DK0857718T3 - Endothelinantagonist - Google Patents

Endothelinantagonist

Info

Publication number: DK0857718T3
Authority: DK; Denmark
Prior art keywords: endothelin antagonist; alpha; chain; carbon atoms; active ingredient
Prior art date: 1996-06-10

Application number

DK97925279T

Other languages

English (en)

Inventor

Ryuji Ueno

Original Assignee

Sucampo Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-10

Filing date

1997-06-04

Publication date

2002-12-16

1997-06-04 Application filed by Sucampo Ag filed Critical Sucampo Ag

2002-12-16 Application granted granted Critical

2002-12-16 Publication of DK0857718T3 publication Critical patent/DK0857718T3/da

Links

239000002308 endothelin receptor antagonist Substances 0.000 title abstract 2
239000004480 active ingredient Substances 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/558—Eicosanoids, e.g. leukotrienes or prostaglandins having heterocyclic rings containing oxygen as the only ring hetero atom, e.g. thromboxanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S502/00—Catalyst, solid sorbent, or support therefor: product or process of making
- Y10S502/50—Stabilized
- Y10S502/503—Crush strength

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK97925279T 1996-06-10 1997-06-04 Endothelinantagonist DK0857718T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP14716696		1996-06-10
JP1019197		1997-01-23
PCT/JP1997/001892 WO1997047595A1 (en)	1996-06-10	1997-06-04	Endothelin antagonist

Publications (1)

Publication Number	Publication Date
DK0857718T3 true DK0857718T3 (da)	2002-12-16

Family

ID=26345421

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97925279T DK0857718T3 (da)	1996-06-10	1997-06-04	Endothelinantagonist

Country Status (14)

Country	Link
US (2)	US6242485B1 (da)
EP (1)	EP0857718B1 (da)
JP (1)	JP3187438B2 (da)
KR (1)	KR19990036322A (da)
CN (3)	CN101085756B (da)
AT (1)	ATE222237T1 (da)
CA (1)	CA2229183C (da)
DE (1)	DE69714698T2 (da)
DK (1)	DK0857718T3 (da)
ES (1)	ES2182088T3 (da)
NO (1)	NO980553L (da)
PT (1)	PT857718E (da)
TW (1)	TW418188B (da)
WO (1)	WO1997047595A1 (da)

Families Citing this family (41)

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JP4619531B2 (ja) *	1997-09-09	2011-01-26	デュークユニバーシティ	Ｆｐアゴニストとして有用な、芳香族のあるｃ１６〜ｃ２０が置換されたテトラヒドロプロスタグランジン類
EP1021402B1 (en) *	1997-09-09	2005-11-23	Duke University	Aromatic c16-c20-substituted tetrahydro prostaglandins useful as fp agonists
AU731153B2 (en) *	1997-09-09	2001-03-22	Duke University	Aromatic C16-C20-substituted tetrahydro prostaglandins useful as FP agonists
ES2310013T3 (es)	1997-11-28	2008-12-16	Sucampo Ag	Uso de compuestos de 15-ceto-prostaglandina e como antagonistas de endotelina.
ATE281432T1 (de)	1999-03-05	2004-11-15	Univ Duke	C-16 ungesätigte fp-selektive prostaglandin analoge
US20020172693A1 (en)	2000-03-31	2002-11-21	Delong Michell Anthony	Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020013294A1 (en)	2000-03-31	2002-01-31	Delong Mitchell Anthony	Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
TWI302100B (en)	2001-05-02	2008-10-21	Sucampo Ag	Composition for treating drug-induced constipation
WO2002094274A1 (en) *	2001-05-18	2002-11-28	Sucampo Ag	Cathartic composition
WO2003020283A2 (en) *	2001-08-29	2003-03-13	Novartis Ag	Method for treating diabetic retinopathy
EP1420794B1 (en)	2001-08-31	2017-12-27	Sucampo AG	Prostaglandin analogs as chloride channel openers
AR037524A1 (es)	2001-11-14	2004-11-17	Sucampo Ag	Unidad de dosificacion que comprende un analogo de prostaglandina para el tratamiento de la constipacion
CA2490409A1 (en)	2002-06-28	2004-01-08	Centocor, Inc.	Mammalian ch1 deleted mimetibodies, compositions, methods and uses
DK1562604T3 (da) *	2002-10-23	2012-04-02	Sucampo Ag	Prostaglandinforbindelser til behandling af fedme
BRPI0317740B8 (pt)	2002-12-27	2021-05-25	Sucampo Ag	uso do composto 13,14-diidro-15-ceto-16,16-diflúorprostaglandina e1
ATE489096T1 (de) *	2003-07-03	2010-12-15	Sucampo Ag	Pharmazeutische magensaftresistent überzogene zusammensetzung enthaltend prostaglandin-analoga als chloridkanalöffner
TWI348386B (en) *	2003-08-12	2011-09-11	R Tech Ueno Ltd	Composition and method for promoting hair growth
ES2431640T3 (es)	2003-08-21	2013-11-27	Sucampo Ag	Composición oftálmica que comprende éster isopropílico de unoprostona y un agente de viscosidad
JP4690814B2 (ja) *	2004-08-02	2011-06-01	株式会社アールテック・ウエノ	プロスタグランジン誘導体の製造法
DK1841433T3 (da)	2005-01-27	2012-01-16	Sucampo Ag	Præparat til behandling af lidelser i centralnervesystemet
DE602006018583D1 (de)	2005-03-04	2011-01-13	Sucampo Ag	Verfahren und zusammensetzung zur behandlung von peripheren gefässkrankheiten
US20060281818A1 (en)	2005-03-21	2006-12-14	Sucampo Ag, North Carolina State University	Method for treating mucosal disorders
KR101396731B1 (ko) *	2005-03-31	2014-05-19	산텐 세이야꾸 가부시키가이샤	프로스타글란딘 Ｆ２ａ 유도체를 유효 성분으로서 함유하는망막신경세포 보호제
WO2006109881A1 (en) *	2005-04-12	2006-10-19	Sucampo Ag	Combined use of prostaglandin compound and proton pump inhibitor for the treatment of gastrointestinal disorders
CA2637274C (en)	2006-01-24	2013-06-04	R-Tech Ueno, Ltd.	Soft-gelatin capsule formulation
EP1984027B1 (en) *	2006-01-24	2015-12-30	R-Tech Ueno, Ltd.	Pharmaceutical composition comprising a bi-cyclic compound and method for stabilizing the bi-cyclic compound
EP2735566A1 (en) *	2006-02-07	2014-05-28	R-Tech Ueno, Ltd.	Method for preparing prostaglandin derivative
JPWO2007105691A1 (ja)	2006-03-13	2009-07-30	株式会社アールテック・ウエノ	水性組成物
SG174050A1 (en) *	2006-04-13	2011-09-29	Actelion Pharmaceuticals Ltd	Endothelin receptor antagonists for early stage idiopathic pulmonary fibrosis
US8871752B2 (en) *	2008-02-19	2014-10-28	Sucampo Ag	Method for modulating stem cell growth
CA2639240A1 (en) *	2008-08-29	2010-02-28	Alphora Research Inc.	Prostaglandin synthesis and intermediates for use therein
US20110293549A1 (en)	2009-02-03	2011-12-01	Athena Cosmetics, Inc.	Composition, method and kit for enhancing hair
US8609729B2 (en)	2009-04-15	2013-12-17	Sucampo Ag	Method for treating macular degeneration
US8569279B2 (en) *	2009-05-27	2013-10-29	Sucampo Ag	Method for modulating claudin mediated functions
US9084815B2 (en) *	2009-09-16	2015-07-21	Sucampo Ag	Method for treating damage induced by an anti-tumor agent, treating mucositis and treating tumor
CN103561748A (zh)	2011-04-07	2014-02-05	苏坎波公司	治疗眼疲劳的方法
RU2648474C2 (ru)	2011-08-05	2018-03-26	Сукампо Аг	Способ лечения шизофрении
AR092821A1 (es)	2012-04-20	2015-05-06	Sucampo Ag	Conjugado de derivado de acido graso-polimero
US20150057351A1 (en)	2013-08-22	2015-02-26	Sucampo Ag	Method for treating neuropathic pain
GB201418567D0 (en) *	2014-10-20	2014-12-03	Syngenta Participations Ag	Improvements in or relating to organic compounds
US20170020890A1 (en)	2015-06-19	2017-01-26	Sucampo Ag	Pharmaceutical composition comprising fatty acid derivative

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3853951A (en) *	1971-07-14	1974-12-10	American Cyanamid Co	Preparation of 9-oxo-13-trans-prostenoic acid esters by alanate addition to cyclopentenone
US4018811A (en) *	1972-02-11	1977-04-19	American Cyanamid Company	3-Alkyl-2-(6-carboxyhexyl)cyclopentanones and esters and salts thereof
CA1027118A (en) *	1972-04-03	1978-02-28	Martin J. Weiss	3-alkyl-2-(6-carboxyhexyl) cyclopentanones and esters and salts thereof
US3981868A (en)	1973-05-31	1976-09-21	American Cyanamid Company	Derivatives of 9-oxo-13-trans-prostenoic acid amides
US3974195A (en)	1974-10-02	1976-08-10	The Upjohn Company	2A,2B-Dihomo-15-alkyl-PGF2.sub.α analogs
US4026909A (en)	1975-07-14	1977-05-31	The Upjohn Company	Cis-13-PGF2.sub.α analogs
US4166187A (en)	1977-04-11	1979-08-28	The Upjohn Company	9-deoxy-9-methylene-16-phenyl-5,6-didehydro-pgf2 or 4,4,5,5-tetradehydro-pgf1 compounds
CA2030345C (en) *	1989-11-22	1998-12-08	Ryuji Ueno	Use of 15-keto-prostaglandin compound for improvement of encephalic function
US5140271A (en)	1989-12-26	1992-08-18	Texaco Inc.	Watercut means and method with debris reducing test cell
US5292754A (en)	1990-03-08	1994-03-08	Shionogi & Co., Ltd.	Treatment for hypertension or glaucoma in eyes
TW224942B (da) *	1990-04-04	1994-06-11	Adka Ueno Kk
BE1004080A6 (fr) *	1990-04-18	1992-09-22	Centre Rech Metallurgique	Procede pour le controle automatique de la qualite d'un composant de carrosserie automobile.
CA2046069C (en) *	1990-07-10	2002-04-09	Ryuji Ueno	Treatment of inflammatory diseases with 15-keto-prostaglandin compounds
JPH07113012B2 (ja) *	1991-01-29	1995-12-06	株式会社アールテック・ウエノ	新規１５−ケト−プロスタグランジン類
EP0503887B1 (en)	1991-03-14	1996-08-28	R-Tech Ueno Ltd.	Promotion of wound-healing with 15-keto-prostaglandin compounds

1997
- 1997-06-04 JP JP50143198A patent/JP3187438B2/ja not_active Expired - Fee Related
- 1997-06-04 KR KR1019980700990A patent/KR19990036322A/ko not_active Ceased
- 1997-06-04 WO PCT/JP1997/001892 patent/WO1997047595A1/ja not_active Ceased
- 1997-06-04 CA CA002229183A patent/CA2229183C/en not_active Expired - Fee Related
- 1997-06-04 US US09/011,218 patent/US6242485B1/en not_active Expired - Lifetime
- 1997-06-04 DK DK97925279T patent/DK0857718T3/da active
- 1997-06-04 AT AT97925279T patent/ATE222237T1/de active
- 1997-06-04 EP EP97925279A patent/EP0857718B1/en not_active Expired - Lifetime
- 1997-06-04 CN CN200710126275XA patent/CN101085756B/zh not_active Expired - Fee Related
- 1997-06-04 ES ES97925279T patent/ES2182088T3/es not_active Expired - Lifetime
- 1997-06-04 CN CNB971910588A patent/CN100337632C/zh not_active Expired - Fee Related
- 1997-06-04 CN CN2010106011957A patent/CN102126998B/zh not_active Expired - Fee Related
- 1997-06-04 PT PT97925279T patent/PT857718E/pt unknown
- 1997-06-04 DE DE69714698T patent/DE69714698T2/de not_active Expired - Lifetime
- 1997-06-07 TW TW086107892A patent/TW418188B/zh not_active IP Right Cessation
1998
- 1998-02-09 NO NO980553A patent/NO980553L/no not_active Application Discontinuation
1999
- 1999-12-30 US US09/475,285 patent/US6452039B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CN100337632C (zh)	2007-09-19
EP0857718B1 (en)	2002-08-14
CN1198737A (zh)	1998-11-11
DE69714698D1 (de)	2002-09-19
ATE222237T1 (de)	2002-08-15
AU3047897A (en)	1998-01-07
ES2182088T3 (es)	2003-03-01
EP0857718A4 (en)	1999-07-28
PT857718E (pt)	2002-11-29
CA2229183A1 (en)	1997-12-18
US6452039B1 (en)	2002-09-17
CA2229183C (en)	2008-11-04
TW418188B (en)	2001-01-11
AU716176B2 (en)	2000-02-17
CN102126998B (zh)	2013-06-12
CN101085756A (zh)	2007-12-12
JP3187438B2 (ja)	2001-07-11
CN102126998A (zh)	2011-07-20
NO980553D0 (no)	1998-02-09
EP0857718A1 (en)	1998-08-12
DE69714698T2 (de)	2002-12-05
WO1997047595A1 (en)	1997-12-18
KR19990036322A (ko)	1999-05-25
CN101085756B (zh)	2011-03-02
NO980553L (no)	1998-04-07
US6242485B1 (en)	2001-06-05

Publication	Publication Date	Title
DK0857718T3 (da)	2002-12-16	Endothelinantagonist
MY126559A (en)	2006-10-31	Fungicidal 2-methoxybenzophenones
PT925298E (pt)	2004-07-30	Derivados 6,6-hetero-biciclicos substituidos
ID25548A (id)	2000-10-12	Senyawa-senyawa heterosiklik spiroazabisiklik terbaru
FI954651A7 (fi)	1995-09-29	Mahdollisesti substituoidut 6,8-kinoliinit
FI960156A7 (fi)	1996-01-12	Bentsyylioksikinuklidiinit aineet P antagonisteina
NO996429L (no)	1999-12-23	2-substituerte 4,5-diarylimidazoler
IT1271014B (it)	1997-05-26	3-aril-benzofuranoni come agenti stabilizzanti
DE69803907D1 (de)	2002-03-28	Fungizide 2-Methoxybenzophenone
DE69300694D1 (de)	1995-11-30	Desinfizierende Zusammensetzungen.
EP0671911A4 (en)	1996-08-21	CARBOXYPEPTIDYL DERIVATIVES AS AN ANTIDEGENERATIVE ACTIVE SUBSTANCES.
ES2188984T3 (es)	2003-07-01	Procedimiento de enriquecimiento en r de epimeros de derivados de 16,17-acetales de derivados de 21-aciloxi-pregnano-1,4-dieno-11-beta, 16alfa-triol-3,20-dionas.
HRP20010238B1 (en)	2006-05-31	2-methyl-thieno-benzodiazepine formulation
DE69818261D1 (en)	2003-10-23	Hydroxycyclopentanone
FI945164A7 (fi)	1994-11-02	Biologisesti aktiivisesti ureidojohdannaiset, jotka ovat käyttökelpoisia antimetastaattisina aineina
EP1008345A4 (en)	2000-09-13	ANTI-ALLERGIC AGENTS
DK1073447T3 (da)	2007-09-03	N1-modificerede glycopeptider
FI914818L (fi)	1993-01-20	Ackumulator, i synnerhet blyackumulator, speciellt foer nyttofordon
FI941149L (fi)	1994-12-22	2,4-diamino-3-hydroksikarboksyylihapon johdannaisia
FR2688308B1 (fr)	1994-05-27	Granulometre a laser.
ITRM940378A0 (it)	1994-06-15	Composizioni erbicide.
KR950700297A (ko)	1995-01-16	5-HT3-수용체 길항제로서의 2,6-메타노-2H-퀴놀리진 유도체(2,6-Methano-2H-quinolizin derivative as 5-HT3-receptor antagonist)
HN1997000013A (es)	1997-06-26	Compuestos 1,4 dihidropiridina
BR9612409A (pt)	1999-07-13	1,2,4,6-Tiatriazinas substituídas úteis como herbididas
IT1267343B1 (it)	1997-01-28	Composizione insetticida.