ATE226091T1 - Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums - Google Patents
Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstumsInfo
- Publication number
- ATE226091T1 ATE226091T1 AT91910707T AT91910707T ATE226091T1 AT E226091 T1 ATE226091 T1 AT E226091T1 AT 91910707 T AT91910707 T AT 91910707T AT 91910707 T AT91910707 T AT 91910707T AT E226091 T1 ATE226091 T1 AT E226091T1
- Authority
- AT
- Austria
- Prior art keywords
- nerve fiber
- controlled release
- fiber growth
- release microcapsules
- stimulating nerve
- Prior art date
Links
- 210000004126 nerve fiber Anatomy 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title 1
- 239000003094 microcapsule Substances 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 239000004005 microsphere Substances 0.000 abstract 2
- 239000012867 bioactive agent Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Medicinal Preparation (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52538390A | 1990-05-16 | 1990-05-16 | |
| PCT/US1991/003356 WO1991017772A1 (en) | 1990-05-16 | 1991-05-14 | Controlled release dopamine and its use to stimulate nerve fiber growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE226091T1 true ATE226091T1 (de) | 2002-11-15 |
Family
ID=24093026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91910707T ATE226091T1 (de) | 1990-05-16 | 1991-05-14 | Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5360610A (de) |
| EP (1) | EP0528978B1 (de) |
| JP (2) | JP3359919B2 (de) |
| AT (1) | ATE226091T1 (de) |
| DE (1) | DE69133136T2 (de) |
| DK (1) | DK0528978T3 (de) |
| ES (1) | ES2185615T3 (de) |
| WO (1) | WO1991017772A1 (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US6217911B1 (en) | 1995-05-22 | 2001-04-17 | The United States Of America As Represented By The Secretary Of The Army | sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres |
| US5693343A (en) | 1984-03-16 | 1997-12-02 | The United States Of America As Represented By The Secretary Of The Army | Microparticle carriers of maximal uptake capacity by both M cells and non-M cells |
| US6410056B1 (en) | 1984-03-16 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix |
| USRE40786E1 (en) | 1984-03-16 | 2009-06-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres |
| US5871472A (en) * | 1987-11-17 | 1999-02-16 | Brown University Research Foundation | Planting devices for the focal release of neuroinhibitory compounds |
| US6517859B1 (en) | 1990-05-16 | 2003-02-11 | Southern Research Institute | Microcapsules for administration of neuroactive agents |
| US5618531A (en) | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| AU8303691A (en) | 1991-04-24 | 1992-12-21 | United States Of America, As Represented By The Secretary Of The Army, The | Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
| DE69331387T2 (de) * | 1992-09-10 | 2002-08-22 | Childrens Medical Center | Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika |
| US5700485A (en) * | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| US5383873A (en) * | 1992-12-09 | 1995-01-24 | Regents Of The University Of Minnesota | Smooth muscle chemical pacemaker |
| US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US6939546B2 (en) | 1993-05-21 | 2005-09-06 | The United States Of America As Represented By The Secretary Of The Army | Model for testing immunogenicity of peptides |
| ATE288270T1 (de) * | 1993-11-19 | 2005-02-15 | Janssen Pharmaceutica Nv | Mikroverkapselte 1,2-benzazole |
| US5962427A (en) | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US5763416A (en) | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
| US6074840A (en) | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
| US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
| US5604198A (en) * | 1994-05-12 | 1997-02-18 | Poduslo; Joseph F. | Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents |
| US6447796B1 (en) | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US6855331B2 (en) | 1994-05-16 | 2005-02-15 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US7033608B1 (en) | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
| US6902743B1 (en) | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
| US5942241A (en) | 1995-06-09 | 1999-08-24 | Euro-Celtique, S.A. | Formulations and methods for providing prolonged local anesthesia |
| WO1998008464A1 (en) | 1996-08-29 | 1998-03-05 | Advanced Research & Technology Institute | Novel pharmacotherapeutic process and composition for central nervous system disorders |
| DK0925067T3 (da) | 1996-09-16 | 2004-05-03 | Purdue Research Foundation | Graft fra submucosavæv til reparation af neurologisk væv |
| CA2296056A1 (en) * | 1997-07-10 | 1999-01-21 | Keith Baker | Methods for universally distributing therapeutic agents to the brain |
| ES2320603T3 (es) | 1997-07-30 | 2009-05-25 | Emory University | Sistemas de expresion, vectores, adn, proteinas de mineralizacion osea novedosos. |
| US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
| EP1079967A4 (de) | 1998-04-13 | 2003-07-23 | Luminex Corp | Flüssige markierung mit fluorezierenden mikropartikeln |
| OA11728A (en) * | 1998-12-16 | 2005-02-01 | Aventis Pharma Inc | Biodegradable polymer encapsulated serotonin receptor antagonist and method for preparing the same. |
| US6455526B1 (en) | 1998-12-16 | 2002-09-24 | Aventis Pharmaceuticals, Inc. | Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same |
| US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
| WO2001080830A2 (en) * | 2000-04-21 | 2001-11-01 | Advanced Research And Technology Institute, Inc. | Pharmacotherapeutic process and composition for central nervous system disorders |
| DE60138641D1 (de) | 2000-10-27 | 2009-06-18 | Baxter Healthcare Sa | Herstellung von mikrokügelchen |
| US20030064033A1 (en) * | 2001-08-16 | 2003-04-03 | Brown Larry R. | Propellant-based microparticle formulations |
| US6488952B1 (en) * | 2001-08-28 | 2002-12-03 | John P. Kennedy | Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system |
| CA2518667C (en) | 2003-03-14 | 2011-07-19 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| US20060076295A1 (en) | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| US8075919B2 (en) * | 2003-07-18 | 2011-12-13 | Baxter International Inc. | Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation |
| US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
| US20070092452A1 (en) * | 2003-07-18 | 2007-04-26 | Julia Rashba-Step | Methods for fabrication, uses, compositions of inhalable spherical particles |
| WO2005009375A2 (en) * | 2003-07-22 | 2005-02-03 | Baxter International Inc. | Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof |
| US7309232B2 (en) * | 2003-10-10 | 2007-12-18 | Dentigenix Inc. | Methods for treating dental conditions using tissue scaffolds |
| US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
| EP1765294B1 (de) | 2004-05-12 | 2008-09-24 | Baxter International Inc. | Nukleinsäure-mikrokügelchen, ihre herstellung und abgabe |
| US7884085B2 (en) | 2004-05-12 | 2011-02-08 | Baxter International Inc. | Delivery of AS-oligonucleotide microspheres to induce dendritic cell tolerance for the treatment of autoimmune type 1 diabetes |
| CN103393601A (zh) | 2004-05-12 | 2013-11-20 | 巴克斯特国际公司 | 含有蛋白并在高浓度蛋白下显示可注射性的微球体 |
| WO2006047299A2 (en) * | 2004-10-22 | 2006-05-04 | University Of Florida Research Foundation, Inc. | Organotypic slice cultures and uses thereof |
| US20060228420A1 (en) * | 2005-03-15 | 2006-10-12 | Queen Mary & Westfield College | Pharmaceutical compositions comprising microparticles for delivery into neurons |
| CA2652173A1 (en) | 2006-05-22 | 2007-11-29 | Edward F. Leonard | Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams |
| WO2008006064A2 (en) * | 2006-07-07 | 2008-01-10 | Georgia Tech Research Corporation | Biomimetic polymers and uses thereof |
| AU2007281737B2 (en) | 2006-08-04 | 2013-09-19 | Baxter Healthcare S.A. | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
| CA2702340C (en) | 2006-10-12 | 2014-12-16 | The University Of Queensland | Compositions and methods for modulating immune responses |
| CN100462105C (zh) * | 2006-10-19 | 2009-02-18 | 中国人民解放军第四军医大学 | 一种重组合神经替代物的制备方法 |
| CN101686939B (zh) | 2007-04-17 | 2013-03-27 | 巴克斯特国际公司 | 用于肺部投送的核酸微粒 |
| EP2249899A4 (de) | 2008-02-04 | 2011-05-11 | Univ Columbia | Fluidtrennvorrichtungen, -systeme und -verfahren |
| AU2009237577B2 (en) | 2008-04-18 | 2014-06-05 | Baxter Healthcare Sa | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
| EP2306991B1 (de) * | 2008-06-27 | 2019-12-25 | Tepha, Inc. | Verbesserte injektionsabgabe von mikroteilchen und zusammensetzungen dafür |
| EP2326336B1 (de) | 2008-07-30 | 2015-05-13 | Mesynthes Limited | Gewebegerüste aus extrazellulärer vormagenmatrix |
| US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
| US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| EP2308478A1 (de) * | 2009-10-06 | 2011-04-13 | Abbott GmbH & Co. KG | Abgabesystem zur verzögerten Freisetzung von Calciumkanalblocker Arzneistoffen |
| BR112013010926A2 (pt) | 2010-11-01 | 2016-08-23 | Univ Technology Sidney | agentes imunomoduladores e seus usos |
| US10695406B2 (en) | 2014-05-27 | 2020-06-30 | The University Of Queensland | Modulation of cellular stress using a B-cell oxidative and/or endoplasmic reticulum stress inhibitor and a targeting agent |
| KR102418503B1 (ko) * | 2020-11-27 | 2022-07-07 | 주식회사 헤리노브 | 탄소섬유를 사용한 파이프 제조방법 및 이를 통해 제조된 파이프 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| JPS6048923A (ja) * | 1983-08-25 | 1985-03-16 | Mitsui Toatsu Chem Inc | 微小粒子の製造方法 |
| JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| US4832686A (en) * | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
| JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
| US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
| ES2058923T3 (es) * | 1989-06-21 | 1994-11-01 | Univ Brown Res Found | Sistema para terapia neurologica. |
| CH679207A5 (de) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
| JP3187410B2 (ja) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
-
1991
- 1991-05-14 ES ES91910707T patent/ES2185615T3/es not_active Expired - Lifetime
- 1991-05-14 EP EP91910707A patent/EP0528978B1/de not_active Expired - Lifetime
- 1991-05-14 JP JP51042891A patent/JP3359919B2/ja not_active Expired - Fee Related
- 1991-05-14 WO PCT/US1991/003356 patent/WO1991017772A1/en not_active Ceased
- 1991-05-14 AT AT91910707T patent/ATE226091T1/de not_active IP Right Cessation
- 1991-05-14 DK DK91910707T patent/DK0528978T3/da active
- 1991-05-14 DE DE69133136T patent/DE69133136T2/de not_active Expired - Fee Related
-
1993
- 1993-03-15 US US08/033,309 patent/US5360610A/en not_active Expired - Lifetime
-
2002
- 2002-05-15 JP JP2002140490A patent/JP4044366B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP3359919B2 (ja) | 2002-12-24 |
| JP2003012506A (ja) | 2003-01-15 |
| DE69133136D1 (de) | 2002-11-21 |
| US5360610A (en) | 1994-11-01 |
| DK0528978T3 (da) | 2003-02-17 |
| DE69133136T2 (de) | 2003-06-18 |
| ES2185615T3 (es) | 2003-05-01 |
| WO1991017772A1 (en) | 1991-11-28 |
| JP4044366B2 (ja) | 2008-02-06 |
| JPH05507486A (ja) | 1993-10-28 |
| EP0528978A4 (en) | 1993-06-23 |
| EP0528978A1 (de) | 1993-03-03 |
| EP0528978B1 (de) | 2002-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0528978 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |