ATE78259T1 - 9-(phosphonylmethoxyalkyl)-adenine, verfahren zu ihrer herstellung und ihre verwendung. - Google Patents

9-(phosphonylmethoxyalkyl)-adenine, verfahren zu ihrer herstellung und ihre verwendung.

Info

Publication number
ATE78259T1
ATE78259T1 AT86302822T AT86302822T ATE78259T1 AT E78259 T1 ATE78259 T1 AT E78259T1 AT 86302822 T AT86302822 T AT 86302822T AT 86302822 T AT86302822 T AT 86302822T AT E78259 T1 ATE78259 T1 AT E78259T1
Authority
AT
Austria
Prior art keywords
sup
phosphonylmethoxyalkyl
preparation
ethylene
compounds
Prior art date
Application number
AT86302822T
Other languages
English (en)
Inventor
Antonin Holy
Ivan Rosenberg
Original Assignee
Ceskoslovenska Akademie Ved
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ceskoslovenska Akademie Ved filed Critical Ceskoslovenska Akademie Ved
Application granted granted Critical
Publication of ATE78259T1 publication Critical patent/ATE78259T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT86302822T 1985-04-25 1986-04-16 9-(phosphonylmethoxyalkyl)-adenine, verfahren zu ihrer herstellung und ihre verwendung. ATE78259T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CS853017A CS263951B1 (en) 1985-04-25 1985-04-25 9-(phosponylmethoxyalkyl)adenines and method of their preparation
EP86302822A EP0206459B1 (de) 1985-04-25 1986-04-16 9-(Phosphonylmethoxyalkyl)-adenine, Verfahren zu ihrer Herstellung und ihre Verwendung

Publications (1)

Publication Number Publication Date
ATE78259T1 true ATE78259T1 (de) 1992-08-15

Family

ID=5369028

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86302822T ATE78259T1 (de) 1985-04-25 1986-04-16 9-(phosphonylmethoxyalkyl)-adenine, verfahren zu ihrer herstellung und ihre verwendung.

Country Status (13)

Country Link
US (1) US4808716A (de)
EP (1) EP0206459B1 (de)
JP (1) JPS61275289A (de)
AT (1) ATE78259T1 (de)
AU (1) AU580151B2 (de)
CA (1) CA1295614C (de)
CS (1) CS263951B1 (de)
DE (1) DE3686002T2 (de)
DK (1) DK173625B1 (de)
EG (1) EG18079A (de)
HK (1) HK213296A (de)
NO (1) NO174510B (de)
NZ (1) NZ215925A (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4845084A (en) * 1984-01-26 1989-07-04 Merck & Co., Inc. Phosphate derivatives of substituted butyl guanines, antiviral compositions containing them, and methods of treating viral infections with them
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
NZ222553A (en) * 1986-11-18 1991-07-26 Bristol Myers Co Phosphonomethoxyalkylene purine and pyrimidine derivatives and pharmaceutical compositions
US5650510A (en) * 1986-11-18 1997-07-22 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
US5247085A (en) * 1987-11-30 1993-09-21 Beecham Group P.L.C. Antiviral purine compounds
IL88518A (en) * 1987-11-30 1994-02-27 Beecham Group Plc 3-(phosphoryl methoxyethoxy) -purine derivatives, their preparation and pharmaceutical compositions containing them
EP0339161A1 (de) * 1988-04-01 1989-11-02 Merrell Dow Pharmaceuticals Inc. Derivate von Fluorphosphonat-Nukleotiden
EP0335770B1 (de) * 1988-04-01 1997-01-15 Merrell Pharmaceuticals Inc. Derivate von Fluorphosphonat-Nukleotiden
US5284837A (en) * 1988-05-06 1994-02-08 Medivir Ab Derivatives of purine, process for their preparation and a pharmaceutical preparation
EP0353955A3 (de) * 1988-08-02 1991-08-14 Beecham Group Plc Chemische Verbindungen
US5744600A (en) * 1988-11-14 1998-04-28 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Phosphonomethoxy carbocyclic nucleosides and nucleotides
US4966895A (en) * 1989-02-02 1990-10-30 Merck & Co. Inc. Cyclic monophosphates of purine and pyrimidine acyclonucleosides as anti-retroviral agents
US5688778A (en) * 1989-05-15 1997-11-18 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Nucleoside analogs
GB8912043D0 (en) * 1989-05-25 1989-07-12 Beecham Group Plc Novel compounds
US5302585A (en) * 1990-04-20 1994-04-12 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Use of chiral 2-(phosphonomethoxy)propyl guanines as antiviral agents
CS387190A3 (en) * 1990-08-06 1992-03-18 Ustav Organicke Chemie A Bioch (2r)-2-/di(2-propyl)phosphonylmethoxy/-3-p-toluenesulfonyloxy -1- trimethylacetoxypropane and process for preparing thereof
JP3116079B2 (ja) * 1990-08-10 2000-12-11 インスティチュート オブ オーガニック ケミストリ アンド バイオケミストリ アカデミー オブ サイエンス オブ ザ チェコ リパブリック ヌクレオチドの新規な製法
EP0481214B1 (de) * 1990-09-14 1998-06-24 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Wirkstoffvorläufer von Phosphonaten
US5208221A (en) * 1990-11-29 1993-05-04 Bristol-Myers Squibb Company Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives
US6057305A (en) * 1992-08-05 2000-05-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic Antiretroviral enantiomeric nucleotide analogs
US5514798A (en) * 1993-06-02 1996-05-07 Gilead Sciences, Inc. Method and cyclic carbonates for nucleotide analogues
CA2171868A1 (en) * 1993-09-17 1995-03-23 Petr Alexander Method for dosing therapeutic compounds
US5656745A (en) * 1993-09-17 1997-08-12 Gilead Sciences, Inc. Nucleotide analogs
US5798340A (en) 1993-09-17 1998-08-25 Gilead Sciences, Inc. Nucleotide analogs
DE4408534A1 (de) * 1994-03-14 1995-09-28 Hoechst Ag Substituierte N-Ethyl-Glycinderivate zur Herstellung von PNA und PNA-/DNA-Hybriden
US6465650B1 (en) 1995-03-13 2002-10-15 Aventis Pharma Deutschland Gmbh Substituted N-ethylglycine derivatives for preparing PNA and PNA/DNA hybrids
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
US5877166A (en) * 1996-04-29 1999-03-02 Sri International Enantiomerically pure 2-aminopurine phosphonate nucleotide analogs as antiviral agents
US5733788A (en) * 1996-07-26 1998-03-31 Gilead Sciences, Inc. PMPA preparation
DK0915894T3 (da) * 1996-07-26 2003-09-15 Gilead Sciences Inc Nukleotidanaloger
ATE305009T1 (de) * 1997-07-25 2005-10-15 Gilead Sciences Inc Nukleotid-analog zusamensetzung und synthese verfahren
US5935946A (en) * 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
AU2645199A (en) * 1998-11-18 2000-06-05 Viktor Veniaminovich Tets Dialkyl-1-aryl-1-(2,4-dioxo-5-amino-1,3-pyrimidin-5-yl)methy lphosphonates
US7205404B1 (en) 1999-03-05 2007-04-17 Metabasis Therapeutics, Inc. Phosphorus-containing prodrugs
US20020119443A1 (en) 2000-07-21 2002-08-29 Gilead Sciences, Inc. Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
EP1406911B1 (de) 2001-06-29 2016-01-06 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic 6-[2-(phosphonomethoxy)alkoxy ]pyrimidinederivate mit antiviraler wirksamkeit
US7388002B2 (en) 2001-11-14 2008-06-17 Biocryst Pharmaceuticals, Inc. Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
PL374525A1 (en) * 2001-11-14 2005-10-31 Biocryst Pharmaceuticals, Inc. Nucleosides preparation thereof and use as inhibitors of rna viral polymerases
EP2223927B1 (de) 2002-05-13 2014-10-15 Metabasis Therapeutics, Inc. Salze einer auf Phosphonsäure basierenden Prodrug von PMEA
WO2003095665A2 (en) 2002-05-13 2003-11-20 Metabasis Therapeutics, Inc. Pmea and pmpa cyclic producing synthesis
KR101101962B1 (ko) * 2002-11-12 2012-01-02 티안진 디실리 인베스트먼트 홀딩 그룹, 리미티드 새로운 결정 형태를 가진 아데포비어 디피복실의 제조 방법
DK1583542T3 (da) 2003-01-14 2008-09-22 Gilead Sciences Inc Sammensætninger og fremgangsmåder til antiviral kombinationsterapi
NZ543864A (en) 2003-06-16 2009-10-30 Leuven K U Res & Dev Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs
US20060252729A1 (en) * 2003-07-30 2006-11-09 Krawczyk Steven H Nucleobase phosphonate analogs for antiviral treatment
CA2565966A1 (en) * 2004-06-08 2005-12-29 Metabasis Therapeutics, Inc. Lewis acid mediated synthesis of cyclic esters
CN100338080C (zh) * 2004-06-16 2007-09-19 山东中科泰斗化学有限公司 9-[2-(膦羧基甲氧基)乙基]腺嘌呤双环醇酯及其制备方法
UA93354C2 (ru) 2004-07-09 2011-02-10 Гилиад Сайенсиз, Инк. Местный противовирусный препарат
ES2401285T3 (es) 2004-12-16 2013-04-18 The Regents Of The University Of California Fármacos con el pulmón como diana
US20090156545A1 (en) * 2005-04-01 2009-06-18 Hostetler Karl Y Substituted Phosphate Esters of Nucleoside Phosphonates
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
TWI375560B (en) 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
MX2008001166A (es) 2005-07-25 2008-03-18 Intermune Inc Nuevos inhibidores macrociclicos de la replicacion del virus de hepatitis c.
EP1907391A1 (de) * 2005-07-26 2008-04-09 Hetero Drugs Limited Neues verfahren für acyclische phosphonatnukleotidanaloga
AU2006301966A1 (en) * 2005-10-11 2007-04-19 Array Biopharma, Inc. Compounds and methods for inhibiting hepatitis C viral replication
RU2008128424A (ru) * 2005-12-14 2010-01-20 Сипла Лимитед (In) Фармацевтическая комбинация, включающая нуклеотидный и нуклеозидный ингибиторы обратной транскриптазы (такие как тенофовир и ламивудин) в различных частях дозы
FR2908133B1 (fr) * 2006-11-08 2012-12-14 Centre Nat Rech Scient Nouveaux analogues de nucleotides comme molecules precurseurs d'antiviraux
AU2008265397C1 (en) 2007-06-18 2013-08-29 Sunshine Lake Pharma Co., Ltd. Bromo-phenyl substituted thiazolyl dihydropyrimidines
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
WO2009120358A1 (en) * 2008-03-27 2009-10-01 Nektar Therapeutics Oligomer-nitrogenous base conjugates
US7935817B2 (en) * 2008-03-31 2011-05-03 Apotex Pharmachem Inc. Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
EA201071034A1 (ru) * 2008-04-15 2011-06-30 Интермьюн, Инк. Новые макроциклические ингибиторы репликаций вируса гепатита с
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
TW201010692A (en) 2008-06-19 2010-03-16 Public Univ Corp Nagoya City Univ Pharmaceutical composition for treatment or prevention of hbv infection
EP2358736A1 (de) * 2008-10-15 2011-08-24 Intermune, Inc. Therapeutische antivirale peptide
NZ593649A (en) 2008-12-23 2013-11-29 Gilead Pharmasset Llc Nucleoside analogs
AU2009329872B2 (en) 2008-12-23 2016-07-07 Gilead Pharmasset Llc Synthesis of purine nucleosides
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
TR201109333T1 (tr) 2009-03-26 2012-01-23 Daewoong Pharmaceutical Co. Ltd. Adefovir dipivoksilin yeni kristal formları ve bunların hazırlama işlemleri.
IN2012DN02693A (de) * 2009-09-28 2015-09-04 Intermune Inc
TW201116540A (en) * 2009-10-01 2011-05-16 Intermune Inc Therapeutic antiviral peptides
SG184324A1 (en) 2010-03-31 2012-11-29 Gilead Pharmasset Llc Nucleoside phosphoramidates
CN114010776A (zh) 2010-06-09 2022-02-08 疫苗技术股份有限公司 用于增强抗逆转录病毒治疗的hiv感染者的治疗性免疫
CN103079561B (zh) 2010-06-11 2015-12-02 吉里德科学公司 用于预防hsv-2传播的局部用抗病毒制剂
WO2012079035A1 (en) 2010-12-10 2012-06-14 Sigmapharm Laboratories, Llc Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs
US9550803B2 (en) * 2011-05-06 2017-01-24 University Of Southern California Method to improve antiviral activity of nucleotide analogue drugs
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
EP2912047B1 (de) 2012-10-29 2016-08-24 Cipla Limited Antivirale phosphonatanaloga und verfahren zur herstellung davon
SG10201800188SA (en) 2013-03-15 2018-02-27 Univ California Acyclic nucleoside phosphonate diesters
AU2015217221A1 (en) 2014-02-13 2016-08-11 Ligand Pharmaceuticals, Inc. Prodrug compounds and their uses
US10167302B2 (en) * 2014-05-23 2019-01-01 University College Cork Phosphonate nucleosides useful in the treatment of viral diseases
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
CN111808136B (zh) 2014-09-15 2024-06-11 加利福尼亚大学董事会 核苷酸类似物
EP3350191B9 (de) 2015-09-15 2021-12-22 The Regents of the University of California Nukleotidanaloga
EP3372227A1 (de) 2017-03-06 2018-09-12 MH10 Spolka z ograniczona odpowiedzialnoscia Tablettenformulierung von adefovir dipivoxil
CA3087932A1 (en) 2018-01-09 2019-07-18 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
KR20250052378A (ko) 2022-07-21 2025-04-18 안티바 바이오사이언시즈, 인크. Hpv 감염 및 hpv-유도 신생물의 치료를 위한 조성물 및 투여 형태

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
CS233665B1 (en) * 1983-01-06 1985-03-14 Antonin Holy Processing of isomere o-phosphonylmethylderivative of anantiomere racemic vicinal diene
AU8092587A (en) * 1986-11-18 1988-05-19 Bristol-Myers Squibb Company Synthesis of purin-9-ylalkylenoxymethyl phosphonic acids

Also Published As

Publication number Publication date
AU5632886A (en) 1986-10-30
NO861621L (no) 1986-10-27
DK167886D0 (da) 1986-04-11
NO174510B (no) 1994-02-07
DK167886A (da) 1986-10-26
DE3686002T2 (de) 1992-12-17
AU580151B2 (en) 1989-01-05
US4808716A (en) 1989-02-28
HK213296A (en) 1996-12-06
JPH0433798B2 (de) 1992-06-04
EP0206459A3 (en) 1987-05-20
CA1295614C (en) 1992-02-11
EP0206459B1 (de) 1992-07-15
EG18079A (en) 1992-06-30
NZ215925A (en) 1989-01-27
DE3686002D1 (de) 1992-08-20
EP0206459A2 (de) 1986-12-30
JPS61275289A (ja) 1986-12-05
DK173625B1 (da) 2001-05-07
NO174510C (de) 1994-05-18
CS263951B1 (en) 1989-05-12

Similar Documents

Publication Publication Date Title
ATE78259T1 (de) 9-(phosphonylmethoxyalkyl)-adenine, verfahren zu ihrer herstellung und ihre verwendung.
NZ210228A (en) 1h-imidazo (4,5-c quinoline derivatives and bronchodilatory and antiviral compositions containing such
GR3019425T3 (en) Hydrochlorofluorocarbon azeotropic or azeotropic-like mixture
ATE22564T1 (de) O-acyl-alkandiol-phospholipide, verfahren zu ihrer herstellung und sie enthaltende pharmateutische zusammensetzungen.
ES8101550A1 (es) Un procedimiento para la preparacion de nuevos derivados de 2-pirrolidin-metanol.
FR2583414B1 (fr) Procede de fabrication de (meth)acrylates d'alkyles fluores.
ATE13880T1 (de) N-2-hydroxypropyl-piperidine und verfahren zu ihrer herstellung.
MX170732B (es) Composicion de derivados de succinimida y su uso
DE3672446D1 (en) Pantothenolderivate.
AU5847386A (en) Derivatives of 1,1,2,2-tetramethyl-1,2-bis-(2-fluoro-4- hydroxphenyl)-ethane
ES8609184A1 (es) Procedimiento de preparar agentes de fluoracion de compuestos organicos.
AU6306886A (en) Alkylcarboxamides of pyridylalkylamines, their preparation and their use in human and veterinary medicine
DE3564426D1 (en) Polyprenyl compound, process of producing it and pharmaceutical use
EP0000972A3 (de) 2-Substituierte-3-Phenylindole, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel
AU2172688A (en) Preparation of dien-1-ols, 9-hydroxydodec-10-enyl 1-tert-butyl ether and use thereof as an intermediate for synthesizing, 8,10-dodecadienol
DE3477003D1 (en) Process for the preparation of 17-alpha-acyloxy-6-chloro-1-alpha,2-alpha-methylene-4,6-pregnadiene-3-20-diones
DE3267690D1 (en) Process for the preparation of 3-alkyl-6-methyl-beta-resorcylic-acid esters
DE59007185D1 (de) Substituierte 1.2.3.4-Oxatriazolium-5-olate, Verfahren zu ihrer Herstellung und ihre Verwendung.
SE8302084D0 (sv) New benzimidazole derivatives
ES8201205A1 (es) Procedimiento para la preparacion de nuevos compuestos de aminoantipirina
ES8304990A1 (es) Procedimiento para la preparacion de derivados espiro-1 farmaceuticamente activos.
ES8305732A1 (es) Procedimiento para preparar derivados de imidazol.
ATE119912T1 (de) Verfahren zur herstellung von 21-brom-4-pregnen- 3,20-dion-derivaten.
JO921B1 (en) Process to produce substituted basic alkyl theophylline
TH3207A (th) อนุพันธ์ของกรดเฟนนอกซีโปรบีโอนิค

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time