ATE221898T1 - Gegen aus thrombin und thrombininhibitoren gebildete komplexe gerichtete monoklonale antikörper - Google Patents
Gegen aus thrombin und thrombininhibitoren gebildete komplexe gerichtete monoklonale antikörperInfo
- Publication number
- ATE221898T1 ATE221898T1 AT91810748T AT91810748T ATE221898T1 AT E221898 T1 ATE221898 T1 AT E221898T1 AT 91810748 T AT91810748 T AT 91810748T AT 91810748 T AT91810748 T AT 91810748T AT E221898 T1 ATE221898 T1 AT E221898T1
- Authority
- AT
- Austria
- Prior art keywords
- thrombin
- monoclonal antibodies
- derivatives
- antibodies against
- complex
- Prior art date
Links
- 108090000190 Thrombin Proteins 0.000 title abstract 4
- 229960004072 thrombin Drugs 0.000 title abstract 4
- 229940122388 Thrombin inhibitor Drugs 0.000 title 1
- 239000003868 thrombin inhibitor Substances 0.000 title 1
- WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 3
- 102000007625 Hirudins Human genes 0.000 abstract 2
- 108010007267 Hirudins Proteins 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 229940006607 hirudin Drugs 0.000 abstract 2
- 210000004408 hybridoma Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 238000003149 assay kit Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000000644 propagated effect Effects 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909021370A GB9021370D0 (en) | 1990-10-02 | 1990-10-02 | Monoclonal antibodies directed against complexes formed by thrombin and thrombin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE221898T1 true ATE221898T1 (de) | 2002-08-15 |
Family
ID=10683074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91810748T ATE221898T1 (de) | 1990-10-02 | 1991-09-24 | Gegen aus thrombin und thrombininhibitoren gebildete komplexe gerichtete monoklonale antikörper |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | ATE221898T1 (de) |
| DE (1) | DE69133082D1 (de) |
| GB (1) | GB9021370D0 (de) |
| IE (1) | IE913458A1 (de) |
| PT (1) | PT99114B (de) |
| SG (1) | SG52676A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2699526T3 (es) * | 2015-07-28 | 2019-02-11 | Hoffmann La Roche | Prueba de endotoxinas bacterianas mejorada para la determinación de endotoxinas |
| CN116162165A (zh) * | 2022-11-22 | 2023-05-26 | 杭州博茵生物技术有限公司 | 抗人凝血酶-抗凝血酶复合物抗体、制备方法、检测试剂及应用 |
-
1990
- 1990-10-02 GB GB909021370A patent/GB9021370D0/en active Pending
-
1991
- 1991-09-24 DE DE69133082T patent/DE69133082D1/de not_active Expired - Lifetime
- 1991-09-24 AT AT91810748T patent/ATE221898T1/de not_active IP Right Cessation
- 1991-09-24 SG SG1996007687A patent/SG52676A1/en unknown
- 1991-09-30 PT PT9911491A patent/PT99114B/pt not_active IP Right Cessation
- 1991-10-01 IE IE345891A patent/IE913458A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9021370D0 (en) | 1990-11-14 |
| PT99114A (pt) | 1992-08-31 |
| DE69133082D1 (de) | 2002-09-12 |
| PT99114B (pt) | 1999-02-26 |
| SG52676A1 (en) | 1998-09-28 |
| IE913458A1 (en) | 1992-04-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |