ATE104965T1 - Chinolinderivate, ihre herstellung und verwendung. - Google Patents

Chinolinderivate, ihre herstellung und verwendung.

Info

Publication number
ATE104965T1
ATE104965T1 AT9191900058T AT91900058T ATE104965T1 AT E104965 T1 ATE104965 T1 AT E104965T1 AT 9191900058 T AT9191900058 T AT 9191900058T AT 91900058 T AT91900058 T AT 91900058T AT E104965 T1 ATE104965 T1 AT E104965T1
Authority
AT
Austria
Prior art keywords
group
lower alkyl
image
hydrogen atom
preparation
Prior art date
Application number
AT9191900058T
Other languages
English (en)
Inventor
Kanji Meguro
Hitoshi Ikeda
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE104965T1 publication Critical patent/ATE104965T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
AT9191900058T 1989-12-11 1990-12-10 Chinolinderivate, ihre herstellung und verwendung. ATE104965T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1322172A JPH03181465A (ja) 1989-12-11 1989-12-11 キノリン誘導体
PCT/JP1990/001617 WO1991009017A1 (en) 1989-12-11 1990-12-10 Quinoline derivatives, their production and use

Publications (1)

Publication Number Publication Date
ATE104965T1 true ATE104965T1 (de) 1994-05-15

Family

ID=18140741

Family Applications (1)

Application Number Title Priority Date Filing Date
AT9191900058T ATE104965T1 (de) 1989-12-11 1990-12-10 Chinolinderivate, ihre herstellung und verwendung.

Country Status (7)

Country Link
US (2) US5362742A (de)
EP (1) EP0505565B1 (de)
JP (2) JPH03181465A (de)
AT (1) ATE104965T1 (de)
CA (1) CA2071224C (de)
DE (1) DE69008542T2 (de)
WO (1) WO1991009017A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW241258B (de) * 1992-04-15 1995-02-21 Takeda Pharm Industry Co Ltd
ATE161530T1 (de) * 1992-09-04 1998-01-15 Takeda Chemical Industries Ltd Kondensierte heterozyklische verbindungen, deren herstellung und verwendung
US5596001A (en) * 1993-10-25 1997-01-21 Pfizer Inc. 4-aryl-3-(heteroarylureido)quinoline derivatves
JP3720395B2 (ja) 1994-09-20 2005-11-24 京都薬品工業株式会社 新規ヘテロ環誘導体、その製造方法およびその医薬用途
US5843957A (en) * 1995-05-19 1998-12-01 Sumitomo Pharmaceuticals Company, Ltd. Naphthyridine derivatives
EP0842933B1 (de) * 1995-05-31 2004-08-04 Sumitomo Pharmaceuticals Company, Limited Neue naphthyridinderivate.
BR9711805A (pt) 1996-06-20 2002-01-15 Regents The Univesity Of Texas Compostos e métodos para providenciar preparações farmacologicamente ativas e uso dos mesmos
AU2547399A (en) 1998-02-25 1999-09-15 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for producing the same
US6452008B2 (en) 1998-02-25 2002-09-17 Sumitomo Pharmaceuticals Company, Limited Pyridone derivatives and process for preparing the same
EP1237987A1 (de) * 1999-10-11 2002-09-11 Henkel Kommanditgesellschaft auf Aktien Schmelz-haftklebstoff in form eines granulates
JP5278983B2 (ja) * 1999-11-17 2013-09-04 塩野義製薬株式会社 アミド化合物の新規用途
SE0102764D0 (sv) 2001-08-17 2001-08-17 Astrazeneca Ab Compounds
EP2284157A1 (de) 2003-12-12 2011-02-16 Wyeth Quinolinen zur behandlung von cardiovascular krankheiten
US7642259B2 (en) 2005-07-09 2010-01-05 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
AR076221A1 (es) 2009-04-09 2011-05-26 Astrazeneca Ab Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO133758C (de) * 1970-04-04 1976-06-23 Takeda Chemical Industries Ltd
BE770249A (fr) * 1970-07-23 1971-12-01 Takeda Chemical Industries Ltd Derives de quinoline
US4232027A (en) * 1979-01-29 1980-11-04 E. R. Squibb & Sons, Inc. 1,2-Dihydro-2-oxo-4-phenyl-3-quinolinecarbonitrile derivatives
US4675405A (en) * 1984-09-21 1987-06-23 American Home Products Corporation Quinoline compounds as antiallergic and antithrombotic agents
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
TW205037B (de) * 1989-10-06 1993-05-01 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
DE69008542T2 (de) 1994-09-01
JPH03181465A (ja) 1991-08-07
JP3040159B2 (ja) 2000-05-08
EP0505565B1 (de) 1994-04-27
US5523407A (en) 1996-06-04
CA2071224A1 (en) 1991-06-12
WO1991009017A1 (en) 1991-06-27
EP0505565A1 (de) 1992-09-30
US5362742A (en) 1994-11-08
CA2071224C (en) 2002-04-09
DE69008542D1 (de) 1994-06-01
JPH06503550A (ja) 1994-04-21

Similar Documents

Publication Publication Date Title
ATE104965T1 (de) Chinolinderivate, ihre herstellung und verwendung.
LTIP390A (lt) Triazolpiridazino junginiai,jų gavimo būdas ir panaudojimas
SE8503922L (sv) Analgetiska 1,2-bensisotiazol-3-ylpiperazin-derivat
MX9504349A (es) Derivados de aroilpiperidina.
ATE117681T1 (de) Chinolinderivate, ihre herstellung und verwendung.
DE69500660D1 (de) Ophthalmische Zusammensetzung enthaltend ein 1,5-Benzoxathiepin-Derivat zur Behandlung von Glaukoma
DE2960820D1 (en) Carbostyrile derivatives, processes for their preparation and pharmaceutical compositions containing them
FI904915A0 (fi) Kinolinderivat, deras framstaellning och anvaendning.
ES2058173T3 (es) Dioxialquilenaril-dihidropiridinas, productos intermedios para su fabricacion, procedimientos para su fabricacion y su utilizacion.
DE69222459D1 (de) Thiazolidindionderivate, ihre Herstellung und Anwendung
CA2264065A1 (en) Acylaminoalkenylene-amide derivatives as nk1 and nk2 antagonists
HUP9802393A2 (hu) Benzotiazolonszármazékok, alkalmazásuk, az ezeket tartalmazó gyógyszerkészítmények, eljárás a vegyületek előállítására és intermedierjeik
ATE95816T1 (de) 2-((4-piperidinyl)methyl>-1,2,3,4tetrahydroisochinolin-derivate, ihre herstellung und ihre therapeutische verwendung.
YU142791A (sh) Heterociklična jedinjenja
DK0462933T3 (da) Hidtil ukendte N-benzyl-N1-phenyl og -phenylalkyl-thiourinstoffer
ES8203867A1 (es) Procedimiento para la obtencion de derivados de benzotiazol
ES8304915A1 (es) Procedimiento para la obtencion de derivados de dioxibencenoeteres.
YU74501A (sh) Sinteza 3-amino-3-aril propionata
ES8604912A1 (es) Procedimiento de preparacion de nuevos derivados de (arilpi-peraziniletilaminoetoxi)-4 fenol
ATE396987T1 (de) Variolinderivate und ihre verwendung als cytostatika
DK513281A (da) Fremgangsaade til fremstilling af 3-thiovinylcephalosproner
IL97611A (en) Heterocyclic compounds, their preparation and pharmaceutical compositions containing them
ATE19629T1 (de) N-substituierte derivate des tetrahydroisophthalimids.
MY107388A (en) Novel antimicrobial dithiocarbamoyl quinolones
ATE12645T1 (de) Phenylethylthiazolderivate, ihre herstellung und ihre anwendung in der therapeutik.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties