ATE221065T1 - Amidinderivate als inhibitoren von no-synthase - Google Patents

Amidinderivate als inhibitoren von no-synthase

Info

Publication number
ATE221065T1
ATE221065T1 AT98921951T AT98921951T ATE221065T1 AT E221065 T1 ATE221065 T1 AT E221065T1 AT 98921951 T AT98921951 T AT 98921951T AT 98921951 T AT98921951 T AT 98921951T AT E221065 T1 ATE221065 T1 AT E221065T1
Authority
AT
Austria
Prior art keywords
amidene
derivatives
synthase inhibitors
synthase
inhibitors
Prior art date
Application number
AT98921951T
Other languages
English (en)
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE221065T1 publication Critical patent/ATE221065T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98921951T 1997-05-05 1998-04-28 Amidinderivate als inhibitoren von no-synthase ATE221065T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701681A SE9701681D0 (sv) 1997-05-05 1997-05-05 New compounds
PCT/SE1998/000785 WO1998050382A1 (en) 1997-05-05 1998-04-28 Amidine derivatives as inhibitors of nitric oxide synthase

Publications (1)

Publication Number Publication Date
ATE221065T1 true ATE221065T1 (de) 2002-08-15

Family

ID=20406835

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98921951T ATE221065T1 (de) 1997-05-05 1998-04-28 Amidinderivate als inhibitoren von no-synthase

Country Status (25)

Country Link
US (1) US6489322B1 (de)
EP (1) EP0983268B1 (de)
JP (1) JP2001523262A (de)
KR (1) KR20010012228A (de)
CN (1) CN1255131A (de)
AR (1) AR012601A1 (de)
AT (1) ATE221065T1 (de)
AU (1) AU734391B2 (de)
BR (1) BR9809218A (de)
CA (1) CA2288333A1 (de)
DE (1) DE69806750T2 (de)
EE (1) EE9900474A (de)
HU (1) HUP0001873A3 (de)
ID (1) ID22885A (de)
IL (1) IL132678A0 (de)
IS (1) IS5236A (de)
MX (1) MXPA99009882A (de)
NO (1) NO995403L (de)
NZ (1) NZ500675A (de)
PL (1) PL336853A1 (de)
SE (1) SE9701681D0 (de)
SK (1) SK140599A3 (de)
TR (1) TR199902720T2 (de)
WO (1) WO1998050382A1 (de)
ZA (1) ZA983736B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
EP1876654B1 (de) * 2005-04-26 2018-03-21 Kabushiki Kaisha Toshiba Weisse led und rücklicht und flüssigkristallanzeige damit
EP1910321A4 (de) * 2005-07-05 2010-09-01 Astrazeneca Ab Neue verbindungen, verfahren zu ihrer herstellung, zwischenprodukte, pharmazeutische zusammensetzungen und ihre verwendung bei der behandlung von durch 5-ht6-vermittelten erkrankungen wie alzheimer-krankheit, kognitiven erkrankungen, mit schizophrenie assoziierten kognitiven störungen, obesitas und parkinson-krankheit
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
ATE528306T1 (de) * 2006-11-02 2011-10-15 Piramal Life Sciences Ltd Benzoxazepin-verbindungen, ihre herstellung und verwendung
WO2008108445A1 (ja) 2007-03-07 2008-09-12 Takeda Pharmaceutical Company Limited ベンゾオキサゼピン誘導体およびその用途
WO2008144483A2 (en) * 2007-05-18 2008-11-27 Armgo Pharma, Inc. Agents for treating disorders involving modulation of ryanodine receptors
BRPI1010974A2 (pt) * 2009-05-22 2019-09-24 Exelixis Inc benzoxazepinas baseada em inibidores p13k/ m tor contra doenças proliferativas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
WO1995005363A1 (en) 1993-08-12 1995-02-23 Astra Aktiebolag Amidine derivatives with nitric oxide synthetase activities
EP0724570B1 (de) 1993-10-21 1999-03-03 G.D. Searle & Co. Amidino-derivate als no-synthetase inhibitoren
EP0759027B1 (de) * 1994-05-07 1999-08-04 Astra Aktiebolag Bicyclische amidinderivate als no-synthetase inhibitoren
TW397812B (en) * 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
KR970706272A (ko) * 1995-08-10 1997-11-03 클래스 빌헬름슨 치료에 유용한 바이시클릭 아미딘 유도체(Bicyclic Amidine Derivatives Useful in Therapy)
TW458978B (en) * 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
CN1255131A (zh) 2000-05-31
DE69806750T2 (de) 2003-03-06
US6489322B1 (en) 2002-12-03
EE9900474A (et) 2000-06-15
EP0983268A1 (de) 2000-03-08
AR012601A1 (es) 2000-11-08
KR20010012228A (ko) 2001-02-15
CA2288333A1 (en) 1998-11-12
PL336853A1 (en) 2000-07-17
NO995403D0 (no) 1999-11-04
AU7459898A (en) 1998-11-27
ID22885A (id) 1999-12-16
ZA983736B (en) 1998-11-05
TR199902720T2 (xx) 2000-02-21
AU734391B2 (en) 2001-06-14
HUP0001873A3 (en) 2001-12-28
WO1998050382A1 (en) 1998-11-12
SK140599A3 (en) 2000-06-12
HUP0001873A2 (hu) 2001-01-29
EP0983268B1 (de) 2002-07-24
NZ500675A (en) 2001-05-25
JP2001523262A (ja) 2001-11-20
MXPA99009882A (es) 2005-11-22
IS5236A (is) 1999-11-01
SE9701681D0 (sv) 1997-05-05
DE69806750D1 (de) 2002-08-29
IL132678A0 (en) 2001-03-19
BR9809218A (pt) 2000-06-27
NO995403L (no) 2000-01-05

Similar Documents

Publication Publication Date Title
DE69725465D1 (de) 6-phenylpyridyl-2-amin-derivate verwendbar als nos-inhibitoren
EE200000031A (et) Uued spiroasabitsüklilised heterotsüklilised ühendid
DE69820906D1 (de) Hydroxamsäure-derivate als matrix metalloproteinaseinhibitoren
ATE245142T1 (de) No-synthase inhibitoren
DK1005446T3 (da) N-aroylphenylalaninderivater
ATE235220T1 (de) Resorcinderivate
ID22781A (id) Turunan-turunan nikotinamida
DK1027332T3 (da) Hidtil ukendte lactametalloproteaseinhibitorer
DE69817186D1 (de) Diaminorhodamin-derivate
DE69813616D1 (de) Cyclohexencarboxylate als inhibitoren der neuraminidase
ATE224366T1 (de) D-prolinderivate
EE200000321A (et) Uudsed ühendid
DE69906311D1 (de) Diarylbenzopyranderivate als cyclooxygenase-2-inhibitoren
PT958287E (pt) Inibidores de sulfamida-metaloprotease
ID22380A (id) Turunan-turunan pirazol sebagai herbisida
ATE255098T1 (de) Substituierte chromanderivate
DE69728139D1 (de) Pyrrolopyrrolone als inhibitoren von neutrophiler elastase
DE59813430D1 (de) Perylenhydrazidimide als Carbonylderivatisierungsreagenzien
DE69841086D1 (de) 5-Deoxy-Cytidin-Derivate
ATE255099T1 (de) Substituierte chromanderivate
ATE210112T1 (de) Substituierte 4-biphenyl-4- hydroxybuttersäurederivate als matrix metallprotease inhibitoren
ID19641A (id) Alat untuk menyediakan tenaga putaran
ATE221065T1 (de) Amidinderivate als inhibitoren von no-synthase
DK0966437T3 (da) 5-Aroylnaphthalenderivater
DE69829682D1 (de) Cis-disubstituierte aminocycloalkyl-pyrrolidin-derivate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties