ATE220894T1 - Zusammensetzung für lokale freigabe von zytostatika - Google Patents
Zusammensetzung für lokale freigabe von zytostatikaInfo
- Publication number
- ATE220894T1 ATE220894T1 AT95905986T AT95905986T ATE220894T1 AT E220894 T1 ATE220894 T1 AT E220894T1 AT 95905986 T AT95905986 T AT 95905986T AT 95905986 T AT95905986 T AT 95905986T AT E220894 T1 ATE220894 T1 AT E220894T1
- Authority
- AT
- Austria
- Prior art keywords
- composition
- cytostatics
- local release
- cytostatic agent
- methods
- Prior art date
Links
- 239000000824 cytostatic agent Substances 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- -1 fatty acid ester Chemical class 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 239000008247 solid mixture Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17515693A | 1993-12-29 | 1993-12-29 | |
| PCT/US1994/014559 WO1995017901A1 (en) | 1993-12-29 | 1994-12-28 | Methods and compositions for the treatment of a host with a cellular proliferative disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE220894T1 true ATE220894T1 (de) | 2002-08-15 |
Family
ID=22639161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95905986T ATE220894T1 (de) | 1993-12-29 | 1994-12-28 | Zusammensetzung für lokale freigabe von zytostatika |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5573781A (de) |
| EP (1) | EP0739210B1 (de) |
| JP (1) | JPH09507233A (de) |
| AT (1) | ATE220894T1 (de) |
| AU (1) | AU681231B2 (de) |
| CA (1) | CA2180260A1 (de) |
| DE (1) | DE69431071T2 (de) |
| WO (1) | WO1995017901A1 (de) |
Families Citing this family (72)
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| US5626862A (en) | 1994-08-02 | 1997-05-06 | Massachusetts Institute Of Technology | Controlled local delivery of chemotherapeutic agents for treating solid tumors |
| US5726181A (en) * | 1995-06-05 | 1998-03-10 | Bionumerik Pharmaceuticals, Inc. | Formulations and compositions of poorly water soluble camptothecin derivatives |
| US5935967A (en) * | 1995-06-05 | 1999-08-10 | Bionumerik Pharmaceuticals, Inc. | Pharmaceutical formulations of highly lipophilic camptothecin derivatives |
| US5968542A (en) * | 1995-06-07 | 1999-10-19 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system as a device |
| DE69634277T2 (de) * | 1995-06-07 | 2006-01-05 | Southern Biosystems, Inc., Birmingham | Kontrolliertes zuführsystem mit einer flüssigkeit von hoher viskosität |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US7833543B2 (en) | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| ES2248847T3 (es) | 1996-05-24 | 2006-03-16 | Angiotech Pharmaceuticals, Inc. | Composiciones y metodos para tratar o prevenir enfermedades de las vias de conduccion del cuerpo. |
| US5773461A (en) * | 1996-06-06 | 1998-06-30 | Bristol-Myers Squibb Company | 7-deoxy-6-substituted paclitaxels |
| NZ334236A (en) * | 1996-08-30 | 2000-06-23 | Peptech Ltd | Composition comprising GnRH, lecithin and stearin |
| US20030157187A1 (en) * | 1996-12-02 | 2003-08-21 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for treating or preventing inflammatory diseases |
| US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| US6458373B1 (en) * | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| US6630168B1 (en) | 1997-02-20 | 2003-10-07 | Biomedicines, Inc. | Gel delivery vehicles for anticellular proliferative agents |
| KR20010006026A (ko) | 1997-04-03 | 2001-01-15 | 존스 홉킨스 유니버시티 스쿨 오브 메디슨 | 생물분해성 테레프탈레이트 폴리에스테르-폴리(포스페이트) 중합체, 조성물, 약품 및 그의 제조방법과 이용방법 |
| US6416740B1 (en) | 1997-05-13 | 2002-07-09 | Bristol-Myers Squibb Medical Imaging, Inc. | Acoustically active drug delivery systems |
| US6485514B1 (en) | 1997-12-12 | 2002-11-26 | Supergen, Inc. | Local delivery of therapeutic agents |
| GB9803448D0 (en) * | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| US7030155B2 (en) * | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
| AUPP466598A0 (en) * | 1998-07-14 | 1998-08-06 | University Of Newcastle Research Associates Limited, The | Product and process |
| US6419709B1 (en) | 1998-10-02 | 2002-07-16 | Guilford Pharmaceuticals, Inc. | Biodegradable terephthalate polyester-poly(Phosphite) compositions, articles, and methods of using the same |
| US6153212A (en) | 1998-10-02 | 2000-11-28 | Guilford Pharmaceuticals Inc. | Biodegradable terephthalate polyester-poly (phosphonate) compositions, articles, and methods of using the same |
| US6350464B1 (en) | 1999-01-11 | 2002-02-26 | Guilford Pharmaceuticals, Inc. | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same |
| WO2000050016A2 (en) * | 1999-02-23 | 2000-08-31 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for improving integrity of compromised body passageways and cavities |
| US6537585B1 (en) | 1999-03-26 | 2003-03-25 | Guilford Pharmaceuticals, Inc. | Methods and compositions for treating solid tumors |
| US6767926B1 (en) * | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| KR100518986B1 (ko) * | 1999-11-15 | 2005-10-06 | 파르마 마르, 에스.에이. | 아플리딘을 사용하여 암을 치료하는 방법 |
| ES2315404T3 (es) * | 2001-10-19 | 2009-04-01 | Pharma Mar, S.A. | Uso de aplidina para el tratamiento de cancer de pancreas. |
| EP2201965A1 (de) * | 2001-11-08 | 2010-06-30 | Ziscoat N.V. | Intraluminale Vorrichtung mit einer therapeutisches-mittel enthaltenden Beschichtung |
| WO2003041645A2 (en) * | 2001-11-09 | 2003-05-22 | Chiron Corporation | Method of vaccinating a human patient to prevent metastatic tumors |
| US6977247B2 (en) * | 2002-02-21 | 2005-12-20 | Supergen, Inc. | Sequential therapy comprising a 20(S)-camptothecin and a pyrimidine base analog |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| US7544674B2 (en) * | 2002-10-25 | 2009-06-09 | Galderma S.A. | Topical skin care composition |
| ATE482695T1 (de) | 2002-12-13 | 2010-10-15 | Durect Corp | Orale darreichungsform mit flüssigen hochviskosen trägersystemen |
| ATE406171T1 (de) * | 2003-03-12 | 2008-09-15 | Dana Farber Cancer Inst Inc | Aplidine zur behandlung von multiplem myelom |
| US20040265351A1 (en) * | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
| EP1696868A1 (de) * | 2003-07-18 | 2006-09-06 | Hill Dermaceuticals, Inc. | Topische hautpflegezusammensetzung mit raffiniertem erdnussöl |
| US20070140999A1 (en) * | 2003-07-18 | 2007-06-21 | Hill Dermaceuticals, Inc. | Topical skin care composition containing refined peanut oil |
| US20060099173A1 (en) * | 2003-10-24 | 2006-05-11 | Nancy Puglia | Topical skin care composition |
| US20050118206A1 (en) * | 2003-11-14 | 2005-06-02 | Luk Andrew S. | Surfactant-based gel as an injectable, sustained drug delivery vehicle |
| US20050208095A1 (en) * | 2003-11-20 | 2005-09-22 | Angiotech International Ag | Polymer compositions and methods for their use |
| BRPI0515372B8 (pt) | 2004-09-17 | 2021-05-25 | Durect Corp | composição líquida para fornecer anestesia local prolongada após administração a um indivíduo, e, uso de bupivacaína, acetato isobutirato de sacarose e álcool benzílico |
| US9000040B2 (en) | 2004-09-28 | 2015-04-07 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| US9012506B2 (en) | 2004-09-28 | 2015-04-21 | Atrium Medical Corporation | Cross-linked fatty acid-based biomaterials |
| WO2007011385A2 (en) | 2004-09-28 | 2007-01-25 | Atrium Medical Corporation | Heat cured gel and method of making |
| US20060141040A1 (en) * | 2004-12-23 | 2006-06-29 | Guohua Chen | Injectable non-aqueous suspension |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| US9278161B2 (en) | 2005-09-28 | 2016-03-08 | Atrium Medical Corporation | Tissue-separating fatty acid adhesion barrier |
| US9427423B2 (en) | 2009-03-10 | 2016-08-30 | Atrium Medical Corporation | Fatty-acid based particles |
| EP1968639A1 (de) * | 2005-12-23 | 2008-09-17 | Miv Therapeutics Inc. | Zusammensetzungen für die lösungsmittel-regulierte freisetzung von arzneimitteln |
| PL2117521T3 (pl) | 2006-11-03 | 2012-11-30 | Durect Corp | Transdermalne systemy dostarczania zawierające bupiwakainę |
| WO2009075782A1 (en) | 2007-12-06 | 2009-06-18 | Durect Corporation | Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition |
| CN101998828A (zh) * | 2008-03-28 | 2011-03-30 | 粒子科学有限公司 | 用于使治疗剂增溶的药物溶液和方法 |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| US20110038910A1 (en) | 2009-08-11 | 2011-02-17 | Atrium Medical Corporation | Anti-infective antimicrobial-containing biomaterials |
| JP5824511B2 (ja) | 2010-05-03 | 2015-11-25 | テイコク ファーマ ユーエスエー インコーポレーテッド | 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法 |
| EP2593141B1 (de) | 2010-07-16 | 2018-07-04 | Atrium Medical Corporation | Zusammensetzung und verfahren zur veränderung der geschwindigkeit einer hydrolyse ausgehärteter materialien auf ölbasis |
| US9867880B2 (en) | 2012-06-13 | 2018-01-16 | Atrium Medical Corporation | Cured oil-hydrogel biomaterial compositions for controlled drug delivery |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| TW201427681A (zh) * | 2013-01-07 | 2014-07-16 | Superlab Far East Ltd | 用空間構象改變的重組干擾素治療腫瘤的方法 |
| CA2905131A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| US20160067241A1 (en) * | 2013-06-13 | 2016-03-10 | Dennis M. Brown | Compositions and methods to improve the therapeutic benefit of suboptimally administered chemical compounds including substituted naphthalimides such as amonafide for the treatment of immunological, metabolic, infectious, and benign or neoplastic hyperproliferative disease conditions |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| US20160303242A1 (en) | 2013-12-09 | 2016-10-20 | Durect Corporation | Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same |
| US12274794B2 (en) | 2016-07-06 | 2025-04-15 | Orient Pharma Co., Ltd. | Oral dosage form with drug composition, barrier layer and drug layer |
| WO2018144094A1 (en) * | 2016-11-03 | 2018-08-09 | Health Research, Inc. | Methods for improving tumor chemotherapy |
| WO2020081148A1 (en) * | 2018-10-16 | 2020-04-23 | US Nano Food & Drug INC | Intratumor injection formulation |
| CA3167217A1 (en) | 2020-01-13 | 2021-07-22 | Durect Corporation | Sustained release drug delivery systems with reduced impurities and related methods |
| CN114929213A (zh) * | 2020-04-13 | 2022-08-19 | 美国纳米食品药品公司 | 碱性化疗药瘤内注射剂组合物 |
| JP2023539154A (ja) * | 2020-08-19 | 2023-09-13 | セラクト ファーマ ジーエムビーエイチ | エトポシドトニリベート製剤 |
| CN116940358A (zh) | 2021-01-12 | 2023-10-24 | 度勒科特公司 | 持续释放药物递送系统和有关的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6317823A (ja) * | 1986-07-10 | 1988-01-25 | Mitsubishi Chem Ind Ltd | 抗固形腫瘍剤 |
| US4879297A (en) * | 1987-06-01 | 1989-11-07 | Warner-Lambert Company | Fatty acids and their small chain esters as penetration enhancers in aqueous systems |
| JPH01156990A (ja) * | 1987-09-26 | 1989-06-20 | Ajinomoto Co Inc | 新規白金錯体及びその用途 |
| US5141751A (en) * | 1988-06-29 | 1992-08-25 | Daiichi Pharmaceutical Co., Ltd. | Lipid membrane structures |
| US5015257A (en) * | 1989-03-20 | 1991-05-14 | Zimmer, Inc. | Prosthetic interpositional device/coupler |
| US5051257A (en) * | 1989-05-09 | 1991-09-24 | Pietronigro Dennis D | Antineoplastic solution and method for treating neoplasms |
| FI905018A7 (fi) * | 1989-10-17 | 1991-04-18 | Bristol Myers Squibb Co | Veteen ja liuottimeen liukenevat aksiaaliset hydroksi- ja mono- ja di-karboksyylihappojohdannaiset, joilla on korkea kasvainaktiivisuus |
| US5143934A (en) * | 1990-11-21 | 1992-09-01 | A/S Dumex (Dumex Ltd.) | Method and composition for controlled delivery of biologically active agents |
-
1994
- 1994-12-28 AT AT95905986T patent/ATE220894T1/de not_active IP Right Cessation
- 1994-12-28 CA CA002180260A patent/CA2180260A1/en not_active Abandoned
- 1994-12-28 EP EP95905986A patent/EP0739210B1/de not_active Expired - Lifetime
- 1994-12-28 DE DE69431071T patent/DE69431071T2/de not_active Expired - Fee Related
- 1994-12-28 JP JP7518106A patent/JPH09507233A/ja not_active Ceased
- 1994-12-28 AU AU14386/95A patent/AU681231B2/en not_active Ceased
- 1994-12-28 WO PCT/US1994/014559 patent/WO1995017901A1/en not_active Ceased
- 1994-12-29 US US08/365,664 patent/US5573781A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69431071D1 (de) | 2002-08-29 |
| US5573781A (en) | 1996-11-12 |
| EP0739210B1 (de) | 2002-07-24 |
| AU681231B2 (en) | 1997-08-21 |
| JPH09507233A (ja) | 1997-07-22 |
| CA2180260A1 (en) | 1995-07-06 |
| EP0739210A4 (de) | 1997-10-15 |
| AU1438695A (en) | 1995-07-17 |
| WO1995017901A1 (en) | 1995-07-06 |
| EP0739210A1 (de) | 1996-10-30 |
| DE69431071T2 (de) | 2003-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |