ATE224909T1 - 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine - Google Patents

1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine

Info

Publication number: ATE224909T1
Authority: AT; Austria
Prior art keywords: arabinofuranosyl; deoxy; thio; fluoro; beta
Prior art date: 1996-04-09

Application number

AT97916633T

Other languages

English (en)

Inventor

Yuichi Yoshimura

Kenji Kitano

Shinji Miura

Haruhiko Machida

Mikari Watanabe

Original Assignee

Yamasa Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-09

Filing date

1997-04-09

Publication date

2002-10-15

1997-04-09 Application filed by Yamasa Corp filed Critical Yamasa Corp

2002-10-15 Application granted granted Critical

2002-10-15 Publication of ATE224909T1 publication Critical patent/ATE224909T1/de

Links

NIDPJRZOVFIBQB-PXBUCIJWSA-N 4-amino-1-[(2r,3s,4s,5r)-3-fluoro-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](F)[C@H](O)[C@@H](CO)S1 NIDPJRZOVFIBQB-PXBUCIJWSA-N 0.000 title abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT97916633T 1996-04-09 1997-04-09 1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine ATE224909T1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP11196896		1996-04-09
JP21508296		1996-07-26
JP27863196		1996-09-30
PCT/JP1997/001206 WO1997038001A1 (en)	1996-04-09	1997-04-09	1-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)CYTOSINES

Publications (1)

Publication Number	Publication Date
ATE224909T1 true ATE224909T1 (de)	2002-10-15

Family

ID=27312140

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97916633T ATE224909T1 (de)	1996-04-09	1997-04-09	1-(2-deoxy-2-fluoro-4-thio-beta-d- arabinofuranosyl)-cytosine

Country Status (10)

Country	Link
US (1)	US6147058A (de)
EP (1)	EP0841344B1 (de)
JP (1)	JP3657008B2 (de)
AT (1)	ATE224909T1 (de)
CA (1)	CA2224155C (de)
DE (1)	DE69715774T2 (de)
DK (1)	DK0841344T3 (de)
ES (1)	ES2182061T3 (de)
PT (1)	PT841344E (de)
WO (1)	WO1997038001A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7138384B1 (en)	1997-08-29	2006-11-21	The Regents Of The University Of California	Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
AU2787199A (en) *	1998-02-25	1999-09-15	Emory University	2'-fluoronucleosides
AU2004274021B2 (en) *	2003-09-18	2009-08-13	Isis Pharmaceuticals, Inc.	4'-thionucleosides and oligomeric compounds
US7524831B2 (en) *	2005-03-02	2009-04-28	Schering Corporation	Treatments for Flaviviridae virus infection
EP2388257A1 (de)	2010-05-20	2011-11-23	LibraMedicina, Inc.	Verfahren zur Herstellung von substituierten 1-O-acyl-2-deoxy-2-fluor-4-thio-ß-D-Arabinfuranosen
US8329925B2 (en)	2009-12-18	2012-12-11	Libramedicina, Inc.	Process for preparing substituted 1-O-acyl-2-deoxy-2-fluoro-4-thio-beta-D-arabinofuranoses
KR20170082650A (ko) *	2012-03-28	2017-07-14	후지필름 가부시키가이샤	1-(2-디옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 염
KR101770248B1 (ko)	2012-08-13	2017-08-22	후지필름 가부시키가이샤	1-(2-데옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 합성 중간체, 티오뉴클레오시드의 합성 중간체, 및 그들의 제조법
WO2014197578A1 (en) *	2013-06-05	2014-12-11	Idenix Pharmaceuticals, Inc.	1',4'-thio nucleosides for the treatment of hcv
JP6351107B2 (ja) *	2014-02-18	2018-07-04	富士フイルム株式会社	チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
WO2015125781A1 (ja) *	2014-02-18	2015-08-27	富士フイルム株式会社	チオラン骨格型糖化合物の製造方法およびチオラン骨格型糖化合物
JP6204223B2 (ja)	2014-02-19	2017-09-27	富士フイルム株式会社	チオピラノース化合物等の製造方法
TWI678373B (zh) *	2014-10-31	2019-12-01	日商富士軟片股份有限公司	硫代核苷衍生物或其鹽及醫藥組合物
WO2016155593A1 (zh) *	2015-04-03	2016-10-06	四川科伦药物研究院有限公司	4'-硫代核苷的新型化合物及其制备方法、药物组合物和应用
JP6450356B2 (ja) *	2016-02-29	2019-01-09	富士フイルム株式会社	液状医薬製剤
RU2752172C2 (ru) *	2016-08-31	2021-07-23	Фуджифилм Корпорэйшн	Противоопухолевый агент, усилитель противоопухолевого действия и противоопухолевый набор
CA3041420A1 (en)	2016-12-22	2018-06-28	Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.	Solid form of 4'-thio-2'-fluoronucleoside phosphamide compound and preparation method therefor and use thereof
CN110831604B (zh) *	2017-09-01	2023-05-02	四川科伦博泰生物医药股份有限公司	用于肿瘤治疗或预防的药物组合物、方法及其用途
AU2018404329B2 (en)	2018-01-29	2021-09-09	Fujifilm Corporation	Antitumor agent for biliary tract cancer and method for treating biliary tract cancer
TW201932120A (zh) *	2018-01-29	2019-08-16	日商富士軟片股份有限公司	用於具有異檸檬酸脫氫酶突變的腫瘤的藥物組成物與抗腫瘤劑及其應用
TW202000207A (zh) *	2018-02-26	2020-01-01	日商富士軟片股份有限公司	膀胱癌用抗腫瘤劑及膀胱癌的處置方法
EP3766502A4 (de) *	2018-03-13	2021-05-05	FUJIFILM Corporation	Antitumormittel, antitumorwirkungsverstärker und antitumor-kit
US20220033387A1 (en) *	2018-09-25	2022-02-03	The Usa, As Represented By The Secretary, Department Of Health And Human Services	2'-halogenated-4'-thio-2'-deoxy-5-azacytidine analogs and use thereof
WO2020108343A1 (zh) *	2018-11-28	2020-06-04	四川科伦博泰生物医药股份有限公司	以4'-硫代核苷类化合物为活性成分的口服药物组合物、其制备方法及其用途
CN114341149A (zh) *	2019-07-30	2022-04-12	匹诺生物股份有限公司	用于治疗癌症的二核苷酸化合物及其医学用途
KR20240028451A (ko)	2021-07-29	2024-03-05	후지필름 가부시키가이샤	Bap1 및 pbrm1 중 적어도 하나의 기능 저하를 갖는 종양에 대한 의약 조성물 및 항종양제

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE74701B1 (en) *	1989-10-04	1997-07-30	Univ Birmingham	Further antiviral pyrimidine nucleosides
US5811408A (en) *	1994-07-12	1998-09-22	Yamasa Corporation	2'-deoxy-2'-(substituted or unsubstituted)methylidene-4'-thionucleosides
JPH0853490A (ja) *	1994-08-09	1996-02-27	Yamasa Shoyu Co Ltd	２’−デオキシ−２’，２’−ジハロゲノ−４’−チオヌクレオシド

1997
- 1997-04-09 DK DK97916633T patent/DK0841344T3/da active
- 1997-04-09 ES ES97916633T patent/ES2182061T3/es not_active Expired - Lifetime
- 1997-04-09 DE DE69715774T patent/DE69715774T2/de not_active Expired - Lifetime
- 1997-04-09 EP EP97916633A patent/EP0841344B1/de not_active Expired - Lifetime
- 1997-04-09 AT AT97916633T patent/ATE224909T1/de active
- 1997-04-09 US US08/973,529 patent/US6147058A/en not_active Expired - Lifetime
- 1997-04-09 JP JP52839997A patent/JP3657008B2/ja not_active Expired - Lifetime
- 1997-04-09 CA CA002224155A patent/CA2224155C/en not_active Expired - Lifetime
- 1997-04-09 WO PCT/JP1997/001206 patent/WO1997038001A1/ja not_active Ceased
- 1997-04-09 PT PT97916633T patent/PT841344E/pt unknown

Also Published As

Publication number	Publication date
EP0841344A1 (de)	1998-05-13
EP0841344B1 (de)	2002-09-25
DE69715774T2 (de)	2003-05-15
PT841344E (pt)	2003-02-28
CA2224155A1 (en)	1997-10-16
WO1997038001A1 (en)	1997-10-16
JP3657008B2 (ja)	2005-06-08
EP0841344A4 (de)	1998-05-13
DE69715774D1 (de)	2002-10-31
DK0841344T3 (da)	2002-12-23
US6147058A (en)	2000-11-14
CA2224155C (en)	2004-10-26
ES2182061T3 (es)	2003-03-01

Legal Events

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2003-04-15

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Publication	Publication Date	Title
DE69715774D1 (de)	2002-10-31	1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)-cytosine
ZA200309887B (en)	2004-07-20	Novel compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents.
AU5211686A (en)	1986-07-24	Pyrazolesulfonamide derivative, process for its production and herbicide containing it
PT1385518E (pt)	2008-10-07	Compostos de benzimidazolona
ATE201195T1 (de)	2001-06-15	Tricyclische verbindungen
EP0503453A3 (en)	1992-12-09	New process for the production of cephalosporines and novel intermediates in this process
EP0714900A3 (de)	1996-07-31	Alkylhydrogenchlorsilane, Verfahren zu deren Herstellung und deren Verwendung
ATE280767T1 (de)	2004-11-15	Antidiabetische thiazolidindione und ihre herstellung
ATE277017T1 (de)	2004-10-15	1,2-disubstituierte 1,4-dihydro-4-oxochinolin- verbindungen
ES2192852T3 (es)	2003-10-16	Proceso de obtencion de 3-aril-benzofuranonas.
YU12000A (sh)	2002-11-15	Supstituisani 1,2,3,4,5,6-heksahidro-2,6-metano-3-benzazocin -10-oli, postupak za njihovo pripremanje i njihova primena kao lekova
AU2001282297A1 (en)	2002-03-04	Catalysts
FI955954A0 (fi)	1995-12-12	Thiolyhdisteitä
ATE223414T1 (de)	2002-09-15	Prozess zur herstellung von zwischebprodukten für imidazodeazepinen
DK0782996T3 (da)	1999-09-20	Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af
EP0747350A4 (de)	2000-03-08	Verfahren zur herstellung von bis(4-alkylthiophenyl)disulfid
ATE206125T1 (de)	2001-10-15	Furoindolizine
AU2407597A (en)	1998-11-24	Eyedrops
DE69601451D1 (de)	1999-03-11	UCK14-Verbindungen
DE69615814D1 (de)	2001-11-15	Uch-15-verbindungen
DK1242390T3 (da)	2004-12-20	Fremgangsmåde til fremstilling af 1,3-disubstituerede 2-nitroguanidiner
FI904981A0 (fi)	1990-10-10	Nya inosin/guanosinderivat.
DE69816095D1 (de)	2003-08-07	Herstellung von beta-mehtylcarbapenem-zwischenprodukten