ATE221078T1 - Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung - Google Patents

Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung

Info

Publication number: ATE221078T1
Authority: AT; Austria
Prior art keywords: azithromycin; isopropanol; clathrates; production; methods
Prior art date: 1998-08-21

Application number

AT99306612T

Other languages

English (en)

Inventor

Khashayar Karimian

Mehrnoush Motamedi

Original Assignee

Apotex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-21

Filing date

1999-08-20

Publication date

2002-08-15

1999-08-20 Application filed by Apotex Inc filed Critical Apotex Inc

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE221078T1 publication Critical patent/ATE221078T1/de

Links

KFZMGEQAYNKOFK-UHFFFAOYSA-N isopropyl alcohol Natural products CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 title abstract 6
HQUPLSLYZHKKQT-WVVFQGGUSA-N (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-o Chemical compound O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 HQUPLSLYZHKKQT-WVVFQGGUSA-N 0.000 title abstract 3
229960003256 azithromycin monohydrate Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
229960004099 azithromycin Drugs 0.000 abstract 3
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99306612T 1998-08-21 1999-08-20 Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung ATE221078T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA002245398A CA2245398C (en)	1998-08-21	1998-08-21	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Publications (1)

Publication Number	Publication Date
ATE221078T1 true ATE221078T1 (de)	2002-08-15

Family

ID=4162751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99306612T ATE221078T1 (de)	1998-08-21	1999-08-20	Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung

Country Status (5)

Country	Link
US (2)	US6245903B1 (de)
EP (1)	EP0984020B1 (de)
AT (1)	ATE221078T1 (de)
CA (1)	CA2245398C (de)
DE (1)	DE69902212T2 (de)

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NZ532063A (en) *	2001-12-21	2006-03-31	Pfizer Prod Inc	Methods for wet granulating azithromycin
RU2283092C2 (ru) *	2002-02-01	2006-09-10	Пфайзер Продактс Инк.	Сухие гранулированные композиции азитромицина
HRP20020614A2 (en) *	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
CA2422972A1 (en) *	2003-03-21	2004-09-21	Apotex Inc.	Isopropanolate of azithromycin and method of manufacturing
EP1648472A2 (de) *	2003-07-01	2006-04-26	Ranbaxy Laboratories, Ltd.	Stabile orale zusammensetzungen von azithromycin-monohydrat
US20050013835A1 (en) *	2003-07-15	2005-01-20	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
ATE421882T1 (de)	2003-07-24	2009-02-15	Pliva Hrvatska D O O	Schnellösliches azithromycin in einzeldosisform
CA2547597A1 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate compositions with improved stability
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KR100844628B1 (ko) *	2003-12-04	2008-07-07	화이자 프로덕츠 인크.	제약상 다입자의 제조 방법
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
ES2600577T3 (es) *	2003-12-04	2017-02-09	Bend Research, Inc.	Procedimiento de pulverización-solidificación que usa un extrusor para preparar composiciones en multipartículas de fármacos cristalinos
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
WO2006011160A1 (en) *	2004-06-28	2006-02-02	Alembic Limited	Process for the preparation of azithromycin monohydrate isopropanol clathrate
US20090130154A1 (en) *	2004-08-26	2009-05-21	Bioderm Research	Topical Delivery of Biological and Cosmetic Agents by Zeolites
US7683162B2 (en) *	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
CA2591744A1 (en) *	2004-12-21	2006-06-29	Pfizer Products Inc.	Stable non-dihydrate azithromycin oral suspensions
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
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US20100158821A1 (en) *	2008-12-22	2010-06-24	Eastman Chemical Company	Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
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1998
- 1998-08-21 CA CA002245398A patent/CA2245398C/en not_active Expired - Fee Related
1999
- 1999-08-13 US US09/373,549 patent/US6245903B1/en not_active Ceased
- 1999-08-20 AT AT99306612T patent/ATE221078T1/de active
- 1999-08-20 EP EP99306612A patent/EP0984020B1/de not_active Expired - Lifetime
- 1999-08-20 DE DE69902212T patent/DE69902212T2/de not_active Expired - Fee Related
2003
- 2003-06-05 US US10/454,586 patent/USRE39087E1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0984020A2 (de)	2000-03-08
USRE39087E1 (en)	2006-05-02
CA2245398C (en)	2002-01-29
EP0984020B1 (de)	2002-07-24
US6245903B1 (en)	2001-06-12
CA2245398A1 (en)	2000-02-21
EP0984020A3 (de)	2000-10-04
DE69902212T2 (de)	2003-03-20
DE69902212D1 (de)	2002-08-29

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ATE221078T1 (de)	2002-08-15	Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung
ATE414094T1 (de)	2008-11-15	Zuckerverbindungen
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EP1300391A4 (de)	2006-01-04	Verfahren zur produktion von 3-amino-2-hydroxypropionsäure-derivaten
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RU95110383A (ru)	1997-06-27	Способ получения антихлорозного препарата
RU97107191A (ru)	1998-12-27	Способ получения гидроксида алюминия