DK1073664T3 - (alfa-aminophosphin)peptidderivater og sammensætninger indeholdende disse - Google Patents

(alfa-aminophosphin)peptidderivater og sammensætninger indeholdende disse

Info

Publication number
DK1073664T3
DK1073664T3 DK99914616T DK99914616T DK1073664T3 DK 1073664 T3 DK1073664 T3 DK 1073664T3 DK 99914616 T DK99914616 T DK 99914616T DK 99914616 T DK99914616 T DK 99914616T DK 1073664 T3 DK1073664 T3 DK 1073664T3
Authority
DK
Denmark
Prior art keywords
group
substituted
hydrogen atom
phenyl
alkyl
Prior art date
Application number
DK99914616T
Other languages
English (en)
Inventor
Bernard Roques
Marie-Claude Fournie-Zaluski
Xuixiong Chen
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Application granted granted Critical
Publication of DK1073664T3 publication Critical patent/DK1073664T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3258—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3264—Esters with hydroxyalkyl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/32—Esters thereof
    • C07F9/3205—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/3211—Esters of acyclic saturated acids which can have further substituents on alkyl

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK99914616T 1998-04-22 1999-04-20 (alfa-aminophosphin)peptidderivater og sammensætninger indeholdende disse DK1073664T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9805009A FR2777780B1 (fr) 1998-04-22 1998-04-22 Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent
PCT/FR1999/000921 WO1999054336A1 (fr) 1998-04-22 1999-04-20 Derives d'(alpha-aminophosphino) peptides et compositions les contenant

Publications (1)

Publication Number Publication Date
DK1073664T3 true DK1073664T3 (da) 2003-02-24

Family

ID=9525515

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99914616T DK1073664T3 (da) 1998-04-22 1999-04-20 (alfa-aminophosphin)peptidderivater og sammensætninger indeholdende disse

Country Status (11)

Country Link
US (1) US6391866B1 (da)
EP (1) EP1073664B1 (da)
JP (1) JP2002512250A (da)
AT (1) ATE226589T1 (da)
AU (1) AU3336599A (da)
CA (1) CA2329637A1 (da)
DE (1) DE69903620T2 (da)
DK (1) DK1073664T3 (da)
ES (1) ES2184431T3 (da)
FR (1) FR2777780B1 (da)
WO (1) WO1999054336A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2823212B1 (fr) * 2001-04-10 2005-12-02 Inst Nat Sante Rech Med Inhibiteurs de la toxine botulique de type b
FR2931151A1 (fr) 2008-05-13 2009-11-20 Pharmaleads Soc Par Actions Si Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique
FR2934267B1 (fr) 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur
FR2997081B1 (fr) 2012-10-23 2015-11-27 Pharmaleads Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine
FR3044227B1 (fr) * 2015-11-30 2017-11-24 Pharmaleads Derives aminophosphiniques pour la prevention et le traitement des douleurs oculaires
FR3098217B1 (fr) 2019-07-05 2023-04-21 Pharmaleads N-Formylhydroxylamines en tant qu’inhibiteurs mixtes de l’aminopeptidase N (APN) et de la néprilysine (NEP)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337201A (en) * 1980-12-04 1982-06-29 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
IT1270260B (it) 1994-06-21 1997-04-29 Zambon Spa Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi
WO1996033201A1 (en) * 1995-04-21 1996-10-24 Centre National De La Recherche Scientifique (Cnrs) Acyclovir derivatives as antiviral agents
IT1276710B1 (it) * 1995-06-14 1997-11-03 Zambon Spa Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
US6391866B1 (en) 2002-05-21
DE69903620D1 (de) 2002-11-28
DE69903620T2 (de) 2003-06-12
FR2777780A1 (fr) 1999-10-29
AU3336599A (en) 1999-11-08
ES2184431T3 (es) 2003-04-01
CA2329637A1 (fr) 1999-10-28
WO1999054336A1 (fr) 1999-10-28
ATE226589T1 (de) 2002-11-15
JP2002512250A (ja) 2002-04-23
EP1073664B1 (fr) 2002-10-23
EP1073664A1 (fr) 2001-02-07
FR2777780B1 (fr) 2001-05-04

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