DK0804456T3 - Peptid-nukleinsyre-konjugater - Google Patents

Peptid-nukleinsyre-konjugater

Info

Publication number
DK0804456T3
DK0804456T3 DK95938726T DK95938726T DK0804456T3 DK 0804456 T3 DK0804456 T3 DK 0804456T3 DK 95938726 T DK95938726 T DK 95938726T DK 95938726 T DK95938726 T DK 95938726T DK 0804456 T3 DK0804456 T3 DK 0804456T3
Authority
DK
Denmark
Prior art keywords
peptide
nucleic acid
acid conjugates
nucleic acids
peptide nucleic
Prior art date
Application number
DK95938726T
Other languages
English (en)
Inventor
Michael Egholm
Ole Di Buchardt
Soren Holst Sonnechsen
Jesper Lohse
Muthiah Manoharan
John Kiely
Michael Griffith
Kelly Sprankle
Peter Nielsen
Original Assignee
Isis Pharmaceuticals Inc
Buchardt Dorte
Nielsen Peter Eigil
Michael Egholm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/319,411 external-priority patent/US7223833B1/en
Application filed by Isis Pharmaceuticals Inc, Buchardt Dorte, Nielsen Peter Eigil, Michael Egholm filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DK0804456T3 publication Critical patent/DK0804456T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C07K14/003—Peptide-nucleic acids (PNAs)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK95938726T 1994-10-06 1995-10-06 Peptid-nukleinsyre-konjugater DK0804456T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/319,411 US7223833B1 (en) 1991-05-24 1994-10-06 Peptide nucleic acid conjugates
PCT/US1995/012931 WO1996011205A1 (en) 1994-10-06 1995-10-06 Peptide nucleic acid conjugates

Publications (1)

Publication Number Publication Date
DK0804456T3 true DK0804456T3 (da) 2002-12-02

Family

ID=23242149

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95938726T DK0804456T3 (da) 1994-10-06 1995-10-06 Peptid-nukleinsyre-konjugater

Country Status (9)

Country Link
EP (1) EP0804456B1 (da)
JP (1) JP3307945B2 (da)
AT (1) ATE222589T1 (da)
AU (1) AU3999495A (da)
DE (1) DE69527857T2 (da)
DK (1) DK0804456T3 (da)
ES (1) ES2181799T3 (da)
PT (1) PT804456E (da)
WO (1) WO1996011205A1 (da)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2336857T3 (es) * 1995-05-04 2010-04-16 Gilead Sciences, Inc. Complejos de ligandos de acido nucleico.
US8071737B2 (en) 1995-05-04 2011-12-06 Glead Sciences, Inc. Nucleic acid ligand complexes
SE506700C2 (sv) 1996-05-31 1998-02-02 Mikael Kubista Sond och förfaranden för analys av nukleinsyra
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US5908845A (en) * 1996-10-30 1999-06-01 Segev; David Polyether nucleic acids
EP0863150A1 (en) * 1997-02-08 1998-09-09 Boehringer Mannheim Gmbh A method for the preparation of nucleic acid binding compound
DE19712530A1 (de) * 1997-03-25 1998-10-01 Boehringer Mannheim Gmbh Neue Monomerbausteine zur Markierung von peptidischen Nukleinsäuren
NZ501289A (en) * 1997-05-28 2001-06-29 Nielsen Peter E Conjugated peptide nucleic acids having enhanced cellular uptake
JPH11332595A (ja) * 1997-07-09 1999-12-07 Masao Karube プローブｐｎａによるｄｎａの検出方法
AU741546B2 (en) * 1997-07-24 2001-12-06 Perseptive Biosystems, Inc. Conjugates of transporter peptides and nucleic acid analogs, and their use
JP2001516562A (ja) * 1997-09-18 2001-10-02 ジーン セラピー システムズ インコーポレーテッド ペプチド核酸コンジュゲートを用いたｄｎａの化学修飾
DE19757516A1 (de) * 1997-12-23 1999-06-24 Roche Diagnostics Gmbh Modifizierte Nukleinsäureanaloga
CA2320390C (en) 1998-02-11 2010-06-08 Applied Biosystems, Llc Pna and dna conjugates and methods for preparation thereof
US20040186071A1 (en) * 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
KR100694914B1 (ko) 1998-07-09 2007-03-14 바이오셉트 인코포레이티드 디엔에이 서열 하이브리드화를 최적화하기 위한 개선된펩티드 핵산 유니버셜 라이브러리의 사용방법
SE9803099D0 (sv) 1998-09-13 1998-09-13 Karolinska Innovations Ab Nucleic acid transfer
AU7773000A (en) * 1998-11-11 2001-04-23 Pantheco A/S Conjugates between a peptides and a nucleic acid analog, such as a pna, lna or amorpholino
US6548651B1 (en) 1998-11-11 2003-04-15 Pantheco A/S Modified peptide nucleic acid (PNA) molecules
DE10019135A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
DE10019136A1 (de) 2000-04-18 2001-10-31 Aventis Pharma Gmbh Polyamidnukleinsäure-Derivate, Mittel und Verfahren zu ihrer Herstellung
EP1334114A2 (en) 2000-10-25 2003-08-13 Mayo Foundation For Medical Education And Research Transcobalamin binding conjugates useful for treating abnormal cellular proliferation
DE10201862A1 (de) 2002-01-18 2003-08-07 Deutsches Krebsforsch Konjugat zur Behandlung prokaryontischer Infektionen
US8604183B2 (en) 2002-11-05 2013-12-10 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
US20050260131A1 (en) * 2004-05-20 2005-11-24 General Electric Company Pharmaceuticals for enhanced delivery to disease targets
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
WO2009067243A2 (en) 2007-11-20 2009-05-28 Isis Pharmaceuticals Inc. Modulation of cd40 expression
MX349035B (es) 2012-05-17 2017-07-07 Extend Biosciences Inc Portadores para el suministro mejorado de farmaco.
CA2889044A1 (en) 2012-11-15 2014-05-22 Roche Innovation Center Copenhagen A/S Anti apob antisense conjugate compounds
WO2014118272A1 (en) 2013-01-30 2014-08-07 Santaris Pharma A/S Antimir-122 oligonucleotide carbohydrate conjugates
CA2893801A1 (en) 2013-01-30 2014-08-07 F. Hoffmann-La Roche Ag Lna oligonucleotide carbohydrate conjugates
MX367083B (es) 2013-06-27 2019-08-05 Roche Innovation Ct Copenhagen As Oligomeros antisentido y conjugados con diana en la proteina-convertasa subtilisina/kexina tipo 9(pcsk9).
MA39171A1 (fr) 2014-01-10 2017-07-31 Glaxosmithkline Intellectual Property (No 2) Ltd Dérivés d'hydroxy formamide et leur utilisation
GB201408623D0 (en) 2014-05-15 2014-07-02 Santaris Pharma As Oligomers and oligomer conjugates
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
US9789197B2 (en) 2014-10-22 2017-10-17 Extend Biosciences, Inc. RNAi vitamin D conjugates
CA3013683C (en) 2016-03-14 2021-07-13 F. Hoffmann-La Roche Ag Oligonucleotides for reduction of pd-l1 expression
CR20230308A (es) 2020-12-11 2023-09-08 Civi Biopharma Inc Entrega oral de conjugados antisentido que tienen por blanco a pcsk9
CN114146187B (zh) * 2021-11-12 2022-11-22 中山大学 一种PDGFR-β基因表达抑制剂及其用途
US12233115B2 (en) 2022-09-30 2025-02-25 Extend Biosciences, Inc. Long-acting parathyroid hormone

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2528107B2 (ja) * 1985-03-15 1996-08-28 サマ−トン，ジエ−ムス ポリヌクレオチド測定試薬と方法
DK51092D0 (da) * 1991-05-24 1992-04-15 Ole Buchardt Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
MX9207334A (es) * 1991-12-18 1993-08-01 Glaxo Inc Acidos nucleicos peptidicos y formulacion farma- ceutica que los contiene
GB2289677A (en) * 1993-12-06 1995-11-29 Pna Diagnostics As Labelling of nucleic acid analogue-peptide chimerae
EP0760008A1 (en) * 1994-05-19 1997-03-05 Dako A/S Pna probes for detection of neisseria gonorrhoeae and chlamydia trachomatis

Also Published As

Publication number Publication date
ES2181799T3 (es) 2003-03-01
EP0804456B1 (en) 2002-08-21
DE69527857D1 (de) 2002-09-26
JPH10503524A (ja) 1998-03-31
JP3307945B2 (ja) 2002-07-29
DE69527857T2 (de) 2003-05-28
EP0804456A4 (en) 1999-05-19
ATE222589T1 (de) 2002-09-15
PT804456E (pt) 2003-01-31
EP0804456A1 (en) 1997-11-05
WO1996011205A1 (en) 1996-04-18
AU3999495A (en) 1996-05-02

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