ATE226091T1 - Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums - Google Patents
Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstumsInfo
- Publication number
- ATE226091T1 ATE226091T1 AT91910707T AT91910707T ATE226091T1 AT E226091 T1 ATE226091 T1 AT E226091T1 AT 91910707 T AT91910707 T AT 91910707T AT 91910707 T AT91910707 T AT 91910707T AT E226091 T1 ATE226091 T1 AT E226091T1
- Authority
- AT
- Austria
- Prior art keywords
- nerve fiber
- controlled release
- fiber growth
- release microcapsules
- stimulating nerve
- Prior art date
Links
- 210000004126 nerve fiber Anatomy 0.000 title abstract 2
- 238000013270 controlled release Methods 0.000 title 1
- 239000003094 microcapsule Substances 0.000 title 1
- 230000004936 stimulating effect Effects 0.000 title 1
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 239000004005 microsphere Substances 0.000 abstract 2
- 239000012867 bioactive agent Substances 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 230000000638 stimulation Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52538390A | 1990-05-16 | 1990-05-16 | |
| PCT/US1991/003356 WO1991017772A1 (en) | 1990-05-16 | 1991-05-14 | Controlled release dopamine and its use to stimulate nerve fiber growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE226091T1 true ATE226091T1 (de) | 2002-11-15 |
Family
ID=24093026
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91910707T ATE226091T1 (de) | 1990-05-16 | 1991-05-14 | Mikrokapseln mit gesteuerter freigabe sowie deren verwendung zur stimulierung des nervenfaserwachstums |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US5360610A (de) |
| EP (1) | EP0528978B1 (de) |
| JP (2) | JP3359919B2 (de) |
| AT (1) | ATE226091T1 (de) |
| DE (1) | DE69133136T2 (de) |
| DK (1) | DK0528978T3 (de) |
| ES (1) | ES2185615T3 (de) |
| WO (1) | WO1991017772A1 (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5693343A (en) | 1984-03-16 | 1997-12-02 | The United States Of America As Represented By The Secretary Of The Army | Microparticle carriers of maximal uptake capacity by both M cells and non-M cells |
| US6217911B1 (en) | 1995-05-22 | 2001-04-17 | The United States Of America As Represented By The Secretary Of The Army | sustained release non-steroidal, anti-inflammatory and lidocaine PLGA microspheres |
| US6309669B1 (en) | 1984-03-16 | 2001-10-30 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
| US6410056B1 (en) | 1984-03-16 | 2002-06-25 | The United States Of America As Represented By The Secretary Of The Army | Chemotherapeutic treatment of bacterial infections with an antibiotic encapsulated within a biodegradable polymeric matrix |
| USRE40786E1 (en) | 1984-03-16 | 2009-06-23 | The United States Of America As Represented By The Secretary Of The Army | Vaccines against intracellular pathogens using antigens encapsulated within biodegradable-biocompatible microspheres |
| US5871472A (en) * | 1987-11-17 | 1999-02-16 | Brown University Research Foundation | Planting devices for the focal release of neuroinhibitory compounds |
| US6517859B1 (en) | 1990-05-16 | 2003-02-11 | Southern Research Institute | Microcapsules for administration of neuroactive agents |
| US5618531A (en) | 1990-10-19 | 1997-04-08 | New York University | Method for increasing the viability of cells which are administered to the brain or spinal cord |
| AU8303691A (en) | 1991-04-24 | 1992-12-21 | United States Of America, As Represented By The Secretary Of The Army, The | Oral-intestinal vaccines against diseases caused by enteropathogenic organisms using antigens encapsulated within biodegradable-biocompatible microspheres |
| US5700485A (en) | 1992-09-10 | 1997-12-23 | Children's Medical Center Corporation | Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid |
| JP3007687B2 (ja) * | 1992-09-10 | 2000-02-07 | チルドレンズ メディカル センター コーポレイション | 局所麻酔剤の持続性送達のための生分解性ポリマーマトリックス |
| US5383873A (en) * | 1992-12-09 | 1995-01-24 | Regents Of The University Of Minnesota | Smooth muscle chemical pacemaker |
| US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US6939546B2 (en) | 1993-05-21 | 2005-09-06 | The United States Of America As Represented By The Secretary Of The Army | Model for testing immunogenicity of peptides |
| CN1074923C (zh) * | 1993-11-19 | 2001-11-21 | 詹森药业有限公司 | 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类 |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US5962427A (en) | 1994-02-18 | 1999-10-05 | The Regent Of The University Of Michigan | In vivo gene transfer methods for wound healing |
| US5763416A (en) | 1994-02-18 | 1998-06-09 | The Regent Of The University Of Michigan | Gene transfer into bone cells and tissues |
| US6074840A (en) | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
| US6551618B2 (en) | 1994-03-15 | 2003-04-22 | University Of Birmingham | Compositions and methods for delivery of agents for neuronal regeneration and survival |
| US5604198A (en) * | 1994-05-12 | 1997-02-18 | Poduslo; Joseph F. | Method to enhance permeability of the blood/brain blood/nerve barriers to therapeutic agents |
| US6447796B1 (en) | 1994-05-16 | 2002-09-10 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US6855331B2 (en) | 1994-05-16 | 2005-02-15 | The United States Of America As Represented By The Secretary Of The Army | Sustained release hydrophobic bioactive PLGA microspheres |
| US7033608B1 (en) | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
| US6902743B1 (en) | 1995-05-22 | 2005-06-07 | The United States Of America As Represented By The Secretary Of The Army | Therapeutic treatment and prevention of infections with a bioactive material(s) encapuslated within a biodegradable-bio-compatable polymeric matrix |
| US5942241A (en) | 1995-06-09 | 1999-08-24 | Euro-Celtique, S.A. | Formulations and methods for providing prolonged local anesthesia |
| AU4239597A (en) | 1996-08-29 | 1998-03-19 | Advanced Research And Technology Institute, Inc. | Novel pharmacotherapeutic process and composition for central nervous system disorders |
| DK0925067T3 (da) * | 1996-09-16 | 2004-05-03 | Purdue Research Foundation | Graft fra submucosavæv til reparation af neurologisk væv |
| CA2296056A1 (en) * | 1997-07-10 | 1999-01-21 | Keith Baker | Methods for universally distributing therapeutic agents to the brain |
| US7923250B2 (en) | 1997-07-30 | 2011-04-12 | Warsaw Orthopedic, Inc. | Methods of expressing LIM mineralization protein in non-osseous cells |
| EP1007673B1 (de) | 1997-07-30 | 2008-12-17 | Emory University | Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme |
| AU3555599A (en) | 1998-04-13 | 1999-11-01 | Luminex Corporation | Liquid labeling with fluorescent microparticles |
| IL143761A0 (en) * | 1998-12-16 | 2002-04-21 | Aventis Pharma Inc | Biodegradable polymer encapsulated serotonin receptor antagonist and method for preparing the same |
| US6455526B1 (en) | 1998-12-16 | 2002-09-24 | Aventis Pharmaceuticals, Inc. | Biodegradable polymer encapsulated pharmaceutical compositions and method for preparing the same |
| US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
| AU2001257129A1 (en) * | 2000-04-21 | 2001-11-07 | Advanced Research And Technology Institute, Inc. | Novel pharmacotherapeutic process and composition for central nervous system disorders |
| DE60138641D1 (de) | 2000-10-27 | 2009-06-18 | Baxter Healthcare Sa | Herstellung von mikrokügelchen |
| ES2307779T3 (es) * | 2001-08-16 | 2008-12-01 | Baxter International Inc. | Formulaciones de microparticulas a base de propelentes. |
| US6488952B1 (en) * | 2001-08-28 | 2002-12-03 | John P. Kennedy | Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system |
| US20060076295A1 (en) | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| US20040225249A1 (en) | 2003-03-14 | 2004-11-11 | Leonard Edward F. | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
| US20070092452A1 (en) * | 2003-07-18 | 2007-04-26 | Julia Rashba-Step | Methods for fabrication, uses, compositions of inhalable spherical particles |
| BRPI0412735A (pt) * | 2003-07-18 | 2006-09-26 | Baxter Int | métodos para a fabricação, uso e composição de partìculas esféricas pequenas preparadas mediante a separação de fase controlada |
| US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
| JP2007508240A (ja) * | 2003-07-22 | 2007-04-05 | バクスター・インターナショナル・インコーポレイテッド | 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法 |
| US7309232B2 (en) * | 2003-10-10 | 2007-12-18 | Dentigenix Inc. | Methods for treating dental conditions using tissue scaffolds |
| US8728525B2 (en) | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
| WO2005112893A1 (en) | 2004-05-12 | 2005-12-01 | Baxter International Inc. | Microspheres comprising protein and showing injectability at high concentrations of said agent |
| JP2007537288A (ja) | 2004-05-12 | 2007-12-20 | バクスター インターナショナル インコーポレイテッド | オリゴヌクレオチド含有マイクロスフェア、1型糖尿病を処置する医薬の製造のための、その使用 |
| EP2335689A1 (de) | 2004-05-12 | 2011-06-22 | Baxter International Inc. | Herstellungsmethode von Nukleinsäure-Mikrokügelchen |
| WO2006047299A2 (en) * | 2004-10-22 | 2006-05-04 | University Of Florida Research Foundation, Inc. | Organotypic slice cultures and uses thereof |
| WO2006097725A2 (en) * | 2005-03-15 | 2006-09-21 | Queen Mary & Westfield College | Pharmaceutical compositions comprising microparticles for delivery into neurons |
| EP2019658B1 (de) | 2006-05-22 | 2012-01-25 | The Trustees of Columbia University in the City of New York | Verfahren für membranlosen mikrofluidaustausch in einem h-filter und filterung der extraktionsflüssigkeitsausgangsströme |
| US8529928B2 (en) * | 2006-07-07 | 2013-09-10 | Georgia Tech Research Corporation | Biomimetic polymers and uses thereof |
| JP5118139B2 (ja) | 2006-08-04 | 2013-01-16 | バクスター・インターナショナル・インコーポレイテッド | 新規発症自己免疫性糖尿病を予防および/または逆転させるためのマイクロスフィアに基づく組成物 |
| EP3590503A1 (de) | 2006-10-12 | 2020-01-08 | The University of Queensland | Zusammensetzungen und verfahren zur modulation von immunreaktionen |
| CN100462105C (zh) * | 2006-10-19 | 2009-02-18 | 中国人民解放军第四军医大学 | 一种重组合神经替代物的制备方法 |
| JP5744513B2 (ja) | 2007-04-17 | 2015-07-08 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 肺送達のための核酸微小粒子 |
| BRPI0907473A2 (pt) | 2008-02-04 | 2019-09-24 | Univ Columbia | métodos, sistemas e dispositivos de separação de fluidos |
| ES2686708T3 (es) | 2008-04-18 | 2018-10-19 | Baxter International Inc. | Composición basada en microesferas para prevenir y/o revertir la diabetes autoinmune de nueva aparición |
| ES2770273T3 (es) * | 2008-06-27 | 2020-07-01 | Tepha Inc | Administración inyectable de micropartículas y composiciones para ello |
| CN103751842A (zh) | 2008-07-30 | 2014-04-30 | 米辛瑟斯有限公司 | 衍生自前胃胞外基质的组织支架 |
| US8323615B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
| US8323685B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| US8367427B2 (en) | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
| EP2308478A1 (de) * | 2009-10-06 | 2011-04-13 | Abbott GmbH & Co. KG | Abgabesystem zur verzögerten Freisetzung von Calciumkanalblocker Arzneistoffen |
| CN103328499A (zh) | 2010-11-01 | 2013-09-25 | 悉尼科技大学 | 免疫调节剂及其用途 |
| US10695406B2 (en) | 2014-05-27 | 2020-06-30 | The University Of Queensland | Modulation of cellular stress using a B-cell oxidative and/or endoplasmic reticulum stress inhibitor and a targeting agent |
| KR102418503B1 (ko) * | 2020-11-27 | 2022-07-07 | 주식회사 헤리노브 | 탄소섬유를 사용한 파이프 제조방법 및 이를 통해 제조된 파이프 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52535B1 (en) * | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| JPS6048923A (ja) * | 1983-08-25 | 1985-03-16 | Mitsui Toatsu Chem Inc | 微小粒子の製造方法 |
| JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
| US4962091A (en) * | 1986-05-23 | 1990-10-09 | Syntex (U.S.A.) Inc. | Controlled release of macromolecular polypeptides |
| US4832686A (en) | 1986-06-24 | 1989-05-23 | Anderson Mark E | Method for administering interleukin-2 |
| JPS63122620A (ja) * | 1986-11-12 | 1988-05-26 | Sanraku Inc | ポリ乳酸マイクロスフエア及びその製造方法 |
| US4883666A (en) * | 1987-04-29 | 1989-11-28 | Massachusetts Institute Of Technology | Controlled drug delivery system for treatment of neural disorders |
| EP0478671B1 (de) * | 1989-06-21 | 1993-05-19 | Brown University Research Foundation | Neurologisches therapiesystem |
| CH679207A5 (de) * | 1989-07-28 | 1992-01-15 | Debiopharm Sa | |
| JP3187410B2 (ja) * | 1989-08-10 | 2001-07-11 | 住友製薬株式会社 | 脳内投与用徐放性製剤 |
-
1991
- 1991-05-14 AT AT91910707T patent/ATE226091T1/de not_active IP Right Cessation
- 1991-05-14 DE DE69133136T patent/DE69133136T2/de not_active Expired - Fee Related
- 1991-05-14 EP EP91910707A patent/EP0528978B1/de not_active Expired - Lifetime
- 1991-05-14 ES ES91910707T patent/ES2185615T3/es not_active Expired - Lifetime
- 1991-05-14 JP JP51042891A patent/JP3359919B2/ja not_active Expired - Fee Related
- 1991-05-14 DK DK91910707T patent/DK0528978T3/da active
- 1991-05-14 WO PCT/US1991/003356 patent/WO1991017772A1/en not_active Ceased
-
1993
- 1993-03-15 US US08/033,309 patent/US5360610A/en not_active Expired - Lifetime
-
2002
- 2002-05-15 JP JP2002140490A patent/JP4044366B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003012506A (ja) | 2003-01-15 |
| DE69133136T2 (de) | 2003-06-18 |
| US5360610A (en) | 1994-11-01 |
| JPH05507486A (ja) | 1993-10-28 |
| EP0528978B1 (de) | 2002-10-16 |
| DE69133136D1 (de) | 2002-11-21 |
| WO1991017772A1 (en) | 1991-11-28 |
| EP0528978A1 (de) | 1993-03-03 |
| JP3359919B2 (ja) | 2002-12-24 |
| JP4044366B2 (ja) | 2008-02-06 |
| ES2185615T3 (es) | 2003-05-01 |
| EP0528978A4 (en) | 1993-06-23 |
| DK0528978T3 (da) | 2003-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0528978 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |