ATE226592T1 - Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung - Google Patents

Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung

Info

Publication number
ATE226592T1
ATE226592T1 AT96915089T AT96915089T ATE226592T1 AT E226592 T1 ATE226592 T1 AT E226592T1 AT 96915089 T AT96915089 T AT 96915089T AT 96915089 T AT96915089 T AT 96915089T AT E226592 T1 ATE226592 T1 AT E226592T1
Authority
AT
Austria
Prior art keywords
metalproteinases
therapeutic use
tnf release
peptides inhibiting
peptides
Prior art date
Application number
AT96915089T
Other languages
English (en)
Inventor
Andrew Douglas Baxter
Road
John Montana
David Alan Owen
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9509434.8A external-priority patent/GB9509434D0/en
Priority claimed from GBGB9525643.4A external-priority patent/GB9525643D0/en
Priority claimed from GBGB9607218.6A external-priority patent/GB9607218D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ATE226592T1 publication Critical patent/ATE226592T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT96915089T 1995-05-10 1996-05-10 Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung ATE226592T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9509434.8A GB9509434D0 (en) 1995-05-10 1995-05-10 Compounds
GBGB9525643.4A GB9525643D0 (en) 1995-12-15 1995-12-15 Compounds
GBGB9607218.6A GB9607218D0 (en) 1996-04-04 1996-04-04 Compounds
PCT/GB1996/001138 WO1996035714A1 (en) 1995-05-10 1996-05-10 Peptide compounds which inhibit metalloproteinase and tnf liberation and their therapeutic uses

Publications (1)

Publication Number Publication Date
ATE226592T1 true ATE226592T1 (de) 2002-11-15

Family

ID=27267715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96915089T ATE226592T1 (de) 1995-05-10 1996-05-10 Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung

Country Status (9)

Country Link
US (1) US6110896A (de)
EP (1) EP0826000B1 (de)
JP (1) JPH11504646A (de)
AT (1) ATE226592T1 (de)
AU (1) AU701279B2 (de)
CA (1) CA2217857A1 (de)
DE (1) DE69624477T2 (de)
ES (1) ES2184861T3 (de)
WO (1) WO1996035714A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406901B1 (en) 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
GB9607120D0 (en) * 1996-04-04 1996-06-12 Chiroscience Ltd Compounds
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
NZ334897A (en) * 1996-12-09 2001-02-23 Warner Lambert Co Medicaments for treating and preventing heart failure and ventricular dilatation
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
EE04295B1 (et) * 1997-02-27 2004-06-15 American Cyanamid Company N-hüdroksü-2-(alküül-, arüül- või heteroarüülsulfanüül-, -sulfinüül- või-sulfonüül-)-3-asendatud-alküülamiidid, -arüülamiidid või -heteroarüülamiididkui maatriksmetalloproteinaasi inhibiitorid
IL136889A0 (en) 1998-01-09 2001-06-14 Pfizer Matrix metalloprotease inhibitors
JP2002501943A (ja) * 1998-01-30 2002-01-22 ダーウィン・ディスカバリー・リミテッド ヒドロキサム酸およびカルボン酸誘導体
US6680338B2 (en) 1998-02-06 2004-01-20 Darwin Discovery Ltd. Hydroxamic and carboxylic acid derivatives
HUP0102073A3 (en) * 1998-02-06 2002-12-28 Darwin Discovery Ltd Cambridge Hydroxamic and carboxylic acid derivatives and medicaments containing them
GB9823334D0 (en) 1998-10-23 1998-12-23 Darwin Discovery Ltd Enzyme coupling
JP2003506411A (ja) * 1999-08-09 2003-02-18 トリペップ アクチ ボラゲット タンパク質重合阻害剤および使用方法
KR100840816B1 (ko) 2000-05-12 2008-06-23 젠자임 코포레이션 ＴＮＦ-α시그널링의 조절물질
US20030228320A1 (en) * 2000-08-18 2003-12-11 Ashdown Martin Leonard Retroviral immunotherapy
US6593455B2 (en) 2001-08-24 2003-07-15 Tripep Ab Tripeptide amides that block viral infectivity and methods of use thereof
WO2003024995A1 (en) 2001-09-19 2003-03-27 Tripep Ab Molecules that block viral infectivity and methods of use thereof
ATE457716T1 (de) 2002-12-30 2010-03-15 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
WO2011151197A1 (en) 2010-05-31 2011-12-08 Syngenta Participations Ag 1, 8 -diazaspiro [4.5] decane- 2, 4 -dione derivatives useful as pesticides
CN103003239A (zh) 2010-05-31 2013-03-27 先正达参股股份有限公司 基于螺杂环吡咯烷衍生物的杀虫剂

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
CA1322073C (en) * 1986-12-24 1993-09-07 Roger E. Markwell Thiol-carboxylic acid derivatives
DE3889726T2 (de) * 1987-03-17 1994-10-13 Res Corp Technologies Inc Synthetische inhibitoren von säugetier-collagenase.
DE4311021A1 (de) * 1993-03-31 1994-10-27 Diagnostikforschung Inst Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel
NZ271893A (en) * 1993-08-23 1997-11-24 Immunex Corp Inhibitors of tnf-alpha secretion
GB9323165D0 (en) * 1993-11-10 1994-01-05 Chiros Ltd Compounds
CZ288436B6 (en) * 1994-10-05 2001-06-13 Darwin Discovery Ltd Peptidyl derivatives, their therapeutic use as inhibitors of metalloproteinases and pharmaceutical preparation in which they are comprised

Also Published As

Publication number Publication date
CA2217857A1 (en) 1996-11-14
WO1996035714A1 (en) 1996-11-14
EP0826000B1 (de) 2002-10-23
JPH11504646A (ja) 1999-04-27
DE69624477T2 (de) 2003-06-26
AU5698096A (en) 1996-11-29
AU701279B2 (en) 1999-01-21
DE69624477D1 (de) 2002-11-28
EP0826000A1 (de) 1998-03-04
US6110896A (en) 2000-08-29
ES2184861T3 (es) 2003-04-16

Similar Documents

Publication Publication Date Title
ATE226592T1 (de) Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung
DE69604860D1 (de) Orthopädisches Befestigungsmittel
EG23871A (en) Protein kinase c inhibitor
DE69632761D1 (de) Ostomiekupplung
EP0611775A3 (de) Krebshemmende Pentapeptid-Amide.
FI980038L (fi) Tuumorinekroositekijän alfa inhibiittoreita
DE69625506D1 (de) Schwefelsubstituierte peptide als inhibitoren für metalloproteinasen und der tnf-freisetzung
DE69632758D1 (de) Ostomiekupplung
DE69627483D1 (de) Peptidartige stoffe, die metalloproteinasen und die tnf-freisetzung hemmen, und ihre therapeutische verwendung
MX9803662A (es) Oligopeptidos novedosos, preparacion y uso de estos.
BR9609368A (pt) Monômetro 4,4-ciclohexan(dissubstituído)-1-óis e compostos correlatos
KR960016814A (ko) 쌀 공급 장치
FR2771372B1 (fr) Ensemble tuyere gouvernail
KR960026792U (ko) 풍구
KR970039033U (ko) 풍구 옥토막이 장치
KR960033308U (ko) 신발끈 고리쇠 자동체결기의 고리쇠 공급장치
KR970007774U (ko) 사료 공급기 먹이통
DE59604362D1 (de) Direktsämaschine
KR960028010U (ko) 돼지 사료 급식기
KR960028540U (ko) 압정
KR970004672U (ko) 압정
KR970016594U (ko) 압정
KR950002559U (ko) 이앙기 장착용 담수직파기
KR960035944U (ko) 양돈용 사료 자동급이기
KR970000055U (ko) 양돈용 먹이통

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties