ATE222237T1 - Endothelin-antagonisten - Google Patents

Endothelin-antagonisten

Info

Publication number: ATE222237T1
Authority: AT; Austria
Prior art keywords: endothelin antagonists; alpha; chain; carbon atoms; active ingredient
Prior art date: 1996-06-10

Application number

AT97925279T

Other languages

English (en)

Inventor

Ryuji Ueno

Original Assignee

Sucampo Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-10

Filing date

1997-06-04

Publication date

2002-08-15

1997-06-04 Application filed by Sucampo Ag filed Critical Sucampo Ag

2002-08-15 Application granted granted Critical

2002-08-15 Publication of ATE222237T1 publication Critical patent/ATE222237T1/de

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
239000004480 active ingredient Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S502/00—Catalyst, solid sorbent, or support therefor: product or process of making
- Y10S502/50—Stabilized
- Y10S502/503—Crush strength

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT97925279T 1996-06-10 1997-06-04 Endothelin-antagonisten ATE222237T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP14716696		1996-06-10
JP1019197		1997-01-23
PCT/JP1997/001892 WO1997047595A1 (en)	1996-06-10	1997-06-04	Endothelin antagonist

Publications (1)

Publication Number	Publication Date
ATE222237T1 true ATE222237T1 (de)	2002-08-15

Family

ID=26345421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97925279T ATE222237T1 (de)	1996-06-10	1997-06-04	Endothelin-antagonisten

Country Status (14)

Country	Link
US (2)	US6242485B1 (de)
EP (1)	EP0857718B1 (de)
JP (1)	JP3187438B2 (de)
KR (1)	KR19990036322A (de)
CN (3)	CN102126998B (de)
AT (1)	ATE222237T1 (de)
CA (1)	CA2229183C (de)
DE (1)	DE69714698T2 (de)
DK (1)	DK0857718T3 (de)
ES (1)	ES2182088T3 (de)
NO (1)	NO980553L (de)
PT (1)	PT857718E (de)
TW (1)	TW418188B (de)
WO (1)	WO1997047595A1 (de)

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IL134840A0 (en) *	1997-09-09	2001-05-20	Procter & Gamble	Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
DE69824966T2 (de) *	1997-09-09	2005-04-07	Duke University	Aromatische c16-c20-substituierte tetrahydro-prostaglandine verwendbar wie fp agoniste
BR9811779A (pt) *	1997-09-09	2000-09-12	Procter & Gamble	Tetrahidro prostaglandina s substituìdas por c16-c20 aromáticos úteis como agonistas fp
AU739343B2 (en)	1997-11-28	2001-10-11	Sucampo Ag	Endothelin antagonist
JP4834224B2 (ja)	1999-03-05	2011-12-14	デュークユニバーシティ	Ｃ１６不飽和ｆｐ−選択的プロスタグランジン類縁体
US20020172693A1 (en)	2000-03-31	2002-11-21	Delong Michell Anthony	Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en)	2000-03-31	2002-01-31	Delong Mitchell Anthony	Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
TWI302100B (en)	2001-05-02	2008-10-21	Sucampo Ag	Composition for treating drug-induced constipation
ATE387204T1 (de) *	2001-05-18	2008-03-15	Sucampo Ag	Zusammensetzung mit induzierendem kathartischen effekt
WO2003020283A2 (en) *	2001-08-29	2003-03-13	Novartis Ag	Method for treating diabetic retinopathy
EP1420794B1 (de)	2001-08-31	2017-12-27	Sucampo AG	Prostaglandin-analoga als chloridkanalöffner
AR037524A1 (es) *	2001-11-14	2004-11-17	Sucampo Ag	Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
AU2003280130B2 (en)	2002-06-28	2009-06-11	Centocor, Inc.	Mammalian CH1 deleted mimetibodies, compositions, methods and uses
WO2005018646A1 (ja)	2003-08-21	2005-03-03	Sucampo Ag	眼科用組成物
NZ539582A (en) *	2002-10-23	2007-07-27	Sucampo Ag	Prostaglandin compounds for the treatment of obesity
EP1575596B1 (de)	2002-12-27	2016-06-22	Sucampo AG	Prostaglandinderivate zur behandlung von reizdarmsyndrom und/oder funktionellen dyspepsie
DE602004030245D1 (de) *	2003-07-03	2011-01-05	Sucampo Ag	Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
TWI495471B (zh) *	2003-08-12	2015-08-11	R Tech Ueno Ltd	促進毛髮生長之組成物及方法
JP4690814B2 (ja) *	2004-08-02	2011-06-01	株式会社アールテック・ウエノ	プロスタグランジン誘導体の製造法
US8202909B2 (en)	2005-01-27	2012-06-19	Sucampo Ag	Method for treating central nervous system disorders
KR20160120809A (ko)	2005-03-04	2016-10-18	수캄포 아게	말초 혈관 질환 치료를 위한 방법 및 조성물
US20060281818A1 (en)	2005-03-21	2006-12-14	Sucampo Ag, North Carolina State University	Method for treating mucosal disorders
WO2006106915A1 (ja) *	2005-03-31	2006-10-12	Asahi Glass Company, Limited	プロスタグランジンＦ2α誘導体を有効成分として含む網膜神経細胞保護剤
RU2468800C2 (ru) *	2005-04-12	2012-12-10	Сукампо Аг	Комбинированное применение производного простагландина и ингибитора протонового насоса для лечения желудочно-кишечных заболеваний
MX2008009650A (es)	2006-01-24	2008-11-06	R Tech Ueno Ltd	Formulacion de capsula de gelatina suave.
JP5265369B2 (ja)	2006-01-24	2013-08-14	株式会社アールテック・ウエノ	二環式化合物を含む医薬組成物およびその二環式化合物の安定化方法
KR101437302B1 (ko) *	2006-02-07	2014-09-02	가부시키가이샤 아루떼꾸 우에노	프로스타글란딘 유도체의 제조 방법
CN101400354B (zh)	2006-03-13	2014-10-22	株式会社·R-技术上野	水性组合物
WO2007119214A2 (en) *	2006-04-13	2007-10-25	Actelion Pharmaceuticals Ltd	Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
US8871752B2 (en)	2008-02-19	2014-10-28	Sucampo Ag	Method for modulating stem cell growth
CA2639240A1 (en) *	2008-08-29	2010-02-28	Alphora Research Inc.	Prostaglandin synthesis and intermediates for use therein
US20110293549A1 (en)	2009-02-03	2011-12-01	Athena Cosmetics, Inc.	Composition, method and kit for enhancing hair
US8609729B2 (en)	2009-04-15	2013-12-17	Sucampo Ag	Method for treating macular degeneration
US8569279B2 (en) *	2009-05-27	2013-10-29	Sucampo Ag	Method for modulating claudin mediated functions
US9084815B2 (en) *	2009-09-16	2015-07-21	Sucampo Ag	Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
TW201247206A (en)	2011-04-07	2012-12-01	Sucampo Ag	Method for treating asthenopia
US8592483B2 (en)	2011-08-05	2013-11-26	Sucampo Ag	Method for treating schizophrenia
AR092821A1 (es)	2012-04-20	2015-05-06	Sucampo Ag	Conjugado de derivado de acido graso-polimero
US20150057351A1 (en)	2013-08-22	2015-02-26	Sucampo Ag	Method for treating neuropathic pain
GB201418567D0 (en) *	2014-10-20	2014-12-03	Syngenta Participations Ag	Improvements in or relating to organic compounds
AR105029A1 (es)	2015-06-19	2017-08-30	Sucampo Ag	Composición farmacéutica que comprende derivado de ácido graso

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US3853951A (en) *	1971-07-14	1974-12-10	American Cyanamid Co	Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en) *	1972-02-11	1977-04-19	American Cyanamid Company	3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
CA1027118A (en) *	1972-04-03	1978-02-28	Martin J. Weiss	3-alkyl-2-(6-carboxyhexyl) cyclopentanones and esters and salts thereof
US3981868A (en) *	1973-05-31	1976-09-21	American Cyanamid Company	Derivatives of 9-oxo-13-trans-prostenoic acid amides
US3974195A (en)	1974-10-02	1976-08-10	The Upjohn Company	2A,2B-Dihomo-15-alkyl-PGF2.sub.α analogs
US4026909A (en) *	1975-07-14	1977-05-31	The Upjohn Company	Cis-13-PGF2.sub.α analogs
US4166187A (en) *	1977-04-11	1979-08-28	The Upjohn Company	9-deoxy-9-methylene-16-phenyl-5,6-didehydro-pgf2 or 4,4,5,5-tetradehydro-pgf1 compounds
CA2030345C (en) *	1989-11-22	1998-12-08	Ryuji Ueno	Use of 15-keto-prostaglandin compound for improvement of encephalic function
US5140271A (en)	1989-12-26	1992-08-18	Texaco Inc.	Watercut means and method with debris reducing test cell
US5292754A (en)	1990-03-08	1994-03-08	Shionogi & Co., Ltd.	Treatment for hypertension or glaucoma in eyes
TW224942B (de) *	1990-04-04	1994-06-11	Adka Ueno Kk
BE1004080A6 (fr) *	1990-04-18	1992-09-22	Centre Rech Metallurgique	Procede pour le controle automatique de la qualite d'un composant de carrosserie automobile.
CA2046069C (en) *	1990-07-10	2002-04-09	Ryuji Ueno	Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
JPH07113012B2 (ja) *	1991-01-29	1995-12-06	株式会社アールテック・ウエノ	新規１５−ケト−プロスタグランジン類
ES2093774T3 (es) *	1991-03-14	1997-01-01	R Tech Ueno Ltd	Estimulacion de la curacion de heridas con un compuesto 15-cetoprostaglandina.

1997
- 1997-06-04 WO PCT/JP1997/001892 patent/WO1997047595A1/ja not_active Ceased
- 1997-06-04 ES ES97925279T patent/ES2182088T3/es not_active Expired - Lifetime
- 1997-06-04 DE DE69714698T patent/DE69714698T2/de not_active Expired - Lifetime
- 1997-06-04 CN CN2010106011957A patent/CN102126998B/zh not_active Expired - Fee Related
- 1997-06-04 AT AT97925279T patent/ATE222237T1/de active
- 1997-06-04 US US09/011,218 patent/US6242485B1/en not_active Expired - Lifetime
- 1997-06-04 PT PT97925279T patent/PT857718E/pt unknown
- 1997-06-04 JP JP50143198A patent/JP3187438B2/ja not_active Expired - Fee Related
- 1997-06-04 CN CNB971910588A patent/CN100337632C/zh not_active Expired - Fee Related
- 1997-06-04 CA CA002229183A patent/CA2229183C/en not_active Expired - Fee Related
- 1997-06-04 KR KR1019980700990A patent/KR19990036322A/ko not_active Ceased
- 1997-06-04 CN CN200710126275XA patent/CN101085756B/zh not_active Expired - Fee Related
- 1997-06-04 DK DK97925279T patent/DK0857718T3/da active
- 1997-06-04 EP EP97925279A patent/EP0857718B1/de not_active Expired - Lifetime
- 1997-06-07 TW TW086107892A patent/TW418188B/zh not_active IP Right Cessation
1998
- 1998-02-09 NO NO980553A patent/NO980553L/no not_active Application Discontinuation
1999
- 1999-12-30 US US09/475,285 patent/US6452039B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2229183A1 (en)	1997-12-18
CA2229183C (en)	2008-11-04
JP3187438B2 (ja)	2001-07-11
DE69714698D1 (de)	2002-09-19
ES2182088T3 (es)	2003-03-01
NO980553L (no)	1998-04-07
CN101085756A (zh)	2007-12-12
CN100337632C (zh)	2007-09-19
PT857718E (pt)	2002-11-29
CN101085756B (zh)	2011-03-02
AU716176B2 (en)	2000-02-17
EP0857718A4 (de)	1999-07-28
CN1198737A (zh)	1998-11-11
US6452039B1 (en)	2002-09-17
CN102126998A (zh)	2011-07-20
DE69714698T2 (de)	2002-12-05
DK0857718T3 (da)	2002-12-16
KR19990036322A (ko)	1999-05-25
WO1997047595A1 (en)	1997-12-18
CN102126998B (zh)	2013-06-12
EP0857718A1 (de)	1998-08-12
TW418188B (en)	2001-01-11
AU3047897A (en)	1998-01-07
US6242485B1 (en)	2001-06-05
NO980553D0 (no)	1998-02-09
EP0857718B1 (de)	2002-08-14

Legal Events

Date	Code	Title	Description
2003-01-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE222237T1 (de)	2002-08-15	Endothelin-antagonisten
FI955258L (fi)	1995-11-30	Takykiniiniantagonisteina käyttökelpoisia substituoituja pyrrolidiini-3-yl-alkyyli-piperidiineja
FI933167A7 (fi)	1993-07-09	N-alkyylikinuklidiniumsuolat aineen P antagonisteina
MY126559A (en)	2006-10-31	Fungicidal 2-methoxybenzophenones
NO996429L (no)	1999-12-23	2-substituerte 4,5-diarylimidazoler
FI953748L (fi)	1995-08-07	Yhdisteitä, joilla on sekä voimakas kalsium antagonisti- että antioksidanttiaktiivisuus sekä niiden käyttö solua suojaavina aineina
ITRM920361A1 (it)	1993-11-12	Composizioni farmaceutiche contenenti un composto allilamminico quale principio attivo.
FI960727L (fi)	1996-02-16	Neurokiniiniantagonisteina käyttökelpoiset heterosyklit
DK1000048T3 (da)	2003-03-03	Substituerede 1,2,3,4-tetrahydronapthalenderivater
DE69300694D1 (de)	1995-11-30	Desinfizierende Zusammensetzungen.
EP0671911A4 (de)	1996-08-21	Carboxypeptidyl-derivate als antidegenerative wirkstoffe.
FI912621A7 (fi)	1991-12-02	Farmakologisesti aktiivisia keskushermostoon vaikuttavia yhdisteitä
BG99863A (bg)	1996-02-29	Антагонисти на фибриногеновия рецептор
ES2188984T3 (es)	2003-07-01	Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas.
BG102589A (en)	1999-09-30	3-azetidinylalkylpiperidines or -pyrrolidines as tachykin antagonists
HRP20010238B1 (en)	2006-05-31	2-methyl-thieno-benzodiazepine formulation
ATE198202T1 (de)	2001-01-15	Fibrinogen receptor antagonisten
FI972684L (fi)	1997-06-19	Piperidiinietikkahappojohdannaisia, joita voidaan käyttää fibrinogeeniantagonisteina
FI912622A7 (fi)	1991-12-02	Farmakologisesti aktiivisia keskushermostoon vaikuttavia yhdisteitä
FI945164A7 (fi)	1994-11-02	Biologisesti aktiivisesti ureidojohdannaiset, jotka ovat käyttökelpoisia antimetastaattisina aineina
EP1008345A4 (de)	2000-09-13	Antiallergische mittel
IT8920405A0 (it)	1989-05-08	Aminoimidazopiridine farmacologicamente attive.
KR950700297A (ko)	1995-01-16	5-HT3-수용체 길항제로서의 2,6-메타노-2H-퀴놀리진 유도체(2,6-Methano-2H-quinolizin derivative as 5-HT3-receptor antagonist)
DK0882044T3 (da)	2002-09-02	1,4-dihydropyridinforbindelser som bradykinin-antagonister
DE59106679D1 (de)	1995-11-16	Spreizwerkzeug.