ATE225351T1 - Thienopyridin und thienopyrimidinderivate und ihre verwendung als entzündungshemmende mittel - Google Patents
Thienopyridin und thienopyrimidinderivate und ihre verwendung als entzündungshemmende mittelInfo
- Publication number
- ATE225351T1 ATE225351T1 AT95936112T AT95936112T ATE225351T1 AT E225351 T1 ATE225351 T1 AT E225351T1 AT 95936112 T AT95936112 T AT 95936112T AT 95936112 T AT95936112 T AT 95936112T AT E225351 T1 ATE225351 T1 AT E225351T1
- Authority
- AT
- Austria
- Prior art keywords
- thienopyridine
- pct
- thienopyrimidene
- derivatives
- inflammatory agents
- Prior art date
Links
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 title abstract 3
- 229940125670 thienopyridine Drugs 0.000 title abstract 3
- 239000002175 thienopyridine Substances 0.000 title abstract 3
- 229940121363 anti-inflammatory agent Drugs 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 208000006386 Bone Resorption Diseases 0.000 abstract 2
- 230000024279 bone resorption Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical class C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27380194 | 1994-11-08 | ||
| JP32005594 | 1994-12-22 | ||
| PCT/JP1995/002271 WO1996014319A1 (en) | 1994-11-08 | 1995-11-07 | Thienopyridine or thienopyrimidine derivatives and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE225351T1 true ATE225351T1 (de) | 2002-10-15 |
Family
ID=26550777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95936112T ATE225351T1 (de) | 1994-11-08 | 1995-11-07 | Thienopyridin und thienopyrimidinderivate und ihre verwendung als entzündungshemmende mittel |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5747486A (de) |
| EP (1) | EP0791000B1 (de) |
| KR (1) | KR970707131A (de) |
| AT (1) | ATE225351T1 (de) |
| AU (1) | AU699354B2 (de) |
| CA (1) | CA2202985A1 (de) |
| DE (1) | DE69528470T2 (de) |
| FI (1) | FI971974A7 (de) |
| HU (1) | HUT77348A (de) |
| NO (1) | NO972043L (de) |
| NZ (1) | NZ294933A (de) |
| WO (1) | WO1996014319A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU715100B2 (en) * | 1996-04-25 | 2000-01-13 | Takeda Chemical Industries Ltd. | Thienopyridine derivatives and their use |
| US6727258B2 (en) | 1997-10-29 | 2004-04-27 | King Pharmaceutical Research & Development, Inc. | Allosteric adenosine receptor modulators |
| US5939432A (en) * | 1997-10-29 | 1999-08-17 | Medco Research, Inc. | Thiophenes useful for modulating the adenosine receptor |
| US6323214B1 (en) | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| TW564247B (en) | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
| TW591031B (en) * | 2000-02-29 | 2004-06-11 | Takeda Chemical Industries Ltd | Thienopyridine derivatives, their production and use |
| US6503914B1 (en) | 2000-10-23 | 2003-01-07 | Board Of Regents, The University Of Texas System | Thienopyrimidine-based inhibitors of the Src family |
| WO2002064598A1 (en) * | 2001-02-14 | 2002-08-22 | Warner-Lambert Company Llc | Thieno'2,3-d pyrimidindione derivatives as matrix metalloproteinase inhibitors |
| WO2003018590A1 (fr) * | 2001-08-24 | 2003-03-06 | Takeda Chemical Industries, Ltd. | Procede de production d'un derive de la thienopyridine |
| US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
| AU2003281170A1 (en) * | 2002-07-17 | 2004-02-02 | Warner-Lambert Company Llc | Pharmaceutical compostions comprising an allosteric carboxylic inhibitor of matrix metalloproteinase-13 and a selective inhibitor of cyclooxygenase-2 |
| AR044743A1 (es) * | 2002-09-26 | 2005-10-05 | Nihon Nohyaku Co Ltd | Herbicida, metodo de emplearlo, derivados de tienopirimidina sustituida,compuestos intermediarios, y procedimientos que se utilizan para producirlos, |
| WO2005003100A2 (en) * | 2003-07-03 | 2005-01-13 | Myriad Genetics, Inc. | 4-arylamino-quinazolines as activators of caspases and inducers of apoptosis |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| WO2006074147A2 (en) | 2005-01-03 | 2006-07-13 | Myriad Genetics, Inc. | Nitrogen containing bicyclic compounds and therapeutical use thereof |
| MX2007007026A (es) * | 2004-12-17 | 2007-07-04 | Hoffmann La Roche | Derivados de tieno-piridina como intensificadores alostericos de gaba-b. |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| CN101189208A (zh) | 2005-06-02 | 2008-05-28 | 弗·哈夫曼-拉罗切有限公司 | 作为gaba-b增强剂的3-甲磺酰基喹啉 |
| WO2007056214A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc | N-alkyl-n-aryl-thienopyrimidin-r-amines and uses thereof |
| WO2007056208A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc. | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US20070099877A1 (en) * | 2005-11-02 | 2007-05-03 | Cytovia, Inc. | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| EP2574610A1 (de) * | 2007-11-15 | 2013-04-03 | Gilead Sciences, Inc. | Hemmer der Replikation des menschlichen Immundefizienz-Virus |
| US8575403B2 (en) | 2010-05-07 | 2013-11-05 | Celanese International Corporation | Hydrolysis of ethyl acetate in ethanol separation process |
| US8859827B2 (en) | 2011-11-18 | 2014-10-14 | Celanese International Corporation | Esterifying acetic acid to produce ester feed for hydrogenolysis |
| US8846988B2 (en) | 2010-07-09 | 2014-09-30 | Celanese International Corporation | Liquid esterification for the production of alcohols |
| WO2012148509A1 (en) | 2011-04-26 | 2012-11-01 | Celanese International Corporation | Process for producing ethanol using a stacked bed reactor |
| US8664454B2 (en) | 2010-07-09 | 2014-03-04 | Celanese International Corporation | Process for production of ethanol using a mixed feed using copper containing catalyst |
| US9272970B2 (en) | 2010-07-09 | 2016-03-01 | Celanese International Corporation | Hydrogenolysis of ethyl acetate in alcohol separation processes |
| US8710279B2 (en) | 2010-07-09 | 2014-04-29 | Celanese International Corporation | Hydrogenolysis of ethyl acetate in alcohol separation processes |
| US8592635B2 (en) | 2011-04-26 | 2013-11-26 | Celanese International Corporation | Integrated ethanol production by extracting halides from acetic acid |
| US8907141B2 (en) | 2011-04-26 | 2014-12-09 | Celanese International Corporation | Process to recover alcohol with secondary reactors for esterification of acid |
| US9000233B2 (en) | 2011-04-26 | 2015-04-07 | Celanese International Corporation | Process to recover alcohol with secondary reactors for hydrolysis of acetal |
| US9073816B2 (en) | 2011-04-26 | 2015-07-07 | Celanese International Corporation | Reducing ethyl acetate concentration in recycle streams for ethanol production processes |
| US8754268B2 (en) | 2011-04-26 | 2014-06-17 | Celanese International Corporation | Process for removing water from alcohol mixtures |
| US8895786B2 (en) | 2011-08-03 | 2014-11-25 | Celanese International Corporation | Processes for increasing alcohol production |
| US8802901B2 (en) | 2011-11-18 | 2014-08-12 | Celanese International Corporation | Continuous ethyl acetate production and hydrogenolysis thereof |
| US8829249B2 (en) | 2011-11-18 | 2014-09-09 | Celanese International Corporation | Integrated esterification and hydrogenolysis process for producing ethanol |
| US8829251B2 (en) | 2011-11-18 | 2014-09-09 | Celanese International Corporation | Liquid esterification method to produce ester feed for hydrogenolysis |
| US8748673B2 (en) | 2011-11-18 | 2014-06-10 | Celanese International Corporation | Process of recovery of ethanol from hydrogenolysis process |
| US9024089B2 (en) | 2011-11-18 | 2015-05-05 | Celanese International Corporation | Esterification process using extractive separation to produce feed for hydrogenolysis |
| US8853468B2 (en) | 2011-11-18 | 2014-10-07 | Celanese International Corporation | Vapor esterification method to produce ester feed for hydrogenolysis |
| US8927790B2 (en) | 2011-12-15 | 2015-01-06 | Celanese International Corporation | Multiple vapor feeds for hydrogenation process to produce alcohol |
| US8975451B2 (en) | 2013-03-15 | 2015-03-10 | Celanese International Corporation | Single phase ester feed for hydrogenolysis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5143796A (ja) * | 1974-10-09 | 1976-04-14 | Yoshitomi Pharmaceutical | Shinkinachenopirimijinruino seizoho |
| JPS5246095A (en) * | 1975-10-07 | 1977-04-12 | Yoshitomi Pharmaceut Ind Ltd | Preparation of novel thienopyrimidine derivatives |
| DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
-
1995
- 1995-11-07 CA CA002202985A patent/CA2202985A1/en not_active Abandoned
- 1995-11-07 FI FI971974A patent/FI971974A7/fi unknown
- 1995-11-07 AU AU38158/95A patent/AU699354B2/en not_active Ceased
- 1995-11-07 EP EP95936112A patent/EP0791000B1/de not_active Expired - Lifetime
- 1995-11-07 HU HU9702020A patent/HUT77348A/hu unknown
- 1995-11-07 US US08/571,915 patent/US5747486A/en not_active Expired - Fee Related
- 1995-11-07 WO PCT/JP1995/002271 patent/WO1996014319A1/en not_active Ceased
- 1995-11-07 AT AT95936112T patent/ATE225351T1/de not_active IP Right Cessation
- 1995-11-07 DE DE69528470T patent/DE69528470T2/de not_active Expired - Fee Related
- 1995-11-07 NZ NZ294933A patent/NZ294933A/xx unknown
- 1995-11-07 KR KR1019970703090A patent/KR970707131A/ko not_active Withdrawn
-
1997
- 1997-05-02 NO NO972043A patent/NO972043L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0791000A1 (de) | 1997-08-27 |
| KR970707131A (ko) | 1997-12-01 |
| US5747486A (en) | 1998-05-05 |
| WO1996014319A1 (en) | 1996-05-17 |
| CA2202985A1 (en) | 1996-05-17 |
| FI971974L (fi) | 1997-06-18 |
| DE69528470D1 (de) | 2002-11-07 |
| NO972043D0 (no) | 1997-05-02 |
| DE69528470T2 (de) | 2003-08-21 |
| AU699354B2 (en) | 1998-12-03 |
| AU3815895A (en) | 1996-05-31 |
| NZ294933A (en) | 1999-05-28 |
| EP0791000B1 (de) | 2002-10-02 |
| HUT77348A (hu) | 1998-03-30 |
| FI971974A0 (fi) | 1997-05-07 |
| FI971974A7 (fi) | 1997-06-18 |
| NO972043L (no) | 1997-06-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |