LU90935I2 - Azopt-brinzolamide - Google Patents

Azopt-brinzolamide

Info

Publication number
LU90935I2
LU90935I2 LU90935C LU90935C LU90935I2 LU 90935 I2 LU90935 I2 LU 90935I2 LU 90935 C LU90935 C LU 90935C LU 90935 C LU90935 C LU 90935C LU 90935 I2 LU90935 I2 LU 90935I2
Authority
LU
Luxembourg
Prior art keywords
azopt
brinzolamide
disclosed
intraocular pressure
controlling intraocular
Prior art date
Application number
LU90935C
Other languages
English (en)
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of LU90935I2 publication Critical patent/LU90935I2/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
LU90935C 1990-04-09 2002-07-05 Azopt-brinzolamide LU90935I2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50673090A 1990-04-09 1990-04-09
US07/618,765 US5153192A (en) 1990-04-09 1990-11-27 Thiophene sulfonamides useful as carbonic anhydrase inhibitors
PCT/US1991/002262 WO1991015486A1 (fr) 1990-04-09 1991-04-03 Sulfamides de thiophene utiles en tant qu'inhibiteurs d'anhydrase carbonique

Publications (1)

Publication Number Publication Date
LU90935I2 true LU90935I2 (en) 2002-09-05

Family

ID=27055558

Family Applications (2)

Application Number Title Priority Date Filing Date
LU90935C LU90935I2 (en) 1990-04-09 2002-07-05 Azopt-brinzolamide
LU91555C LU91555I2 (fr) 1990-04-09 2009-04-22 "Brinzolamide et timolol optionnellement sous de sels pharmaceutiquement acceptables te que la combination du produit brinzolamide/timolol maléate (AZARGA)"

Family Applications After (1)

Application Number Title Priority Date Filing Date
LU91555C LU91555I2 (fr) 1990-04-09 2009-04-22 "Brinzolamide et timolol optionnellement sous de sels pharmaceutiquement acceptables te que la combination du produit brinzolamide/timolol maléate (AZARGA)"

Country Status (19)

Country Link
US (2) US5153192A (fr)
EP (1) EP0527801B1 (fr)
JP (1) JP2562394B2 (fr)
KR (1) KR100196414B1 (fr)
AT (1) ATE221527T1 (fr)
AU (1) AU655924B2 (fr)
BR (1) BR9106330A (fr)
CA (1) CA2080223C (fr)
DE (3) DE69133080T2 (fr)
DK (1) DK0527801T3 (fr)
ES (1) ES2180530T3 (fr)
FI (2) FI924553A7 (fr)
IL (1) IL97800A (fr)
LU (2) LU90935I2 (fr)
NL (2) NL300098I2 (fr)
NO (1) NO923948L (fr)
NZ (1) NZ237754A (fr)
WO (1) WO1991015486A1 (fr)
ZA (1) ZA912580B (fr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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US5585377A (en) * 1990-04-09 1996-12-17 Alcon Laboratories, Inc. Sulfonamides useful as carbonic anhydrase inhibitors
FR2662439B1 (fr) * 1990-05-23 1993-11-19 Rhone Poulenc Chimie Reactif et procede de perfluoroalkylation de substrats nucleophiles par les perfluoroalcanesulfinates de sodium en milieu oxydant.
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
EP0625903B1 (fr) * 1992-02-21 1998-08-12 Alcon Laboratories, Inc. Compositions antiglaucome a usage local comprenant des inhibiteurs d'anhydrase carbonique et de beta-bloquants
US5932572A (en) * 1992-02-21 1999-08-03 Alcon Laboratories, Inc. Topical anti-glaucoma compositions
US5276025A (en) * 1992-09-09 1994-01-04 Merck & Co., Inc. Heterobicyclic sulfonamides
US5308842A (en) * 1992-09-09 1994-05-03 Merck & Co., Inc. Tricyclic derivatives of the thienodiazocine and thienothiadiazocine classes of compounds
WO1994006411A1 (fr) * 1992-09-17 1994-03-31 Alcon Laboratories, Inc. Compositions topique d'inhibiteur d'anhydrase carbonique
US5344929A (en) * 1993-02-18 1994-09-06 Alcon Laboratories, Inc. Preparation of carbonic anhydrase inhibitors
AU1684895A (en) * 1994-01-21 1995-08-08 Alcon Laboratories, Inc. Thienothiazine sulfonamide derivatives process and intermediates for their preparation and their use as carbonic anhydrase inhibitors
US5538966A (en) * 1994-01-21 1996-07-23 Alcon Laboratories, Inc. Carbonic anhydrase inhibitors
US5646142A (en) * 1994-07-08 1997-07-08 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5464831A (en) * 1994-09-09 1995-11-07 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5510347A (en) * 1994-09-09 1996-04-23 Alcon Laboratories, Inc. Thienothiadiazine sulfonamides useful as carbonic anhydrase inhibitors
US5470973A (en) * 1994-10-03 1995-11-28 Alcon Laboratories, Inc. Synthesis of sulfonamide intermediates
US5620970A (en) * 1995-06-05 1997-04-15 Alcon Laboratories, Inc. Topical ophthalmic carbonic anhydrase inhibitor formulations
US6172054B1 (en) 1995-06-15 2001-01-09 Alcon Laboratories, Inc. Combination therapy for lowering and controlling intraocular pressure
AU2998995A (en) * 1995-07-12 1997-02-10 Alcon Laboratories, Inc. Thiophene sulfonamides useful as carbonic anhydrase inhibitors
EP1057486A1 (fr) * 1995-11-17 2000-12-06 Alcon Laboratories, Inc. L'utilisation d'une combinaison de produits pharmacologiques dans le traitement du glaucome
US6441047B2 (en) 1995-11-17 2002-08-27 Alcon Manufacturing Ltd.. Combination therapy for treating glaucoma
CA2247063C (fr) * 1996-02-26 2004-01-06 Advanced Research & Technology Institute Traitement contre l'oedeme maculaire
US5900427A (en) * 1996-05-03 1999-05-04 Wisconsin Alumni Research Foundation N-heteroarenesulfonyl-protected amino acid reagents for peptide synthesis
AUPO227896A0 (en) * 1996-09-13 1996-10-03 Fujisawa Pharmaceutical Co., Ltd. Novel compounds and their preparation
BR9814497A (pt) 1997-12-23 2000-10-10 Alcon Lab Inc Processo para prevenir ou retardar perda de campo visual associada com glaucoma ou hipertensão ocular
US6156785A (en) * 1998-01-23 2000-12-05 Merck Sharp & Dohme B.V. Method for increasing oxygen tension in the optic nerve and retina
EP1058546A4 (fr) * 1998-03-06 2004-07-28 Univ Texas Traitement de troubles maculaires et composition appropriee
US5948801A (en) * 1998-03-09 1999-09-07 Alcon Laboratories, Inc. Treatment of retinal edema with brinzolamide
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
EP1251862B1 (fr) 2000-01-18 2008-10-01 Merck & Co., Inc. Compositions ophthalmiques pour traiter l'hypertension oculaire
US6548535B2 (en) 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
CA2397203A1 (fr) * 2000-03-31 2001-10-11 Sandra C. Tobias Promedicaments a base de phorphoramidates
AU1770901A (en) * 2000-11-16 2002-05-27 Alcon Lab Inc Combination therapy for lowering and controlling intraocular pressure
US20040067992A1 (en) * 2001-08-10 2004-04-08 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a carbonic anhydrase inhibitor for the treatment of neoplasia
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
AU2003216547A1 (en) * 2002-03-15 2003-09-29 Merck And Co., Inc. Compositions and methods for treating glaucoma and ocular hypertension
US20060258726A1 (en) * 2002-06-06 2006-11-16 Xavier Billot 1,5-Disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
WO2003105847A1 (fr) * 2002-06-14 2003-12-24 Merck & Co., Inc. Compositions ophthalmiques pour traiter l'hypertension oculaire
EP1515974A4 (fr) * 2002-06-17 2007-02-28 Merck & Co Inc Nouveaux bloqueurs de canaux maxi k, methodes d'utilisation et procedes de fabrication associes
JP2005532361A (ja) * 2002-06-17 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧症の治療用の眼科用組成物
US20050239787A1 (en) * 2002-06-17 2005-10-27 Goetz Michael A Novel maxi-k channel blockers, methods of use and process for making the same
WO2004019938A1 (fr) * 2002-08-28 2004-03-11 Merck Frosst Canada & Co. Derives de l'oxazolidin-2-one et de la thiazolidin-2-one antagonistes du recepteur ep4, pour le traitement du glaucome
JP2006505572A (ja) * 2002-10-25 2006-02-16 メルク フロスト カナダ アンド カンパニー Ｅｐ４受容体アゴニストとしての２−ピロリドン
KR100503618B1 (ko) * 2002-11-07 2005-07-26 안헌상 케이크용 장식용품
US20040216749A1 (en) * 2003-01-23 2004-11-04 Hosheng Tu Vasomodulation during glaucoma surgery
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US20050119262A1 (en) * 2003-08-21 2005-06-02 Pharmacia Corporation Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
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CN101801375B (zh) 2007-01-25 2014-01-01 韦尔瓦制药有限公司 胰岛素增敏剂和治疗方法
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EP1985618A1 (fr) * 2007-04-27 2008-10-29 Duke Chem, S. A. Procédé de préparation de brinzolamide et intermédiaires correspondants
US20110015158A1 (en) 2007-12-11 2011-01-20 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitors using metal binding moieties in combination with targeting moieties
ITMI20081084A1 (it) * 2008-06-16 2009-12-17 Phf Sa Processo per la preparazione di brinzolamide
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension
WO2010103115A1 (fr) * 2009-03-13 2010-09-16 Azad Pharmaceutical Ingredients Ag Procédé de préparation de brinzolamide
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
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EP2348026A1 (fr) * 2009-12-22 2011-07-27 Duke Chem, S. A. Procédé de préparation de brinzolamide et des intermédiares
EP2394637A1 (fr) 2010-05-21 2011-12-14 Zaklady Farmaceutyczne Polpharma SA Procédé pour l'obtention de suspensions stériles de brinzolamide
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US20110021974A1 (en) * 2010-10-05 2011-01-27 Shantha Totada R Retinitis pigmentosa treatment and prophalaxis
WO2012053011A2 (fr) 2010-10-18 2012-04-26 Usv Limited Compositions ophthalmiques comprenant de la brinzolamide
EP4193907A1 (fr) 2011-09-13 2023-06-14 Glaukos Corporation Capteur physiologique intraoculaire
JP5836851B2 (ja) * 2012-03-12 2015-12-24 株式会社トクヤマ ブリンゾラミドの製造方法
EP2638909A1 (fr) 2012-03-15 2013-09-18 Azad Pharmaceutical Ingredients AG Procédé de préparation stérile brinzolamide
JP5881514B2 (ja) * 2012-04-09 2016-03-09 株式会社トクヤマ アミン誘導体の製造方法
JP5914246B2 (ja) * 2012-08-10 2016-05-11 株式会社トクヤマ ブリンゾラミドの精製方法
CN102936236A (zh) * 2012-11-13 2013-02-20 江苏吉贝尔药业有限公司 一种布林佐胺中间体(3-乙酰基-5-氯-2-(苄基巯基)噻酚)的制备方法
US9730638B2 (en) 2013-03-13 2017-08-15 Glaukos Corporation Intraocular physiological sensor
EA030535B1 (ru) 2013-10-17 2018-08-31 Сентисс Фарма Прайвет Лимитед Не содержащий консерванта офтальмологический фармацевтический состав
US9820991B2 (en) 2013-11-08 2017-11-21 Sentiss Pharma Private Limited Pharmaceutical composition comprising brinzolamide
WO2015068105A1 (fr) 2013-11-08 2015-05-14 Sentiss Pharma Private Limited Procédé amélioré de fabrication de suspensions pharmaceutiques ophtalmiques stériles
PT3096740T (pt) * 2014-01-24 2020-12-24 Sentiss Pharma Private Ltd Composição farmacêutica que compreende brinzolamida
WO2016063184A1 (fr) 2014-10-20 2016-04-28 Sentiss Pharma Private Limited Solution ophtalmique
WO2017099207A1 (fr) * 2015-12-10 2017-06-15 千寿製薬株式会社 Produit pharmaceutique ophtalmique
KR20190093205A (ko) 2016-12-21 2019-08-08 바이오테릭스, 인코포레이티드 단백질 표적화에 사용하기 위한 티에노피롤 유도체, 조성물, 방법 및 이의 용도
WO2019207380A1 (fr) 2018-04-25 2019-10-31 Shilpa Medicare Limited Compositions ophtalmiques de brinzolamide
WO2024236599A1 (fr) 2023-05-16 2024-11-21 Micro Labs Limited Solution ophtalmique de brinzolamide

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CA661731A (en) * 1963-04-23 Farbwerke Hoechst Aktiengesellschaft Vormals Meister Lucius And Bruning Substituted thiophene-3,5-disulfonamides and a process for preparing them
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Also Published As

Publication number Publication date
ATE221527T1 (de) 2002-08-15
DE69133080D1 (de) 2002-09-05
IL97800A0 (en) 1992-06-21
FI924553L (fi) 1992-10-08
JP2562394B2 (ja) 1996-12-11
NO923948D0 (no) 1992-10-09
JPH05508832A (ja) 1993-12-09
KR930700490A (ko) 1993-03-15
NZ237754A (en) 1992-08-26
NL300389I1 (nl) 2009-07-01
CA2080223A1 (fr) 1991-10-10
ES2180530T3 (es) 2003-02-16
AU655924B2 (en) 1995-01-19
KR100196414B1 (ko) 1999-06-15
US5240923A (en) 1993-08-31
WO1991015486A1 (fr) 1991-10-17
ZA912580B (en) 1992-01-29
DK0527801T3 (da) 2002-11-25
DE122009000026I1 (de) 2010-01-28
BR9106330A (pt) 1993-04-20
NO923948L (no) 1992-12-08
CA2080223C (fr) 2000-11-07
EP0527801A1 (fr) 1993-02-24
EP0527801A4 (en) 1993-03-10
EP0527801B1 (fr) 2002-07-31
FI924553A0 (fi) 1992-10-08
US5153192A (en) 1992-10-06
FI924553A7 (fi) 1992-10-08
FI963424L (fi) 1996-09-02
LU91555I2 (fr) 2009-06-22
IL97800A (en) 1997-08-14
HK1014186A1 (en) 1999-09-24
FI963424A0 (fi) 1996-09-02
DE10299054I1 (de) 2006-06-08
NL300098I1 (nl) 2002-11-01
NL300098I2 (nl) 2003-01-06
DE69133080T2 (de) 2003-03-27
AU7746791A (en) 1991-10-30
FI963424A7 (fi) 1996-09-02

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