ATE477272T1 - Verwendung von stefin a als gerüstprotein - Google Patents

Verwendung von stefin a als gerüstprotein

Info

Publication number
ATE477272T1
ATE477272T1 AT06744166T AT06744166T ATE477272T1 AT E477272 T1 ATE477272 T1 AT E477272T1 AT 06744166 T AT06744166 T AT 06744166T AT 06744166 T AT06744166 T AT 06744166T AT E477272 T1 ATE477272 T1 AT E477272T1
Authority
AT
Austria
Prior art keywords
stefin
scaffold
mutations
relates
leu73
Prior art date
Application number
AT06744166T
Other languages
English (en)
Inventor
Robbie Woodman
Johannes Yeh
Sophie Laurenson
Ferrigno Paul Ko
Original Assignee
Medical Res Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0511873A external-priority patent/GB0511873D0/en
Priority claimed from GB0608836A external-priority patent/GB0608836D0/en
Application filed by Medical Res Council filed Critical Medical Res Council
Application granted granted Critical
Publication of ATE477272T1 publication Critical patent/ATE477272T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1044Preparation or screening of libraries displayed on scaffold proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT06744166T 2005-06-10 2006-06-08 Verwendung von stefin a als gerüstprotein ATE477272T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0511873A GB0511873D0 (en) 2005-06-10 2005-06-10 Scaffold
GB0608836A GB0608836D0 (en) 2006-05-04 2006-05-04 Scaffold
PCT/GB2006/002115 WO2006131749A2 (en) 2005-06-10 2006-06-08 Scaffold

Publications (1)

Publication Number Publication Date
ATE477272T1 true ATE477272T1 (de) 2010-08-15

Family

ID=37314237

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06744166T ATE477272T1 (de) 2005-06-10 2006-06-08 Verwendung von stefin a als gerüstprotein

Country Status (9)

Country Link
US (2) US8063019B2 (de)
EP (1) EP1904529B1 (de)
JP (1) JP4989638B2 (de)
AT (1) ATE477272T1 (de)
AU (1) AU2006256530B2 (de)
CA (1) CA2610976C (de)
DE (1) DE602006016133D1 (de)
DK (1) DK1904529T3 (de)
WO (1) WO2006131749A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8063019B2 (en) * 2005-06-10 2011-11-22 Medical Research Council Scaffold polypeptides for heterologous peptide display
GB0807065D0 (en) 2008-04-18 2008-05-21 Univ Leeds Novel scaffolds
GB201302597D0 (en) 2013-02-14 2013-04-03 Univ Leeds Novel Synthetic Proteins
HK1231496A1 (zh) * 2014-06-20 2017-12-22 豪夫迈.罗氏有限公司 基於chagasin的支架组合物、方法和应用
EP3405579A1 (de) 2016-01-22 2018-11-28 Modernatx, Inc. Boten-ribonukleinsäuren (mrna) zur herstellung intrazellulärer bindungspolypeptide und verfahren zur verwendung davon
EP4575499A3 (de) 2017-01-04 2025-07-09 MGI Tech Co., Ltd. Schrittweise sequenzierung durch nichtmarkierte reversible terminatoren oder natürliche nukleotide
CN110462403B (zh) 2017-05-19 2024-01-12 菲利普莫里斯生产公司 用于区分受试者的吸烟状况的诊断测试
GB201710973D0 (en) * 2017-07-07 2017-08-23 Avacta Life Sciences Ltd Scaffold proteins
EP4045536A4 (de) * 2019-10-16 2023-11-01 Lg Chem, Ltd. Neonatale fc-rezeptor bindende affimere
GB202101299D0 (en) 2020-06-09 2021-03-17 Avacta Life Sciences Ltd Diagnostic polypetides and methods
EP4225933A4 (de) 2020-10-09 2024-11-27 BGI Shenzhen Co., Limited Verfahren und zusammensetzungen zur biolumineszenzbasierten sequenzierung
EP4477665A4 (de) * 2022-02-10 2025-08-20 Affyxell Therapeutics Co Ltd Stefin-a-proteinvarianten mit spezifischer bindung an cd40l und verwendungen davon
EP4499664A2 (de) * 2022-03-24 2025-02-05 Agency for Science, Technology and Research Herstellung von peptiden unter verwendung der evolution von peptidepitoplinkern
WO2024141788A1 (en) * 2022-12-29 2024-07-04 Affyxell Therapeutics Co., Ltd. Genetically modified stem cells expressing exogenous binding agents and uses thereof
GB202403780D0 (en) 2024-03-15 2024-05-01 Avacta Life Sciences Ltd Polypeptides and methods for detecting and quantifying small molecules

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996016173A2 (en) * 1994-11-21 1996-05-30 The University Of Leeds Modified proteinase inhibitors
SK692001A3 (en) * 1998-07-20 2001-12-03 M & E Biotech As Novel methods for the identification of ligand and target biomolecules
ATE513917T1 (de) 2003-11-06 2011-07-15 Genencor Int Bakterielle expression von proteaseinhibitoren und varianten davon
US8063019B2 (en) * 2005-06-10 2011-11-22 Medical Research Council Scaffold polypeptides for heterologous peptide display

Also Published As

Publication number Publication date
CA2610976C (en) 2020-11-24
WO2006131749A2 (en) 2006-12-14
DE602006016133D1 (de) 2010-09-23
US20080207509A1 (en) 2008-08-28
AU2006256530A1 (en) 2006-12-14
US8481491B2 (en) 2013-07-09
JP4989638B2 (ja) 2012-08-01
CA2610976A1 (en) 2006-12-14
WO2006131749A3 (en) 2007-05-18
EP1904529A2 (de) 2008-04-02
US20120190819A1 (en) 2012-07-26
US8063019B2 (en) 2011-11-22
DK1904529T3 (da) 2010-11-15
EP1904529B1 (de) 2010-08-11
JP2008541776A (ja) 2008-11-27
AU2006256530B2 (en) 2012-12-20

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