ES2183092T3 - Proceso para la preparacion de iohexol cristalino purificado. - Google Patents

Proceso para la preparacion de iohexol cristalino purificado.

Info

Publication number
ES2183092T3
ES2183092T3 ES97308629T ES97308629T ES2183092T3 ES 2183092 T3 ES2183092 T3 ES 2183092T3 ES 97308629 T ES97308629 T ES 97308629T ES 97308629 T ES97308629 T ES 97308629T ES 2183092 T3 ES2183092 T3 ES 2183092T3
Authority
ES
Spain
Prior art keywords
iohexol
ethanol
preparation
purified crystal
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97308629T
Other languages
English (en)
Inventor
Boulay Villax Guido Du
Perez Carlos Manuel Alvarez
De Carvalho Alexandre Ganchas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hovione Inter AG
Original Assignee
Hovione Inter AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Inter AG filed Critical Hovione Inter AG
Application granted granted Critical
Publication of ES2183092T3 publication Critical patent/ES2183092T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION SE REFIERE A LA ELIMINACION DE CONTAMINANTES HIDROFOBOS Y DISOLVENTES ORGANICOS RESIDUALES A PARTIR DE IOHEXOL, MEDIANTE LA UTILIZACION DE UN FLUIDO, COMO ETANOL, EN EL CUAL EL IOHEXOL ES INSOLUBLE. EN UN PROCEDIMIENTO, EL ETANOL SE AÑADE A UNA SOLUCION ACUOSA DE IOHEXOL. EN OTRO PROCEDIMIENTO, EL IOHEXOL SE SUSPENDE EN ETANOL Y, A CONTINUACION, SE DEJA CRISTALIZAR. DE ESTA FORMA SE PUEDE OBTENER IOHEXOL CRISTALINO CON UN CONTENIDO DE DISOLVENTE RESIDUAL INFERIOR A 100 PPM.
ES97308629T 1996-09-30 1997-10-29 Proceso para la preparacion de iohexol cristalino purificado. Expired - Lifetime ES2183092T3 (es)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
PT101919A PT101919B (pt) 1996-09-30 1996-09-30 Um processo para a purificacao de tohexol
AU42807/97A AU696647B1 (en) 1996-09-30 1997-10-21 Process for the preparation of crystalline and solvent free iohexol
ZA9709448A ZA979448B (en) 1996-09-30 1997-10-22 Process for the preparation of crystalline and solvent free iohexol.
HU9701706A HU219881B (hu) 1996-09-30 1997-10-22 Eljárás kristályos és oldószermentes iohexol elõállítására és az elõállított iohexol
NO974898A NO307927B1 (no) 1996-09-30 1997-10-23 FremgangsmÕte ved rensing av ioheksol
EP97308629A EP0919540B1 (en) 1996-09-30 1997-10-29 Process for the preparation of purified crystalline iohexol
US08/964,339 US6469208B1 (en) 1996-09-30 1997-11-04 Process for the preparation of crystalline and solvent free iohexol
JP9302830A JP3045697B2 (ja) 1996-09-30 1997-11-05 残留溶媒量の少ない結晶質イオヘキソールの製造方法
CZ973499A CZ285922B6 (cs) 1996-09-30 1997-11-05 Způsob průmyslové výroby krystalického iohexolu
CN97122538A CN1217314A (zh) 1996-09-30 1997-11-12 制备晶态的且不含溶剂的碘己醇的方法
CA002223373A CA2223373A1 (en) 1996-09-30 1997-12-03 Process for the preparation of crystalline and solvent free iohexol
BR9706099A BR9706099A (pt) 1996-09-30 1997-12-16 Processo para a preparação de iohexol cristalino isento de solventes e iohexol cristalino obtido

Publications (1)

Publication Number Publication Date
ES2183092T3 true ES2183092T3 (es) 2003-03-16

Family

ID=89995677

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97308629T Expired - Lifetime ES2183092T3 (es) 1996-09-30 1997-10-29 Proceso para la preparacion de iohexol cristalino purificado.

Country Status (17)

Country Link
US (1) US6469208B1 (es)
EP (1) EP0919540B1 (es)
JP (1) JP3045697B2 (es)
CN (1) CN1217314A (es)
AT (1) ATE224359T1 (es)
AU (1) AU696647B1 (es)
BR (1) BR9706099A (es)
CA (1) CA2223373A1 (es)
CZ (1) CZ285922B6 (es)
DE (1) DE69715638T2 (es)
DK (1) DK0919540T3 (es)
ES (1) ES2183092T3 (es)
HU (1) HU219881B (es)
NO (1) NO307927B1 (es)
PT (1) PT101919B (es)
TW (1) TW457225B (es)
ZA (1) ZA979448B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20010773A1 (it) 2001-04-11 2002-10-11 Chemi Spa Processo per la produzione di ioexolo ad elevata purezza
KR20030032184A (ko) * 2001-10-16 2003-04-26 동국제약 주식회사 이오헥솔의 결정화방법
DE602004019685D1 (de) * 2003-12-26 2009-04-09 Allergan Inc DISUBSTITUIERTE CHALCOGENOXIME MIT ANTAGONISTISCHER WIRKUNG AM RAR(Gamma)-RETINOIDREZEPTOR
NO20053676D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process
NO20053687D0 (no) * 2005-07-29 2005-07-29 Amersham Health As Crystallisation Process.
PT103391B (pt) * 2005-11-24 2008-10-30 Hovione Farmaciencia S A Processo para fabrico de lohexol
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
AU2015224847C1 (en) * 2014-03-04 2021-03-04 Otsuka Pharmaceutical Co., Ltd. Iohexol powder and method of using the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
US5204086A (en) * 1982-10-01 1993-04-20 Nycomed Imaging As X-ray contrast agent
US5191119A (en) * 1983-10-20 1993-03-02 Cook Imaging Corp. Process for producing non-ionic radiographic contrast media utilizing N-allylation
US5527926A (en) * 1990-11-26 1996-06-18 Bracco International B.V. Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
AU642066B2 (en) * 1991-01-25 1993-10-07 Nanosystems L.L.C. X-ray contrast compositions useful in medical imaging
IL110391A (en) * 1993-07-30 1998-12-06 Zambon Spa Process for the crystallization of iopamidol
US5705929A (en) 1995-05-23 1998-01-06 Fibercorp. Inc. Battery capacity monitoring system
PT101720A (pt) * 1995-06-08 1997-01-31 Hovione Sociedade Quimica S A Processo para a purificacao e cristalizacao de iopamidol

Also Published As

Publication number Publication date
ATE224359T1 (de) 2002-10-15
CA2223373A1 (en) 1999-06-03
HU9701706D0 (en) 1997-12-29
NO974898D0 (no) 1997-10-23
CZ349997A3 (cs) 1999-07-14
US6469208B1 (en) 2002-10-22
CN1217314A (zh) 1999-05-26
NO307927B1 (no) 2000-06-19
BR9706099A (pt) 1999-07-13
DE69715638D1 (de) 2002-10-24
CZ285922B6 (cs) 1999-11-17
DE69715638T2 (de) 2003-08-07
HU219881B (hu) 2001-08-28
TW457225B (en) 2001-10-01
AU696647B1 (en) 1998-09-17
PT101919B (pt) 2000-01-31
NO974898L (no) 1999-04-26
JP3045697B2 (ja) 2000-05-29
HUP9701706A2 (hu) 1999-06-28
EP0919540B1 (en) 2002-09-18
DK0919540T3 (da) 2003-01-13
EP0919540A1 (en) 1999-06-02
HUP9701706A3 (en) 1999-12-28
PT101919A (pt) 1998-04-30
JPH11158136A (ja) 1999-06-15
ZA979448B (en) 1998-07-29

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