ATE223916T1 - Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung - Google Patents
Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellungInfo
- Publication number
- ATE223916T1 ATE223916T1 AT95917497T AT95917497T ATE223916T1 AT E223916 T1 ATE223916 T1 AT E223916T1 AT 95917497 T AT95917497 T AT 95917497T AT 95917497 T AT95917497 T AT 95917497T AT E223916 T1 ATE223916 T1 AT E223916T1
- Authority
- AT
- Austria
- Prior art keywords
- crystals
- production
- crystalline
- lyophilized preparations
- warming
- Prior art date
Links
- 239000013078 crystal Substances 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- XLJMOHKQRRPBDS-IENPIDJESA-N (5S)-4-pyrrolidin-1-ylsulfanyl-1-azabicyclo[3.2.0]hept-2-en-7-one Chemical class N1(CCCC1)SC1C=CN2[C@H]1CC2=O XLJMOHKQRRPBDS-IENPIDJESA-N 0.000 title 1
- 238000001816 cooling Methods 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 238000010792 warming Methods 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9353794 | 1994-05-02 | ||
| JP10855494 | 1994-05-23 | ||
| PCT/JP1995/000858 WO1995029913A1 (en) | 1994-05-02 | 1995-04-28 | Crystal of pyrrolidylthiocarbapenem derivative, lyophilized preparation containing said crystal, and process for producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE223916T1 true ATE223916T1 (de) | 2002-09-15 |
Family
ID=26434878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95917497T ATE223916T1 (de) | 1994-05-02 | 1995-04-28 | Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6111098A (de) |
| EP (1) | EP0758651B1 (de) |
| KR (1) | KR100314558B1 (de) |
| CN (1) | CN1048248C (de) |
| AT (1) | ATE223916T1 (de) |
| AU (1) | AU700545B2 (de) |
| DE (1) | DE69528166T2 (de) |
| ES (1) | ES2183874T3 (de) |
| PT (1) | PT758651E (de) |
| TW (1) | TW387889B (de) |
| WO (1) | WO1995029913A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2215731T3 (es) * | 1999-10-12 | 2004-10-16 | Daiichi Suntory Pharma Co., Ltd. | Composiciones medicamentosas para uso oral. |
| AU2001244692B2 (en) | 2000-03-31 | 2004-10-14 | Shionogi & Co., Ltd. | Novel crystal form of pyrrolidylthiocarbapenem derivative |
| JP5004355B2 (ja) * | 2001-05-10 | 2012-08-22 | 塩野義製薬株式会社 | アセチルチオピロリジン誘導体の製法 |
| US6727277B1 (en) | 2002-11-12 | 2004-04-27 | Kansas State University Research Foundation | Compounds affecting cholesterol absorption |
| US20060121080A1 (en) * | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
| TWI353855B (en) * | 2005-05-26 | 2011-12-11 | Shionogi & Co | Method for preparing an aqueous solution of doripe |
| CN100582106C (zh) * | 2006-01-27 | 2010-01-20 | 上海医药工业研究院 | 一种吡咯烷硫基碳青霉烯衍生物的制备方法及其中间体 |
| WO2007142212A1 (ja) * | 2006-06-08 | 2007-12-13 | Dainippon Sumitomo Pharma Co., Ltd. | 製剤組成物 |
| WO2008006298A1 (en) * | 2006-07-03 | 2008-01-17 | Chengdu Di'ao Jiuhong Pharmaceutical Factory | Novel crystal form of doripenem, preparation method and uses thereof |
| CN101333219B (zh) * | 2007-06-26 | 2010-10-13 | 山东轩竹医药科技有限公司 | 含有巯基吡咯烷甲酰胺苯烷基杂环的培南衍生物 |
| EP2209787A4 (de) * | 2007-10-08 | 2011-08-03 | Orchid Chemicals & Pharm Ltd | Verfahren zur herstellung eines carbapenem-antibiotikums |
| EP2276762B1 (de) * | 2008-03-24 | 2014-10-01 | Ranbaxy Laboratories Limited | Verfahren zur herstellung von sterilem doripenem |
| US20120035357A1 (en) * | 2009-02-26 | 2012-02-09 | Orchid Chemicals & Pharmaceuticals Ltd. | Process for the preparation of carbapenem antibiotic |
| US8691803B2 (en) * | 2011-01-24 | 2014-04-08 | Savior Lifetec Corporation | Process for the preparation of antibiotic compounds |
| CN102285988B (zh) * | 2011-09-08 | 2012-09-05 | 上海希迈医药科技有限公司 | 一种多尼培南水合物晶体及其制备方法 |
| WO2013068910A1 (en) * | 2011-11-08 | 2013-05-16 | Ranbaxy Laboratories Limited | Process for the preparation of polymorphs of doripenem |
| CN105859609B (zh) | 2012-05-30 | 2019-04-09 | 明治制果药业株式会社 | β-内酰胺酶抑制剂及其制备方法 |
| CN104072497B (zh) * | 2013-03-29 | 2017-10-03 | 石药集团中奇制药技术（石家庄）有限公司 | 一种多尼培南新结晶及其制备方法 |
| MX372585B (es) | 2013-09-24 | 2020-04-17 | Meiji Seika Pharma Co Ltd | Proceso para producir derivado de diazabiciclooctano y su intermediario |
| US10131665B2 (en) | 2013-10-08 | 2018-11-20 | Meiji Seika Pharma Co., Ltd. | Processes for producing diazabicyclooctane compounds |
| CN106255694A (zh) | 2014-04-28 | 2016-12-21 | Jw制药公司 | 新型多尼培南晶体及其制备方法 |
| KR102555657B1 (ko) * | 2014-12-05 | 2023-07-18 | 메이지 세이카 파루마 가부시키가이샤 | 디아자비시클로옥탄 유도체의 결정 및 안정된 동결 건조 제제의 제조법 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3697506A (en) * | 1970-08-07 | 1972-10-10 | Pfizer | Crystalline alkali metal salts of {60 -carboxybenzylpenicillin and process therefor |
| US4029655A (en) * | 1975-04-11 | 1977-06-14 | Eli Lilly And Company | Method of preparing stable sterile crystalline cephalosporins for parenteral administration |
| JPS5294970A (en) * | 1976-02-06 | 1977-08-10 | Shimomura Seisakushiyo Kk | Method of fixing parts |
| IL53427A0 (en) * | 1976-11-24 | 1978-01-31 | Lilly Co Eli | Method of preparing a rapidly dissolving powder of sterile crystalline cefozolin sodium for parenteral administration |
| US4432987A (en) * | 1982-04-23 | 1984-02-21 | Pfizer Inc. | Crystalline benzenesulfonate salts of sultamicillin |
| JPS6019758A (ja) * | 1983-07-15 | 1985-01-31 | Mitsui Toatsu Chem Inc | ビウレツト構造を有するポリイソシアナ−トの製造方法 |
| JPS6019759A (ja) * | 1983-07-15 | 1985-01-31 | Nippon Soda Co Ltd | ホルムアミドオキシム誘導体その製造方法及び農園芸用殺菌剤 |
| US4748238A (en) * | 1984-03-14 | 1988-05-31 | Merck & Co., Inc. | Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid |
| JPS6143356A (ja) * | 1984-08-07 | 1986-03-01 | Nec Corp | 共用フアイル管理装置 |
| JPS61129123A (ja) * | 1984-11-27 | 1986-06-17 | Sankyo Co Ltd | カルバペネム誘導体の安定な凍結乾燥製剤の製造法 |
| JPS61172878A (ja) * | 1985-01-28 | 1986-08-04 | Sankyo Co Ltd | カルバペネム誘導体の安定な凍結乾燥製剤の製法 |
| JP2522671B2 (ja) * | 1986-07-30 | 1996-08-07 | 住友製薬 株式会社 | 結晶態のカルバペネム化合物、その製造方法およびその化合物を含有する注射用抗菌剤 |
| JPS63174927A (ja) * | 1987-01-14 | 1988-07-19 | Tanabe Seiyaku Co Ltd | 抗菌性凍結乾燥製剤 |
| PL157979B1 (pl) * | 1989-02-14 | 1992-07-31 | Sprezyna z dwoma stanami równowagi trwalej PL PL | |
| JPH0459730A (ja) * | 1990-06-26 | 1992-02-26 | Dai Ichi Seiyaku Co Ltd | セフェム系抗生物質含有凍結乾燥製剤 |
| JPH0466202A (ja) * | 1990-06-29 | 1992-03-02 | Aichi Steel Works Ltd | 溝形材の製造方法 |
| JP2919112B2 (ja) * | 1991-05-13 | 1999-07-12 | 武田薬品工業株式会社 | セファロスポリン注射剤およびその製造法 |
| US5317016A (en) * | 1991-08-20 | 1994-05-31 | Shionogi Seiyaku Kabushiki Kaisha | Pyrrolidylthiocarbapenem derivative |
| TW264475B (de) * | 1991-09-20 | 1995-12-01 | Takeda Pharm Industry Co Ltd | |
| US5539102A (en) * | 1992-02-21 | 1996-07-23 | Shionogi Seiyaku Kabushiki Kaisha | Production method for sulfamide |
-
1995
- 1995-04-28 DE DE69528166T patent/DE69528166T2/de not_active Expired - Lifetime
- 1995-04-28 AT AT95917497T patent/ATE223916T1/de active
- 1995-04-28 EP EP95917497A patent/EP0758651B1/de not_active Expired - Lifetime
- 1995-04-28 KR KR1019960706032A patent/KR100314558B1/ko not_active Expired - Lifetime
- 1995-04-28 ES ES95917497T patent/ES2183874T3/es not_active Expired - Lifetime
- 1995-04-28 WO PCT/JP1995/000858 patent/WO1995029913A1/ja not_active Ceased
- 1995-04-28 US US08/718,543 patent/US6111098A/en not_active Expired - Lifetime
- 1995-04-28 AU AU23533/95A patent/AU700545B2/en not_active Expired
- 1995-04-28 PT PT95917497T patent/PT758651E/pt unknown
- 1995-04-28 CN CN95193672A patent/CN1048248C/zh not_active Expired - Lifetime
- 1995-05-01 TW TW084104313A patent/TW387889B/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0758651B1 (de) | 2002-09-11 |
| KR100314558B1 (ko) | 2002-02-28 |
| ES2183874T3 (es) | 2003-04-01 |
| WO1995029913A1 (en) | 1995-11-09 |
| DE69528166D1 (de) | 2002-10-17 |
| US6111098A (en) | 2000-08-29 |
| CN1048248C (zh) | 2000-01-12 |
| EP0758651A4 (de) | 1997-05-02 |
| EP0758651A1 (de) | 1997-02-19 |
| AU700545B2 (en) | 1999-01-07 |
| AU2353395A (en) | 1995-11-29 |
| CN1151162A (zh) | 1997-06-04 |
| PT758651E (pt) | 2002-12-31 |
| DE69528166T2 (de) | 2003-04-30 |
| TW387889B (en) | 2000-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE223916T1 (de) | Kristalline pyrrolidylthiocarbapenem derivate, lyophilisierste präparationen dieser kristalle und verfahren zu deren herstellung | |
| NZ275647A (en) | Tricyclic amide and urea derivatives and medicaments | |
| AU7137591A (en) | New derivatives having naphthalene structure, process for preparing these and pharmaceutical compositions containing them | |
| NZ508842A (en) | Novel form of irbesartan, methods for obtaining said form and pharmaceutical compositions containing same | |
| GB2198135B (en) | Derivatives of cyclohexane | |
| HU9300110D0 (en) | Method for producing aryl-cycloalkyl derivatives and medical preparatives containing them as active substance | |
| PT101077A (pt) | Processo para a preparacao de derivados de tiazolidinodiona susbtituidos | |
| DE69331003D1 (de) | Kristalle von derivaten von chinozon carbonsäure-hydraten | |
| BR9301098A (pt) | Processo integrado para produção de frutose cristalina | |
| ATE100210T1 (de) | Lyophilisiertes mdm enthaltende zusammensetzung und verfahren zu deren herstellung. | |
| DE69124330D1 (de) | Optisch aktive Thienotriazolodiazepin-Verbindungen | |
| CA2344647A1 (en) | New derivatives of 6-(4-phenylbutoxy)hexylamine and process for producing salmeterol | |
| AU636178B2 (en) | 7 (alanylaminothiazol-iminoacetamide) substituted cephalosporin derivatives | |
| US3405165A (en) | Sulfonic acid compound | |
| FI103120B (fi) | Menetelmä laktitolin kiteyttämiseksi | |
| JPS6434927A (en) | Method for asymmetric photochemical reaction | |
| FR2572404B2 (fr) | Nouveaux derives de l'acide 4-oh-3-quinoleine carboxylique substitues en 2, leur procede de preparation, leur application comme medicaments et les compositions les renfermant | |
| HUT56571A (en) | Process for producing crystalline (5r, 6s(-2-) carbamoiloxymethyl)-6-brackets open (1r)-hydroxyethyl brackets closed-2-pnemcarboxylic acid and pharmaceutical compositions comprising such compound | |
| ATE186730T1 (de) | Herstellung von kristallen aus diester phosphat monokazium-salz | |
| JPS6442489A (en) | Method for crystallization and purification of 7-acylamidodeacetoxycephalosporanic acid | |
| ES2193027T3 (es) | Procedimiento para la preparacion de sales del ester-2-fosforico del acido ascorbico. | |
| TH26135B (th) | วิธีการตกผลึกของผลึกของโมโนโซเดียมกลูตาเมท โมโนไฮเดรท | |
| TH54272A (th) | วิธีการตกผลึกของผลึกของโมโนโซเดียมกลูตาเมท โมโนไฮเดรท | |
| CA2132417A1 (en) | A crystalline modification of 2,4-dioxo-6-methyl-1, 2,3,4-tetrahydropyrimidine, a method for the preparation thereof and a medical preparation based on it | |
| LV12664A (lv) | Synthesis of 4-substituted 2-oxobutenic acid sodium salts |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0758651 Country of ref document: EP |