ATE140965T1 - Protein, dna und ihre verwendung - Google Patents

Protein, dna und ihre verwendung

Info

Publication number
ATE140965T1
ATE140965T1 AT90117079T AT90117079T ATE140965T1 AT E140965 T1 ATE140965 T1 AT E140965T1 AT 90117079 T AT90117079 T AT 90117079T AT 90117079 T AT90117079 T AT 90117079T AT E140965 T1 ATE140965 T1 AT E140965T1
Authority
AT
Austria
Prior art keywords
bmp
dna
xenopus laevis
protein
peptides
Prior art date
Application number
AT90117079T
Other languages
English (en)
Inventor
Kazuo Murakami
Naoto Ueno
Yukio Kato
Original Assignee
Takeda Chemical Industries Ltd
Chichibu Onoda Cement Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd, Chichibu Onoda Cement Corp filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE140965T1 publication Critical patent/ATE140965T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Obesity (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
AT90117079T 1989-09-06 1990-09-05 Protein, dna und ihre verwendung ATE140965T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22925089 1989-09-06
JP19077490 1990-07-20

Publications (1)

Publication Number Publication Date
ATE140965T1 true ATE140965T1 (de) 1996-08-15

Family

ID=26506304

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90117079T ATE140965T1 (de) 1989-09-06 1990-09-05 Protein, dna und ihre verwendung

Country Status (6)

Country Link
US (2) US5453419A (de)
EP (1) EP0416578B1 (de)
JP (1) JP3045398B2 (de)
AT (1) ATE140965T1 (de)
CA (1) CA2024629C (de)
DE (1) DE69027961T2 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
US5939388A (en) * 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5366875A (en) * 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US7378392B1 (en) 1990-05-16 2008-05-27 Genetics Institute, Llc Bone and cartilage inductive proteins
WO1992007004A1 (en) * 1990-10-18 1992-04-30 Creative Biomolecules, Inc. Osteogenic protein
US6399569B1 (en) 1991-03-11 2002-06-04 Curis, Inc. Morphogen treatments for limiting proliferation of epithelial cells
US6495513B1 (en) 1991-03-11 2002-12-17 Curis, Inc. Morphogen-enhanced survival and repair of neural cells
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5652118A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. Nucleic acid encoding a novel morphogenic protein, OP-3
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US6077823A (en) * 1991-03-11 2000-06-20 Creative Biomolecules, Inc. Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury
US5656593A (en) * 1991-03-11 1997-08-12 Creative Biomolecules, Inc. Morphogen induced periodontal tissue regeneration
US5849686A (en) * 1991-03-11 1998-12-15 Creative Biomolecules, Inc. Morphogen-induced liver regeneration
CA2104678C (en) 1991-03-11 2002-05-14 Charles M. Cohen Protein-induced morphogenesis
US6800603B2 (en) 1991-03-11 2004-10-05 Curis, Inc. Morphogen-induced neural cell adhesion
US6090776A (en) * 1991-03-11 2000-07-18 Creative Bio Molecules, Inc. Morphogen treatment of organ implants
US6395883B1 (en) 1991-03-11 2002-05-28 Curis, Inc. Soluble morphogenic protein complex compositions of matter
US5652337A (en) * 1991-03-11 1997-07-29 Creative Biomolecules, Inc. OP-3-induced morphogenesis
US5972884A (en) * 1991-03-11 1999-10-26 Creative Biomolecules, Inc. Morphogen treatment of gastrointestinal ulcers
US5693615A (en) * 1991-06-05 1997-12-02 The Procter & Gamble Company Therapeutic compositions for osteoinduction
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
DK0592562T3 (da) * 1991-06-25 1999-08-30 Genetics Inst BMP-9-præparater
US6022853A (en) * 1991-08-30 2000-02-08 Creative Biomolecules, Inc. Morphogen-enriched dietary composition
DE69233559T2 (de) * 1991-08-30 2006-08-31 Curis, Inc., Cambridge Osteogenische proteine in der behandlung von metabolischen knochenkrankheiten
DE69233022T2 (de) * 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
CZ287715B6 (en) * 1992-02-12 2001-01-17 Bioph Biotech Entw Pharm Gmbh DNA sequence, recombinant DNA molecule containing thereof, process for preparing protein from the group of TGF-beta substances, pharmaceutical preparation containing such protein, antibody or fragment thereof and its use
US5637480A (en) * 1993-05-12 1997-06-10 Genetics Institute, Inc. DNA molecules encoding bone morphogenetic protein-10
CA2124422A1 (en) * 1993-05-27 1994-11-28 Yukio Fujisawa Heterodimers of tgf-.beta. superfamily
US6291206B1 (en) 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
US6027919A (en) * 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
AU689184B2 (en) 1993-12-07 1998-03-26 Genetics Institute, Llc BMP-12, BMP-13 and tendon-inducing compositions thereof
US6492508B1 (en) 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US6008013A (en) * 1996-07-05 1999-12-28 University Of Rochester Chondrocyte proteins
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
WO1998031788A1 (en) * 1997-01-21 1998-07-23 Genetics Institute, Inc. Injectable formulations for treatment of osteoporotic bone
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
EP1053002A1 (de) 1998-02-10 2000-11-22 Oregon Health Sciences University Behandlung von knochendefekten osteoblast-vorläuferzellen
EP2050762A3 (de) 1998-03-10 2009-07-08 Genentech, Inc. Neue Polypeptide und für diese kodierende Nukleinsäuren
PT2016951E (pt) 1998-03-17 2012-09-27 Genentech Inc Polipéptidos homólogos de vegf e de bmp1
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
EP2286847A1 (de) 1999-10-15 2011-02-23 Genetics Institute, LLC Hyaluronsäure enthaltende Zusammensetzungen zur Abgabe osteogener Proteine
US7226587B2 (en) 2001-06-01 2007-06-05 Wyeth Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
JP4257909B2 (ja) * 2002-02-27 2009-04-30 サイエンスパーク株式会社 電子計算機のファイルシステムドライバの制御プログラム及びプログラムの記録媒体
ES2282904T3 (es) 2003-09-12 2007-10-16 Wyeth Barras solidas de fosfato calcico inyectables para el suministro de proteinas osteogenicas.
EP2406281B1 (de) * 2009-03-12 2016-02-17 Haase Investments UG Varianten des knochenmorphogenetischen proteins 2 (bone morphogenetic protein 2, bmp2) mit reduzierter bmp-antagonistischer empfindlichkeit

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4761471A (en) * 1980-08-04 1988-08-02 The Regents Of The University Of California Bone morphogenetic protein composition
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4619989A (en) * 1981-05-05 1986-10-28 The Regents Of The University Of Cal. Bone morphogenetic protein composition
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4472840A (en) * 1981-09-21 1984-09-25 Jefferies Steven R Method of inducing osseous formation by implanting bone graft material
US4526909A (en) * 1984-01-09 1985-07-02 Regents Of The University Of California Polymethylmethacrylate delivery system for bone morphogenetic protein
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4596574A (en) * 1984-05-14 1986-06-24 The Regents Of The University Of California Biodegradable porous ceramic delivery system for bone morphogenetic protein
US4563350A (en) * 1984-10-24 1986-01-07 Collagen Corporation Inductive collagen based bone repair preparations
US4857456A (en) * 1985-04-30 1989-08-15 The Regents Of The University Of California Assay of Bone morphogenetic protein (BMP) and anti-BMP antibody for the diagnosis of bone disorders
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Osteoinductive factors
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
WO1989007880A2 (en) * 1988-02-10 1989-09-08 Nygene Corporation Process for producing biochemicals
EP1225225A3 (de) * 1988-04-08 2003-01-08 Stryker Corporation Osteogene Vorrichtungen

Also Published As

Publication number Publication date
JP3045398B2 (ja) 2000-05-29
US5670338A (en) 1997-09-23
DE69027961D1 (de) 1996-09-05
JPH04154799A (ja) 1992-05-27
CA2024629A1 (en) 1991-03-07
US5453419A (en) 1995-09-26
DE69027961T2 (de) 1997-01-09
EP0416578A2 (de) 1991-03-13
EP0416578A3 (en) 1992-04-22
EP0416578B1 (de) 1996-07-31
CA2024629C (en) 2001-07-24

Similar Documents

Publication Publication Date Title
DE69027961D1 (de) Protein, DNA und ihre Verwendung
ATE188736T1 (de) Endothelin-dna und verwendung davon
HUT43630A (en) Mammalian interleukine-4 and process for producing it
CA2244659A1 (en) Biological reactor for the cultivation of cells
ATE127844T1 (de) Dns und ihre verwendung.
ATE295412T1 (de) Methoden für die ex-vivo replikation und stabile genetische transformation von menschlichen stamm- zellen
ATE178354T1 (de) Plasmid das für die aminosäuresequenz von tcf-ii kodierende dns enthalt, transformierte zelle und produktion einer physiologisch aktiven substanz mit ihrer verwendung
AU704515C (en) Novel protein and process for producing the same
DE69019609D1 (de) Proteine und deren Herstellung.
GR3026751T3 (en) Process for producing collagen fibres
IL94361A0 (en) Polypeptides,recombinant dna molecules and method of producing a human hemoglobin like protein
HUT56880A (en) Process for producing biologically active protein
DE3751269D1 (de) Expression des biologisch aktiven Faktors XIII.
ZA895661B (en) Human nerve growth factor
DE69012377D1 (de) Polypeptid und dessen Herstellung.
HU902850D0 (en) Process for producing and purifying recombinant human interleucine-3 and its muteines
YU179489A (en) Process for preparing new derivatives of human/cattle basis fibroblast growth factor
HUT58037A (en) Process for producing n-2,3-butadienyl tri- and tetraaminoalkane derivatives
EP0336779A3 (de) Durch kovalenten Ersatz von Wasserstoffbrücken stabilisierte Polypeptide
DE69017793D1 (de) Produktion von menschlichen Nervenwachstumsfaktoren.
EP1127104A4 (de) Methoden zur massenkultivierung von zellen die rekombinantes menschliches erythropoietin produzieren
EP0462792A3 (en) Process for obtaining cellular protein having anti-hiv activity
IE900685L (en) Improved tissue culture method
DE68916559D1 (de) Polypeptide und dafür kodierende DNA.
Capano The chemical synthesis, and biomedical and dental applications of the first truly successful, in vivo replacements for bones, teeth, and similar materials.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties