ATE223494T1 - Verfahren zur herstellung von asparaginsäure - Google Patents

Verfahren zur herstellung von asparaginsäure

Info

Publication number: ATE223494T1
Authority: AT; Austria
Prior art keywords: fumarate; calcium; ammonium; pct; ammonia
Prior art date: 1996-01-22

Application number

AT97901152T

Other languages

English (en)

Inventor

Aharon Eyal

Pierre Cami

Original Assignee

Amylum Europe Nv

Staley Mfg Co A E

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-22

Filing date

1997-01-21

Publication date

2002-09-15

1997-01-21 Application filed by Amylum Europe Nv, Staley Mfg Co A E filed Critical Amylum Europe Nv

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223494T1 publication Critical patent/ATE223494T1/de

Links

CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 title 1
CKLJMWTZIZZHCS-UWTATZPHSA-N D-aspartic acid Chemical compound OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 title 1
229960005261 aspartic acid Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 6
235000019297 ammonium fumarate Nutrition 0.000 abstract 5
CKKXWJDFFQPBQL-SEPHDYHBSA-N azane;(e)-but-2-enedioic acid Chemical compound N.N.OC(=O)\C=C\C(O)=O CKKXWJDFFQPBQL-SEPHDYHBSA-N 0.000 abstract 5
239000001729 Ammonium fumarate Substances 0.000 abstract 4
RWYRUDPAALLKPX-UHFFFAOYSA-N 2,2-difluoro-n-methylethanamine;hydrochloride Chemical compound Cl.CNCC(F)F RWYRUDPAALLKPX-UHFFFAOYSA-N 0.000 abstract 3
239000001749 Calcium fumarate Substances 0.000 abstract 3
229910021529 ammonia Inorganic materials 0.000 abstract 3
235000019296 calcium fumarate Nutrition 0.000 abstract 3
238000000855 fermentation Methods 0.000 abstract 3
230000004151 fermentation Effects 0.000 abstract 3
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 2
235000003704 aspartic acid Nutrition 0.000 abstract 2
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 2
229910052791 calcium Inorganic materials 0.000 abstract 2
239000011575 calcium Substances 0.000 abstract 2
239000003153 chemical reaction reagent Substances 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
239000000047 product Substances 0.000 abstract 2
ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 abstract 1
239000001099 ammonium carbonate Substances 0.000 abstract 1
235000012501 ammonium carbonate Nutrition 0.000 abstract 1
229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 abstract 1
239000000920 calcium hydroxide Substances 0.000 abstract 1
229910001861 calcium hydroxide Inorganic materials 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
YEOCBTKAGVNPMO-JIZZDEOASA-N diazanium;(2s)-2-aminobutanedioate Chemical compound [NH4+].[NH4+].[O-]C(=O)[C@@H](N)CC([O-])=O YEOCBTKAGVNPMO-JIZZDEOASA-N 0.000 abstract 1
239000001530 fumaric acid Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000006386 neutralization reaction Methods 0.000 abstract 1
239000002244 precipitate Substances 0.000 abstract 1
230000008929 regeneration Effects 0.000 abstract 1
238000011069 regeneration method Methods 0.000 abstract 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/44—Polycarboxylic acids
- C12P7/46—Dicarboxylic acids having four or less carbon atoms, e.g. fumaric acid, maleic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/20—Aspartic acid; Asparagine

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Microbiology (AREA)
General Chemical & Material Sciences (AREA)
Biotechnology (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97901152T 1996-01-22 1997-01-21 Verfahren zur herstellung von asparaginsäure ATE223494T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IL11684996A IL116849A (en)	1996-01-22	1996-01-22	Process for the preparation of aspartic acid
PCT/GB1997/000176 WO1997027312A1 (en)	1996-01-22	1997-01-21	Process for the preparation of aspartic acid

Publications (1)

Publication Number	Publication Date
ATE223494T1 true ATE223494T1 (de)	2002-09-15

Family

ID=11068464

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97901152T ATE223494T1 (de)	1996-01-22	1997-01-21	Verfahren zur herstellung von asparaginsäure

Country Status (8)

Country	Link
US (1)	US5972662A (de)
EP (1)	EP0876499B1 (de)
AT (1)	ATE223494T1 (de)
AU (1)	AU1449797A (de)
DE (1)	DE69715151T2 (de)
ES (1)	ES2182020T3 (de)
IL (1)	IL116849A (de)
WO (1)	WO1997027312A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6071728A (en) *	1997-01-09	2000-06-06	Amylum Belgium, N.V.	Process for the production of crystalline aspartic acid
IL119986A (en) *	1997-01-09	2000-10-31	Amylum Nv	Process for the production of crystalline aspartic acid
RU2174558C1 (ru) *	2000-12-07	2001-10-10	Закрытое акционерное общество "Биоамид"	Способ получения l-аспарагиновой кислоты
US20060035310A1 (en) *	2004-08-13	2006-02-16	Millipore Corporation	Media for recovery of microorganism in the presence of antibiotics
CN107475320A (zh) *	2017-08-23	2017-12-15	安徽雪郎生物科技股份有限公司	L‑天门冬氨酸的绿色生产方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB146411A (en) *	1915-09-28	1921-10-03	Carl Wehmer	Improved manufacture of fumaric acid
US2327191A (en) *	1939-12-07	1943-08-17	Pfizer & Co C	Production of fumaric acid
US3030276A (en) *	1960-02-09	1962-04-17	Alfred M Thomsen	Method of making fumaric acid and urea from lignified cellulose
GB1004218A (en) *	1962-05-26	1965-09-15	Ajinomoto Kk	A process for producing l-aspartic acid
IT1023343B (it) *	1974-11-21	1978-05-10	Liquichimica Spa	Metodo di produzione di acido l aspartico per fermentazione di idrocarburi
JPS57138383A (en) *	1981-02-20	1982-08-26	Tanabe Seiyaku Co Ltd	Preparation of l-aspartic acid
US4877731A (en) *	1988-06-27	1989-10-31	E. I. Du Pont De Nemours And Company	Fermentation process for carboxylic acids
US5352825A (en) *	1993-07-06	1994-10-04	Hoarmann & Reimer Corp.	Recovery of organic acid salts from impure process streams by addition of bases

1996
- 1996-01-22 IL IL11684996A patent/IL116849A/xx not_active IP Right Cessation
1997
- 1997-01-21 AU AU14497/97A patent/AU1449797A/en not_active Abandoned
- 1997-01-21 ES ES97901152T patent/ES2182020T3/es not_active Expired - Lifetime
- 1997-01-21 AT AT97901152T patent/ATE223494T1/de not_active IP Right Cessation
- 1997-01-21 US US09/101,779 patent/US5972662A/en not_active Expired - Lifetime
- 1997-01-21 WO PCT/GB1997/000176 patent/WO1997027312A1/en not_active Ceased
- 1997-01-21 DE DE69715151T patent/DE69715151T2/de not_active Expired - Fee Related
- 1997-01-21 EP EP97901152A patent/EP0876499B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69715151D1 (de)	2002-10-10
DE69715151T2 (de)	2003-02-27
EP0876499B1 (de)	2002-09-04
WO1997027312A1 (en)	1997-07-31
ES2182020T3 (es)	2003-03-01
EP0876499A1 (de)	1998-11-11
IL116849A (en)	1999-12-31
US5972662A (en)	1999-10-26
AU1449797A (en)	1997-08-20
IL116849A0 (en)	1996-07-23

Legal Events

Date	Code	Title	Description
2002-12-15	UEP	Publication of translation of european patent specification
2005-10-15	REN	Ceased due to non-payment of the annual fee

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HUP9900215A2 (hu)	1999-10-28	Eljárás Z-L-aszparaginsav-dinátriumsó előállítására fumársavból
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