ATE220067T1 - 4-(2-amino-6-(cyclopropylamino)-9h-pyrin-9-yl)- - cyclopenten-1-methanol-succinat als antivirales mittel - Google Patents

4-(2-amino-6-(cyclopropylamino)-9h-pyrin-9-yl)- - cyclopenten-1-methanol-succinat als antivirales mittel

Info

Publication number
ATE220067T1
ATE220067T1 AT95929954T AT95929954T ATE220067T1 AT E220067 T1 ATE220067 T1 AT E220067T1 AT 95929954 T AT95929954 T AT 95929954T AT 95929954 T AT95929954 T AT 95929954T AT E220067 T1 ATE220067 T1 AT E220067T1
Authority
AT
Austria
Prior art keywords
cyclopropylamino
amino
pyrine
cyclopent
antiviral agent
Prior art date
Application number
AT95929954T
Other languages
English (en)
Inventor
Susan Mary Daluge
Jeffrey Douglas Wilson
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Application granted granted Critical
Publication of ATE220067T1 publication Critical patent/ATE220067T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Seasonings (AREA)
AT95929954T 1994-08-26 1995-08-25 4-(2-amino-6-(cyclopropylamino)-9h-pyrin-9-yl)- - cyclopenten-1-methanol-succinat als antivirales mittel ATE220067T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9417249A GB9417249D0 (en) 1994-08-26 1994-08-26 A novel salt
PCT/GB1995/002014 WO1996006844A1 (en) 1994-08-26 1995-08-25 4-(2-amino-6-(cyclopropylamino)-9h-purin-9-yl)-2-cyclopentene-1-methanol succinate as antiviral agent

Publications (1)

Publication Number Publication Date
ATE220067T1 true ATE220067T1 (de) 2002-07-15

Family

ID=10760434

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95929954T ATE220067T1 (de) 1994-08-26 1995-08-25 4-(2-amino-6-(cyclopropylamino)-9h-pyrin-9-yl)- - cyclopenten-1-methanol-succinat als antivirales mittel

Country Status (23)

Country Link
EP (1) EP0777669B1 (de)
JP (1) JPH10505593A (de)
KR (1) KR100376240B1 (de)
CN (1) CN1051550C (de)
AT (1) ATE220067T1 (de)
AU (1) AU702618B2 (de)
BR (1) BR9508629A (de)
CA (1) CA2198010C (de)
DE (1) DE69527294T2 (de)
DK (1) DK0777669T3 (de)
ES (1) ES2179110T3 (de)
FI (1) FI120403B (de)
GB (1) GB9417249D0 (de)
HU (1) HU221302B1 (de)
IL (1) IL115074A (de)
MX (1) MX9701273A (de)
NO (1) NO315200B1 (de)
NZ (1) NZ291862A (de)
PT (1) PT777669E (de)
RU (1) RU2145324C1 (de)
SI (1) SI0777669T1 (de)
WO (1) WO1996006844A1 (de)
ZA (1) ZA957166B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY115461A (en) 1995-03-30 2003-06-30 Wellcome Found Synergistic combinations of zidovudine, 1592u89 and 3tc
EP1019056A1 (de) * 1997-05-17 2000-07-19 Glaxo Group Limited Antivirale kombinationen enthaltend das carbocyclische nucleosid 1592u89
BR9809127A (pt) * 1997-05-17 2000-08-01 Glaxo Group Ltd Combinação, formulação farmacêutica, processo para o tratamento de uma infecção por hiv em um animal infectado, uso de (-) -(1s,4r)-4-[2-amino-6-(ciclopropil amino)-9h-purin-9-il)-2-ciclopenteno-1-metanol, e, pacote de paciente
GB9709945D0 (en) * 1997-05-17 1997-07-09 Glaxo Group Ltd A novel salt
CZ298144B6 (cs) * 1997-11-27 2007-07-04 Lonza Ag Zpusob výroby (1S,4R)- nebo (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyklopenten-1-methanolu
GB9802472D0 (en) * 1998-02-06 1998-04-01 Glaxo Group Ltd Pharmaceutical compositions
GB9903091D0 (en) * 1999-02-12 1999-03-31 Glaxo Group Ltd Therapeutic nucleoside compound
GB9918035D0 (en) * 1999-07-30 1999-09-29 Novartis Ag Organic compounds
BR0109602A (pt) * 2000-03-30 2004-06-29 Bristol Myers Squibb Co Glóbulos de liberação controlada contendo estavudina
NZ524252A (en) * 2000-07-20 2004-03-26 Lauras As Cox-2 inhibitors for treating HIV and AIDS
US7462733B2 (en) 2001-07-30 2008-12-09 University Of Southern California Preparation and use of α-keto phosphonates
RU2242243C2 (ru) * 2001-09-27 2004-12-20 Вертелецкий Павел Васильевич Композиции и способы потенцирования терапевтических эффектов интерферонов
AU2004287416C1 (en) * 2003-10-27 2010-09-09 Merck Sharp & Dohme Corp. CCR-2 antagonist salt
EP1905772A1 (de) * 2006-09-28 2008-04-02 Esteve Quimica, S.A. Verfahren zur Herstellung von Abacavir
EP2305680A3 (de) 2009-09-30 2011-05-18 Aurobindo Pharma Limited Neuartige Salze von (1S,4R)-cis-4-[2-amino-6-(cyclopropylamin)-9H-purin-9-yl]-2-cyclopenten-1-methanol
CN103282369A (zh) 2011-04-08 2013-09-04 劳乐斯实验室私营有限公司 抗逆转录病毒化合物与抗氧化酸的固体形式、其制备方法以及其药物组合物
JP6391561B2 (ja) 2013-02-27 2018-09-19 国立大学法人京都大学 がんの予防または治療用医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3025492A1 (de) * 1980-07-04 1982-02-04 Siemens AG, 1000 Berlin und 8000 München Filterelement fuer die optische nachrichtentechnik
IE830186L (en) * 1982-02-01 1983-08-01 Syntex Inc Purines
US5003462A (en) * 1988-05-31 1991-03-26 International Business Machines Corporation Apparatus and method for implementing precise interrupts on a pipelined processor with multiple functional units with separate address translation interrupt means
GB8815265D0 (en) * 1988-06-27 1988-08-03 Wellcome Found Therapeutic nucleosides
MY104575A (en) * 1989-12-22 1994-04-30 The Wellcome Foundation Ltd Therapeutic nucleosides.
IL104283A (en) * 1992-12-30 1996-12-05 Agis Ind 1983 Ltd Non-emulsion antiviral topical pharmaceutical composition comprising acyclovir an aqueous gel agent and an alkali oleate

Also Published As

Publication number Publication date
KR970705563A (ko) 1997-10-09
DK0777669T3 (da) 2002-10-28
CA2198010A1 (en) 1996-03-07
NO315200B1 (no) 2003-07-28
SI0777669T1 (en) 2002-12-31
CN1051550C (zh) 2000-04-19
RU2145324C1 (ru) 2000-02-10
NO970847L (no) 1997-02-25
NO970847D0 (no) 1997-02-25
PT777669E (pt) 2002-11-29
CA2198010C (en) 2006-05-02
FI970786L (fi) 1997-02-25
FI120403B (fi) 2009-10-15
MX9701273A (es) 1997-05-31
WO1996006844A1 (en) 1996-03-07
ES2179110T3 (es) 2003-01-16
HU221302B1 (en) 2002-09-28
AU3350995A (en) 1996-03-22
CN1156456A (zh) 1997-08-06
FI970786A0 (fi) 1997-02-25
HUT77222A (hu) 1998-03-02
EP0777669A1 (de) 1997-06-11
GB9417249D0 (en) 1994-10-19
AU702618B2 (en) 1999-02-25
JPH10505593A (ja) 1998-06-02
ZA957166B (en) 1997-02-25
KR100376240B1 (ko) 2003-06-11
EP0777669B1 (de) 2002-07-03
IL115074A0 (en) 1995-12-08
NZ291862A (en) 1998-02-26
IL115074A (en) 1998-10-30
DE69527294T2 (de) 2003-02-13
DE69527294D1 (en) 2002-08-08
BR9508629A (pt) 1997-11-25

Similar Documents

Publication Publication Date Title
FI970786A0 (fi) 4-/2-amino-6-(syklopropyyliamino)-9H-purin-9-yyli)-2-syklopenteeni-1-metanoli-sukkinaatti viruksia torjuvana aineena
TW371660B (en) Therapeutic nucleosides a purine carbocyclic nucleosides for treatment of HIV and HBV infections
MD1224B2 (en) Application of nucleoside analogues with 1,3-oxathiolan for treatment of hepatitis B
WO1998056761A3 (en) Benzimidazole derivatives
MY117892A (en) Therapeutic compounds
FI20001231A7 (fi) 2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina
RU94002475A (ru) Фармацевтическая композиция и ее применение для лечения вирусных инфекций
MY104043A (en) Therapeutic nucleosides.
NO302574B1 (no) Indolkarbazolimider og deres anvendelse
DK602988A (da) Nukleosidderivater med antiviral virkning og laegemiddelpraeparat indeholdende saadanne forbindelser
UA29429C2 (uk) Фармацевтична композиція для лікування вірусних інфекцій, спосіб отримання композиції, спосіб лікування або профілактики віл-інфекції у людини
DE69323183D1 (de) Weitere indolderivate mit antiviraler wirkung
GEP20084377B (en) Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
HUP0002754A2 (hu) (1S,4R)-cisz-4-[2-amino-6-(ciklopropil-amino)-9H-purin-9-il]-2-ciklopentén-1-metanol-hemiszulfát, eljárás előállítására, ezt tartalmazó gyógyszerkészítmény, valamint intermedierek
MY105855A (en) Therapeutic nucleotides.
MY111746A (en) Therapeutic nucleosides.
GR3017335T3 (en) Oligophosphates with antiviral activity.
ATE189604T1 (de) Extrakte von piliostigma thonningii, deren verwendung und diese enthaltende zubereitungen
SU1565027A1 (ru) Инактиватор вируса западного нила

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification