hepatite c |
| ATE490778T1 (de) * | 2004-10-01 | 2010-12-15 | Debiopharm Sa | Verwendung von äd-mealaü3-äetvalü4-ciclosporin zur behandlung von hepatitis-c-infektion |
| US7196161B2 (en) * | 2004-10-01 | 2007-03-27 | Scynexis Inc. | 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection |
| WO2006041631A2 (en) | 2004-10-06 | 2006-04-20 | Amr Technology, Inc. | Novel cyclosporin alkynes and their utility as pharmaceutical agents |
| WO2006071619A1 (en) * | 2004-12-23 | 2006-07-06 | Novartis Ag | Compositions for hcv treatment |
| NZ555142A (en) * | 2004-12-23 | 2010-03-26 | Novartis Ag | Compounds for flaviviridae treatment |
| WO2007041631A1 (en) | 2005-09-30 | 2007-04-12 | Scynexis, Inc. | ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION |
| WO2007041632A2 (en) | 2005-09-30 | 2007-04-12 | Scynexis, Inc. | Methods and pharmaceutical compositions for the treatment and prevention of hepatitis c infection |
| US7696165B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders |
| US7696166B2 (en) | 2006-03-28 | 2010-04-13 | Albany Molecular Research, Inc. | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders |
| CA2652662C (en) | 2006-05-19 | 2015-11-03 | Scynexis, Inc. | Methods for the treatment and prevention of ocular disorders |
| KR101089112B1 (ko) * | 2006-06-02 | 2011-12-06 | 피씨 제스띠옹 에스.아.에스. | 활성 전자 관리 |
| KR20090083902A (ko) * | 2006-10-12 | 2009-08-04 | 노파르티스 아게 | 개질된 사이클로스포린의 용도 |
| WO2008069917A2 (en) | 2006-11-20 | 2008-06-12 | Scynexis, Inc. | Novel cyclic peptides |
| WO2008127613A1 (en) * | 2007-04-11 | 2008-10-23 | Scynexis, Inc. | New pharmaceutical compositions |
| US8394763B2 (en) | 2007-09-26 | 2013-03-12 | Oregon Health & Science University | Cyclic undecapeptides and derivatives as multiple sclerosis therapies |
| JP5820722B2 (ja) | 2008-06-06 | 2015-11-24 | スシネキス インク | シクロスポリン類似体及びｈｃｖ感染の治療におけるその使用 |
| US20090306033A1 (en) * | 2008-06-06 | 2009-12-10 | Keqiang Li | Novel cyclic peptides |
| US8716238B2 (en) * | 2008-07-10 | 2014-05-06 | Allergan, Inc. | Cyclosporin derivatives for treating ocular and dermal diseases and conditions |
| DE102008060549A1 (de) | 2008-12-04 | 2010-06-10 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung |
| US8536114B2 (en) | 2008-12-31 | 2013-09-17 | Scynexis, Inc. | Macrocycles |
| JP2012528163A (ja) * | 2009-05-27 | 2012-11-12 | アラーガン、インコーポレイテッド | 炎症性疾患および状態を処置するためのシクロスポリン誘導体 |
| GB0912584D0 (en) * | 2009-07-20 | 2009-08-26 | Ucl Business Plc | Cyclosporin conjugates |
| US9217015B2 (en) * | 2010-07-16 | 2015-12-22 | S&T Global Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
| CN103153330B (zh) * | 2010-08-12 | 2017-08-18 | 美国科技环球有限公司 | 新的环孢霉素衍生物在病毒感染的治疗和预防中的应用 |
| AU2011316690C1 (en) | 2010-10-12 | 2017-01-19 | Allergan, Inc. | Cyclosporin analogs |
| EP2627663B1 (en) * | 2010-10-12 | 2018-02-21 | Allergan, Inc. | Cyclosporin analogs |
| US9890198B2 (en) | 2010-12-03 | 2018-02-13 | S&T Global Inc. | Cyclosporin derivatives and uses thereof |
| AU2011342284C1 (en) | 2010-12-15 | 2017-07-13 | Contravir Pharmaceuticals, Inc. | Cyclosporine analogue molecules modified at amino acid 1 and 3 |
| EP2705856A1 (en) | 2012-09-07 | 2014-03-12 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. | Compounds for the treatment of neurodegenerative disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0194972B1 (en) * | 1985-03-11 | 1992-07-29 | Sandoz Ag | Novel cyclosporins |
| US4814323A (en) * | 1986-03-25 | 1989-03-21 | Andrieu J M | Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus |
| FI111730B (fi) * | 1990-11-02 | 2003-09-15 | Novartis Ag | Menetelmä ei-immunosuppressiivisen syklosporiinin valmistamiseksi |
| CN1141317C (zh) * | 1995-07-17 | 2004-03-10 | 碳化学公司 | 有抗人体免疫缺损病毒作用的环孢菌素衍生物 |
-
1996
- 1996-12-24 FR FR9615956A patent/FR2757522B1/fr not_active Expired - Fee Related
-
1997
- 1997-12-19 MA MA24908A patent/MA26459A1/fr unknown
- 1997-12-23 EP EP97952998A patent/EP0948527B1/fr not_active Expired - Lifetime
- 1997-12-23 US US08/996,699 patent/US5965527A/en not_active Expired - Fee Related
- 1997-12-23 TN TNTNSN97211A patent/TNSN97211A1/fr unknown
- 1997-12-23 ES ES97952998T patent/ES2178037T3/es not_active Expired - Lifetime
- 1997-12-23 AT AT97952998T patent/ATE218580T1/de active
- 1997-12-23 DE DE69713148T patent/DE69713148D1/de not_active Expired - Lifetime
- 1997-12-23 WO PCT/FR1997/002405 patent/WO1998028329A1/fr not_active Ceased
- 1997-12-23 ZA ZA9711606A patent/ZA9711606B/xx unknown
- 1997-12-23 PT PT97952998T patent/PT948527E/pt unknown
- 1997-12-23 DK DK97952998T patent/DK0948527T3/da active
- 1997-12-23 JP JP52848998A patent/JP4172822B2/ja not_active Expired - Fee Related
- 1997-12-23 AU AU56692/98A patent/AU5669298A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK0948527T3 (da) | 2002-09-16 |
| US5965527A (en) | 1999-10-12 |
| DE69713148D1 (de) | 2002-07-11 |
| ATE218580T1 (de) | 2002-06-15 |
| AU5669298A (en) | 1998-07-17 |
| FR2757522A1 (fr) | 1998-06-26 |
| JP2001507346A (ja) | 2001-06-05 |
| JP4172822B2 (ja) | 2008-10-29 |
| EP0948527A1 (fr) | 1999-10-13 |
| MA26459A1 (fr) | 2004-12-20 |
| EP0948527B1 (fr) | 2002-06-05 |
| FR2757522B1 (fr) | 1999-01-29 |
| TNSN97211A1 (fr) | 2005-03-15 |
| WO1998028329A1 (fr) | 1998-07-02 |
| ZA9711606B (en) | 1998-06-25 |
| PT948527E (pt) | 2002-11-29 |
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