ATE223923T1 - Verfahren zur herstellung von bis(phosphinoxid)- und bis(phosphonat)-verbindungen - Google Patents

Verfahren zur herstellung von bis(phosphinoxid)- und bis(phosphonat)-verbindungen

Info

Publication number
ATE223923T1
ATE223923T1 AT98123996T AT98123996T ATE223923T1 AT E223923 T1 ATE223923 T1 AT E223923T1 AT 98123996 T AT98123996 T AT 98123996T AT 98123996 T AT98123996 T AT 98123996T AT E223923 T1 ATE223923 T1 AT E223923T1
Authority
AT
Austria
Prior art keywords
bis
bisphosphine
compounds
phosphonate
bisphosphonates
Prior art date
Application number
AT98123996T
Other languages
English (en)
Inventor
Joseph Foricher
Rudolf Schmid
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE223923T1 publication Critical patent/ATE223923T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/50Organo-phosphines
    • C07F9/53Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5325Aromatic phosphine oxides or thioxides (P-C aromatic linkage)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025Esters of poly(thio)phosphonic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B37/00Reactions without formation or introduction of functional groups containing hetero atoms, involving either the formation of a carbon-to-carbon bond between two carbon atoms not directly linked already or the disconnection of two directly linked carbon atoms
    • C07B37/04Substitution
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/50Organo-phosphines
    • C07F9/53Organo-phosphine oxides; Organo-phosphine thioxides
    • C07F9/5329Polyphosphine oxides or thioxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
    • C07F9/655345Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring
    • C07F9/655354Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT98123996T 1997-12-23 1998-12-17 Verfahren zur herstellung von bis(phosphinoxid)- und bis(phosphonat)-verbindungen ATE223923T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97122720 1997-12-23

Publications (1)

Publication Number Publication Date
ATE223923T1 true ATE223923T1 (de) 2002-09-15

Family

ID=8227865

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98123996T ATE223923T1 (de) 1997-12-23 1998-12-17 Verfahren zur herstellung von bis(phosphinoxid)- und bis(phosphonat)-verbindungen

Country Status (10)

Country Link
US (1) US6162929A (de)
EP (1) EP0926152B1 (de)
JP (1) JP4326614B2 (de)
KR (1) KR100657060B1 (de)
CN (1) CN1132839C (de)
AT (1) ATE223923T1 (de)
CA (1) CA2256828C (de)
DE (1) DE69807832T2 (de)
DK (1) DK0926152T3 (de)
ES (1) ES2182211T3 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19918420A1 (de) * 1999-04-23 2000-10-26 Aventis Res & Tech Gmbh & Co Bidentate Organophosphorliganden und ihre Verwendung
US6288280B1 (en) * 1999-07-09 2001-09-11 Hoffmann-La Roche Inc. Racemization of atropisomeric bis(phosphine oxide) compounds
JP3844927B2 (ja) 2000-01-07 2006-11-15 高砂香料工業株式会社 ジホスフィンオキシドおよびジホスホナートの製造方法
DE10056310A1 (de) * 2000-11-14 2002-05-16 Bayer Ag Verbessertes Verfahren zur Herstellung von enantiomerenreinen(5,5`-Dichlor-6,6`-dimethoxybiphenyl-2,2`-diyl)-bis-(diphenylphosphinoxiden)
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
US6558702B2 (en) * 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
GB0129112D0 (en) * 2001-12-05 2002-01-23 Chirotech Technology Ltd Chiral ligands for asymmetric catalysis
US7396947B2 (en) * 2003-06-13 2008-07-08 Lanxess Deutschland Gmbh Chiral ligands for application in asymmetric syntheses
CA2556891C (en) 2004-02-19 2012-12-18 Lonza Ag Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
DE102004022397A1 (de) * 2004-05-06 2005-12-01 Consortium für elektrochemische Industrie GmbH Chirale C2-symmetrische Biphenyle, deren Herstellung sowie Metallkomplexe enthaltend diese Liganden und deren Verwendung als Katalysatoren in chirogenen Synthesen
US20110065838A1 (en) * 2009-09-11 2011-03-17 Chemtura Corporation Hydroxyphenyl Phosphine Oxide Mixtures and their use as Flame Retardants for Epoxy Resins
FR2952638A1 (fr) 2009-11-17 2011-05-20 Univ Strasbourg Procede de phosphination catalytique double ou triple de composes di, tri ou tetrahalobiaryles, intermediaires employes, composes obtenus et leurs utilisations
AU2011301115B2 (en) * 2010-09-10 2015-10-08 Kanata Chemical Technologies Inc. Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis
CN103204877A (zh) * 2012-01-11 2013-07-17 中国科学院大连化学物理研究所 一类具有轴手性的缺电子双膦配体及其制备方法
ITMI20121489A1 (it) * 2012-09-06 2014-03-07 Univ Degli Studi Milano Metodo per la riduzione di nitro derivati ad ammine
CN114805436B (zh) * 2022-05-27 2023-09-05 海南大学 一种有机膦氧类化合物及其合成方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3032589A (en) * 1959-08-04 1962-05-01 American Cyanamid Co Method of preparing organophosphorus oxides
GB8429537D0 (en) * 1984-11-22 1985-01-03 Shell Int Research Bis-phosphineoxide compounds
US4879008A (en) * 1987-11-09 1989-11-07 Eastman Kodak Company Preparation of bidentate ligands
ATE128140T1 (de) * 1989-05-18 1995-10-15 Hoffmann La Roche Phosphorverbindungen.
WO1992016536A1 (de) * 1991-03-15 1992-10-01 F. Hoffmann-La Roche Ag Chirale phosphine
ATE141278T1 (de) * 1991-03-15 1996-08-15 Hoffmann La Roche Diphosphonsaurederivate als zwischenprodukte zur herstellung von diphosphinliganden
DK0579797T3 (da) * 1992-01-31 1999-10-25 Hoffmann La Roche Diphosphinligander
DE4330730A1 (de) * 1993-09-10 1995-03-16 Bayer Ag Neue Bisphosphine für asymmetrische Hydrierkatalysatoren
IT1270082B (it) * 1994-07-12 1997-04-28 Univ Degli Studi Milano Difosfine eteroaromatiche come leganti chirali, complessi tra dette difosfine e metalli di transizione ed impiego di detti complessi come catalizzatori chirali
JP3148136B2 (ja) * 1996-12-26 2001-03-19 高砂香料工業株式会社 新規なキラルジホスフィン化合物、その製造中間体、該ジホス フィン化合物を配位子とする遷移金属錯体並びに該錯体を含む 不斉水素化触媒

Also Published As

Publication number Publication date
CA2256828A1 (en) 1999-06-23
US6162929A (en) 2000-12-19
EP0926152A1 (de) 1999-06-30
ES2182211T3 (es) 2003-03-01
EP0926152B1 (de) 2002-09-11
KR100657060B1 (ko) 2007-04-25
CN1224019A (zh) 1999-07-28
KR19990063389A (ko) 1999-07-26
DK0926152T3 (da) 2003-01-20
JPH11246576A (ja) 1999-09-14
CN1132839C (zh) 2003-12-31
JP4326614B2 (ja) 2009-09-09
DE69807832T2 (de) 2003-07-31
DE69807832D1 (de) 2002-10-17
CA2256828C (en) 2009-04-07

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