ATE225329T1 - Verfahren zur herstellung von r-(-)-carnitin - Google Patents

Verfahren zur herstellung von r-(-)-carnitin

Info

Publication number: ATE225329T1
Authority: AT; Austria
Prior art keywords: yield; compound; carnitine; conversion; cyano
Prior art date: 1998-07-31

Application number

AT99936972T

Other languages

English (en)

Inventor

Fabio Giannessi

Maria Ornella Tinti

Angelis Francesco De

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-31

Filing date

1999-07-27

Publication date

2002-10-15

1999-07-27 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

2002-10-15 Application granted granted Critical

2002-10-15 Publication of ATE225329T1 publication Critical patent/ATE225329T1/de

Links

PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title 1
238000006243 chemical reaction Methods 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
CCTUWCSMWLBKKI-SCSAIBSYSA-N 2-[(5R)-4-oxo-2H-1,3-oxazol-2-id-5-yl]acetonitrile Chemical compound C(#N)C[C@@H]1C(N=[C-]O1)=O CCTUWCSMWLBKKI-SCSAIBSYSA-N 0.000 abstract 2
125000005907 alkyl ester group Chemical group 0.000 abstract 2
YQGDEPYYFWUPGO-GSVOUGTGSA-N (3r)-4-amino-3-hydroxybutanoic acid Chemical compound NC[C@H](O)CC(O)=O YQGDEPYYFWUPGO-GSVOUGTGSA-N 0.000 abstract 1
JGNICYPMHKZAGS-SCSAIBSYSA-N (3r)-4-cyano-3-hydroxybutanamide Chemical compound NC(=O)C[C@H](O)CC#N JGNICYPMHKZAGS-SCSAIBSYSA-N 0.000 abstract 1
ADZQCEUEGXRCJY-SCSAIBSYSA-N (3r)-4-cyano-3-hydroxybutanoic acid Chemical compound N#CC[C@@H](O)CC(O)=O ADZQCEUEGXRCJY-SCSAIBSYSA-N 0.000 abstract 1
FUDDLSHBRSNCBV-VKHMYHEASA-N (4s)-4-hydroxyoxolan-2-one Chemical compound O[C@@H]1COC(=O)C1 FUDDLSHBRSNCBV-VKHMYHEASA-N 0.000 abstract 1
MEKOFIRRDATTAG-UHFFFAOYSA-N 2,2,5,8-tetramethyl-3,4-dihydrochromen-6-ol Chemical compound C1CC(C)(C)OC2=C1C(C)=C(O)C=C2C MEKOFIRRDATTAG-UHFFFAOYSA-N 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000001408 amides Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
239000012948 isocyanate Substances 0.000 abstract 1
150000002513 isocyanates Chemical class 0.000 abstract 1
229960001518 levocarnitine Drugs 0.000 abstract 1
230000011987 methylation Effects 0.000 abstract 1
238000007069 methylation reaction Methods 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1
238000006467 substitution reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Luminescent Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

AT99936972T 1998-07-31 1999-07-27 Verfahren zur herstellung von r-(-)-carnitin ATE225329T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1998MI001796A IT1301977B1 (it)	1998-07-31	1998-07-31	Procedimento per la preparazione di r-(-)-carnitina
PCT/IT1999/000241 WO2000006532A2 (en)	1998-07-31	1999-07-27	Process for the preparation of r-(-)-carnitine

Publications (1)

Publication Number	Publication Date
ATE225329T1 true ATE225329T1 (de)	2002-10-15

Family

ID=11380580

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99936972T ATE225329T1 (de)	1998-07-31	1999-07-27	Verfahren zur herstellung von r-(-)-carnitin

Country Status (12)

Country	Link
US (1)	US6316667B2 (de)
EP (1)	EP1100768B1 (de)
JP (1)	JP2002521469A (de)
KR (1)	KR100614545B1 (de)
AT (1)	ATE225329T1 (de)
AU (1)	AU5193499A (de)
DE (1)	DE69903320T2 (de)
DK (1)	DK1100768T3 (de)
ES (1)	ES2184488T3 (de)
IT (1)	IT1301977B1 (de)
PT (1)	PT1100768E (de)
WO (1)	WO2000006532A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6288239B1 (en) *	2000-09-19	2001-09-11	Board Of Trustees Operating Michigan State University	5-trityloxymethyl-oxazolidinones and process for the preparation thereof
EP1534255B1 (de) *	2002-08-06	2011-01-19	Pharmasset, Inc.	Verfahren zur herstellung von 1,3-dioxolan-nucleosiden
CN100335457C (zh) *	2005-09-08	2007-09-05	上海交通大学	3－位手性羟基被保护的3，4－二羟基丁酸酯及其制备方法
KR100846673B1 (ko)	2006-03-22	2008-07-16	엔자이텍 주식회사	엘-카르니틴의 제조방법
CN105801572B (zh) *	2016-05-12	2018-11-06	山东罗欣药业集团恒欣药业有限公司	一种利伐沙班的制备方法
CN106749073B (zh) *	2016-11-08	2019-06-18	山东裕欣药业有限公司	一种利奈唑胺的制备方法
CN116655481B (zh) *	2023-06-14	2023-11-28	海南卓科制药有限公司	一种工业化合成左卡尼汀的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2710688B2 (ja) *	1990-10-09	1998-02-10	鐘淵化学工業株式会社	４―ブロモ―３―ヒドロキシ酪酸エステル誘導体の製造法
IT1256705B (it) *	1992-12-21	1995-12-12	Sigma Tau Ind Farmaceuti	Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
US5473104A (en) *	1994-09-13	1995-12-05	Neurocrine Biosciences, Inc.	Process for the preparation of L-carnitine

1998
- 1998-07-31 IT IT1998MI001796A patent/IT1301977B1/it active IP Right Grant
1999
- 1999-07-27 AU AU51934/99A patent/AU5193499A/en not_active Abandoned
- 1999-07-27 WO PCT/IT1999/000241 patent/WO2000006532A2/en not_active Ceased
- 1999-07-27 DK DK99936972T patent/DK1100768T3/da active
- 1999-07-27 AT AT99936972T patent/ATE225329T1/de not_active IP Right Cessation
- 1999-07-27 EP EP99936972A patent/EP1100768B1/de not_active Expired - Lifetime
- 1999-07-27 KR KR1020017000539A patent/KR100614545B1/ko not_active Expired - Fee Related
- 1999-07-27 PT PT99936972T patent/PT1100768E/pt unknown
- 1999-07-27 DE DE69903320T patent/DE69903320T2/de not_active Expired - Fee Related
- 1999-07-27 ES ES99936972T patent/ES2184488T3/es not_active Expired - Lifetime
- 1999-07-27 JP JP2000562339A patent/JP2002521469A/ja active Pending
2000
- 2000-12-21 US US09/740,806 patent/US6316667B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1100768B1 (de)	2002-10-02
WO2000006532A2 (en)	2000-02-10
DE69903320T2 (de)	2003-06-18
DE69903320D1 (de)	2002-11-07
AU5193499A (en)	2000-02-21
KR20010071884A (ko)	2001-07-31
PT1100768E (pt)	2003-02-28
US20010031892A1 (en)	2001-10-18
JP2002521469A (ja)	2002-07-16
EP1100768A2 (de)	2001-05-23
ES2184488T3 (es)	2003-04-01
US6316667B2 (en)	2001-11-13
IT1301977B1 (it)	2000-07-20
ITMI981796A0 (it)	1998-07-31
DK1100768T3 (da)	2003-02-03
WO2000006532A3 (en)	2000-05-11
KR100614545B1 (ko)	2006-08-25
ITMI981796A1 (it)	2000-01-31

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Legal Events

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2003-02-15

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Publication of translation of european patent specification

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2009-04-15

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