ATE261434T1 - Triptolid-derivate geeignet zur behandlung von autoimmunkrankheiten - Google Patents
Triptolid-derivate geeignet zur behandlung von autoimmunkrankheitenInfo
- Publication number
- ATE261434T1 ATE261434T1 AT98920897T AT98920897T ATE261434T1 AT E261434 T1 ATE261434 T1 AT E261434T1 AT 98920897 T AT98920897 T AT 98920897T AT 98920897 T AT98920897 T AT 98920897T AT E261434 T1 ATE261434 T1 AT E261434T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- autoimmune diseases
- derivatives suitable
- triptolide derivatives
- triptolide
- Prior art date
Links
- 208000023275 Autoimmune disease Diseases 0.000 title 1
- DFBIRQPKNDILPW-CIVMWXNOSA-N Triptolide Chemical class O=C1OCC([C@@H]2C3)=C1CC[C@]2(C)[C@]12O[C@H]1[C@@H]1O[C@]1(C(C)C)[C@@H](O)[C@]21[C@H]3O1 DFBIRQPKNDILPW-CIVMWXNOSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86248997A | 1997-05-23 | 1997-05-23 | |
| PCT/US1998/008562 WO1998052933A1 (en) | 1997-05-23 | 1998-04-27 | Novel triptolide derivatives useful in the treatment of autoimmune diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE261434T1 true ATE261434T1 (de) | 2004-03-15 |
Family
ID=25338618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98920897T ATE261434T1 (de) | 1997-05-23 | 1998-04-27 | Triptolid-derivate geeignet zur behandlung von autoimmunkrankheiten |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0983256B1 (de) |
| JP (1) | JP2002500647A (de) |
| KR (1) | KR20010012820A (de) |
| AR (1) | AR012737A1 (de) |
| AT (1) | ATE261434T1 (de) |
| AU (1) | AU741209B2 (de) |
| BR (1) | BR9809673A (de) |
| CA (1) | CA2288327A1 (de) |
| DE (1) | DE69822297T2 (de) |
| ES (1) | ES2213279T3 (de) |
| HU (1) | HUP0003244A3 (de) |
| IL (1) | IL133089A0 (de) |
| NO (1) | NO995722L (de) |
| NZ (1) | NZ500699A (de) |
| TW (1) | TW462966B (de) |
| WO (1) | WO1998052933A1 (de) |
| ZA (1) | ZA984177B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6569893B2 (en) * | 2001-03-15 | 2003-05-27 | Pharmagenesis, Inc. | Amino acid derivatives of triptolide compounds as immune modulators and anticancer agents |
| JP4680589B2 (ja) | 2002-05-31 | 2011-05-11 | ファーマジェネシス， インコーポレイテッド | アポトーシスおよび免疫抑制の調節のためのトリプトリド誘導体 |
| US7820834B2 (en) | 2003-12-24 | 2010-10-26 | Pharmagenesis, Inc. | Triptolide 5,6-derivatives as immunomodulators and anticancer agents |
| CN1917893A (zh) | 2004-02-09 | 2007-02-21 | 美国泛华医药公司 | 从雷公藤多苷中分离雷公藤内酯醇化合物的方法 |
| DK1732536T3 (da) | 2004-03-02 | 2012-06-25 | Pharmagenesis Inc | Tripolidlactonringderivater som immunomodulatorer og anticancermidler |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| US8617906B2 (en) | 2004-10-13 | 2013-12-31 | Pharmagenesis, Inc. | Identification and screening of triptolide target molecules |
| US20120020954A1 (en) | 2009-03-30 | 2012-01-26 | Anat Achiron | Methods of predicting clinical course and treating multiple sclerosis |
| WO2012123938A1 (en) | 2011-03-17 | 2012-09-20 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Quinolone analogs for treating autoimmune diseases |
| WO2015079411A1 (en) | 2013-11-28 | 2015-06-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Rna polymerase i inhibitors and uses thereof |
| CN113768939A (zh) * | 2021-09-30 | 2021-12-10 | 深圳艾克斯恩生物科技有限公司 | 雷公藤二醇在制备预防和/或治疗nlrp3炎症小体介导的炎症性疾病药物中的应用 |
| KR102875701B1 (ko) * | 2022-12-28 | 2025-10-23 | 구주제약주식회사 | 신규 트립톨라이드 유도체 및 이의 용도 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994026265A1 (en) * | 1993-05-06 | 1994-11-24 | Pharmagenesis, Inc. | 16-hydroxytriptolide composition and method for immunotherapy |
| US5663335A (en) * | 1996-03-01 | 1997-09-02 | Pharmagenesis, Inc. | Immunosuppressive compounds and methods |
-
1998
- 1998-04-27 IL IL13308998A patent/IL133089A0/xx unknown
- 1998-04-27 JP JP55038298A patent/JP2002500647A/ja active Pending
- 1998-04-27 ES ES98920897T patent/ES2213279T3/es not_active Expired - Lifetime
- 1998-04-27 AU AU73634/98A patent/AU741209B2/en not_active Ceased
- 1998-04-27 NZ NZ500699A patent/NZ500699A/en not_active IP Right Cessation
- 1998-04-27 WO PCT/US1998/008562 patent/WO1998052933A1/en not_active Ceased
- 1998-04-27 BR BR9809673-7A patent/BR9809673A/pt not_active Application Discontinuation
- 1998-04-27 HU HU0003244A patent/HUP0003244A3/hu unknown
- 1998-04-27 DE DE69822297T patent/DE69822297T2/de not_active Expired - Lifetime
- 1998-04-27 EP EP98920897A patent/EP0983256B1/de not_active Expired - Lifetime
- 1998-04-27 KR KR1019997010784A patent/KR20010012820A/ko not_active Withdrawn
- 1998-04-27 CA CA002288327A patent/CA2288327A1/en not_active Abandoned
- 1998-04-27 AT AT98920897T patent/ATE261434T1/de not_active IP Right Cessation
- 1998-05-18 ZA ZA984177A patent/ZA984177B/xx unknown
- 1998-05-19 TW TW087107730A patent/TW462966B/zh not_active IP Right Cessation
- 1998-05-22 AR ARP980102373A patent/AR012737A1/es unknown
-
1999
- 1999-11-22 NO NO995722A patent/NO995722L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR012737A1 (es) | 2000-11-08 |
| JP2002500647A (ja) | 2002-01-08 |
| NO995722L (no) | 2000-01-21 |
| ES2213279T3 (es) | 2004-08-16 |
| AU741209B2 (en) | 2001-11-22 |
| DE69822297D1 (de) | 2004-04-15 |
| KR20010012820A (ko) | 2001-02-26 |
| NO995722D0 (no) | 1999-11-22 |
| TW462966B (en) | 2001-11-11 |
| ZA984177B (en) | 1998-11-23 |
| NZ500699A (en) | 2001-08-31 |
| HUP0003244A3 (en) | 2001-09-28 |
| HK1025954A1 (en) | 2000-12-01 |
| HUP0003244A2 (en) | 2001-03-28 |
| DE69822297T2 (de) | 2004-07-29 |
| BR9809673A (pt) | 2000-07-11 |
| AU7363498A (en) | 1998-12-11 |
| CA2288327A1 (en) | 1998-11-26 |
| EP0983256B1 (de) | 2004-03-10 |
| WO1998052933A1 (en) | 1998-11-26 |
| EP0983256A1 (de) | 2000-03-08 |
| IL133089A0 (en) | 2001-03-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE241977T1 (de) | Verwendung von anti-mikrotubuli mitteln zur behandlung von entzündlichen darmerkrankungen | |
| ATE235481T1 (de) | Substituierte benzopyranderivate zur behandlung von entzündungen | |
| DE69734513D1 (de) | Phenylamino-substituierte triicyclische derivate zur behandlung hyperproliferativer krankheiten | |
| DE59711321D1 (de) | Neue substituierte pyrazolderivate zur behandlung von herzkreislauferkrankungen | |
| DE60019556D1 (de) | 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit | |
| ATE224189T1 (de) | Antikonvulsive sulfamatderivate zur behandlung von fettleibigkeit | |
| DE60019555D1 (de) | 2-oxy-benzoxazinonderivate zur behandlung von fettleibigkeit | |
| EP0709090A3 (de) | Zusammensetzungen zur Behandlung von resistenten Tumoren | |
| DE69918687D1 (de) | 4-phenylpiperidine zur behandlung von prutitischen hauterkrankungen | |
| DE69630479D1 (de) | Arzneimittel zur Behandlung von entzündlichen Herzkrankheiten | |
| DE122009000012I1 (de) | Substituierte pyrazolyl-benzolsulfonamide zur behandlung von entzundungen. | |
| FI952721A7 (fi) | Aine maksa-sappi-sairauksien hoitamiseksi | |
| DE69109583D1 (de) | Verfahren zur Behandlung von entzündlichen Darmerkrankungen. | |
| ATE267180T1 (de) | Phosphorderivate zur behandlung von aids | |
| DE69807466D1 (de) | Triptolid-derivate nützlich zur behandlung von autoimmunkrankheiten | |
| DE69737067D1 (de) | Vakzine zur behandlung von mycosen | |
| DE69822297D1 (de) | Triptolid-derivate geeignet zur behandlung von autoimmunkrankheiten | |
| FI971527L (fi) | Indolijohdannaisten käyttö erilaisten sairauksien hoitoon | |
| DE69729735D1 (de) | Verwendung von benzopyranolen zur behandlung von neurologischen erkrankungen | |
| DE69735417D1 (de) | 2,5-dihydroxybenzylsulfonderivate zur behandlung von sexuellen störungen | |
| DE69834937D1 (de) | Antibiotika zur behandlung von magengeschwuren | |
| DE59704933D1 (de) | Verwendung von PHMB zur Behandlung von Tumorerkrankungen | |
| NO913117D0 (no) | Fremgangsmaate for behandling av benoedeleggende sykdommer. | |
| ATE230741T1 (de) | 3-tetrahydropyridin-4-yl-indole zur behandlung von psychotischen störungen | |
| ATE251167T1 (de) | Oxazinocarbazole zur behandlung von cns- erkrankungen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |