NO995403L - Amidinderivater som inhibitorer av nitrogenoksydsyntase - Google Patents

Amidinderivater som inhibitorer av nitrogenoksydsyntase

Info

Publication number
NO995403L
NO995403L NO995403A NO995403A NO995403L NO 995403 L NO995403 L NO 995403L NO 995403 A NO995403 A NO 995403A NO 995403 A NO995403 A NO 995403A NO 995403 L NO995403 L NO 995403L
Authority
NO
Norway
Prior art keywords
nitric oxide
oxide synthase
inhibitors
amidine derivatives
compounds
Prior art date
Application number
NO995403A
Other languages
English (en)
Other versions
NO995403D0 (no
Inventor
James Macdonald
James Matz
William Shakespeare
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of NO995403D0 publication Critical patent/NO995403D0/no
Publication of NO995403L publication Critical patent/NO995403L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nye forbindelser av formel (I) HN hvor R1 representerer en 2-tienyl- eller 3-tienylring og R2 representerer hydrogen eller C l-4 alkyl og optiske isomerer og racemater derav og farmasøytisk akseptable salter derav; samt fremgangsmåter for deres fremstilling, preparater inneholdende forbindelsene og deres anvendelse i terapi. Forbindelsene er selektive inhibitorer av den neuronale isoformen av nitrogenoksydsyntase.
NO995403A 1997-05-05 1999-11-04 Amidinderivater som inhibitorer av nitrogenoksydsyntase NO995403L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9701681A SE9701681D0 (sv) 1997-05-05 1997-05-05 New compounds
PCT/SE1998/000785 WO1998050382A1 (en) 1997-05-05 1998-04-28 Amidine derivatives as inhibitors of nitric oxide synthase

Publications (2)

Publication Number Publication Date
NO995403D0 NO995403D0 (no) 1999-11-04
NO995403L true NO995403L (no) 2000-01-05

Family

ID=20406835

Family Applications (1)

Application Number Title Priority Date Filing Date
NO995403A NO995403L (no) 1997-05-05 1999-11-04 Amidinderivater som inhibitorer av nitrogenoksydsyntase

Country Status (25)

Country Link
US (1) US6489322B1 (no)
EP (1) EP0983268B1 (no)
JP (1) JP2001523262A (no)
KR (1) KR20010012228A (no)
CN (1) CN1255131A (no)
AR (1) AR012601A1 (no)
AT (1) ATE221065T1 (no)
AU (1) AU734391B2 (no)
BR (1) BR9809218A (no)
CA (1) CA2288333A1 (no)
DE (1) DE69806750T2 (no)
EE (1) EE9900474A (no)
HU (1) HUP0001873A3 (no)
ID (1) ID22885A (no)
IL (1) IL132678A0 (no)
IS (1) IS5236A (no)
MX (1) MXPA99009882A (no)
NO (1) NO995403L (no)
NZ (1) NZ500675A (no)
PL (1) PL336853A1 (no)
SE (1) SE9701681D0 (no)
SK (1) SK140599A3 (no)
TR (1) TR199902720T2 (no)
WO (1) WO1998050382A1 (no)
ZA (1) ZA983736B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
JPWO2006118104A1 (ja) * 2005-04-26 2008-12-18 株式会社東芝 白色ｌｅｄおよびそれを用いたバックライト並びに液晶表示装置
EP1910321A4 (en) * 2005-07-05 2010-09-01 Astrazeneca Ab NEW COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF, INTERMEDIATE PRODUCTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OF 5-HT6-MEDIATED ILLNESSES SUCH AS ALZHEIMER'S DISEASE, COGNITIVE ILLUSTRATIONS, SCHOISOPHRENIC ASSOCIATED COGNITIVE DISORDERS, OBESITAS AND PARKINSON DISEASE
MY148644A (en) 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
ATE528306T1 (de) * 2006-11-02 2011-10-15 Piramal Life Sciences Ltd Benzoxazepin-verbindungen, ihre herstellung und verwendung
EP2123644B1 (en) 2007-03-07 2014-12-17 Takeda Pharmaceutical Company Limited Benzoxazepine derivatives and use thereof
WO2008144483A2 (en) * 2007-05-18 2008-11-27 Armgo Pharma, Inc. Agents for treating disorders involving modulation of ryanodine receptors
BRPI1010974A2 (pt) * 2009-05-22 2019-09-24 Exelixis Inc benzoxazepinas baseada em inibidores p13k/ m tor contra doenças proliferativas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504278A (ja) 1944-06-01 1997-04-28 ザ、ウェルカム、ファンデーション、リミテッド Ｎｏシンターゼインヒビターとしての置換尿素およびイソチオ尿素誘導体
PL180081B1 (pl) 1993-08-12 2000-12-29 Astra Ab Nowe pochodne amidyny i sposób ich wytwarzania PL PL PL PL PL PL PL
KR100342275B1 (ko) 1993-10-21 2002-12-05 지.디. 썰 엘엘씨 산화질소신타제저해제로서유용한아미디노유도체
CA2188680A1 (en) * 1994-05-07 1996-01-25 James Edwin Macdonald Bicyclic amidine derivatives as inhibitors of nitric oxide synthetase
TW397812B (en) 1995-02-11 2000-07-11 Astra Ab Bicyclic isothiourea derivatives useful in therapy
KR970706272A (ko) * 1995-08-10 1997-11-03 클래스 빌헬름슨 치료에 유용한 바이시클릭 아미딘 유도체(Bicyclic Amidine Derivatives Useful in Therapy)
TW458978B (en) 1995-11-07 2001-10-11 Astra Ab Amidine and isothiourea derivatives as inhibitors of nitric oxide synthase

Also Published As

Publication number Publication date
CN1255131A (zh) 2000-05-31
ZA983736B (en) 1998-11-05
NZ500675A (en) 2001-05-25
SE9701681D0 (sv) 1997-05-05
IS5236A (is) 1999-11-01
EP0983268A1 (en) 2000-03-08
WO1998050382A1 (en) 1998-11-12
US6489322B1 (en) 2002-12-03
AR012601A1 (es) 2000-11-08
ATE221065T1 (de) 2002-08-15
SK140599A3 (en) 2000-06-12
EE9900474A (et) 2000-06-15
PL336853A1 (en) 2000-07-17
KR20010012228A (ko) 2001-02-15
EP0983268B1 (en) 2002-07-24
JP2001523262A (ja) 2001-11-20
ID22885A (id) 1999-12-16
HUP0001873A2 (hu) 2001-01-29
BR9809218A (pt) 2000-06-27
AU734391B2 (en) 2001-06-14
AU7459898A (en) 1998-11-27
NO995403D0 (no) 1999-11-04
TR199902720T2 (xx) 2000-02-21
MXPA99009882A (es) 2005-11-22
IL132678A0 (en) 2001-03-19
HUP0001873A3 (en) 2001-12-28
DE69806750T2 (de) 2003-03-06
CA2288333A1 (en) 1998-11-12
DE69806750D1 (de) 2002-08-29

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Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application