ATE219681T1 - Behandlung von krebs durch verwendung von hsv- mutanten - Google Patents

Behandlung von krebs durch verwendung von hsv- mutanten

Info

Publication number
ATE219681T1
ATE219681T1 AT95927034T AT95927034T ATE219681T1 AT E219681 T1 ATE219681 T1 AT E219681T1 AT 95927034 T AT95927034 T AT 95927034T AT 95927034 T AT95927034 T AT 95927034T AT E219681 T1 ATE219681 T1 AT E219681T1
Authority
AT
Austria
Prior art keywords
treating cancer
mutant
gamma
gene
hsv mutants
Prior art date
Application number
AT95927034T
Other languages
English (en)
Inventor
Alasdair Roderick Maclean
Susanne Moira Brown
Nigel William Fraser
Bruce Paul Randazzo
Original Assignee
Univ Glasgow
Wistar Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10759079&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE219681(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Glasgow, Wistar Inst filed Critical Univ Glasgow
Application granted granted Critical
Publication of ATE219681T1 publication Critical patent/ATE219681T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/763—Herpes virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16621—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16632—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT95927034T 1994-07-29 1995-07-28 Behandlung von krebs durch verwendung von hsv- mutanten ATE219681T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9415320A GB9415320D0 (en) 1994-07-29 1994-07-29 Cancer treatment
PCT/GB1995/001791 WO1996003997A2 (en) 1994-07-29 1995-07-28 Treatment of cancer using hsv mutant

Publications (1)

Publication Number Publication Date
ATE219681T1 true ATE219681T1 (de) 2002-07-15

Family

ID=10759079

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95927034T ATE219681T1 (de) 1994-07-29 1995-07-28 Behandlung von krebs durch verwendung von hsv- mutanten

Country Status (12)

Country Link
US (3) US7674468B2 (de)
EP (2) EP0773785B1 (de)
JP (2) JP4321723B2 (de)
AT (1) ATE219681T1 (de)
AU (1) AU3119995A (de)
CA (1) CA2196315C (de)
DE (1) DE69527204T2 (de)
DK (1) DK0773785T3 (de)
ES (1) ES2179880T3 (de)
GB (1) GB9415320D0 (de)
PT (1) PT773785E (de)
WO (1) WO1996003997A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9415320D0 (en) 1994-07-29 1994-09-21 Medical Res Council Cancer treatment
ZA966287B (en) * 1995-07-27 1998-03-09 American Cyanamid Co Avirulent herpetic viruses useful as tumoricidal agents and vaccines.
ATE241994T1 (de) * 1996-01-25 2003-06-15 Univ Glasgow Hsv-mutant-1716 zur behandlung von mesotheliomen
US5824318A (en) * 1996-07-24 1998-10-20 American Cyanamid Company Avirulent herpetic viruses useful as tumoricidal agents and vaccines
GB9615794D0 (en) 1996-07-26 1996-09-04 Medical Res Council Mutant herpes simplex virus strains and uses thereof
US7780962B2 (en) 1997-10-09 2010-08-24 Wellstat Biologics Corporation Treatment of neoplasms with RNA viruses
US7470426B1 (en) 1997-10-09 2008-12-30 Wellstat Biologics Corporation Treatment of neoplasms with viruses
US20030044384A1 (en) 1997-10-09 2003-03-06 Pro-Virus, Inc. Treatment of neoplasms with viruses
IL145899A0 (en) 1999-04-15 2002-07-25 Pro Virus Inc Treatment of neoplasms with viruses
US6897057B1 (en) 1999-08-31 2005-05-24 The General Hospital Corporation Cell-specific and/or tumor-specific promoter retargeting of herpes γ 34.5 gene expression
PT1212428E (pt) * 1999-08-31 2005-03-31 Gen Hospital Corp Redireccionamento da expressao do gene gama 34.5 de herpes atraves de um promotor especifico de celulas e/ou especifico de tumores
US8147822B1 (en) 1999-09-17 2012-04-03 Wellstat Biologics Corporation Oncolytic virus
IL148621A0 (en) 1999-09-17 2002-09-12 Pro Virus Inc Oncolytic virus
EP1381280B1 (de) 2001-03-27 2011-05-11 Catherex, Inc. Virusvektoren und ihre verwendung bei therapeutischen methoden
GB0203285D0 (en) 2002-02-12 2002-03-27 Brown Susanne M An herpes simplex virus complex
JP2004099584A (ja) * 2002-05-02 2004-04-02 Keio Gijuku Ｈｓｖを用いた抗腫瘍剤
JP4800924B2 (ja) 2003-03-07 2011-10-26 ロバーツ リサーチ インスティテュート 癌および慢性ウイルス感染の治療処置のための粘液腫症ウイルスの使用
JP2007524363A (ja) 2003-03-27 2007-08-30 オタワ ヘルス リサーチ インスティチュート 変異体水疱性口内炎ウイルスおよびそれらの使用
US7731974B2 (en) 2003-03-27 2010-06-08 Ottawa Hospital Research Institute Mutant vesicular stomatitis viruses and uses thereof
US7897146B2 (en) 2003-11-17 2011-03-01 Crusade Laboratories Limited Treatment using herpes simplex virus
US20070003520A1 (en) 2003-11-17 2007-01-04 Brown Susanne M Mutant viruses
US20090035276A1 (en) 2005-03-07 2009-02-05 Robarts Research Institute Use of a combination of myxoma virus and rapamycin for therapeutic treatment
WO2009016433A2 (en) 2006-09-15 2009-02-05 Ottawa Health Research Institute Oncolytic rhabdovirus
AU2016403583B2 (en) * 2016-04-22 2020-05-28 Immvira Co., Limited Construction of oncolytic herpes simplex viruses (oHSV) obligate vector and constructs for cancer therapy
WO2022048631A1 (zh) * 2020-09-04 2022-03-10 上海翊石医药科技有限公司 一种具有抗肿瘤活性的化合物及其用途

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859587A (en) 1984-06-04 1989-08-22 Institut Merieux Recombinant herpes simplex viruses, vaccines and methods
US5328688A (en) 1990-09-10 1994-07-12 Arch Development Corporation Recombinant herpes simplex viruses vaccines and methods
CA2051289C (en) 1990-09-14 2002-11-26 Robert L. Martuza Viral mediated destruction of neoplastic cells
GB9102126D0 (en) * 1991-01-31 1991-03-13 Smithkline Beecham Biolog Novel vaccine
JP3974167B2 (ja) 1992-03-31 2007-09-12 アーチ デベロプメント コーポレイション 遺伝子，腫瘍及びウイルス感染の治療，並びにプログラムされた細胞死（アポプトーシス）を予防するための方法及び組成物
US6139834A (en) 1994-06-23 2000-10-31 Georgetown University Replication-competent Herpes simplex virus mediates destruction of neplastic cells
US5728379A (en) 1994-06-23 1998-03-17 Georgetown University Tumor- or cell-specific herpes simplex virus replication
US5585096A (en) * 1994-06-23 1996-12-17 Georgetown University Replication-competent herpes simplex virus mediates destruction of neoplastic cells
GB9415320D0 (en) 1994-07-29 1994-09-21 Medical Res Council Cancer treatment
JPH11513390A (ja) 1995-10-06 1999-11-16 アーチ デベロップメント コーポレイション 細胞殺傷のウイルス増強のための方法および組成物
ATE241994T1 (de) * 1996-01-25 2003-06-15 Univ Glasgow Hsv-mutant-1716 zur behandlung von mesotheliomen
GB0203285D0 (en) 2002-02-12 2002-03-27 Brown Susanne M An herpes simplex virus complex
GB0326798D0 (en) 2003-11-17 2003-12-24 Crusade Lab Ltd Methods for generating mutant virus
US20070003520A1 (en) 2003-11-17 2007-01-04 Brown Susanne M Mutant viruses
WO2007026146A1 (en) 2005-08-30 2007-03-08 Crusade Laboratories Limited Treatment using herpes simplex virus
US9085777B2 (en) 2006-05-11 2015-07-21 Virttu Biologics Limited Mutant HSV, materials and methods for generation of mutant HSV
GB2446721B (en) 2007-02-16 2009-03-25 Crusade Lab Ltd Herpes simplex viruses and methods of viral replication
GB0714578D0 (en) 2007-07-26 2007-09-05 Crusade Lab Ltd Viruses

Also Published As

Publication number Publication date
EP0773785A2 (de) 1997-05-21
CA2196315A1 (en) 1996-02-15
US20120141418A1 (en) 2012-06-07
JP4321723B2 (ja) 2009-08-26
US20050260169A1 (en) 2005-11-24
DE69527204D1 (de) 2002-08-01
EP1192948A2 (de) 2002-04-03
WO1996003997A2 (en) 1996-02-15
DK0773785T3 (da) 2002-10-07
EP1192948A3 (de) 2002-09-04
US20100172872A1 (en) 2010-07-08
GB9415320D0 (en) 1994-09-21
AU3119995A (en) 1996-03-04
WO1996003997A3 (en) 1996-05-02
US7674468B2 (en) 2010-03-09
JP2008037869A (ja) 2008-02-21
CA2196315C (en) 2010-02-09
JPH10503766A (ja) 1998-04-07
EP0773785B1 (de) 2002-06-26
PT773785E (pt) 2002-11-29
US8067012B2 (en) 2011-11-29
DE69527204T2 (de) 2003-02-20
ES2179880T3 (es) 2003-02-01

Similar Documents

Publication Publication Date Title
DE69527204D1 (de) Behandlung von krebs durch verwendung von hsv-mutanten
TR199701545T1 (xx) Yeni dolastatin t�revleri,haz�rlanmalar� ve kullan�mlar�
FI853622A0 (fi) Diarylacetylener, deras framstaellning och anvaendning.
EP0290133A3 (de) Ternar-Photoinitiatorsystem für Additionspolymerisation
DK0555370T3 (da) Metoder og anvendelser for effektive, genetiske suppressorelementer
SE9103183L (sv) Virus-antikroppskomplex
AU1550797A (en) Treatment of non-neuronal cancer using hsv mutant
DE69731756D1 (de) Melanomzellinien, welche immundominante melanomantigene teilen und verfahren zu deren anwendung
DK0642530T3 (da) Dolastatinderivater
EP0389428A3 (de) N,N-Bis(1-hydroxycarbyloxy-2,2,6,6-tetramethyl-piperidin-4-yl) aminotriazine und damit stabilisierte Mischungen
GR75124B (de)
HUT70218A (en) Process for the manufacture of (s)-3-amino-1-substituted-pyrrolidines
ATE187722T1 (de) Cycloaliphatische acryloyl-monomere
FI98987B (fi) Varjoainekoostumus
ATE41940T1 (de) Wasserloesliche copolymerisate und deren verwendung als baustoffhilfsmittel.
DE3689853D1 (de) Verwendung von Gyrasehemmern zur Dekontamination von Mycoplasma-infizierten Zellkulturen.
FI882444A0 (fi) Substituerade vinylkefalosporiner, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
ES2053686T3 (es) Nuevos di(met)acrilatos, procedimiento para su fabricacion y su empleo.
DE59000772D1 (de) Seitenstaendige carbazolyl-gruppen enthaltende methacrylat-(co)polymerisate und elektrophotographische aufzeichnungselemente, enthaltend dieselben.
DE59104376D1 (de) Montageelement.
ATE34987T1 (de) Neue antibiotika, verfahren zu ihrer herstellung, ihre verwendung als arzneimittel und zwischenprodukte zu ihrer herstellung.
ZA818683B (en) Trifluoromethoxyphenyl-(di)thiophosphoric acid esters and their use in pest control
Yi Negative effect of nepotism on the development of Korean society and an exploration of an alternative
BR8304780A (pt) Mistura fotopolimerizavel e 1,3-diaza-9-tia-antracen-2,4-dionas
Lee RIT Scholar Work s

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification