ATE222589T1 - Peptid-nukleinsäure-konjugate - Google Patents

Peptid-nukleinsäure-konjugate

Info

Publication number
ATE222589T1
ATE222589T1 AT95938726T AT95938726T ATE222589T1 AT E222589 T1 ATE222589 T1 AT E222589T1 AT 95938726 T AT95938726 T AT 95938726T AT 95938726 T AT95938726 T AT 95938726T AT E222589 T1 ATE222589 T1 AT E222589T1
Authority
AT
Austria
Prior art keywords
peptide
acid conjugates
nuclic acid
nucleic acids
peptide nucleic
Prior art date
Application number
AT95938726T
Other languages
English (en)
Inventor
Peter Nielsen
Michael Egholm
Ole Di Buchardt
Soren Holst Sonnechsen
Jesper Lohse
Muthiah Manoharan
John Kiely
Michael Griffith
Kelly Sprankle
Original Assignee
Isis Pharmaceuticals Inc
Buchardt Dorte
Nielsen Peter Eigil
Michael Egholm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,411 external-priority patent/US7223833B1/en
Application filed by Isis Pharmaceuticals Inc, Buchardt Dorte, Nielsen Peter Eigil, Michael Egholm filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE222589T1 publication Critical patent/ATE222589T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95938726T 1994-10-06 1995-10-06 Peptid-nukleinsäure-konjugate ATE222589T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/319,411 US7223833B1 (en) 1991-05-24 1994-10-06 Peptide nucleic acid conjugates
PCT/US1995/012931 WO1996011205A1 (en) 1994-10-06 1995-10-06 Peptide nucleic acid conjugates

Publications (1)

Publication Number Publication Date
ATE222589T1 true ATE222589T1 (de) 2002-09-15

Family

ID=23242149

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95938726T ATE222589T1 (de) 1994-10-06 1995-10-06 Peptid-nukleinsäure-konjugate

Country Status (9)

Country Link
EP (1) EP0804456B1 (de)
JP (1) JP3307945B2 (de)
AT (1) ATE222589T1 (de)
AU (1) AU3999495A (de)
DE (1) DE69527857T2 (de)
DK (1) DK0804456T3 (de)
ES (1) ES2181799T3 (de)
PT (1) PT804456E (de)
WO (1) WO1996011205A1 (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU728176B2 (en) * 1995-05-04 2001-01-04 Gilead Sciences, Inc. Nucleic acid ligand complexes
US8071737B2 (en) 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids
EP0863150A1 (de) * 1997-02-08 1998-09-09 Boehringer Mannheim Gmbh Verfahren zur Herstellung einer Nukleinsäure-bindende Substanz
DE19712530A1 (de) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren
CA2291839A1 (en) * 1997-05-28 1998-12-03 Peter E. Nielsen Conjugated peptide nucleic acids having enhanced cellular uptake
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブｐｎａによるｄｎａの検出方法
AU741546B2 (en) * 1997-07-24 2001-12-06 Perseptive Biosystems, Inc. Conjugates of transporter peptides and nucleic acid analogs, and their use
AU9570898A (en) * 1997-09-18 1999-04-05 Gene Therapy Systems, Inc. Chemical modification of dna using peptide nucleic acid conjugates
DE19757516A1 (de) * 1997-12-23 1999-06-24 Roche Diagnostics Gmbh Modifizierte Nukleinsäureanaloga
CA2320390C (en) 1998-02-11 2010-06-08 Applied Biosystems, Llc Pna and dna conjugates and methods for preparation thereof
US20040186071A1 (en) * 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
AU4965499A (en) 1998-07-09 2000-02-01 Biocept, Inc. Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation
SE9803099D0 (sv) 1998-09-13 1998-09-13 Karolinska Innovations Ab Nucleic acid transfer
US6548651B1 (en) 1998-11-11 2003-04-15 Pantheco A/S Modified peptide nucleic acid (PNA) molecules
CA2388991A1 (en) * 1998-11-11 2001-04-19 Peter E. Nielsen Conjugates between a peptides and a nucleic acid analog, such as a pna, lna or a morpholino
DE10019135A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019136A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
CA2427146A1 (en) 2000-10-25 2002-07-18 Mayo Foundation For Medical Education And Research Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
DE10201862A1 (de) * 2002-01-18 2003-08-07 Deutsches Krebsforsch Konjugat zur Behandlung prokaryontischer Infektionen
AU2003291755A1 (en) 2002-11-05 2004-06-07 Isis Pharmaceuticals, Inc. Oligomers comprising modified bases for binding cytosine and uracil or thymine and their use
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US20050260131A1 (en) * 2004-05-20 2005-11-24 General Electric Company Pharmaceuticals for enhanced delivery to disease targets
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US8916531B2 (en) 2007-11-20 2014-12-23 Isis Pharmaceuticals, Inc. Modulation of CD40 expression
AU2013263349B2 (en) 2012-05-17 2016-09-08 Extend Biosciences, Inc Carriers for improved drug delivery
CN104837996A (zh) 2012-11-15 2015-08-12 罗氏创新中心哥本哈根有限公司 抗apob反义缀合物化合物
AU2014211406B2 (en) 2013-01-30 2019-07-18 Roche Innovation Center Copenhagen A/S LNA oligonucleotide carbohydrate conjugates
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
HUE048738T2 (hu) 2013-06-27 2020-08-28 Roche Innovation Ct Copenhagen As Antiszensz oligomerek és konjugátumok, amelyek a PCK9-t célozzák meg
BR112016016130A2 (pt) 2014-01-10 2017-08-08 Glaxosmithkline Ip No 2 Ltd Compostos e métodos
GB201408623D0 (en) 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
WO2016065042A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Therapeutic vitamin d conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
US9616109B2 (en) 2014-10-22 2017-04-11 Extend Biosciences, Inc. Insulin vitamin D conjugates
RU2747822C2 (ru) 2016-03-14 2021-05-14 Ф. Хоффманн-Ля Рош Аг Олигонуклеотиды для понижения экспрессии pd-l1
CR20230308A (es) 2020-12-11 2023-09-08 Civi Biopharma Inc Entrega oral de conjugados antisentido que tienen por blanco a pcsk9
CN114146187B (zh) * 2021-11-12 2022-11-22 中山大学 一种PDGFR-β基因表达抑制剂及其用途
KR20250075704A (ko) 2022-09-30 2025-05-28 익스텐드 바이오사이언시즈, 인크. 장기-지속형 부갑상선 호르몬

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005519A1 (en) * 1985-03-15 1986-09-25 James Summerton Polynucleotide assay reagent and method
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
GB2289677A (en) * 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
JPH10500310A (ja) * 1994-05-19 1998-01-13 ダコ アクティーゼルスカブ 淋菌及びトラコーマ クラミジアの検出のためのｐｎａ プローブ

Also Published As

Publication number Publication date
DE69527857D1 (de) 2002-09-26
AU3999495A (en) 1996-05-02
ES2181799T3 (es) 2003-03-01
DK0804456T3 (da) 2002-12-02
EP0804456A1 (de) 1997-11-05
DE69527857T2 (de) 2003-05-28
WO1996011205A1 (en) 1996-04-18
PT804456E (pt) 2003-01-31
JP3307945B2 (ja) 2002-07-29
EP0804456B1 (de) 2002-08-21
EP0804456A4 (de) 1999-05-19
JPH10503524A (ja) 1998-03-31

Similar Documents

Publication Publication Date Title
ATE222589T1 (de) Peptid-nukleinsäure-konjugate
ATE515569T1 (de) Peptidnucleinsäuren
ATE225369T1 (de) Doppelsträngige peptidenukleinsäuren
EP1310507A3 (de) Neue Peptid-Nukleinsäuren
DE69528061D1 (de) Gereinigte polyporus laccasen und dafür kodierende nukleinsäuren
NO20020348D0 (no) Peptid acceptor ligeringsmetoder
EP0743958A4 (de) Nicht-viraler vektor
NO20000097D0 (no) Isolerte dendrittcellemembranproteingener
ATE285474T1 (de) Haemophilus adhäsionsproteinen
MX9806041A (es) Proteina purificada sr-p70.
WO1996015240A3 (en) Ribozyme analogs
CO4480058A1 (es) Genes codificantes y procedimiento de expresion de una nueva enzima: ftalil amidasa
SE9602822D0 (sv) New receptor
HUT77435A (hu) Aminosavat tartalmazó nukleotid monomer analógok
DE69836485D1 (de) Hepatitis e-virus aus dem schwein und dessen verwendungen
EA200000567A1 (ru) Бактериальные плазмиды
IT1290444B1 (it) Coniugati di bis-fosfonati con funzionalita' alchilanti aventi attivita' antitumorale
BR9808278A (pt) Sequências de ácido nucleico isolado, de proteìna isolada e de dna, célula de planta transformada, e, planta
RU93048604A (ru) Линкер для твердофазного синтеза пептидов
IT8921396A0 (it) Procedimento per la sintesi di peptidi preventivamente identificati come siti di interazione di proteine interagenti.
GB9716620D0 (en) Nucleic acid vaccine molecules

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0804456

Country of ref document: EP

REN Ceased due to non-payment of the annual fee