ATE221527T1 - Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide - Google Patents

Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Info

Publication number: ATE221527T1
Authority: AT; Austria
Prior art keywords: usable; thiophene sulfonamides; sulfonamides; carbohydrase; inhibitors
Prior art date: 1990-04-09

Application number

AT91908317T

Other languages

English (en)

Inventor

Thomas R Dean

Hwang-Hsing Chen

Jesse A May

Anura Pathmaciri Dantanarayana

Daniel Kuzmich

Paul W Zinke

Raymond Eugene Conrow

Michael E Deason

Mark Thomas Dupriest

Original Assignee

Alcon Lab Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-09

Filing date

1991-04-03

Publication date

2002-08-15

1991-04-03 Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE221527T1 publication Critical patent/ATE221527T1/de

Links

229940124530 sulfonamide Drugs 0.000 title abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Divinylene sulfide Natural products C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
-1 THIOPHENE SULFONAMIDES Chemical class 0.000 title 1
108010089934 carbohydrase Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229930192474 thiophene Natural products 0.000 title 1
230000004410 intraocular pressure Effects 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003456 sulfonamides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Lubricants (AREA)

AT91908317T 1990-04-09 1991-04-03 Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide ATE221527T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US50673090A	1990-04-09	1990-04-09
US07/618,765 US5153192A (en)	1990-04-09	1990-11-27	Thiophene sulfonamides useful as carbonic anhydrase inhibitors
PCT/US1991/002262 WO1991015486A1 (en)	1990-04-09	1991-04-03	Thiophene sulfonamides useful as carbonic anydrase inhibitors

Publications (1)

Publication Number	Publication Date
ATE221527T1 true ATE221527T1 (de)	2002-08-15

Family

ID=27055558

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91908317T ATE221527T1 (de)	1990-04-09	1991-04-03	Als carbohydrase-inhibitoren verwendbare thiophen sulfonamide

Country Status (19)

Country	Link
US (2)	US5153192A (de)
EP (1)	EP0527801B1 (de)
JP (1)	JP2562394B2 (de)
KR (1)	KR100196414B1 (de)
AT (1)	ATE221527T1 (de)
AU (1)	AU655924B2 (de)
BR (1)	BR9106330A (de)
CA (1)	CA2080223C (de)
DE (3)	DE69133080T2 (de)
DK (1)	DK0527801T3 (de)
ES (1)	ES2180530T3 (de)
FI (2)	FI963424A0 (de)
IL (1)	IL97800A (de)
LU (2)	LU90935I2 (de)
NL (2)	NL300098I2 (de)
NO (1)	NO923948L (de)
NZ (1)	NZ237754A (de)
WO (1)	WO1991015486A1 (de)
ZA (1)	ZA912580B (de)

Families Citing this family (82)

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US5344929A (en) *	1993-02-18	1994-09-06	Alcon Laboratories, Inc.	Preparation of carbonic anhydrase inhibitors
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JP2001526231A (ja)	1997-12-23	2001-12-18	アルコンラボラトリーズ，インコーポレーテッド	視野欠損を予防するためのブリンゾルアミドの使用
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AU741525B2 (en) *	1998-03-06	2001-12-06	Board Of Regents, The University Of Texas System	Composition and method for treating macular disorders
US5948801A (en) *	1998-03-09	1999-09-07	Alcon Laboratories, Inc.	Treatment of retinal edema with brinzolamide
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CA661731A (en) *		1963-04-23	Farbwerke Hoechst Aktiengesellschaft Vormals Meister Lucius And Bruning	Substituted thiophene-3,5-disulfonamides and a process for preparing them
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1990
- 1990-11-27 US US07/618,765 patent/US5153192A/en not_active Expired - Lifetime
1991
- 1991-04-03 DE DE69133080T patent/DE69133080T2/de not_active Expired - Lifetime
- 1991-04-03 EP EP91908317A patent/EP0527801B1/de not_active Expired - Lifetime
- 1991-04-03 WO PCT/US1991/002262 patent/WO1991015486A1/en not_active Ceased
- 1991-04-03 DE DE1991633080 patent/DE10299054I1/de active Pending
- 1991-04-03 ES ES91908317T patent/ES2180530T3/es not_active Expired - Lifetime
- 1991-04-03 BR BR919106330A patent/BR9106330A/pt not_active Application Discontinuation
- 1991-04-03 DE DE122009000026C patent/DE122009000026I1/de active Pending
- 1991-04-03 FI FI963424A patent/FI963424A0/fi not_active Application Discontinuation
- 1991-04-03 FI FI924553A patent/FI924553L/fi not_active Application Discontinuation
- 1991-04-03 JP JP3508001A patent/JP2562394B2/ja not_active Expired - Lifetime
- 1991-04-03 AU AU77467/91A patent/AU655924B2/en not_active Expired
- 1991-04-03 DK DK91908317T patent/DK0527801T3/da active
- 1991-04-03 KR KR1019920702476A patent/KR100196414B1/ko not_active Expired - Lifetime
- 1991-04-03 AT AT91908317T patent/ATE221527T1/de active
- 1991-04-03 CA CA002080223A patent/CA2080223C/en not_active Expired - Lifetime
- 1991-04-08 ZA ZA912580A patent/ZA912580B/xx unknown
- 1991-04-09 IL IL9780091A patent/IL97800A/xx not_active IP Right Cessation
- 1991-04-09 NZ NZ237754A patent/NZ237754A/en unknown
- 1991-10-09 US US07/775,313 patent/US5240923A/en not_active Expired - Lifetime
1992
- 1992-10-09 NO NO92923948A patent/NO923948L/no unknown
2002
- 2002-07-05 LU LU90935C patent/LU90935I2/fr unknown
- 2002-09-04 NL NL300098C patent/NL300098I2/nl unknown
2009
- 2009-04-22 LU LU91555C patent/LU91555I2/fr unknown
- 2009-05-11 NL NL300389C patent/NL300389I1/nl unknown

Also Published As

Publication number	Publication date
CA2080223C (en)	2000-11-07
DE69133080T2 (de)	2003-03-27
ES2180530T3 (es)	2003-02-16
US5240923A (en)	1993-08-31
HK1014186A1 (en)	1999-09-24
LU91555I2 (fr)	2009-06-22
DK0527801T3 (da)	2002-11-25
NZ237754A (en)	1992-08-26
AU7746791A (en)	1991-10-30
IL97800A (en)	1997-08-14
FI963424L (fi)	1996-09-02
FI924553A0 (fi)	1992-10-08
EP0527801A4 (en)	1993-03-10
ZA912580B (en)	1992-01-29
LU90935I2 (en)	2002-09-05
FI924553A7 (fi)	1992-10-08
DE69133080D1 (de)	2002-09-05
NL300098I2 (nl)	2003-01-06
CA2080223A1 (en)	1991-10-10
KR100196414B1 (ko)	1999-06-15
FI963424A7 (fi)	1996-09-02
DE10299054I1 (de)	2006-06-08
KR930700490A (ko)	1993-03-15
FI963424A0 (fi)	1996-09-02
EP0527801B1 (de)	2002-07-31
EP0527801A1 (de)	1993-02-24
NL300098I1 (nl)	2002-11-01
WO1991015486A1 (en)	1991-10-17
NO923948D0 (no)	1992-10-09
NO923948L (no)	1992-12-08
US5153192A (en)	1992-10-06
BR9106330A (pt)	1993-04-20
JPH05508832A (ja)	1993-12-09
AU655924B2 (en)	1995-01-19
DE122009000026I1 (de)	2010-01-28
FI924553L (fi)	1992-10-08
IL97800A0 (en)	1992-06-21
NL300389I1 (nl)	2009-07-01
JP2562394B2 (ja)	1996-12-11

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FI913034A0 (fi)	1991-06-20	Foerening med magsyrainhiberande effekt och foerfarande foer dess framstaellning.
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ATE164066T1 (de)	1998-04-15	Neue pharmazeutische formulierungen von 5-(2- chlor-1-hydroxyethyl)-4-methylthiazol
PT100241A (pt)	1994-05-31	Composicoes farmaceuticas liquidas a base de derivados da piperidina substituida em 1,4
YU2394A (sh)	1996-10-18	Lizin so 6-hloro-5-fluoro-3-(-2-tenoil)-2-oksindol-1-karboksamida
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IT8920570A0 (it)	1989-05-19	Procedimento di preparazione di derivati eterociclici.