DK0777669T3 - 4-[2-amino-6-(cyclopropylamino)-9H-purin-yl]-2-cyclopenten-1-methanolsuccinat som antiviralt middel - Google Patents

4-[2-amino-6-(cyclopropylamino)-9H-purin-yl]-2-cyclopenten-1-methanolsuccinat som antiviralt middel

Info

Publication number: DK0777669T3
Authority: DK; Denmark
Prior art keywords: purin; cyclopropylamino; amino; cyclopenten; antiviral agent
Prior art date: 1994-08-26

Application number

DK95929954T

Other languages

English (en)

Inventor

Susan Mary Daluge

Jeffrey Douglas Wilson

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-26

Filing date

1995-08-25

Publication date

2002-10-28

1995-08-25 Application filed by Wellcome Found filed Critical Wellcome Found

2002-10-28 Application granted granted Critical

2002-10-28 Publication of DK0777669T3 publication Critical patent/DK0777669T3/da

Links

BOONDNCXQPMXQT-UHFFFAOYSA-N [4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol;butanedioic acid Chemical compound OC(=O)CCC(O)=O.C=12N=CN(C3C=CC(CO)C3)C2=NC(N)=NC=1NC1CC1 BOONDNCXQPMXQT-UHFFFAOYSA-N 0.000 title 1
239000003443 antiviral agent Substances 0.000 title 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 2
239000008194 pharmaceutical composition Substances 0.000 abstract 2
241000700721 Hepatitis B virus Species 0.000 abstract 1
208000036142 Viral infection Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
238000013160 medical therapy Methods 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
150000003890 succinate salts Chemical class 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1
230000009385 viral infection Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Virology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Seasonings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK95929954T 1994-08-26 1995-08-25 4-[2-amino-6-(cyclopropylamino)-9H-purin-yl]-2-cyclopenten-1-methanolsuccinat som antiviralt middel DK0777669T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9417249A GB9417249D0 (en)	1994-08-26	1994-08-26	A novel salt
PCT/GB1995/002014 WO1996006844A1 (en)	1994-08-26	1995-08-25	4-(2-amino-6-(cyclopropylamino)-9h-purin-9-yl)-2-cyclopentene-1-methanol succinate as antiviral agent

Publications (1)

Publication Number	Publication Date
DK0777669T3 true DK0777669T3 (da)	2002-10-28

Family

ID=10760434

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK95929954T DK0777669T3 (da)	1994-08-26	1995-08-25	4-[2-amino-6-(cyclopropylamino)-9H-purin-yl]-2-cyclopenten-1-methanolsuccinat som antiviralt middel

Country Status (23)

Country	Link
EP (1)	EP0777669B1 (da)
JP (1)	JPH10505593A (da)
KR (1)	KR100376240B1 (da)
CN (1)	CN1051550C (da)
AT (1)	ATE220067T1 (da)
AU (1)	AU702618B2 (da)
BR (1)	BR9508629A (da)
CA (1)	CA2198010C (da)
DE (1)	DE69527294T2 (da)
DK (1)	DK0777669T3 (da)
ES (1)	ES2179110T3 (da)
FI (1)	FI120403B (da)
GB (1)	GB9417249D0 (da)
HU (1)	HU221302B1 (da)
IL (1)	IL115074A (da)
MX (1)	MX9701273A (da)
NO (1)	NO315200B1 (da)
NZ (1)	NZ291862A (da)
PT (1)	PT777669E (da)
RU (1)	RU2145324C1 (da)
SI (1)	SI0777669T1 (da)
WO (1)	WO1996006844A1 (da)
ZA (1)	ZA957166B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY115461A (en)	1995-03-30	2003-06-30	Wellcome Found	Synergistic combinations of zidovudine, 1592u89 and 3tc
AR012702A1 (es) *	1997-05-17	2000-11-08	Glaxo Group Ltd	Combinacion de (-)-(1s,4r)-4-[2-amino-6-(ciclopropilamino)-9h-purin-9-il]- 2-ciclopenteno-1-metanol y un inhibidor dee transcriptasa reversa no nucleosidouna formulacion farmaceutica que comprende la combinacion, su uso medico en terapia para tratar la infeccion de vih, y un empaque para el paciente
GB9709945D0 (en) *	1997-05-17	1997-07-09	Glaxo Group Ltd	A novel salt
AU8017298A (en) *	1997-05-17	1998-12-11	Glaxo Group Limited	Antiviral combinations containing the carbocyclic nucleoside 1592u89
CZ298144B6 (cs) *	1997-11-27	2007-07-04	Lonza Ag	Zpusob výroby (1S,4R)- nebo (1R,4S)-4-(2-amino-6-chlor-9-H-purin-9-yl)-2-cyklopenten-1-methanolu
GB9802472D0 (en) *	1998-02-06	1998-04-01	Glaxo Group Ltd	Pharmaceutical compositions
GB9903091D0 (en) *	1999-02-12	1999-03-31	Glaxo Group Ltd	Therapeutic nucleoside compound
GB9918035D0 (en) *	1999-07-30	1999-09-29	Novartis Ag	Organic compounds
BR0109602A (pt) *	2000-03-30	2004-06-29	Bristol Myers Squibb Co	Glóbulos de liberação controlada contendo estavudina
EP1303265B1 (en) *	2000-07-20	2007-07-11	Lauras AS	Use of cox-2 inhibitors as immunostimulants in the treatment of hiv or aids
US7462733B2 (en)	2001-07-30	2008-12-09	University Of Southern California	Preparation and use of α-keto phosphonates
RU2242243C2 (ru) *	2001-09-27	2004-12-20	Вертелецкий Павел Васильевич	Композиции и способы потенцирования терапевтических эффектов интерферонов
MXPA06004647A (es) *	2003-10-27	2006-06-27	Merck & Co Inc	Sal antagonista de ccr-2.
EP1905772A1 (en) *	2006-09-28	2008-04-02	Esteve Quimica, S.A.	Process for the preparation of abacavir
EP2305680A3 (en)	2009-09-30	2011-05-18	Aurobindo Pharma Limited	Novel salts of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
WO2012137227A2 (en)	2011-04-08	2012-10-11	Laurus Labs Private Limited	Solid forms of antiretroviral compounds, process for the preparation and their pharmaceutical composition thereof
WO2014133085A1 (ja)	2013-02-27	2014-09-04	国立大学法人京都大学	がんの予防または治療用医薬組成物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3025492A1 (de) *	1980-07-04	1982-02-04	Siemens AG, 1000 Berlin und 8000 München	Filterelement fuer die optische nachrichtentechnik
JPS58135885A (ja) *	1982-02-01	1983-08-12	シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド	置換されたプリン、その製造方法およびそれからなる抗ウイルス剤
US5003462A (en) *	1988-05-31	1991-03-26	International Business Machines Corporation	Apparatus and method for implementing precise interrupts on a pipelined processor with multiple functional units with separate address translation interrupt means
GB8815265D0 (en) *	1988-06-27	1988-08-03	Wellcome Found	Therapeutic nucleosides
MY104575A (en) *	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
IL104283A (en) *	1992-12-30	1996-12-05	Agis Ind 1983 Ltd	Non-emulsion antiviral topical pharmaceutical composition comprising acyclovir an aqueous gel agent and an alkali oleate

1994
- 1994-08-26 GB GB9417249A patent/GB9417249D0/en active Pending
1995
- 1995-08-25 KR KR1019970701213A patent/KR100376240B1/ko not_active Expired - Lifetime
- 1995-08-25 NZ NZ291862A patent/NZ291862A/en not_active IP Right Cessation
- 1995-08-25 IL IL11507495A patent/IL115074A/en not_active IP Right Cessation
- 1995-08-25 BR BR9508629A patent/BR9508629A/pt not_active Application Discontinuation
- 1995-08-25 WO PCT/GB1995/002014 patent/WO1996006844A1/en not_active Ceased
- 1995-08-25 EP EP95929954A patent/EP0777669B1/en not_active Expired - Lifetime
- 1995-08-25 RU RU97104483A patent/RU2145324C1/ru active
- 1995-08-25 SI SI9530614T patent/SI0777669T1/xx unknown
- 1995-08-25 HU HU9701756A patent/HU221302B1/hu unknown
- 1995-08-25 CN CN95194789A patent/CN1051550C/zh not_active Expired - Lifetime
- 1995-08-25 DK DK95929954T patent/DK0777669T3/da active
- 1995-08-25 AT AT95929954T patent/ATE220067T1/de active
- 1995-08-25 JP JP8508550A patent/JPH10505593A/ja active Pending
- 1995-08-25 ZA ZA9507166A patent/ZA957166B/xx unknown
- 1995-08-25 MX MX9701273A patent/MX9701273A/es active IP Right Grant
- 1995-08-25 CA CA002198010A patent/CA2198010C/en not_active Expired - Lifetime
- 1995-08-25 AU AU33509/95A patent/AU702618B2/en not_active Expired
- 1995-08-25 PT PT95929954T patent/PT777669E/pt unknown
- 1995-08-25 ES ES95929954T patent/ES2179110T3/es not_active Expired - Lifetime
- 1995-08-25 DE DE69527294T patent/DE69527294T2/de not_active Expired - Lifetime
1997
- 1997-02-25 FI FI970786A patent/FI120403B/fi not_active IP Right Cessation
- 1997-02-25 NO NO19970847A patent/NO315200B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE220067T1 (de)	2002-07-15
FI970786A0 (fi)	1997-02-25
GB9417249D0 (en)	1994-10-19
DE69527294D1 (en)	2002-08-08
DE69527294T2 (de)	2003-02-13
BR9508629A (pt)	1997-11-25
IL115074A0 (en)	1995-12-08
AU3350995A (en)	1996-03-22
EP0777669A1 (en)	1997-06-11
PT777669E (pt)	2002-11-29
CA2198010C (en)	2006-05-02
NO970847L (no)	1997-02-25
RU2145324C1 (ru)	2000-02-10
ZA957166B (en)	1997-02-25
MX9701273A (es)	1997-05-31
ES2179110T3 (es)	2003-01-16
CN1156456A (zh)	1997-08-06
JPH10505593A (ja)	1998-06-02
NO315200B1 (no)	2003-07-28
KR970705563A (ko)	1997-10-09
FI120403B (fi)	2009-10-15
IL115074A (en)	1998-10-30
FI970786L (fi)	1997-02-25
NO970847D0 (no)	1997-02-25
AU702618B2 (en)	1999-02-25
EP0777669B1 (en)	2002-07-03
WO1996006844A1 (en)	1996-03-07
KR100376240B1 (ko)	2003-06-11
SI0777669T1 (en)	2002-12-31
HUT77222A (hu)	1998-03-02
NZ291862A (en)	1998-02-26
CA2198010A1 (en)	1996-03-07
CN1051550C (zh)	2000-04-19
HU221302B1 (en)	2002-09-28

Publication	Publication Date	Title
DK0777669T3 (da)	2002-10-28	4-[2-amino-6-(cyclopropylamino)-9H-purin-yl]-2-cyclopenten-1-methanolsuccinat som antiviralt middel
MD1224B2 (en)	1999-05-31	Application of nucleoside analogues with 1,3-oxathiolan for treatment of hepatitis B
TW371660B (en)	1999-10-11	Therapeutic nucleosides a purine carbocyclic nucleosides for treatment of HIV and HBV infections
FI20001231A7 (fi)	2000-05-23	2-Deoksi-2,3-didehydro-N-asetyylineuramiinihapon johdannaisia ja niiden analogeja ja niiden käyttö antiviraalisina aineina
CA2293470A1 (en)	1998-12-17	Benzimidazole derivatives
MY117892A (en)	2004-08-30	Therapeutic compounds
UA29429C2 (uk)	2000-11-15	Фармацевтична композиція для лікування вірусних інфекцій, спосіб отримання композиції, спосіб лікування або профілактики віл-інфекції у людини
MY104043A (en)	1993-10-30	Therapeutic nucleosides.
RU94002475A (ru)	1996-11-10	Фармацевтическая композиция и ее применение для лечения вирусных инфекций
DK602988D0 (da)	1988-10-28	Nukleosidderivater med antiviral virkning og laegemiddelpraeparat indeholdende saadanne forbindelser
TW371662B (en)	1999-10-11	Antiviral acyclic phosphonomethoxyalkyl substituted alkenyl purine and pyrimidine derivatives
HUP0002754A2 (hu)	2001-06-28	(1S,4R)-cisz-4-[2-amino-6-(ciklopropil-amino)-9H-purin-9-il]-2-ciklopentén-1-metanol-hemiszulfát, eljárás előállítására, ezt tartalmazó gyógyszerkészítmény, valamint intermedierek
MX9805441A (es)	1998-11-30	Compuestos terapeuticos.
MY105855A (en)	1995-02-28	Therapeutic nucleotides.
AU7806187A (en)	1988-02-24	Sulphonamide derivatives for the treatment and prevention of viral diseases
MY111746A (en)	2000-12-30	Therapeutic nucleosides.
AU6751794A (en)	1996-01-04	Extracts of piliostigma thonningii, the use thereof and formulations containing them
GR3017335T3 (en)	1995-12-31	Oligophosphates with antiviral activity.
CA2193665A1 (en)	1996-01-25	Benzimidazole derivatives for the treatment and prophylaxis of virus infections