ATE219078T1 - Cyclische piperidinylaminomethyl-trifluoromethyl- etherderivate als substanz p-antagonisten - Google Patents

Cyclische piperidinylaminomethyl-trifluoromethyl- etherderivate als substanz p-antagonisten

Info

Publication number
ATE219078T1
ATE219078T1 AT98947726T AT98947726T ATE219078T1 AT E219078 T1 ATE219078 T1 AT E219078T1 AT 98947726 T AT98947726 T AT 98947726T AT 98947726 T AT98947726 T AT 98947726T AT E219078 T1 ATE219078 T1 AT E219078T1
Authority
AT
Austria
Prior art keywords
piperidinylaminomethyl
antagonists
cyclic
substance
ether derivatives
Prior art date
Application number
AT98947726T
Other languages
English (en)
Inventor
Kunio Satake
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE219078T1 publication Critical patent/ATE219078T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98947726T 1997-11-19 1998-10-26 Cyclische piperidinylaminomethyl-trifluoromethyl- etherderivate als substanz p-antagonisten ATE219078T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IB9701466 1997-11-19
PCT/IB1998/001704 WO1999025714A1 (en) 1997-11-19 1998-10-26 Piperidinylaminomethyl trifluoromethyl cyclic ether compounds as substance p antagonists

Publications (1)

Publication Number Publication Date
ATE219078T1 true ATE219078T1 (de) 2002-06-15

Family

ID=11004634

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98947726T ATE219078T1 (de) 1997-11-19 1998-10-26 Cyclische piperidinylaminomethyl-trifluoromethyl- etherderivate als substanz p-antagonisten

Country Status (39)

Country Link
US (2) US20030208079A1 (de)
EP (1) EP1032571B1 (de)
JP (2) JP3394239B2 (de)
KR (1) KR100366902B1 (de)
CN (1) CN1173974C (de)
AP (1) AP909A (de)
AR (1) AR016422A1 (de)
AT (1) ATE219078T1 (de)
AU (1) AU734218B2 (de)
BG (1) BG63969B1 (de)
CA (1) CA2310627C (de)
CO (1) CO4771153A1 (de)
CZ (1) CZ297315B6 (de)
DE (1) DE69806045T2 (de)
DK (1) DK1032571T3 (de)
DZ (1) DZ2655A1 (de)
EA (1) EA002621B1 (de)
ES (1) ES2177058T3 (de)
HR (1) HRP20000313B1 (de)
HU (1) HUP0101112A3 (de)
ID (1) ID24240A (de)
IL (1) IL135631A0 (de)
IS (1) IS2202B (de)
MA (1) MA26567A1 (de)
MY (1) MY120558A (de)
NO (2) NO20002544L (de)
NZ (1) NZ503912A (de)
OA (1) OA11380A (de)
PA (1) PA8463001A1 (de)
PE (1) PE20000021A1 (de)
PL (1) PL193484B1 (de)
PT (1) PT1032571E (de)
RS (1) RS49792B (de)
SK (1) SK283460B6 (de)
TN (1) TNSN98210A1 (de)
TR (1) TR200001463T2 (de)
TW (1) TW426667B (de)
UA (1) UA59417C2 (de)
WO (1) WO1999025714A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9812662D0 (en) * 1998-06-11 1998-08-12 Merck Sharp & Dohme Therapeutic use
GB9812617D0 (en) * 1998-06-11 1998-08-12 Merck Sharp & Dohme Therapeutic use
IL145945A0 (en) * 1999-05-06 2002-07-25 Pfizer Prod Inc Substituted benzolactam compounds
RS49964B (sr) 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
IL145949A0 (en) * 1999-05-21 2002-07-25 Pfizer Prod Inc 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
AU7557000A (en) * 1999-10-07 2001-05-10 Hisamitsu Pharmaceutical Co. Inc. Piperidine derivatives
PT1095939E (pt) * 1999-10-18 2004-04-30 Pfizer Prod Inc Processo para a preparacao de eteres ciclicos de compostos com piperidinilaminometilo
CA2324116A1 (en) * 1999-10-25 2001-04-25 Susan Beth Sobolov-Jaynes Nk-1 receptor antagonists and eletriptan for the treatment of migraine
IL142810A0 (en) * 2000-05-03 2002-03-10 Pfizer Prod Inc Pharmaceutical uses for fluoroalkoxybenzylamino derivatives of nitrogen containing heterocycles
US20020049211A1 (en) * 2000-09-06 2002-04-25 Sobolov-Jaynes Susan Beth Combination treatment for depression and anxiety
EP1192952A3 (de) * 2000-09-28 2003-03-26 Pfizer Products Inc. Ein NK-3 rezeptorantagonisten und ein ZNS-penetrierende NK-1 rezeptorantagonisten enthaltende Zusammensetzung zur Behandlung von Depression und Angst
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
JP2004525109A (ja) 2001-02-15 2004-08-19 キング・ファーマシューティカルズ・インコーポレイティッド 安定化された甲状腺ホルモン医薬組成物、及びその製法
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
ATE332897T1 (de) 2001-08-30 2006-08-15 Pfizer Prod Inc Verfahren zur herstellung von 2-(4-alkyl-1- piperazinyl)-benzaldehyd und -benzylidenyl- derivaten durch nucleophile substitution von 2- fluorobenzaldehyd mit 4-alkyl-1-piperazinen in wasser als lösungsmittel
US20040001895A1 (en) * 2002-06-17 2004-01-01 Pfizer Inc. Combination treatment for depression and anxiety
WO2004019865A2 (en) * 2002-08-27 2004-03-11 Witten Mark L Amelioration of effects of cigarette smoke
US6911544B2 (en) * 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
US7122700B2 (en) 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes
DE102008000891A1 (de) 2008-03-31 2009-10-01 Robert Bosch Gmbh Schutzsystem für Werkzeugmaschinen
WO2013004766A1 (en) 2011-07-04 2013-01-10 Ferrari Giulio Nk-1 receptor antagonists for treating corneal neovascularisation
RU2020131446A (ru) 2018-02-26 2022-03-28 Оспедале Сан Раффаэле С.Р.Л. Антагонисты nk-1 для применения в лечении глазной боли
EP4117673A1 (de) 2020-03-11 2023-01-18 Ospedale San Raffaele S.r.l. Behandlung von stammzellenmangel

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9317987D0 (en) * 1993-08-26 1993-10-13 Glaxo Group Ltd Chemical compounds
DE69617226T2 (de) * 1995-03-27 2002-07-25 Hisamitsu Pharmaceutical Co., Inc. Piperidinderivate.
RU2156250C2 (ru) * 1995-04-24 2000-09-20 Новартис Аг Производные хромона, способ их получения и фармацевтическая композиция
JP3042894B2 (ja) * 1995-07-07 2000-05-22 ファイザー製薬株式会社 サブスタンスｐアンタゴニストとしての置換ベンゾラクタム化合物
TW340842B (en) * 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds
US6329396B1 (en) * 1996-06-10 2001-12-11 Pfizer Inc. Substituted benzylaminopiperidine compounds
IL145949A0 (en) * 1999-05-21 2002-07-25 Pfizer Prod Inc 1-trifluoromethyl-4-hydroxy-7-piperidinyl-aminomethylchroman derivatives
PT1095939E (pt) * 1999-10-18 2004-04-30 Pfizer Prod Inc Processo para a preparacao de eteres ciclicos de compostos com piperidinilaminometilo

Also Published As

Publication number Publication date
SK7232000A3 (en) 2001-09-11
IS5470A (is) 2000-04-26
AR016422A1 (es) 2001-07-04
CZ20001834A3 (cs) 2001-07-11
IS2202B (is) 2007-02-15
NZ503912A (en) 2002-09-27
ES2177058T3 (es) 2002-12-01
NO20042879L (no) 2000-07-17
JP3394239B2 (ja) 2003-04-07
DE69806045T2 (de) 2002-11-14
CN1279681A (zh) 2001-01-10
AP9801402A0 (en) 1998-12-31
DK1032571T3 (da) 2002-07-15
IL135631A0 (en) 2001-05-20
DZ2655A1 (fr) 2003-03-22
CN1173974C (zh) 2004-11-03
PT1032571E (pt) 2002-09-30
OA11380A (en) 2004-01-27
JP2001523680A (ja) 2001-11-27
HUP0101112A3 (en) 2002-06-28
CZ297315B6 (cs) 2006-11-15
PL193484B1 (pl) 2007-02-28
EP1032571B1 (de) 2002-06-12
WO1999025714A1 (en) 1999-05-27
HK1033313A1 (en) 2001-08-24
CA2310627C (en) 2005-08-09
YU29400A (sh) 2003-02-28
TNSN98210A1 (fr) 2005-03-15
HRP20000313A2 (en) 2000-12-31
ID24240A (id) 2000-07-13
KR100366902B1 (ko) 2003-01-09
NO20002544D0 (no) 2000-05-18
JP2003040777A (ja) 2003-02-13
MA26567A1 (fr) 2004-12-20
HRP20000313B1 (en) 2002-04-30
EA002621B1 (ru) 2002-06-27
AU734218B2 (en) 2001-06-07
TW426667B (en) 2001-03-21
SK283460B6 (sk) 2003-08-05
RS49792B (sr) 2008-06-05
AP909A (en) 2000-12-04
UA59417C2 (uk) 2003-09-15
PE20000021A1 (es) 2000-02-25
US20050171354A1 (en) 2005-08-04
HUP0101112A2 (hu) 2002-05-29
MY120558A (en) 2005-11-30
CA2310627A1 (en) 1999-05-27
AU9454998A (en) 1999-06-07
BG63969B1 (bg) 2003-08-29
CO4771153A1 (es) 1999-04-30
BG104437A (en) 2001-02-28
EP1032571A1 (de) 2000-09-06
US20030208079A1 (en) 2003-11-06
TR200001463T2 (tr) 2000-12-21
EA200000432A1 (ru) 2000-12-25
NO20002544L (no) 2000-07-17
PA8463001A1 (es) 2000-09-29
DE69806045D1 (en) 2002-07-18
PL340642A1 (en) 2001-02-12

Similar Documents

Publication Publication Date Title
PT950059E (pt) Derivados de sulfona ciclicos
BR9913811B1 (pt) amostrador de cosmÉtico de dose unitÁria
DE69930518D1 (de) Als antikrebsmittel verwendbare alkinyl-substituierte chinolin-2-on-derivate
ATE284389T1 (de) Zyklische n-acylamin-derivate
DE69905038D1 (de) Cyclische boroprolinverbindungen
FI974338A0 (fi) Serviceprofiler foer en abonnent i ett telekommunikationssystem
FI973772A0 (fi) Riktad allmaen saendning i ett radionaet
DE69827328D1 (de) Vormontierte Spritze
DE69712331D1 (de) Pyrimidin-4-on derivate als pestizidesmittel
PT884053E (pt) Formulacoes de insulina estaveis
ATE235220T1 (de) Resorcinderivate
ATE260243T1 (de) N-aroylphenylalaninderivate
ATE485823T1 (de) Kombinationspräparate enthaltend (e)-7-ä4-(4- fluorophenyl)-6-isopropyl-2-
DE69817186D1 (de) Diaminorhodamin-derivate
DE59813899D1 (de) Piperazin-derivate
FI973595A0 (fi) Telefonsamtals dirigering i ett radiosystem
DK1032571T3 (da) Cykliske peridinylaminomethyl-triflourmethyl-ether-forbindelser som substans P-antagonister
IS5536A (is) Efnablanda fyrir snyrtivörur
DE69806141D1 (de) Indazoleamid-verbindungen als serotoninergene mittel
DE59813430D1 (de) Perylenhydrazidimide als Carbonylderivatisierungsreagenzien
ATE255098T1 (de) Substituierte chromanderivate
ATE440854T1 (de) 5-deoxy-cytidin-derivate
ATE255099T1 (de) Substituierte chromanderivate
NO20002966L (no) Statin-karboksyalkyleter kombinasjoner
DE60003072D1 (de) Thiazolidindion-derivate als antidiabetika

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee