ATE22564T1 - O-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und sie enthaltende pharmateutische zusammensetzungen. - Google Patents
O-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und sie enthaltende pharmateutische zusammensetzungen.Info
- Publication number
- ATE22564T1 ATE22564T1 AT84102005T AT84102005T ATE22564T1 AT E22564 T1 ATE22564 T1 AT E22564T1 AT 84102005 T AT84102005 T AT 84102005T AT 84102005 T AT84102005 T AT 84102005T AT E22564 T1 ATE22564 T1 AT E22564T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- residue
- alkanediol
- acyl
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/147—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of carboxylic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C31/18—Polyhydroxylic acyclic alcohols
- C07C31/20—Dihydroxylic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
- C07C43/14—Unsaturated ethers
- C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
- C07C43/1782—Unsaturated ethers containing hydroxy or O-metal groups containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19833307925 DE3307925A1 (de) | 1983-03-05 | 1983-03-05 | Neue 0-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| EP84102005A EP0121088B1 (fr) | 1983-03-05 | 1984-02-25 | O-Acyl-alcanediol-phospholipides, procédé pour les préparer et compositions pharmaceutiques les contenant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE22564T1 true ATE22564T1 (de) | 1986-10-15 |
Family
ID=6192681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT84102005T ATE22564T1 (de) | 1983-03-05 | 1984-02-25 | O-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und sie enthaltende pharmateutische zusammensetzungen. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4610979A (fr) |
| EP (1) | EP0121088B1 (fr) |
| JP (1) | JPS59170097A (fr) |
| AT (1) | ATE22564T1 (fr) |
| DE (2) | DE3307925A1 (fr) |
| ZA (1) | ZA841533B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0209239B1 (fr) * | 1985-07-15 | 1989-03-01 | Takeda Chemical Industries, Ltd. | Dérivés d'alcanoyloxy-2 propane, leur production et leur utilisation |
| IE59664B1 (en) * | 1985-12-04 | 1994-03-09 | Max Planck Gesellschaft | Phosphorus-containing organic compounds, process for the preparation thereof and medicaments containing them |
| US5185334A (en) * | 1989-07-31 | 1993-02-09 | Schering Corporation | 2,2-disubstituted glycerol and glycerol-like compounds, compositions and methods of use |
| US5290769A (en) * | 1989-09-27 | 1994-03-01 | Asta Pharma Aktiengesellschaft | Use of hexadecylphosphocholine for the treatment of psoriasis |
| JP2512019Y2 (ja) * | 1991-01-31 | 1996-09-25 | 三菱重工業株式会社 | 容器洗浄装置 |
| DE4234130A1 (de) * | 1992-10-09 | 1994-04-14 | Max Planck Gesellschaft | Phospholipase A¶2¶ inhibierende Phosphatidylcholinverbindungen |
| GB9301702D0 (en) * | 1993-01-28 | 1993-03-17 | Biocompatibles Ltd | New materials |
| US8071740B2 (en) | 2000-11-17 | 2011-12-06 | Vascular Biogenics Ltd. | Promoters exhibiting endothelial cell specificity and methods of using same for regulation of angiogenesis |
| US6838452B2 (en) | 2000-11-24 | 2005-01-04 | Vascular Biogenics Ltd. | Methods employing and compositions containing defined oxidized phospholipids for prevention and treatment of atherosclerosis |
| WO2002041827A2 (fr) * | 2000-11-24 | 2002-05-30 | Vascular Biogenics Ltd. | Procedes faisant appels a des phospholipides oxydes definis, ainsi que compositions contenant ces derniers, pour la prevention et le traitement de l'atherosclerose |
| CN100506284C (zh) | 2001-10-19 | 2009-07-01 | 脉管生物生长有限公司 | 多核苷酸构建体、药物组合物以及靶向的下调血管生成和抗癌的治疗方法 |
| US7807847B2 (en) | 2004-07-09 | 2010-10-05 | Vascular Biogenics Ltd. | Process for the preparation of oxidized phospholipids |
| US9006217B2 (en) | 2007-01-09 | 2015-04-14 | Vascular Biogenics Ltd. | High-purity phospholipids |
| US8569529B2 (en) | 2007-01-09 | 2013-10-29 | Vascular Biogenics Ltd. | High-purity phospholipids |
| KR100951108B1 (ko) * | 2008-04-15 | 2010-04-07 | 엔자이텍 주식회사 | 라세믹 또는 광학적으로 활성이 있는 α-글리세로포스포릴콜린 및 그 유도체의 제조방법 |
| EP2826370A3 (fr) | 2008-11-06 | 2015-04-08 | Vascular Biogenics Ltd. | Composés lipidiques oxydés et leurs utilisations |
| EP3223824B1 (fr) | 2014-11-26 | 2021-01-06 | Vascular Biogenics Ltd. | Lipides oxydés et traitement ou prévention de la fibrose |
| US9771385B2 (en) | 2014-11-26 | 2017-09-26 | Vascular Biogenics Ltd. | Oxidized lipids |
| ES2739773B2 (es) * | 2018-08-02 | 2020-11-17 | Univ Alicante | Compuestos zwitterionicos de acidos 2-fosfocolina carboxilicos y su uso como agentes citotoxicos |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3542820A (en) * | 1968-10-08 | 1970-11-24 | American Home Prod | Alpha,omega - alkanediolphosphorylalkanolamine derivatives and process for preparing thereof |
| DE2345057C3 (de) * | 1973-09-06 | 1982-05-13 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur Herstellung von Propandiol (1,3)-phosphatiden |
| US4408052A (en) * | 1980-02-27 | 1983-10-04 | Takeda Chemical Industries, Ltd. | Phospholipid carbamates |
| US4493832A (en) * | 1981-07-03 | 1985-01-15 | Fujisawa Pharmaceutical Co., Ltd. | Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same |
-
1983
- 1983-03-05 DE DE19833307925 patent/DE3307925A1/de not_active Withdrawn
-
1984
- 1984-02-25 AT AT84102005T patent/ATE22564T1/de not_active IP Right Cessation
- 1984-02-25 DE DE8484102005T patent/DE3460843D1/de not_active Expired
- 1984-02-25 EP EP84102005A patent/EP0121088B1/fr not_active Expired
- 1984-02-27 US US06/584,103 patent/US4610979A/en not_active Expired - Fee Related
- 1984-02-29 ZA ZA841533A patent/ZA841533B/xx unknown
- 1984-03-05 JP JP59040615A patent/JPS59170097A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA841533B (en) | 1984-10-31 |
| DE3307925A1 (de) | 1984-09-06 |
| JPS59170097A (ja) | 1984-09-26 |
| EP0121088A1 (fr) | 1984-10-10 |
| US4610979A (en) | 1986-09-09 |
| EP0121088B1 (fr) | 1986-10-01 |
| DE3460843D1 (en) | 1986-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |