ATE222910T1 - Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten - Google Patents
Triptolid-derivate nützlich zur behandlung von autoimmunkrankheitenInfo
- Publication number
- ATE222910T1 ATE222910T1 AT98919928T AT98919928T ATE222910T1 AT E222910 T1 ATE222910 T1 AT E222910T1 AT 98919928 T AT98919928 T AT 98919928T AT 98919928 T AT98919928 T AT 98919928T AT E222910 T1 ATE222910 T1 AT E222910T1
- Authority
- AT
- Austria
- Prior art keywords
- autoimmune diseases
- derivatives useful
- treating autoimmune
- triptolide derivatives
- triptolide
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical class O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86248897A | 1997-05-23 | 1997-05-23 | |
| PCT/US1998/008470 WO1998052951A1 (en) | 1997-05-23 | 1998-04-27 | Novel triptolide derivatives useful in the treatment of autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE222910T1 true ATE222910T1 (de) | 2002-09-15 |
Family
ID=25338616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98919928T ATE222910T1 (de) | 1997-05-23 | 1998-04-27 | Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0983275B1 (de) |
| JP (1) | JP2001525851A (de) |
| KR (1) | KR20010012822A (de) |
| CN (1) | CN1257507A (de) |
| AR (1) | AR012723A1 (de) |
| AT (1) | ATE222910T1 (de) |
| AU (1) | AU741917B2 (de) |
| BR (1) | BR9809678A (de) |
| CA (1) | CA2287977A1 (de) |
| DE (1) | DE69807466T2 (de) |
| DK (1) | DK0983275T3 (de) |
| ES (1) | ES2178207T3 (de) |
| HU (1) | HUP0003398A3 (de) |
| IL (1) | IL133088A0 (de) |
| NO (1) | NO995723L (de) |
| NZ (1) | NZ500762A (de) |
| PT (1) | PT983275E (de) |
| TW (1) | TW434235B (de) |
| WO (1) | WO1998052951A1 (de) |
| ZA (1) | ZA984174B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6329148B1 (en) | 1999-02-16 | 2001-12-11 | The Board Of Trustees Of The Leland Stanford University | Combined therapy of diterpenoid triepoxides and death domain receptor ligands for synergistic killing of tumor cells |
| US6569893B2 (en) * | 2001-03-15 | 2003-05-27 | Pharmagenesis, Inc. | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents |
| JP4680589B2 (ja) * | 2002-05-31 | 2011-05-11 | ファーマジェネシス， インコーポレイテッド | アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体 |
| CN100398544C (zh) * | 2002-09-18 | 2008-07-02 | 成都达远药物有限公司 | 高免疫抑制活性的水溶性雷公藤内酯醇衍生物及其应用 |
| JP2006513209A (ja) * | 2002-12-17 | 2006-04-20 | ファーマジェネシス， インコーポレイテッド | 免疫調節因子および抗癌剤としてのトリプトライド誘導体 |
| CN1223595C (zh) | 2002-12-27 | 2005-10-19 | 中国科学院上海药物研究所 | 雷公藤内酯醇衍生物及其应用 |
| US6943259B2 (en) * | 2003-02-25 | 2005-09-13 | Pharmagenesis, Inc. | Halogenated triptolide derivatives as immunomodulators and anticancer agents |
| US7820834B2 (en) | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| EP1722806A4 (de) | 2004-02-09 | 2009-09-16 | Pharmagenesis Inc | Verfahren zur isolierung von triptolid-verbindungen aus tripterygium wilfordii |
| ES2385716T3 (es) | 2004-03-02 | 2012-07-30 | Pharmagenesis, Inc. | Derivados en el anillo de lactona de triptolida como inmunomoduladores y agentes anticáncer |
| US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US8617906B2 (en) | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| AU2010210594B2 (en) * | 2009-02-05 | 2015-02-12 | Pharmagenesis, Inc. | Triptolide C-ring derivatives as anticancer agents and immune modulators |
| CN107207525B (zh) * | 2015-10-29 | 2018-11-27 | 杭州卫本药业有限公司 | C14-位羟基酯化的雷公藤甲素氨基酸衍生物、及其制备方法和应用 |
| CN114716503B (zh) * | 2022-03-23 | 2024-03-12 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 一种雷公藤氯内酯醇的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005108A (en) * | 1973-04-03 | 1977-01-25 | Research Corporation | Novel anti-leukemic diterpenoid triepoxides |
| US5430054A (en) * | 1989-12-22 | 1995-07-04 | Jiangsu Family Planning Institute | Preparation methods of diterpene lactone compounds and application of the same to antifertility |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
-
1998
- 1998-04-27 EP EP98919928A patent/EP0983275B1/de not_active Expired - Lifetime
- 1998-04-27 CN CN98805397A patent/CN1257507A/zh active Pending
- 1998-04-27 DE DE69807466T patent/DE69807466T2/de not_active Expired - Lifetime
- 1998-04-27 ES ES98919928T patent/ES2178207T3/es not_active Expired - Lifetime
- 1998-04-27 BR BR9809678-8A patent/BR9809678A/pt not_active Application Discontinuation
- 1998-04-27 AU AU72607/98A patent/AU741917B2/en not_active Ceased
- 1998-04-27 DK DK98919928T patent/DK0983275T3/da active
- 1998-04-27 PT PT98919928T patent/PT983275E/pt unknown
- 1998-04-27 HU HU0003398A patent/HUP0003398A3/hu unknown
- 1998-04-27 WO PCT/US1998/008470 patent/WO1998052951A1/en not_active Ceased
- 1998-04-27 AT AT98919928T patent/ATE222910T1/de active
- 1998-04-27 IL IL13308898A patent/IL133088A0/xx unknown
- 1998-04-27 KR KR19997010786A patent/KR20010012822A/ko not_active Withdrawn
- 1998-04-27 NZ NZ500762A patent/NZ500762A/en not_active IP Right Cessation
- 1998-04-27 CA CA002287977A patent/CA2287977A1/en not_active Abandoned
- 1998-04-27 JP JP55037798A patent/JP2001525851A/ja active Pending
- 1998-05-18 ZA ZA984174A patent/ZA984174B/xx unknown
- 1998-05-19 TW TW087107719A patent/TW434235B/zh not_active IP Right Cessation
- 1998-05-20 AR ARP980102327A patent/AR012723A1/es unknown
-
1999
- 1999-11-22 NO NO995723A patent/NO995723L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DK0983275T3 (da) | 2002-12-23 |
| BR9809678A (pt) | 2000-07-11 |
| CA2287977A1 (en) | 1998-11-26 |
| KR20010012822A (ko) | 2001-02-26 |
| DE69807466D1 (de) | 2002-10-02 |
| AR012723A1 (es) | 2000-11-08 |
| JP2001525851A (ja) | 2001-12-11 |
| HK1026096A1 (en) | 2000-12-01 |
| HUP0003398A2 (en) | 2001-03-28 |
| AU7260798A (en) | 1998-12-11 |
| WO1998052951A1 (en) | 1998-11-26 |
| NO995723D0 (no) | 1999-11-22 |
| ZA984174B (en) | 1998-11-23 |
| ES2178207T3 (es) | 2002-12-16 |
| AU741917B2 (en) | 2001-12-13 |
| EP0983275A1 (de) | 2000-03-08 |
| TW434235B (en) | 2001-05-16 |
| CN1257507A (zh) | 2000-06-21 |
| PT983275E (pt) | 2003-01-31 |
| HUP0003398A3 (en) | 2001-09-28 |
| EP0983275B1 (de) | 2002-08-28 |
| DE69807466T2 (de) | 2003-04-24 |
| IL133088A0 (en) | 2001-03-19 |
| NZ500762A (en) | 2001-08-31 |
| NO995723L (no) | 2000-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner |