ATE221078T1 - Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung - Google Patents

Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung

Info

Publication number: ATE221078T1
Authority: AT; Austria
Prior art keywords: azithromycin; isopropanol; clathrates; production; methods
Prior art date: 1998-08-21

Application number

AT99306612T

Other languages

English (en)

Inventor

Khashayar Karimian

Mehrnoush Motamedi

Original Assignee

Apotex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-21

Filing date

1999-08-20

Publication date

2002-08-15

1998-08-21 Priority claimed from CA2245398A external-priority patent/CA2245398E/en

1999-08-20 Application filed by Apotex Inc filed Critical Apotex Inc

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE221078T1 publication Critical patent/ATE221078T1/de

Links

KFZMGEQAYNKOFK-UHFFFAOYSA-N isopropyl alcohol Natural products CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 title abstract 6
HQUPLSLYZHKKQT-WVVFQGGUSA-N (2r,3s,4r,5r,8r,10r,11r,12s,13s,14r)-11-[(2s,3r,4s,6r)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2r,4r,5s,6s)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-o Chemical compound O.O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 HQUPLSLYZHKKQT-WVVFQGGUSA-N 0.000 title abstract 3
229960003256 azithromycin monohydrate Drugs 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
229960004099 azithromycin Drugs 0.000 abstract 3
MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 abstract 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT99306612T 1998-08-21 1999-08-20 Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung ATE221078T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA2245398A CA2245398E (en)		1998-08-21	Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Publications (1)

Publication Number	Publication Date
ATE221078T1 true ATE221078T1 (de)	2002-08-15

Family

ID=4162751

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99306612T ATE221078T1 (de)	1998-08-21	1999-08-20	Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung

Country Status (4)

Country	Link
US (2)	US6245903B1 (de)
EP (1)	EP0984020B1 (de)
AT (1)	ATE221078T1 (de)
DE (1)	DE69902212T2 (de)

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EP1455758A1 (de) *	2001-12-21	2004-09-15	Pfizer Products Inc.	Direktkomprimierbare formulierungen von azithromycin
EP1478347A1 (de) *	2002-02-01	2004-11-24	Pfizer Products Inc.	Trockene granulierte formulierungen von azithromycin
HRP20020614A2 (en) *	2002-07-22	2004-06-30	PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o.	Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
CA2422972A1 (en) *	2003-03-21	2004-09-21	Apotex Inc.	Isopropanolate of azithromycin and method of manufacturing
EP1648472A2 (de) *	2003-07-01	2006-04-26	Ranbaxy Laboratories, Ltd.	Stabile orale zusammensetzungen von azithromycin-monohydrat
US20050013835A1 (en) *	2003-07-15	2005-01-20	Pfizer Inc.	Stable non-dihydrate azithromycin oral suspensions
PL1648473T3 (pl)	2003-07-24	2009-07-31	Pliva Hrvatska D O O	Pojedyncza dawka szybko rozpuszczającej się azytromycyny
BRPI0417348A (pt) *	2003-12-04	2007-03-13	Pfizer Prod Inc	processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
RU2331410C2 (ru) *	2003-12-04	2008-08-20	Пфайзер Продактс Инк.	Способ получения фармацевтических мультичастиц
WO2005053652A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
WO2005053639A2 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Controlled release multiparticulates formed with dissolution enhancers
MXPA06005913A (es) *	2003-12-04	2006-06-27	Pfizer Prod Inc	Formas de dosificacion de multiparticulas de azitromicina por procedimientos basados en liquidos.
CA2547597A1 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate compositions with improved stability
US7384921B2 (en) *	2004-02-20	2008-06-10	Enanta Pharmaceuticals, Inc.	Polymorphic forms of 6-11 bicyclic ketolide derivatives
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
WO2006011160A1 (en) *	2004-06-28	2006-02-02	Alembic Limited	Process for the preparation of azithromycin monohydrate isopropanol clathrate
US20090130154A1 (en) *	2004-08-26	2009-05-21	Bioderm Research	Topical Delivery of Biological and Cosmetic Agents by Zeolites
US7683162B2 (en) *	2004-08-30	2010-03-23	Taro Pharmaceutical Industries Limited	Process of preparing a crystalline azithromycin monohydrate
CA2591744A1 (en) *	2004-12-21	2006-06-29	Pfizer Products Inc.	Stable non-dihydrate azithromycin oral suspensions
US7384922B2 (en) *	2005-05-04	2008-06-10	Enanta Pharmaceuticals, Inc.	6-11 bridged oxime erythromycin derivatives
US20090318375A1 (en) *	2005-06-08	2009-12-24	Hanmi Pharm Co., Ltd	Crystalline Azithromycin L-Malate Monohydrate and Pharmaceutical Composition Containing Same
US20100158821A1 (en) *	2008-12-22	2010-06-24	Eastman Chemical Company	Antimicrobial agents, compositions and products containing the same, and methods of using the compositions and products
BRPI1009823A2 (pt)	2009-03-13	2019-09-24	Da Volterra Assistance Publique Hopitaux De Paris E Univ Paris Diderot Paris 7	"composição compreendendo um sistema de dispensação de droga, conjunto de uma primeira e uma segunda composição, e, kit."
US8106111B2 (en) *	2009-05-15	2012-01-31	Eastman Chemical Company	Antimicrobial effect of cycloaliphatic diol antimicrobial agents in coating compositions
US20130059805A1 (en)	2009-12-18	2013-03-07	North-West University	Composition comprising an amorphous non-crystalline glass form of azithromycin
WO2013088274A1 (en)	2011-12-14	2013-06-20	Wockhardt Limited	Anhydrous amorphous azithromycin composition free of azithromycin dihydrate

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1999
- 1999-08-13 US US09/373,549 patent/US6245903B1/en not_active Ceased
- 1999-08-20 AT AT99306612T patent/ATE221078T1/de active
- 1999-08-20 DE DE69902212T patent/DE69902212T2/de not_active Expired - Fee Related
- 1999-08-20 EP EP99306612A patent/EP0984020B1/de not_active Expired - Lifetime
2003
- 2003-06-05 US US10/454,586 patent/USRE39087E1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2245398C (en)	2002-01-29
DE69902212D1 (de)	2002-08-29
EP0984020A2 (de)	2000-03-08
EP0984020A3 (de)	2000-10-04
US6245903B1 (en)	2001-06-12
USRE39087E1 (en)	2006-05-02
DE69902212T2 (de)	2003-03-20
CA2245398A1 (en)	2000-02-21
EP0984020B1 (de)	2002-07-24

Publication	Publication Date	Title
ATE221078T1 (de)	2002-08-15	Azithromycinmonohydrat-isopropanol-clathrate und methoden zu deren herstellung
ATE414094T1 (de)	2008-11-15	Zuckerverbindungen
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JP2004513603A5 (de)	2006-10-19
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HUP9901713A2 (hu)	1999-10-28	Eljárás enantiomer-tiszta 2-azetidinkarbonsav előállítására
CA2427199A1 (en)	2002-05-30	Process for the production of ceftiofur sodium salt
BR9805267A (pt)	1999-11-09	Processo para a produção de sulfeto de sódio desidratado.
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FR2825362B1 (fr)	2003-08-15	Procede de fabrication de l'oxime de la 2,2,4,4-tetramethyl- 3-pentanone et de sels d'hydroxylammonium
PT859795E (pt)	2003-08-29	Processo para a preparacao de ferro-dextrano cristalino
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