ATE223486T1 - Bmp-9 zusammensetzungen - Google Patents
Bmp-9 zusammensetzungenInfo
- Publication number
- ATE223486T1 ATE223486T1 AT95923706T AT95923706T ATE223486T1 AT E223486 T1 ATE223486 T1 AT E223486T1 AT 95923706 T AT95923706 T AT 95923706T AT 95923706 T AT95923706 T AT 95923706T AT E223486 T1 ATE223486 T1 AT E223486T1
- Authority
- AT
- Austria
- Prior art keywords
- bmp
- compositions
- proteins
- bone
- processes
- Prior art date
Links
- 102000037280 Growth Differentiation Factor 2 Human genes 0.000 title abstract 2
- 108010090290 Growth Differentiation Factor 2 Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 230000012010 growth Effects 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000017423 tissue regeneration Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/84—Bones; tendons; teeth; cartilage
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Diabetes (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Dental Preparations (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/254,353 US6287816B1 (en) | 1991-06-25 | 1994-06-06 | BMP-9 compositions |
| PCT/US1995/007084 WO1995033830A1 (en) | 1994-06-06 | 1995-06-05 | Bmp-9 compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE223486T1 true ATE223486T1 (de) | 2002-09-15 |
Family
ID=22963968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95923706T ATE223486T1 (de) | 1994-06-06 | 1995-06-05 | Bmp-9 zusammensetzungen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6287816B1 (de) |
| EP (2) | EP0764208B1 (de) |
| JP (1) | JP3706133B2 (de) |
| KR (1) | KR100255417B1 (de) |
| AT (1) | ATE223486T1 (de) |
| AU (1) | AU709869B2 (de) |
| DE (1) | DE69528058T2 (de) |
| WO (1) | WO1995033830A1 (de) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6150328A (en) | 1986-07-01 | 2000-11-21 | Genetics Institute, Inc. | BMP products |
| US5656593A (en) * | 1991-03-11 | 1997-08-12 | Creative Biomolecules, Inc. | Morphogen induced periodontal tissue regeneration |
| KR100259827B1 (ko) | 1991-11-04 | 2000-06-15 | 브루스 엠. 에이센, 토마스 제이 데스로저 | 재조합 골형태 형성 단백질 헤테로다이머, 그 조성물 및 사용방법 |
| US20080070842A1 (en) * | 1991-11-04 | 2008-03-20 | David Israel | Recombinant bone morphogenetic protein heterodimers, compositions and methods of use |
| US6291206B1 (en) | 1993-09-17 | 2001-09-18 | Genetics Institute, Inc. | BMP receptor proteins |
| EP0733109B9 (de) | 1993-12-07 | 2006-07-05 | Genetics Institute, LLC | Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen |
| US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
| US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| AU6267798A (en) | 1997-02-07 | 1998-08-26 | Stryker Corporation | Matrix-free osteogenic devices, implants and methods of use thereof |
| US6034062A (en) * | 1997-03-13 | 2000-03-07 | Genetics Institute, Inc. | Bone morphogenetic protein (BMP)-9 compositions and their uses |
| US7041641B2 (en) | 1997-03-20 | 2006-05-09 | Stryker Corporation | Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects |
| US20010016646A1 (en) | 1998-03-20 | 2001-08-23 | David C. Rueger | Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects |
| AU743510B2 (en) | 1997-05-05 | 2002-01-24 | Stryker Corporation | Therapies for acute renal failure |
| JP2001526788A (ja) | 1997-05-30 | 2001-12-18 | クリエイティブ バイオモレキュールズ,インコーポレイテッド | 組織形態形成および活性を評価するための方法 |
| US7147839B2 (en) | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
| JP4892131B2 (ja) * | 1998-11-13 | 2012-03-07 | ストライカー コーポレイション | 癌の症状を緩和する方法 |
| US6727224B1 (en) | 1999-02-01 | 2004-04-27 | Genetics Institute, Llc. | Methods and compositions for healing and repair of articular cartilage |
| AU7355500A (en) * | 1999-09-08 | 2001-04-10 | Genetics Institute Inc. | Bmp-9 compositions and methods for inducing differentiation of cholinergic neurons |
| EP1223990B1 (de) | 1999-10-15 | 2004-07-28 | Genetics Institute, LLC | Hyaluronsäure enthaltende zusammensetzungen zur abgabe osteogener proteine |
| US6723334B1 (en) * | 2000-03-01 | 2004-04-20 | Iowa State University Research Foundation, Inc. | Biologically compatible bone cements and orthopedic methods |
| WO2002077006A1 (en) * | 2001-03-23 | 2002-10-03 | Human Genome Sciences, Inc. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
| US20030082233A1 (en) * | 2000-12-01 | 2003-05-01 | Lyons Karen M. | Method and composition for modulating bone growth |
| US20020114795A1 (en) | 2000-12-22 | 2002-08-22 | Thorne Kevin J. | Composition and process for bone growth and repair |
| WO2002067978A1 (en) * | 2001-02-23 | 2002-09-06 | Wyeth | Chondrogenic potential of human bone marrow-derived cd105+ cells by bmp |
| US7226587B2 (en) | 2001-06-01 | 2007-06-05 | Wyeth | Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins |
| TWI267378B (en) | 2001-06-08 | 2006-12-01 | Wyeth Corp | Calcium phosphate delivery vehicles for osteoinductive proteins |
| AU2003221582A1 (en) * | 2002-05-03 | 2003-11-17 | Millenium Biologix Inc. | Connective tissue stimulating peptides |
| WO2003099992A2 (en) * | 2002-05-17 | 2003-12-04 | Wyeth | Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins |
| JP2007524376A (ja) * | 2003-03-27 | 2007-08-30 | チルドレンズ ホスピタル メディカル センター | 軟骨形成を誘導するfgf−18タンパク質、標的タンパク質、およびそれぞれをコードするヌクレオチド配列の使用 |
| TW200518767A (en) | 2003-09-12 | 2005-06-16 | Wyeth Corp | Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins |
| WO2005089829A2 (en) | 2004-03-10 | 2005-09-29 | Scil Technology Gmbh | Coated implants, their manufacturing and use thereof |
| CA2567405A1 (en) | 2004-05-25 | 2005-12-08 | Stryker Corporation | Use of morphogenic proteins for treating cartilage defects |
| JP2008507288A (ja) | 2004-07-23 | 2008-03-13 | アクセルロン ファーマ インコーポレーテッド | ActRII受容体ポリペプチド、方法、および組成物 |
| US20060166251A1 (en) * | 2005-01-26 | 2006-07-27 | Archambault Joanne M | Use of sFRPs as markers of BMP activity |
| JP2008534607A (ja) * | 2005-03-30 | 2008-08-28 | ワイス | Bmpを投与することによって毛髪の成長を刺激するための方法 |
| BRPI0618947B1 (pt) | 2005-11-23 | 2022-07-19 | Acceleron Pharma Inc | Polipeptídeo actriia que se liga à ativina, polinucleotídeo isolado, polinucleotídeo recombinante, métodopara preparar um polipeptídeo actriia que se liga à ativina, preparação farmacêutica e uso de uma proteína de fusão actriia-fc para promover o crescimento ósseo e inibir a ressorção óssea |
| US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
| US20090298761A1 (en) | 2006-05-17 | 2009-12-03 | Donald Engelman | Methods of treating cartilage defects using a soluble morphogenic protein complex |
| AU2007234612B2 (en) | 2006-12-14 | 2013-06-27 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein stabilization formulations |
| US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
| US7718616B2 (en) | 2006-12-21 | 2010-05-18 | Zimmer Orthobiologics, Inc. | Bone growth particles and osteoinductive composition thereof |
| EP2120859B1 (de) | 2006-12-21 | 2013-11-20 | Stryker Corporation | Formulierungen mit verzögerter freisetzung mit kristallen von bmp-7 |
| TWI584815B (zh) | 2007-02-01 | 2017-06-01 | 艾瑟勒朗法瑪公司 | 活化素-ActRIIa拮抗劑及其治療或預防乳癌之用途 |
| TW201627320A (zh) | 2007-02-02 | 2016-08-01 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
| MX2009008510A (es) | 2007-02-09 | 2010-01-15 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para promover el crecimiento de huesos en pacientes con cancer. |
| DE102007006843A1 (de) | 2007-02-12 | 2008-08-14 | Bioregeneration Gmbh | Verfahren und Stützstruktur zum Kultivieren lebender Zellen |
| US7678764B2 (en) | 2007-06-29 | 2010-03-16 | Johnson & Johnson Regenerative Therapeutics, Llc | Protein formulations for use at elevated temperatures |
| CN101801405A (zh) | 2007-08-07 | 2010-08-11 | 先进科技及再生医学有限责任公司 | 包含于酸性水溶液中的gdf-5的蛋白质配方 |
| CA2699936A1 (en) | 2007-09-18 | 2009-03-26 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
| AU2009214629A1 (en) | 2008-02-13 | 2009-08-20 | Eric T. Choi | BMP-7 for use in treating vascular sclerosis |
| JP5599778B2 (ja) | 2008-04-14 | 2014-10-01 | デピュイ・シンセス・プロダクツ・エルエルシー | 液体緩衝gdf−5製剤 |
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| DK3750552T5 (da) | 2008-08-14 | 2024-08-26 | Acceleron Pharma Inc | Gdf-fælder |
| AU2010204985A1 (en) | 2009-01-13 | 2011-08-04 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
| US20100204123A1 (en) | 2009-02-12 | 2010-08-12 | Mary Elizabeth Pecquet Goad | Peripheral Administration of Proteins Including TGF-beta Superfamily Members for Treatment of Systemic Disorders and Disease |
| EP2396026A2 (de) | 2009-02-12 | 2011-12-21 | Stryker Corporation | Zusammensetzungen und verfahren für die minimal invasive systemische abgabe von proteinen einschliesslich mitglieder der tgf-superfamilie |
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| MX355042B (es) | 2009-06-08 | 2018-04-02 | Acceleon Pharma Inc | Metodos para aumentar adipositos termogenicos. |
| CN107267520A (zh) | 2009-06-12 | 2017-10-20 | 阿塞勒隆制药公司 | 截短的actriib‑fc融合蛋白 |
| EP3202459B1 (de) * | 2009-09-09 | 2021-04-14 | Acceleron Pharma Inc. | Actriib-antagonisten sowie dosierung und verwendungen davon zur behandlung von fettleibigkeit oder type 2 diabetes durch körperfettkontrolle |
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| EP2352750B1 (de) | 2009-09-17 | 2012-06-13 | Stryker Corporation | Puffer zur steuerung des ph-wertes knochenmorphogenetischer proteine |
| EP3260130B1 (de) * | 2009-11-03 | 2021-03-10 | Acceleron Pharma Inc. | Verfahren zur behandlung von fettleber |
| ES2658292T3 (es) | 2009-11-17 | 2018-03-09 | Acceleron Pharma, Inc. | Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular |
| CA2785038A1 (en) | 2009-12-22 | 2011-07-21 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| PH12013500294A1 (en) | 2010-08-20 | 2017-08-23 | Wyeth Llc | Designer osteogenic proteins |
| US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| CA2817008A1 (en) | 2010-11-08 | 2012-05-18 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
| WO2012068135A1 (en) | 2010-11-15 | 2012-05-24 | Zimmer Orthobiologics, Inc. | Bone void fillers |
| US9809636B2 (en) * | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
| EP2875125B1 (de) * | 2012-07-20 | 2018-10-24 | Alfred C. Kuo | Verfahren zur herstellung von knorpel und knochen |
| US9833481B2 (en) * | 2012-09-01 | 2017-12-05 | Ken Muneoka | Method for articular cartilage and joint formation |
| RU2678117C2 (ru) | 2012-11-02 | 2019-01-23 | Селджин Корпорейшн | Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений |
| KR20160078375A (ko) * | 2013-10-17 | 2016-07-04 | 재단법인 제이씨비 공동생물과학연구소 | 박테리아로부터 발현 및 분리된 생체활성 재조합 bmp-9 단백질인 mb109 |
| CN114699529A (zh) | 2014-06-13 | 2022-07-05 | 阿塞勒隆制药公司 | 用于治疗溃疡的方法和组合物 |
| GB201412290D0 (en) | 2014-07-10 | 2014-08-27 | Cambridge Entpr Ltd | Novel use |
| MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
| EP3227675B1 (de) | 2014-12-03 | 2023-03-15 | Celgene Corporation | Activin-actrii-antagonisten und verwendungen davon zur behandlung von myelodysplastischem syndrom |
| SG11201707815RA (en) | 2015-06-05 | 2017-12-28 | Novartis Ag | Antibodies targeting bone morphogenetic protein 9 (bmp9) and methods therefor |
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|---|---|---|---|---|
| US4455256A (en) | 1981-05-05 | 1984-06-19 | The Regents Of The University Of California | Bone morphogenetic protein |
| US4294753A (en) | 1980-08-04 | 1981-10-13 | The Regents Of The University Of California | Bone morphogenetic protein process |
| US4619989A (en) | 1981-05-05 | 1986-10-28 | The Regents Of The University Of Cal. | Bone morphogenetic protein composition |
| US4761471A (en) | 1980-08-04 | 1988-08-02 | The Regents Of The University Of California | Bone morphogenetic protein composition |
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| US4795804A (en) | 1983-08-16 | 1989-01-03 | The Regents Of The University Of California | Bone morphogenetic agents |
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-
1994
- 1994-06-06 US US08/254,353 patent/US6287816B1/en not_active Expired - Fee Related
-
1995
- 1995-06-05 EP EP95923706A patent/EP0764208B1/de not_active Expired - Lifetime
- 1995-06-05 JP JP50125096A patent/JP3706133B2/ja not_active Expired - Fee Related
- 1995-06-05 WO PCT/US1995/007084 patent/WO1995033830A1/en not_active Ceased
- 1995-06-05 EP EP01129313A patent/EP1230930A3/de not_active Withdrawn
- 1995-06-05 KR KR1019960707067A patent/KR100255417B1/ko not_active Expired - Fee Related
- 1995-06-05 DE DE69528058T patent/DE69528058T2/de not_active Expired - Fee Related
- 1995-06-05 AU AU28170/95A patent/AU709869B2/en not_active Ceased
- 1995-06-05 AT AT95923706T patent/ATE223486T1/de not_active IP Right Cessation
-
1996
- 1996-12-04 US US08/750,222 patent/US6034061A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6034061A (en) | 2000-03-07 |
| AU2817095A (en) | 1996-01-04 |
| DE69528058D1 (de) | 2002-10-10 |
| DE69528058T2 (de) | 2003-05-28 |
| JPH10503927A (ja) | 1998-04-14 |
| EP0764208B1 (de) | 2002-09-04 |
| EP1230930A2 (de) | 2002-08-14 |
| AU709869B2 (en) | 1999-09-09 |
| KR100255417B1 (ko) | 2000-05-01 |
| US6287816B1 (en) | 2001-09-11 |
| JP3706133B2 (ja) | 2005-10-12 |
| EP1230930A3 (de) | 2002-11-27 |
| EP0764208A1 (de) | 1997-03-26 |
| WO1995033830A1 (en) | 1995-12-14 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |