ATE220925T1 - Trizyklische funktional farbstoffe zur verbesserung von kontrast und optische bilderzeugung - Google Patents

Trizyklische funktional farbstoffe zur verbesserung von kontrast und optische bilderzeugung

Info

Publication number: ATE220925T1
Authority: AT; Austria
Prior art keywords: alkyl; alkoxyalkyl; hydroxyalkyl; group; optical imaging
Prior art date: 1996-05-13

Application number

AT97924639T

Other languages

English (en)

Inventor

Ella Y Fung

Raghavan Rajagopalan

Original Assignee

Mallinckrodt Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-05-13

Filing date

1997-05-09

Publication date

2002-08-15

1997-05-09 Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE220925T1 publication Critical patent/ATE220925T1/de

Links

238000012634 optical imaging Methods 0.000 title 1
125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 6
125000004183 alkoxy alkyl group Chemical group 0.000 abstract 4
125000004181 carboxyalkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 4
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 3
150000002431 hydrogen Chemical class 0.000 abstract 3
125000005358 mercaptoalkyl group Chemical group 0.000 abstract 3
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000004414 alkyl thio group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000000027 (C1-C10) alkoxy group Chemical group 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000000975 dye Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 abstract 1
125000003396 thiol group Chemical class [H]S* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Optical Filters (AREA)
Photoreceptors In Electrophotography (AREA)

AT97924639T 1996-05-13 1997-05-09 Trizyklische funktional farbstoffe zur verbesserung von kontrast und optische bilderzeugung ATE220925T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/645,376 US5709845A (en)	1996-05-13	1996-05-13	Tricyclic functional dyes for contrast enhancement in optical imaging
PCT/US1997/007861 WO1997042976A1 (en)	1996-05-13	1997-05-09	Tricyclic functional dyes for contrast enhancement in optical imaging

Publications (1)

Publication Number	Publication Date
ATE220925T1 true ATE220925T1 (de)	2002-08-15

Family

ID=24588768

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97924639T ATE220925T1 (de)	1996-05-13	1997-05-09	Trizyklische funktional farbstoffe zur verbesserung von kontrast und optische bilderzeugung

Country Status (8)

Country	Link
US (1)	US5709845A (de)
EP (1)	EP0946203B1 (de)
JP (1)	JP2000511521A (de)
AT (1)	ATE220925T1 (de)
CA (1)	CA2254905C (de)
DE (1)	DE69714287T2 (de)
ES (1)	ES2180992T3 (de)
WO (1)	WO1997042976A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998048838A1 (en) *	1997-04-29	1998-11-05	Nycomed Imaging As	Compounds
US7547721B1 (en)	1998-09-18	2009-06-16	Bayer Schering Pharma Ag	Near infrared fluorescent contrast agent and fluorescence imaging
JP2000095758A (ja)	1998-09-18	2000-04-04	Schering Ag	近赤外蛍光造影剤および蛍光造影方法
US20030180221A1 (en) *	1998-09-18	2003-09-25	Schering Ag	Near infrared fluorescent contrast agent and fluorescence imaging
CO5261573A1 (es)	1999-11-19	2003-03-31	Novartis Ag	Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion
US6180086B1 (en)	2000-01-18	2001-01-30	Mallinckrodt Inc.	Hydrophilic cyanine dyes
US20080233050A1 (en) *	2000-01-18	2008-09-25	Mallinckrodt Inc.	Diagnostic and therapeutic optical agents
US6395257B1 (en)	2000-01-18	2002-05-28	Mallinckrodt Inc.	Dendrimer precursor dyes for imaging
US6939532B2 (en)	2000-01-18	2005-09-06	Mallinckrodt, Inc.	Versatile hydrophilic dyes
US7198778B2 (en) *	2000-01-18	2007-04-03	Mallinckrodt Inc.	Tumor-targeted optical contrast agents
US6180087B1 (en)	2000-01-18	2001-01-30	Mallinckrodt Inc.	Tunable indocyanine dyes for biomedical applications
US7790144B2 (en) *	2000-01-18	2010-09-07	Mallinckrodt Inc.	Receptor-avid exogenous optical contrast and therapeutic agents
US20070092450A1 (en) *	2000-10-16	2007-04-26	Mallinckrodt Inc.	Tissue-specific exogenous optical agents
US20040180809A1 (en) *	2000-10-16	2004-09-16	Mallinckrodt Inc.	Tissue-specific exogenous optical agents
US20040173051A1 (en) *	2003-03-05	2004-09-09	Sinka Aaron Alexander	Breather system for a housing containing a lubricant sump
US20100022449A1 (en) *	2006-03-09	2010-01-28	Mallinckrodt Inc.	Receptor-avid exogenous optical contrast and therapeutic agents

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3855210A (en) *	1969-02-03	1974-12-17	Itek Corp	Improved bis(hydroxyalkyl) styryl dye compounds and photosensitive media containing such compounds
US3655392A (en) *	1969-06-04	1972-04-11	Eastman Kodak Co	Photographic silver halide emulsion sensitized with a methine dye
JPH08509260A (ja) *	1993-04-20	1996-10-01	マリンクロット・メディカル・インコーポレイテッド	電圧感受性染料の安定化
DE4445065A1 (de) *	1994-12-07	1996-06-13	Diagnostikforschung Inst	Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung

1996
- 1996-05-13 US US08/645,376 patent/US5709845A/en not_active Expired - Lifetime
1997
- 1997-05-09 AT AT97924639T patent/ATE220925T1/de not_active IP Right Cessation
- 1997-05-09 DE DE69714287T patent/DE69714287T2/de not_active Expired - Lifetime
- 1997-05-09 WO PCT/US1997/007861 patent/WO1997042976A1/en not_active Ceased
- 1997-05-09 JP JP09540960A patent/JP2000511521A/ja not_active Withdrawn
- 1997-05-09 EP EP97924639A patent/EP0946203B1/de not_active Expired - Lifetime
- 1997-05-09 ES ES97924639T patent/ES2180992T3/es not_active Expired - Lifetime
- 1997-05-09 CA CA002254905A patent/CA2254905C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5709845A (en)	1998-01-20
WO1997042976A1 (en)	1997-11-20
CA2254905A1 (en)	1997-11-20
DE69714287D1 (de)	2002-08-29
DE69714287T2 (de)	2003-03-06
EP0946203B1 (de)	2002-07-24
JP2000511521A (ja)	2000-09-05
CA2254905C (en)	2003-01-28
EP0946203A1 (de)	1999-10-06
ES2180992T3 (es)	2003-02-16
EP0946203A4 (de)	2000-03-29

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Legal Events

Date	Code	Title	Description
2003-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties