ATE223927T1 - Mu-opioidligande: agonisten und antagonisten - Google Patents

Mu-opioidligande: agonisten und antagonisten

Info

Publication number: ATE223927T1
Authority: AT; Austria
Prior art keywords: trp; seq; xaa; tyr; phe
Prior art date: 1995-06-07

Application number

AT96919169T

Other languages

English (en)

Inventor

Colette T Dooley

Richard A Houghten

Original Assignee

Torrey Pines Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-07

Filing date

1996-06-06

Publication date

2002-09-15

1996-06-06 Application filed by Torrey Pines Inst filed Critical Torrey Pines Inst

2002-09-15 Application granted granted Critical

2002-09-15 Publication of ATE223927T1 publication Critical patent/ATE223927T1/de

Links

239000000556 agonist Substances 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
239000003446 ligand Substances 0.000 title 1
102000001490 Opioid Peptides Human genes 0.000 abstract 3
108010093625 Opioid Peptides Proteins 0.000 abstract 3
239000003399 opiate peptide Substances 0.000 abstract 3
UHXOYRWHIQZAKV-SZMVWBNQSA-N Trp-Pro-Arg Chemical compound O=C([C@H](CC=1C2=CC=CC=C2NC=1)N)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O UHXOYRWHIQZAKV-SZMVWBNQSA-N 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT96919169T 1995-06-07 1996-06-06 Mu-opioidligande: agonisten und antagonisten ATE223927T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US47643895A	1995-06-07	1995-06-07
PCT/US1996/009321 WO1996040208A1 (en)	1995-06-07	1996-06-06	Novel mu opioid receptor ligands: agonists and antagonists

Publications (1)

Publication Number	Publication Date
ATE223927T1 true ATE223927T1 (de)	2002-09-15

Family

ID=23891841

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96919169T ATE223927T1 (de)	1995-06-07	1996-06-06	Mu-opioidligande: agonisten und antagonisten

Country Status (8)

Country	Link
EP (1)	EP0853484B1 (de)
AT (1)	ATE223927T1 (de)
AU (1)	AU707245B2 (de)
CA (1)	CA2223428A1 (de)
DE (1)	DE69623635T2 (de)
DK (1)	DK0853484T3 (de)
ES (1)	ES2180781T3 (de)
WO (1)	WO1996040208A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5885958A (en)	1997-03-25	1999-03-23	Administrators Of The Tulane Educational Fund	Mu-opiate receptor peptides
TW460478B (en) *	1997-08-15	2001-10-21	Chugai Pharmaceutical Co Ltd	Phenethylamine derivatives
US6548637B1 (en)	1998-06-18	2003-04-15	Sepracor, Inc.	Ligands for opioid receptors
TW509699B (en)	1998-09-24	2002-11-11	Chugau Pharmaceutical Co Ltd	Ethylamine derivatives
KR100440643B1 (ko)	1999-01-28	2004-07-21	쥬가이 세이야쿠 가부시키가이샤	치환 페네틸아민 유도체
US7115664B2 (en)	2000-03-16	2006-10-03	Sepracor Inc.	Peptidomimetic ligands for cellular receptors and ion channels
AU2001296994A1 (en) *	2000-10-06	2002-04-15	Regents Of The University Of California	Nmda receptor channel blocker with neuroprotective activity
EP2079491B1 (de) *	2006-10-17	2013-02-27	Reva Medical, Inc.	N-substituierte monomere und polymere

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2090171A1 (en) *	1993-02-23	1994-08-24	Peter W. Schiller	Opioid receptor antagonists, their synthesis and use as analgesic and immunosuppressive compounds
IS4261A (is) *	1994-02-21	1995-08-22	Astra Aktiebolag	Nýir peptíð-ópíóíðar til meðhöndlunar á verkjum og notkun þeirra

1996
- 1996-06-06 DE DE69623635T patent/DE69623635T2/de not_active Expired - Fee Related
- 1996-06-06 EP EP96919169A patent/EP0853484B1/de not_active Expired - Lifetime
- 1996-06-06 CA CA002223428A patent/CA2223428A1/en not_active Abandoned
- 1996-06-06 AU AU61576/96A patent/AU707245B2/en not_active Ceased
- 1996-06-06 DK DK96919169T patent/DK0853484T3/da active
- 1996-06-06 ES ES96919169T patent/ES2180781T3/es not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/009321 patent/WO1996040208A1/en not_active Ceased
- 1996-06-06 AT AT96919169T patent/ATE223927T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0853484A1 (de)	1998-07-22
DK0853484T3 (da)	2003-01-20
DE69623635D1 (de)	2002-10-17
EP0853484B1 (de)	2002-09-11
CA2223428A1 (en)	1996-12-19
DE69623635T2 (de)	2003-05-08
EP0853484A4 (de)	1999-11-03
ES2180781T3 (es)	2003-02-16
WO1996040208A1 (en)	1996-12-19
AU6157696A (en)	1996-12-30
AU707245B2 (en)	1999-07-08

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Legal Events

Date

Code

Title

Description

2003-03-15

UEP

Publication of translation of european patent specification

Ref document number: 0853484

Country of ref document: EP

2004-09-15

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