ATE225351T1 - Thienopyridin und thienopyrimidinderivate und ihre verwendung als entzündungshemmende mittel - Google Patents
Thienopyridin und thienopyrimidinderivate und ihre verwendung als entzündungshemmende mittelInfo
- Publication number
- ATE225351T1 ATE225351T1 AT95936112T AT95936112T ATE225351T1 AT E225351 T1 ATE225351 T1 AT E225351T1 AT 95936112 T AT95936112 T AT 95936112T AT 95936112 T AT95936112 T AT 95936112T AT E225351 T1 ATE225351 T1 AT E225351T1
- Authority
- AT
- Austria
- Prior art keywords
- thienopyridine
- pct
- thienopyrimidene
- derivatives
- inflammatory agents
- Prior art date
Links
- DBDCNCCRPKTRSD-UHFFFAOYSA-N thieno[3,2-b]pyridine Chemical compound C1=CC=C2SC=CC2=N1 DBDCNCCRPKTRSD-UHFFFAOYSA-N 0.000 title abstract 3
- 229940125670 thienopyridine Drugs 0.000 title abstract 3
- 239000002175 thienopyridine Substances 0.000 title abstract 3
- 229940121363 anti-inflammatory agent Drugs 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 208000006386 Bone Resorption Diseases 0.000 abstract 2
- 230000024279 bone resorption Effects 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical class C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP27380194 | 1994-11-08 | ||
| JP32005594 | 1994-12-22 | ||
| PCT/JP1995/002271 WO1996014319A1 (en) | 1994-11-08 | 1995-11-07 | Thienopyridine or thienopyrimidine derivatives and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE225351T1 true ATE225351T1 (de) | 2002-10-15 |
Family
ID=26550777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95936112T ATE225351T1 (de) | 1994-11-08 | 1995-11-07 | Thienopyridin und thienopyrimidinderivate und ihre verwendung als entzündungshemmende mittel |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5747486A (de) |
| EP (1) | EP0791000B1 (de) |
| KR (1) | KR970707131A (de) |
| AT (1) | ATE225351T1 (de) |
| AU (1) | AU699354B2 (de) |
| CA (1) | CA2202985A1 (de) |
| DE (1) | DE69528470T2 (de) |
| FI (1) | FI971974A7 (de) |
| HU (1) | HUT77348A (de) |
| NO (1) | NO972043L (de) |
| NZ (1) | NZ294933A (de) |
| WO (1) | WO1996014319A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ331802A (en) * | 1996-04-25 | 1999-06-29 | Takeda Chemical Industries Ltd | Thienopyridine derivatives and their use as an anti-inflammatory drug for preventing or treating arthritis and inhibiting bone resorption |
| US5939432A (en) * | 1997-10-29 | 1999-08-17 | Medco Research, Inc. | Thiophenes useful for modulating the adenosine receptor |
| US6323214B1 (en) | 1997-10-29 | 2001-11-27 | Medco Research, Inc | Allosteric adenosine receptor modulators |
| US6727258B2 (en) * | 1997-10-29 | 2004-04-27 | King Pharmaceutical Research & Development, Inc. | Allosteric adenosine receptor modulators |
| US6232320B1 (en) | 1998-06-04 | 2001-05-15 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| TW564247B (en) * | 1999-04-08 | 2003-12-01 | Akzo Nobel Nv | Bicyclic heteraromatic compound |
| TW591031B (en) * | 2000-02-29 | 2004-06-11 | Takeda Chemical Industries Ltd | Thienopyridine derivatives, their production and use |
| US6503914B1 (en) | 2000-10-23 | 2003-01-07 | Board Of Regents, The University Of Texas System | Thienopyrimidine-based inhibitors of the Src family |
| BR0207216A (pt) * | 2001-02-14 | 2004-03-09 | Warner Lambert Co | Derivados de tieno 2,3-d-pirimidindiona como inibidores de metaloproteinase matriz |
| WO2003018590A1 (fr) * | 2001-08-24 | 2003-03-06 | Takeda Chemical Industries, Ltd. | Procede de production d'un derive de la thienopyridine |
| US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
| BR0312744A (pt) * | 2002-07-17 | 2005-04-26 | Warner Lambert Co | Associação de um inibidor carboxìlico alostérico da metaloproteinase-13 de matriz com um inibidor selectivo da ciclooxigenase-2, à excepção do celecoxib ou valdecoxib |
| TW200410975A (en) * | 2002-09-26 | 2004-07-01 | Nihon Nohyaku Co Ltd | New pesticide and method for using it, new substituted thienopyrimidine derivative, its intermediate, and method for producing it |
| CN1984660B (zh) | 2003-07-03 | 2010-12-15 | 美瑞德生物工程公司 | 作为天冬氨酸特异性半胱氨酸蛋白酶活化剂和细胞程序死亡诱导剂的4-芳基氨基-喹唑啉 |
| US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
| DE602005014383D1 (en) * | 2004-12-17 | 2009-06-18 | Hoffmann La Roche | Thienopyridinderivate als allostere gaba-b-enhancer |
| US8258145B2 (en) | 2005-01-03 | 2012-09-04 | Myrexis, Inc. | Method of treating brain cancer |
| EP1833482A4 (de) | 2005-01-03 | 2011-02-16 | Myriad Genetics Inc | Verbindungen und ihre therapeutische verwendung |
| MX2007014929A (es) | 2005-06-02 | 2008-02-15 | Hoffmann La Roche | 3-metansulfonilquinolinas como mejoradores de gaba-b. |
| WO2007056214A2 (en) * | 2005-11-02 | 2007-05-18 | Cytovia, Inc | N-alkyl-n-aryl-thienopyrimidin-r-amines and uses thereof |
| US20070099941A1 (en) * | 2005-11-02 | 2007-05-03 | Cytovia, Inc. | N-arylalkyl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US20070099877A1 (en) * | 2005-11-02 | 2007-05-03 | Cytovia, Inc. | N-aryl-thienopyrimidin-4-amines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
| US7956068B2 (en) * | 2007-11-15 | 2011-06-07 | Boehringer Ingelheim International Gmbh | Inhibitors of human immunodeficiency virus replication |
| US8575403B2 (en) | 2010-05-07 | 2013-11-05 | Celanese International Corporation | Hydrolysis of ethyl acetate in ethanol separation process |
| US8859827B2 (en) | 2011-11-18 | 2014-10-14 | Celanese International Corporation | Esterifying acetic acid to produce ester feed for hydrogenolysis |
| US8664454B2 (en) | 2010-07-09 | 2014-03-04 | Celanese International Corporation | Process for production of ethanol using a mixed feed using copper containing catalyst |
| US8846988B2 (en) | 2010-07-09 | 2014-09-30 | Celanese International Corporation | Liquid esterification for the production of alcohols |
| US8710279B2 (en) | 2010-07-09 | 2014-04-29 | Celanese International Corporation | Hydrogenolysis of ethyl acetate in alcohol separation processes |
| US8704008B2 (en) | 2010-07-09 | 2014-04-22 | Celanese International Corporation | Process for producing ethanol using a stacked bed reactor |
| US9272970B2 (en) | 2010-07-09 | 2016-03-01 | Celanese International Corporation | Hydrogenolysis of ethyl acetate in alcohol separation processes |
| US8907141B2 (en) | 2011-04-26 | 2014-12-09 | Celanese International Corporation | Process to recover alcohol with secondary reactors for esterification of acid |
| US8592635B2 (en) | 2011-04-26 | 2013-11-26 | Celanese International Corporation | Integrated ethanol production by extracting halides from acetic acid |
| US9073816B2 (en) | 2011-04-26 | 2015-07-07 | Celanese International Corporation | Reducing ethyl acetate concentration in recycle streams for ethanol production processes |
| US9000233B2 (en) | 2011-04-26 | 2015-04-07 | Celanese International Corporation | Process to recover alcohol with secondary reactors for hydrolysis of acetal |
| US8754268B2 (en) | 2011-04-26 | 2014-06-17 | Celanese International Corporation | Process for removing water from alcohol mixtures |
| US8895786B2 (en) | 2011-08-03 | 2014-11-25 | Celanese International Corporation | Processes for increasing alcohol production |
| US8829251B2 (en) | 2011-11-18 | 2014-09-09 | Celanese International Corporation | Liquid esterification method to produce ester feed for hydrogenolysis |
| US8802901B2 (en) | 2011-11-18 | 2014-08-12 | Celanese International Corporation | Continuous ethyl acetate production and hydrogenolysis thereof |
| US8748673B2 (en) | 2011-11-18 | 2014-06-10 | Celanese International Corporation | Process of recovery of ethanol from hydrogenolysis process |
| US8853468B2 (en) | 2011-11-18 | 2014-10-07 | Celanese International Corporation | Vapor esterification method to produce ester feed for hydrogenolysis |
| US8829249B2 (en) | 2011-11-18 | 2014-09-09 | Celanese International Corporation | Integrated esterification and hydrogenolysis process for producing ethanol |
| US9024089B2 (en) | 2011-11-18 | 2015-05-05 | Celanese International Corporation | Esterification process using extractive separation to produce feed for hydrogenolysis |
| US8927790B2 (en) | 2011-12-15 | 2015-01-06 | Celanese International Corporation | Multiple vapor feeds for hydrogenation process to produce alcohol |
| US8975451B2 (en) | 2013-03-15 | 2015-03-10 | Celanese International Corporation | Single phase ester feed for hydrogenolysis |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5143796A (ja) * | 1974-10-09 | 1976-04-14 | Yoshitomi Pharmaceutical | Shinkinachenopirimijinruino seizoho |
| JPS5246095A (en) * | 1975-10-07 | 1977-04-12 | Yoshitomi Pharmaceut Ind Ltd | Preparation of novel thienopyrimidine derivatives |
| DE3502392A1 (de) * | 1985-01-25 | 1986-07-31 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue thieno-triazolo-1,4-diazepino-2- carbonsaeureamide, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen |
-
1995
- 1995-11-07 AU AU38158/95A patent/AU699354B2/en not_active Ceased
- 1995-11-07 KR KR1019970703090A patent/KR970707131A/ko not_active Withdrawn
- 1995-11-07 CA CA002202985A patent/CA2202985A1/en not_active Abandoned
- 1995-11-07 DE DE69528470T patent/DE69528470T2/de not_active Expired - Fee Related
- 1995-11-07 HU HU9702020A patent/HUT77348A/hu unknown
- 1995-11-07 NZ NZ294933A patent/NZ294933A/xx unknown
- 1995-11-07 EP EP95936112A patent/EP0791000B1/de not_active Expired - Lifetime
- 1995-11-07 FI FI971974A patent/FI971974A7/fi unknown
- 1995-11-07 AT AT95936112T patent/ATE225351T1/de not_active IP Right Cessation
- 1995-11-07 WO PCT/JP1995/002271 patent/WO1996014319A1/en not_active Ceased
- 1995-11-07 US US08/571,915 patent/US5747486A/en not_active Expired - Fee Related
-
1997
- 1997-05-02 NO NO972043A patent/NO972043L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ294933A (en) | 1999-05-28 |
| FI971974A0 (fi) | 1997-05-07 |
| EP0791000A1 (de) | 1997-08-27 |
| AU699354B2 (en) | 1998-12-03 |
| NO972043D0 (no) | 1997-05-02 |
| FI971974L (fi) | 1997-06-18 |
| WO1996014319A1 (en) | 1996-05-17 |
| NO972043L (no) | 1997-06-25 |
| DE69528470D1 (de) | 2002-11-07 |
| CA2202985A1 (en) | 1996-05-17 |
| FI971974A7 (fi) | 1997-06-18 |
| HUT77348A (hu) | 1998-03-30 |
| EP0791000B1 (de) | 2002-10-02 |
| US5747486A (en) | 1998-05-05 |
| DE69528470T2 (de) | 2003-08-21 |
| AU3815895A (en) | 1996-05-31 |
| KR970707131A (ko) | 1997-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |