ATE224359T1 - Verfahren zur herstellung von gereinigtem kristallinen iohexol - Google Patents

Verfahren zur herstellung von gereinigtem kristallinen iohexol

Info

Publication number
ATE224359T1
ATE224359T1 AT97308629T AT97308629T ATE224359T1 AT E224359 T1 ATE224359 T1 AT E224359T1 AT 97308629 T AT97308629 T AT 97308629T AT 97308629 T AT97308629 T AT 97308629T AT E224359 T1 ATE224359 T1 AT E224359T1
Authority
AT
Austria
Prior art keywords
iohexol
producing purified
purified crystalline
crystalline iohexol
residual solvents
Prior art date
Application number
AT97308629T
Other languages
English (en)
Inventor
Boulay Villax Guido Du
Perez Carlos Manuel Alvarez
De Carvalho Alexandre Ganchas
Original Assignee
Hovione Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Int Ltd filed Critical Hovione Int Ltd
Application granted granted Critical
Publication of ATE224359T1 publication Critical patent/ATE224359T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97308629T 1996-09-30 1997-10-29 Verfahren zur herstellung von gereinigtem kristallinen iohexol ATE224359T1 (de)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
PT101919A PT101919B (pt) 1996-09-30 1996-09-30 Um processo para a purificacao de tohexol
AU42807/97A AU696647B1 (en) 1996-09-30 1997-10-21 Process for the preparation of crystalline and solvent free iohexol
ZA9709448A ZA979448B (en) 1996-09-30 1997-10-22 Process for the preparation of crystalline and solvent free iohexol.
HU9701706A HU219881B (hu) 1996-09-30 1997-10-22 Eljárás kristályos és oldószermentes iohexol elõállítására és az elõállított iohexol
NO974898A NO307927B1 (no) 1996-09-30 1997-10-23 FremgangsmÕte ved rensing av ioheksol
EP97308629A EP0919540B1 (de) 1996-09-30 1997-10-29 Verfahren zur Herstellung von gereinigtem kristallinen Iohexol
US08/964,339 US6469208B1 (en) 1996-09-30 1997-11-04 Process for the preparation of crystalline and solvent free iohexol
CZ973499A CZ285922B6 (cs) 1996-09-30 1997-11-05 Způsob průmyslové výroby krystalického iohexolu
JP9302830A JP3045697B2 (ja) 1996-09-30 1997-11-05 残留溶媒量の少ない結晶質イオヘキソールの製造方法
CN97122538A CN1217314A (zh) 1996-09-30 1997-11-12 制备晶态的且不含溶剂的碘己醇的方法
CA002223373A CA2223373A1 (en) 1996-09-30 1997-12-03 Process for the preparation of crystalline and solvent free iohexol
BR9706099A BR9706099A (pt) 1996-09-30 1997-12-16 Processo para a preparação de iohexol cristalino isento de solventes e iohexol cristalino obtido

Publications (1)

Publication Number Publication Date
ATE224359T1 true ATE224359T1 (de) 2002-10-15

Family

ID=89995677

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97308629T ATE224359T1 (de) 1996-09-30 1997-10-29 Verfahren zur herstellung von gereinigtem kristallinen iohexol

Country Status (17)

Country Link
US (1) US6469208B1 (de)
EP (1) EP0919540B1 (de)
JP (1) JP3045697B2 (de)
CN (1) CN1217314A (de)
AT (1) ATE224359T1 (de)
AU (1) AU696647B1 (de)
BR (1) BR9706099A (de)
CA (1) CA2223373A1 (de)
CZ (1) CZ285922B6 (de)
DE (1) DE69715638T2 (de)
DK (1) DK0919540T3 (de)
ES (1) ES2183092T3 (de)
HU (1) HU219881B (de)
NO (1) NO307927B1 (de)
PT (1) PT101919B (de)
TW (1) TW457225B (de)
ZA (1) ZA979448B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20010773A1 (it) * 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
KR20030032184A (ko) * 2001-10-16 2003-04-26 동국제약 주식회사 이오헥솔의 결정화방법
JP2007518719A (ja) * 2003-12-26 2007-07-12 アラーガン　インコーポレイテッド ＲＡＲγレチノイド受容体アンタゴニスト活性を有する二置換カルコンオキシム
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
NO20053676D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
PT103391B (pt) * 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
JP6571100B2 (ja) * 2014-03-04 2019-09-04 大塚製薬株式会社 イオヘキソール粉末及びそれを使用する方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US5191119A (en) * 1983-10-20 1993-03-02 Cook Imaging Corp. Process for producing non-ionic radiographic contrast media utilizing N-allylation
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol
US5705929A (en) 1995-05-23 1998-01-06 Fibercorp. Inc. Battery capacity monitoring system
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol

Also Published As

Publication number Publication date
NO974898D0 (no) 1997-10-23
CN1217314A (zh) 1999-05-26
HU219881B (hu) 2001-08-28
NO974898L (no) 1999-04-26
EP0919540A1 (de) 1999-06-02
ZA979448B (en) 1998-07-29
CZ285922B6 (cs) 1999-11-17
PT101919A (pt) 1998-04-30
ES2183092T3 (es) 2003-03-16
AU696647B1 (en) 1998-09-17
HUP9701706A2 (hu) 1999-06-28
CZ349997A3 (cs) 1999-07-14
BR9706099A (pt) 1999-07-13
JP3045697B2 (ja) 2000-05-29
EP0919540B1 (de) 2002-09-18
DK0919540T3 (da) 2003-01-13
NO307927B1 (no) 2000-06-19
PT101919B (pt) 2000-01-31
HUP9701706A3 (en) 1999-12-28
HU9701706D0 (en) 1997-12-29
DE69715638T2 (de) 2003-08-07
US6469208B1 (en) 2002-10-22
DE69715638D1 (de) 2002-10-24
JPH11158136A (ja) 1999-06-15
TW457225B (en) 2001-10-01
CA2223373A1 (en) 1999-06-03

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