ES2177373B1 - Preparacion de azitromicina en su forma no cristalina - Google Patents

Preparacion de azitromicina en su forma no cristalina

Info

Publication number
ES2177373B1
ES2177373B1 ES009902620A ES9902620A ES2177373B1 ES 2177373 B1 ES2177373 B1 ES 2177373B1 ES 009902620 A ES009902620 A ES 009902620A ES 9902620 A ES9902620 A ES 9902620A ES 2177373 B1 ES2177373 B1 ES 2177373B1
Authority
ES
Spain
Prior art keywords
azithromycin
preparation
crystalline form
invention describes
lyophilization
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES009902620A
Other languages
English (en)
Other versions
ES2177373A1 (es
Inventor
Jasanada Miguel Santos Bayod
Garcia Isidro Llorente
Mari Felix Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AsturPharma SA
Original Assignee
AsturPharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AsturPharma SA filed Critical AsturPharma SA
Priority to ES009902620A priority Critical patent/ES2177373B1/es
Priority to EP01204550A priority patent/EP1234833B1/en
Priority to EP00500028A priority patent/EP1103558B1/en
Priority to DE60003509T priority patent/DE60003509T2/de
Priority to DE60027919T priority patent/DE60027919D1/de
Priority to AT00500028T priority patent/ATE243704T1/de
Priority to AT01204550T priority patent/ATE325805T1/de
Priority to US09/718,833 priority patent/US6451990B1/en
Priority to TR2000/03474A priority patent/TR200003474A3/tr
Priority to CA002485433A priority patent/CA2485433C/en
Priority to CA002326930A priority patent/CA2326930C/en
Priority to PL344101A priority patent/PL195910B1/pl
Priority to JP2000359948A priority patent/JP4260354B2/ja
Priority to ES200202318A priority patent/ES2207403B1/es
Publication of ES2177373A1 publication Critical patent/ES2177373A1/es
Application granted granted Critical
Publication of ES2177373B1 publication Critical patent/ES2177373B1/es
Priority to JP2008217072A priority patent/JP2009007376A/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparación de azitromicina en su forma no cristalina. La invención describe un procedimiento en el que el producto final se obtiene por liofilización de azitromicina en una solución de un alcohol alifático o de un éter cíclico. La invención describe métodos analíticos para diferenciar las formas no cristalina y la dihidrato cristalizada de azitromicina.
ES009902620A 1999-11-26 1999-11-26 Preparacion de azitromicina en su forma no cristalina Expired - Fee Related ES2177373B1 (es)

Priority Applications (15)

Application Number Priority Date Filing Date Title
ES009902620A ES2177373B1 (es) 1999-11-26 1999-11-26 Preparacion de azitromicina en su forma no cristalina
EP01204550A EP1234833B1 (en) 1999-11-26 2000-02-23 Preparation of crystalline azithromycin dihydrate.
EP00500028A EP1103558B1 (en) 1999-11-26 2000-02-23 Preparation of non-crystalline and crystalline dihydrate forms of azithromycin
DE60003509T DE60003509T2 (de) 1999-11-26 2000-02-23 Herstellung von nicht-kristallinen und kristallinen Dihydratformen von Azithromycin
DE60027919T DE60027919D1 (de) 1999-11-26 2000-02-23 Herstellung von kristalliner Dihydratform von Azithromycin
AT00500028T ATE243704T1 (de) 1999-11-26 2000-02-23 Herstellung von nicht-kristallinen und kristallinen dihydratformen von azithromycin
AT01204550T ATE325805T1 (de) 1999-11-26 2000-02-23 Herstellung von kristalliner dihydratform von azithromycin
US09/718,833 US6451990B1 (en) 1999-11-26 2000-11-22 Azithromycin preparation in its noncryst alline and crystalline dihydrate forms
TR2000/03474A TR200003474A3 (tr) 1999-11-26 2000-11-23 Azitromisinin kristalli olmayan ve kristalli dihitrat formlarinin hazirlanmasi
CA002485433A CA2485433C (en) 1999-11-26 2000-11-24 Preparation of non-crystalline and crystalline dihydrate forms of azithromycin
CA002326930A CA2326930C (en) 1999-11-26 2000-11-24 Preparation of non-crystalline and crystalline dihydrate forms of azithromycin
PL344101A PL195910B1 (pl) 1999-11-26 2000-11-24 Sposób wytwarzania 9-deokso-9a-aza-9a-metylo-9a-homoerytromycyny A w formie niekrystalicznej
JP2000359948A JP4260354B2 (ja) 1999-11-26 2000-11-27 非結晶および結晶二水和物形態のアジスロマイシンの調製
ES200202318A ES2207403B1 (es) 1999-11-26 2002-10-09 Preparacion de azitromicina en su forma dihidrato cristalina.
JP2008217072A JP2009007376A (ja) 1999-11-26 2008-08-26 非結晶および結晶二水和物形態のアジスロマイシンの調製

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009902620A ES2177373B1 (es) 1999-11-26 1999-11-26 Preparacion de azitromicina en su forma no cristalina

Publications (2)

Publication Number Publication Date
ES2177373A1 ES2177373A1 (es) 2002-12-01
ES2177373B1 true ES2177373B1 (es) 2003-11-01

Family

ID=8310747

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009902620A Expired - Fee Related ES2177373B1 (es) 1999-11-26 1999-11-26 Preparacion de azitromicina en su forma no cristalina
ES200202318A Expired - Fee Related ES2207403B1 (es) 1999-11-26 2002-10-09 Preparacion de azitromicina en su forma dihidrato cristalina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES200202318A Expired - Fee Related ES2207403B1 (es) 1999-11-26 2002-10-09 Preparacion de azitromicina en su forma dihidrato cristalina.

Country Status (9)

Country Link
US (1) US6451990B1 (es)
EP (2) EP1234833B1 (es)
JP (2) JP4260354B2 (es)
AT (2) ATE243704T1 (es)
CA (1) CA2326930C (es)
DE (2) DE60027919D1 (es)
ES (2) ES2177373B1 (es)
PL (1) PL195910B1 (es)
TR (1) TR200003474A3 (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) * 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US6245903B1 (en) 1998-08-21 2001-06-12 Apotex, Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
ES2162764B1 (es) * 2000-05-17 2003-04-01 Ercros Ind Sa Forma polimorfica del dihidrato de azitromicina, y su procedimiento deobtencion.
HU229488B1 (hu) * 2000-11-27 2014-01-28 Sandoz Ag Eljárás makrolid hidrátok elõállítására
IN190080B (es) * 2001-01-29 2003-06-07 Alembic Ltd
KR100491183B1 (ko) * 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
EP1652851A1 (en) * 2001-05-22 2006-05-03 Pfizer Products Inc. New crystal form of Azithromycin
US6861413B2 (en) 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
DE60209704T2 (de) 2001-05-22 2006-11-16 Pfizer Products Inc., Groton Neue kristallforme von azithromycin
NZ532707A (en) 2001-12-21 2006-07-28 Pfizer Prod Inc Directly compressible formulations of azithromycin
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
EP1474404A4 (en) 2002-02-13 2006-01-11 Biogal Gyogyszergyar PROCESS FOR EXTRACTION OF A BIOLOGICAL MATERIAL
HRP20020614A2 (en) 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
KR20050114262A (ko) * 2003-03-31 2005-12-05 테바 기오기스제르갸르 레스즈베니타르사사그 마크로라이드의 결정화 및 정제
EP1558622B1 (en) 2003-07-24 2007-11-14 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method of purifying macrolides
RU2331410C2 (ru) * 2003-12-04 2008-08-20 Пфайзер Продактс Инк. Способ получения фармацевтических мультичастиц
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
WO2006115494A1 (en) * 2005-04-26 2006-11-02 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7683162B2 (en) 2004-08-30 2010-03-23 Taro Pharmaceutical Industries Limited Process of preparing a crystalline azithromycin monohydrate
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
WO2006060615A1 (en) 2004-12-01 2006-06-08 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Non-hygroscopic and powdery amorphous pimecrolimus
WO2007007148A1 (en) * 2005-07-14 2007-01-18 Pfizer Products Inc. Process for forming amorphous azithromycin particles
JP2009518648A (ja) * 2005-12-07 2009-05-07 ワイス 結晶性ラパマイシンを調製するための方法およびを示差走査熱量測定使用してラパマイシン化合物の結晶化度を測定するための方法
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
WO2011015219A1 (en) 2009-08-06 2011-02-10 Shifa Pharmed Industrial Group Co. Process for the purification of azithromycin by separation from its thermal degradation products and/or isomers
KR20120107989A (ko) * 2009-12-18 2012-10-04 노스-웨스트 유니버시티 아지트로마이신의 무정형 비결정성 글래스 형태를 포함하는 조성물
WO2013088274A1 (en) * 2011-12-14 2013-06-20 Wockhardt Limited Anhydrous amorphous azithromycin composition free of azithromycin dihydrate
CN106188177A (zh) * 2016-07-12 2016-12-07 浙江亚太药业股份有限公司 一种阿奇霉素化合物的制备方法及其药物制剂
CN108003109A (zh) * 2017-12-18 2018-05-08 南开大学 一种大环内酯化合物的晶型及其制备方法与用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
MX12213A (es) 1987-07-09 1993-05-01 Pfizer Metodo de preparacion de dihidrato de azitromicina cristalino
WO1994026758A1 (en) * 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
ECSP951389A (es) 1995-02-21 1996-05-10 Un procedimiento de obtencion de hidrato de azitromicina
ES2122905B1 (es) 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
US6245903B1 (en) * 1998-08-21 2001-06-12 Apotex, Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Also Published As

Publication number Publication date
ES2177373A1 (es) 2002-12-01
DE60003509T2 (de) 2004-04-15
TR200003474A2 (tr) 2001-07-23
PL195910B1 (pl) 2007-11-30
CA2326930C (en) 2005-03-22
CA2326930A1 (en) 2001-05-26
TR200003474A3 (tr) 2001-07-23
EP1234833B1 (en) 2006-05-10
ATE325805T1 (de) 2006-06-15
ATE243704T1 (de) 2003-07-15
EP1103558B1 (en) 2003-06-25
EP1234833A2 (en) 2002-08-28
JP2001187797A (ja) 2001-07-10
DE60027919D1 (de) 2006-06-14
PL344101A1 (en) 2001-06-04
US6451990B1 (en) 2002-09-17
EP1103558A3 (en) 2001-07-04
EP1234833A3 (en) 2003-03-12
JP4260354B2 (ja) 2009-04-30
JP2009007376A (ja) 2009-01-15
DE60003509D1 (de) 2003-07-31
ES2207403A1 (es) 2004-05-16
ES2207403B1 (es) 2005-03-01
EP1103558A2 (en) 2001-05-30

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