ATE223971T1 - Neue methoden zum auffinden von liganden- und ziel-biomolekülen - Google Patents

Neue methoden zum auffinden von liganden- und ziel-biomolekülen

Info

Publication number
ATE223971T1
ATE223971T1 AT99932689T AT99932689T ATE223971T1 AT E223971 T1 ATE223971 T1 AT E223971T1 AT 99932689 T AT99932689 T AT 99932689T AT 99932689 T AT99932689 T AT 99932689T AT E223971 T1 ATE223971 T1 AT E223971T1
Authority
AT
Austria
Prior art keywords
peptide
methods
rna
identified
identification
Prior art date
Application number
AT99932689T
Other languages
English (en)
Inventor
Torben Halkier
Lene Jespersen
Allan Jensen
Original Assignee
Inoxell As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inoxell As filed Critical Inoxell As
Application granted granted Critical
Publication of ATE223971T1 publication Critical patent/ATE223971T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT99932689T 1998-07-20 1999-07-16 Neue methoden zum auffinden von liganden- und ziel-biomolekülen ATE223971T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199800956 1998-07-20
US9486898P 1998-07-29 1998-07-29
PCT/DK1999/000408 WO2000005406A1 (en) 1998-07-20 1999-07-16 Novel methods for the identification of ligand and target biomolecules

Publications (1)

Publication Number Publication Date
ATE223971T1 true ATE223971T1 (de) 2002-09-15

Family

ID=26064970

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99932689T ATE223971T1 (de) 1998-07-20 1999-07-16 Neue methoden zum auffinden von liganden- und ziel-biomolekülen

Country Status (17)

Country Link
EP (1) EP1098991B1 (de)
JP (1) JP2002521652A (de)
KR (1) KR20010103560A (de)
AT (1) ATE223971T1 (de)
AU (1) AU751055B2 (de)
CA (1) CA2335343A1 (de)
DE (1) DE69902924T2 (de)
DK (1) DK1098991T3 (de)
EA (1) EA003637B1 (de)
EE (1) EE200100040A (de)
HU (1) HUP0102457A2 (de)
NO (1) NO20010300L (de)
NZ (1) NZ509013A (de)
PL (1) PL346126A1 (de)
SK (1) SK692001A3 (de)
TR (1) TR200100206T2 (de)
WO (1) WO2000005406A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365344B1 (en) 1996-01-23 2002-04-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening for transdominant effector peptides and RNA molecules
DK0877752T3 (da) 1996-01-23 2003-09-15 Univ Leland Stanford Junior Fremgangsmåder til screening af transdominante effektorpeptider og RNA molekyler
WO2001059071A2 (en) 2000-02-09 2001-08-16 Genvec, Inc. Methods of preparing and using a viral vector library
WO2002068630A1 (en) * 2001-02-22 2002-09-06 Praecis Pharmaceuticals Incorporated Methods for identifying peptides which modulate a biological process
US6872544B2 (en) 2001-09-25 2005-03-29 Kemin Consumer Care, L.C. Raw material selection and analysis for the isolation of proteinase inhibitor II from whole potatoes
EP1689766B1 (de) * 2003-11-06 2012-04-25 Danisco US Inc. Expression von proteaseinhibitoren und varianten davon in filamentösen pilzen
ATE482972T1 (de) * 2003-11-06 2010-10-15 Danisco Us Inc Tgf-beta1-bindende und geträgerte peptide
JP4989638B2 (ja) * 2005-06-10 2012-08-01 メディカル リサーチ カウンシル 足場
US8043830B2 (en) * 2008-02-01 2011-10-25 The Regents Of The University Of California Biotin-ligase system for secretion of biotinylated protein
US7803902B2 (en) 2008-10-15 2010-09-28 Danisco Us Inc. Modified variant bowman birk protease inhibitors
BRPI0823193A2 (pt) * 2008-10-15 2019-09-24 Danisco Us Inc inibidores de protease de bowman birk variantes modificados
US7772181B2 (en) 2008-10-15 2010-08-10 Danisco Us Inc. Personal care compositions comprising modified variant Bowman Birk Protease Inhibitors
CN103808945B (zh) * 2014-03-12 2016-02-10 山东农业大学 一种j亚群禽白血病免疫胶体金抗体检测试纸条
US10876109B2 (en) 2015-04-24 2020-12-29 University Of Florida Research Foundation, Inc. Methods of identifying biologically active random peptides in prokaryotic cells and libraries of prokaryotic cells expressing candidate biologically active random peptides
US10801023B2 (en) * 2015-04-24 2020-10-13 University Of Florida Research Foundation, Inc. Methods of identifying biologically active random peptides in plants and libraries of plants expressing candidate biologically active random peptides
WO2016172445A2 (en) * 2015-04-24 2016-10-27 The University Of Florida Research Foundation, Inc. Methods of identifying biologically active random peptides in plants and libraries of plants expressing candidate biologically active random peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038553A1 (en) * 1995-06-02 1996-12-05 M&E Biotech A/S A method for identification of biologically active peptides and nucleic acids
DK0877752T3 (da) * 1996-01-23 2003-09-15 Univ Leland Stanford Junior Fremgangsmåder til screening af transdominante effektorpeptider og RNA molekyler
US6605429B1 (en) * 1997-01-23 2003-08-12 Immusol, Incorporated Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries

Also Published As

Publication number Publication date
EP1098991B1 (de) 2002-09-11
HUP0102457A2 (hu) 2001-10-28
NZ509013A (en) 2002-12-20
KR20010103560A (ko) 2001-11-23
SK692001A3 (en) 2001-12-03
DE69902924T2 (de) 2003-05-28
EA200100160A1 (ru) 2001-06-25
DE69902924D1 (de) 2002-10-17
EA003637B1 (ru) 2003-08-28
JP2002521652A (ja) 2002-07-16
AU4898599A (en) 2000-02-14
NO20010300L (no) 2001-03-19
DK1098991T3 (da) 2003-01-20
NO20010300D0 (no) 2001-01-18
EE200100040A (et) 2002-06-17
WO2000005406A1 (en) 2000-02-03
PL346126A1 (en) 2002-01-28
TR200100206T2 (tr) 2001-06-21
AU751055B2 (en) 2002-08-08
EP1098991A1 (de) 2001-05-16
CA2335343A1 (en) 2000-02-03

Similar Documents

Publication Publication Date Title
ATE223971T1 (de) Neue methoden zum auffinden von liganden- und ziel-biomolekülen
Brody et al. The use of aptamers in large arrays for molecular diagnostics
Raines Ribonuclease a
Meldal The one‐bead two‐compound assay for solid phase screening of combinatorial libraries
DE69921982D1 (de) Neuartiges verfahren zur identifizierung von klonen mit einer gewünschten biologischen eigenschaft, ausgehend von einer expressionsgenbank
WO2003099999A3 (en) Generation and selection of protein library in silico
EP1774019A4 (de) Look-through-mutagenese zur entwicklung veränderter polypeptide mit verbesserten eigenschaften
DE69841674D1 (de) Vermischen von heterologen dns-sequenzen
ATE369440T1 (de) Rationale auswahl von mutmasslichen peptiden aus identifizierten nukleotid- beziehungsweise peptidsequenzen
ATE108205T1 (de) Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu.
DE69831500D1 (de) Humane checkpointkinase, hcds1, zusammensetzungen und verfahren
WO2002086081A3 (en) Methods and systems for identifying proteins
KR850006550A (ko) 단백질의 제조방법
US10760084B2 (en) α-amylase-binding nucleic acid molecule and use thereof
WO2002044409A3 (en) Substrate linked directed evolution (slide)
WO2003073351A3 (en) Screening process
YU4101A (sh) Novi postupci za identifikovanje liganada i ciljnih biomolekula
DE69637724D1 (de) Polypeptide mit spezieller, funktioneller domäne, verfahren zu ihrer identifikation und anwendungen derselben
Ishigami et al. The origin of the genetic code
ATE269907T1 (de) Methoden und reagentien zur bestmmung der enzym- substatspezifität und damit verbundene anwendungen
Ekici et al. Profiling the substrate specificity of viral protease VP4 by a FRET-based peptide library approach
Claushuis et al. In-depth specificity profiling of Pro-Pro endopeptidases (PPEPs) using combinatorial synthetic peptide libraries
WO1999023109A3 (en) A method for mapping the active sites bound by enzymes that covalently modify substrate molecules
Toh Homology Search and Prediction of Biological Function of Protein from Amino Acid Sequences
JPH05130889A (ja) 生理活性ポリペプチド又はポリヌクレオチド中の作用部位の推定方法

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties