ATE221061T1 - Chemilumineszente 1,2-dioxetane mit verbesserter leistung - Google Patents

Chemilumineszente 1,2-dioxetane mit verbesserter leistung

Info

Publication number
ATE221061T1
ATE221061T1 AT96935803T AT96935803T ATE221061T1 AT E221061 T1 ATE221061 T1 AT E221061T1 AT 96935803 T AT96935803 T AT 96935803T AT 96935803 T AT96935803 T AT 96935803T AT E221061 T1 ATE221061 T1 AT E221061T1
Authority
AT
Austria
Prior art keywords
group
moiety
stabilizing
polycyclic
aryloxy
Prior art date
Application number
AT96935803T
Other languages
English (en)
Inventor
Irena Bronstein
Brooks Edwards
Alison Sparks
Original Assignee
Tropix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/544,172 external-priority patent/US5840919A/en
Priority claimed from US08/547,372 external-priority patent/US5679803A/en
Application filed by Tropix Inc filed Critical Tropix Inc
Application granted granted Critical
Publication of ATE221061T1 publication Critical patent/ATE221061T1/de

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D321/00Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07GCOMPOUNDS OF UNKNOWN CONSTITUTION
    • C07G3/00Glycosides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Polyethers (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Laminated Bodies (AREA)
  • Shaping By String And By Release Of Stress In Plastics And The Like (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Magnetic Record Carriers (AREA)
AT96935803T 1995-10-17 1996-10-17 Chemilumineszente 1,2-dioxetane mit verbesserter leistung ATE221061T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/544,172 US5840919A (en) 1993-05-07 1995-10-17 Chemiluminescent 1,2-dioxetanes
US08/547,372 US5679803A (en) 1995-10-25 1995-10-25 1,2 chemiluminescent dioxetanes of improved performance
PCT/US1996/014390 WO1997014692A1 (en) 1995-10-17 1996-10-17 1,2 chemiluminescent dioxetanes of improved performance

Publications (1)

Publication Number Publication Date
ATE221061T1 true ATE221061T1 (de) 2002-08-15

Family

ID=27067531

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96935803T ATE221061T1 (de) 1995-10-17 1996-10-17 Chemilumineszente 1,2-dioxetane mit verbesserter leistung

Country Status (8)

Country Link
US (1) US5869699A (de)
EP (1) EP1019390B1 (de)
JP (1) JP4068144B2 (de)
AT (1) ATE221061T1 (de)
AU (1) AU708266B2 (de)
DE (1) DE69622605T2 (de)
MX (1) MX9802062A (de)
WO (1) WO1997014692A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE36536E (en) * 1986-07-24 2000-01-25 Tropix. Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
DE3788203T2 (de) * 1986-07-24 1994-03-31 Tropix Inc Verfahren zum nachweis einer verbindung unter verwendung des enzymatisch induzierten zerfalls von dioxethanen.
US6022964A (en) 1989-07-17 2000-02-08 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US6613578B1 (en) * 1999-02-16 2003-09-02 Emp Biotech Gmbh Activating film for chemiluminescent assays and methods for use
EP1185710A2 (de) * 1999-04-16 2002-03-13 Zymetx, Inc. Verfahren zum nachweis von viren, das viralisch-codierte enzymen und chemilumineszentsubstraten verwendet
US6783948B1 (en) 1999-07-30 2004-08-31 Bayer Corporation Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US20060079699A1 (en) * 2004-08-27 2006-04-13 Brooks Edwards Intermediate compounds and methods for synthesizing chemiluminescent dioxetane substrates
EP2390663B1 (de) * 2007-05-23 2013-11-13 Life Technologies Corporation Reagenzien, Kits und Verfahren zur Erkennung von biologischen Molekülen durch Energieübertragung aus einem aktivierten chemilumineszenten Trägerstoff in eine Energieannahmefarbstoff
JP2014516947A (ja) * 2011-05-03 2014-07-17 ライフ テクノロジーズ コーポレーション フラッシュ・グロー型の1,2−ジオキセタン
CN117385378B (zh) * 2023-10-13 2024-09-24 厦门大学 一种缺电子芳香缩醛的电氧化制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616729A (en) * 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
US5625077A (en) * 1987-12-31 1997-04-29 Tropix, Inc. 1,2-dioxetanes
US5582980A (en) * 1989-07-17 1996-12-10 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5721370A (en) * 1995-07-31 1998-02-24 Lumigen Inc. Water soluble tri-substituted 1,2-dioxetane compounds and assay compositions having increased storage stability
US5777135A (en) * 1995-07-31 1998-07-07 Lumigen, Inc. Di-substituted 1,2-dioxetane compounds having increased water solubility and assay compositions
US5679803A (en) * 1995-10-25 1997-10-21 Tropix, Inc. 1,2 chemiluminescent dioxetanes of improved performance

Also Published As

Publication number Publication date
EP1019390B1 (de) 2002-07-24
DE69622605T2 (de) 2003-03-13
AU7359796A (en) 1997-05-07
US5869699A (en) 1999-02-09
DE69622605D1 (de) 2002-08-29
EP1019390A1 (de) 2000-07-19
JP4068144B2 (ja) 2008-03-26
MX9802062A (es) 1998-11-30
WO1997014692A1 (en) 1997-04-24
AU708266B2 (en) 1999-07-29
EP1019390A4 (de) 2000-07-19

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Legal Events

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