ATE226589T1 - Alpha-aminophosphinopeptid-derivate und sie enthaltende zusammensetzungen - Google Patents

Alpha-aminophosphinopeptid-derivate und sie enthaltende zusammensetzungen

Info

Publication number: ATE226589T1
Authority: AT; Austria
Prior art keywords: group; substituted; hydrogen atom; phenyl; alkyl
Prior art date: 1998-04-22

Application number

AT99914616T

Other languages

English (en)

Inventor

Bernard Roques

Marie-Claude Fournie-Zaluski

Xuixiong Chen

Original Assignee

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-22

Filing date

1999-04-20

Publication date

2002-11-15

1999-04-20 Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE226589T1 publication Critical patent/ATE226589T1/de

Links

239000000203 mixture Substances 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 4
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002466 imines Chemical class 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3264—Esters with hydroxyalkyl compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/32—Esters thereof
- C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT99914616T 1998-04-22 1999-04-20 Alpha-aminophosphinopeptid-derivate und sie enthaltende zusammensetzungen ATE226589T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9805009A FR2777780B1 (fr)	1998-04-22	1998-04-22	Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
PCT/FR1999/000921 WO1999054336A1 (fr)	1998-04-22	1999-04-20	Derives d'(alpha-aminophosphino) peptides et compositions les contenant

Publications (1)

Publication Number	Publication Date
ATE226589T1 true ATE226589T1 (de)	2002-11-15

Family

ID=9525515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99914616T ATE226589T1 (de)	1998-04-22	1999-04-20	Alpha-aminophosphinopeptid-derivate und sie enthaltende zusammensetzungen

Country Status (11)

Country	Link
US (1)	US6391866B1 (de)
EP (1)	EP1073664B1 (de)
JP (1)	JP2002512250A (de)
AT (1)	ATE226589T1 (de)
AU (1)	AU3336599A (de)
CA (1)	CA2329637A1 (de)
DE (1)	DE69903620T2 (de)
DK (1)	DK1073664T3 (de)
ES (1)	ES2184431T3 (de)
FR (1)	FR2777780B1 (de)
WO (1)	WO1999054336A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2823212B1 (fr) *	2001-04-10	2005-12-02	Inst Nat Sante Rech Med	Inhibiteurs de la toxine botulique de type b
FR2931151A1 (fr)	2008-05-13	2009-11-20	Pharmaleads Soc Par Actions Si	Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
FR2934267B1 (fr)	2008-07-23	2010-08-13	Pharmaleads	Derives aminophosphiniques utiles dans le traitement de la douleur
FR2997081B1 (fr)	2012-10-23	2015-11-27	Pharmaleads	Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine
FR3044227B1 (fr) *	2015-11-30	2017-11-24	Pharmaleads	Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
FR3098217B1 (fr)	2019-07-05	2023-04-21	Pharmaleads	N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4337201A (en) *	1980-12-04	1982-06-29	E. R. Squibb & Sons, Inc.	Phosphinylalkanoyl substituted prolines
IT1270260B (it)	1994-06-21	1997-04-29	Zambon Spa	Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
WO1996033201A1 (en) *	1995-04-21	1996-10-24	Centre National De La Recherche Scientifique (Cnrs)	Acyclovir derivatives as antiviral agents
IT1276710B1 (it) *	1995-06-14	1997-11-03	Zambon Spa	Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
FR2755135B1 (fr) *	1996-10-25	2002-12-27	Inst Nat Sante Rech Med	Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent

1998
- 1998-04-22 FR FR9805009A patent/FR2777780B1/fr not_active Expired - Fee Related
1999
- 1999-04-20 WO PCT/FR1999/000921 patent/WO1999054336A1/fr not_active Ceased
- 1999-04-20 ES ES99914616T patent/ES2184431T3/es not_active Expired - Lifetime
- 1999-04-20 JP JP2000544675A patent/JP2002512250A/ja active Pending
- 1999-04-20 AT AT99914616T patent/ATE226589T1/de not_active IP Right Cessation
- 1999-04-20 CA CA002329637A patent/CA2329637A1/fr not_active Abandoned
- 1999-04-20 DE DE69903620T patent/DE69903620T2/de not_active Expired - Fee Related
- 1999-04-20 AU AU33365/99A patent/AU3336599A/en not_active Abandoned
- 1999-04-20 US US09/673,842 patent/US6391866B1/en not_active Expired - Fee Related
- 1999-04-20 EP EP99914616A patent/EP1073664B1/de not_active Expired - Lifetime
- 1999-04-20 DK DK99914616T patent/DK1073664T3/da active

Also Published As

Publication number	Publication date
US6391866B1 (en)	2002-05-21
ES2184431T3 (es)	2003-04-01
EP1073664B1 (de)	2002-10-23
JP2002512250A (ja)	2002-04-23
DE69903620D1 (de)	2002-11-28
DK1073664T3 (da)	2003-02-24
AU3336599A (en)	1999-11-08
FR2777780B1 (fr)	2001-05-04
EP1073664A1 (de)	2001-02-07
DE69903620T2 (de)	2003-06-12
WO1999054336A1 (fr)	1999-10-28
FR2777780A1 (fr)	1999-10-29
CA2329637A1 (fr)	1999-10-28

Similar Documents

Publication	Publication Date	Title
FR2662162B1 (fr)	1995-01-20	Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DE60129210D1 (de)	2007-08-16	Zyklische amid-derivate
DK0421364T3 (da)	1995-08-14	Pleuromutiliner
TR199701427T1 (xx)	1998-04-21	�nsektisidler olarak kullan�lan bisiklik aminler.
DK0590919T3 (da)	2000-04-17	Terapeutiske midler mod Parkinsons sygdom
KR960701019A (ko)	1996-02-24	신규의 4-아미노피리딘, 이것의 제조방법 및 이것을 함유하는 약제(new 4-aminopyridines, process for preparing the same and me-dicaments containing the same)
DK0842661T3 (da)	2001-09-24	Anvendelse af estrogenagonister og -antagonister til fremstilling af et lægemiddel til behandling af atherosclerose, uafhængigt af lipidsænkning
DK0487620T3 (da)	1995-05-01	Hidtil ukendte aminosyrederivater, fremgangsmåde til fremstilling heraf og terapeutisk anvendelse heraf
BR8502972A (pt)	1986-03-04	Processo para a preparacao de 5-amino-4-heterociclil-1-fenilpirazois,composicoes herbicidas,aplicacao,processos para a preparacao de composicoes e para a preparacao de derivados de acrilonitrila
HRP20000508B1 (hr)	2007-02-28	Supstituirani 2-benzilamino-2-fenil-acetamidni spojevi
ATE226589T1 (de)	2002-11-15	Alpha-aminophosphinopeptid-derivate und sie enthaltende zusammensetzungen
TW360654B (en)	1999-06-11	Oxazolidinone derivatives, their preparation and therapeutical use
DK0453197T3 (da)	1994-10-24	Aminderivater
MY131762A (en)	2007-08-30	Pharmaceutical compounds
ATE197706T1 (de)	2000-12-15	Anellierte dihydropyridine und deren verwendung für die herstellung von pharmazeutischen zubereitungen
YU43902A (sh)	2005-03-15	Novi razgranati supstituisani amino derivati od 3-amino-1- -fenil-1h(1,2,4) triazola, postupak za njihovo dobijanje i farmaceutski preparati koji ih sadrže
MXPA01013148A (es)	2004-08-19	Nuevos derivados de amonio cuaternario, metodo para la preparacion de los mismos y uso farmaceutico.
HUT75649A (en)	1997-05-28	Optically active imidazolidinone derivative and pharmaceutical compositions containing them
TW259785B (en)	1995-10-11	Chemical compounds
EP0407594A4 (en)	1991-09-25	Novel tetrahydropyrimidine derivatives, process for their preparation and insecticides containing same as active ingredients
DK0486385T3 (da)	1995-06-12	Imidazolderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
MY106503A (en)	1995-06-30	Imidazolidine derivatives, process for producing the same and pesticides containing the same
DK439384A (da)	1985-03-16	Derivater af 4-(3-alkynyloxy-2-hydroxypropyl)-piperazin-1-yl-n-phenylacetamid, fremgangsmaade til fremstilling deraf samt farmaceutisk middel indeholdende disse
DK0435235T3 (da)	1995-05-22	Nye isoquinolinderivater og salte deraf
DK0743306T3 (da)	2001-02-05	Fremgangsmåde til fremstilling af eventuelt 2-substituerede 5-chlor-imidazol-4-carbaldehyder

Legal Events

Date	Code	Title	Description
2003-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties