ATE226633T1 - Bindungsdomänen in notch- und delta-proteinen - Google Patents

Bindungsdomänen in notch- und delta-proteinen

Info

Publication number
ATE226633T1
ATE226633T1 AT92911557T AT92911557T ATE226633T1 AT E226633 T1 ATE226633 T1 AT E226633T1 AT 92911557 T AT92911557 T AT 92911557T AT 92911557 T AT92911557 T AT 92911557T AT E226633 T1 ATE226633 T1 AT E226633T1
Authority
AT
Austria
Prior art keywords
notch
binding domain
toporythmic protein
delta proteins
fragment
Prior art date
Application number
AT92911557T
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Ilaria Rebay
Christine Marie Blaumueller
St Prospect
Scott Brockwell Shepard
Original Assignee
Univ Yale
Advanced Res & Tech Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE226633(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale, Advanced Res & Tech Inst filed Critical Univ Yale
Application granted granted Critical
Publication of ATE226633T1 publication Critical patent/ATE226633T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT92911557T 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen ATE226633T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14
PCT/US1992/003651 WO1992019734A1 (en) 1991-05-03 1992-05-01 Binding domains in notch and delta proteins

Publications (1)

Publication Number Publication Date
ATE226633T1 true ATE226633T1 (de) 2002-11-15

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins
AT92911557T ATE226633T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins

Country Status (12)

Country Link
US (1) US5849869A (de)
EP (4) EP0930366B1 (de)
JP (7) JPH07503123A (de)
AT (4) ATE473754T1 (de)
AU (1) AU675203B2 (de)
CA (1) CA2102208C (de)
DE (4) DE69233735D1 (de)
DK (4) DK0576623T4 (de)
ES (4) ES2303363T3 (de)
IE (2) IE85350B1 (de)
IL (1) IL101728A (de)
WO (1) WO1992019734A1 (de)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
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IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
US6004924A (en) * 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
US5869282A (en) * 1991-12-11 1999-02-09 Imperial Cancer Research Technology, Ltd. Nucleotide and protein sequences of the serrate gene and methods based thereon
US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5786158A (en) * 1992-04-30 1998-07-28 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
AU723939B2 (en) 1995-06-28 2000-09-07 Imperial Cancer Research Technology Ltd Nucleotide and protein sequences of vertebrate delta genes and methods based thereon
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US6337387B1 (en) 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
WO1997018822A1 (en) * 1995-11-22 1997-05-29 Yale University Vertebrate deltex proteins, nucleic acids, and antibodies, and related methods and compositions
WO1998002458A1 (en) * 1996-07-16 1998-01-22 Asahi Kasei Kogyo Kabushiki Kaisha Differentiation inhibitor
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
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GB9623236D0 (en) * 1996-11-07 1997-01-08 Imperial College Notch
US6121045A (en) * 1997-04-04 2000-09-19 Millennium Biotherapeutics, Inc. Human Delta3 nucleic acid molecules
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US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
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US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US6984522B2 (en) 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
WO2003050502A2 (en) * 2001-12-07 2003-06-19 Regents Of The University Of Michigan Prospective identification and characterization of breast cancer stem cells
WO2002018544A2 (en) * 2000-08-31 2002-03-07 Loyola University Chicago Method and reagents for treatment of skin disorders by modulating the notch pathway
WO2002059285A1 (en) * 2000-10-27 2002-08-01 Fred Hutchinson Cancer Research Center Methods for immortalizing cells
GB0118155D0 (en) 2001-07-25 2001-09-19 Lorantis Ltd Superantigen
EP2481814A3 (de) * 2003-06-09 2012-10-10 The Regents of the University of Michigan Zusammensetzungen und Verfahren zur Behandlung und Diagnose von Krebs
US20050232927A1 (en) * 2004-02-03 2005-10-20 The Regents Of The University Of Michigan Compositions and methods for characterizing, regulating, diagnosing, and treating cancer
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US8148147B2 (en) * 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
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PE20090321A1 (es) 2007-06-04 2009-04-20 Genentech Inc Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
WO2009063838A1 (ja) 2007-11-12 2009-05-22 Gs Yuasa Corporation リチウム二次電池用活物質、リチウム二次電池及びその製造方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
ES2531541T3 (es) 2008-07-08 2015-03-17 Oncomed Pharmaceuticals, Inc. Agentes de unión del receptor Notch1 y procedimientos de uso de los mismos
DK2331136T3 (en) 2008-09-26 2018-03-05 Oncomed Pharm Inc FRIZZLED BINDING AGENTS AND APPLICATIONS THEREOF
ES2575152T3 (es) 2009-10-16 2016-06-24 Oncomed Pharmaceuticals, Inc. Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensores
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US3884853A (en) * 1973-11-14 1975-05-20 Staley Mfg Co A E Alkali-curable cationic/anionic starch for paper coating binders
US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
US5098833A (en) * 1989-02-23 1992-03-24 Genentech, Inc. DNA sequence encoding a functional domain of a lymphocyte homing receptor
US5368712A (en) * 1989-11-02 1994-11-29 Synporin Technologies, Inc. Biologically mimetic synthetic ion channel transducers
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
DE69329037T2 (de) * 1992-12-11 2001-03-22 The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer Delta ähnliches gen welches in neuroendokrinen tumoren exprimiert wird

Also Published As

Publication number Publication date
EP0576623A1 (de) 1994-01-05
EP0576623B1 (de) 2002-10-23
JP4430891B2 (ja) 2010-03-10
EP0930366A2 (de) 1999-07-21
ES2181674T5 (es) 2008-03-01
EP0930365A2 (de) 1999-07-21
IL101728A0 (en) 1992-12-30
JP4604228B2 (ja) 2011-01-05
ATE386116T1 (de) 2008-03-15
EP0933082A1 (de) 1999-08-04
DK0930366T3 (da) 2008-10-13
US5849869A (en) 1998-12-15
DE69232832T2 (de) 2003-06-18
ES2310933T3 (es) 2009-01-16
IL101728A (en) 2007-08-19
AU1919792A (en) 1992-12-21
JPH07503123A (ja) 1995-04-06
DE69232832D1 (de) 2002-11-28
EP0576623A4 (de) 1995-01-18
DE69233735D1 (de) 2008-07-17
EP0930365B1 (de) 2008-02-13
JP2008005843A (ja) 2008-01-17
IE85350B1 (en) 2009-10-14
DK0576623T4 (da) 2008-01-02
DE69232832T3 (de) 2008-02-28
ES2348919T3 (es) 2010-12-16
EP0930365A3 (de) 1999-07-28
IE20030774A1 (en) 2003-12-10
ES2303363T3 (es) 2008-08-01
ATE473754T1 (de) 2010-07-15
JP4604227B2 (ja) 2011-01-05
CA2102208A1 (en) 1992-11-12
IE921367A1 (en) 1992-11-04
AU675203B2 (en) 1997-01-30
JP2007330259A (ja) 2007-12-27
EP0576623B2 (de) 2007-10-03
EP0933082B1 (de) 2010-07-14
DE69233724D1 (de) 2008-03-27
WO1992019734A1 (en) 1992-11-12
ES2181674T3 (es) 2003-03-01
JP2011135886A (ja) 2011-07-14
DK0930365T3 (da) 2008-06-02
JP2011155979A (ja) 2011-08-18
EP0930366B1 (de) 2008-06-04
CA2102208C (en) 2003-04-29
DK0576623T3 (da) 2003-02-24
ATE397661T1 (de) 2008-06-15
EP0930366A3 (de) 1999-07-28
DE69233791D1 (de) 2010-08-26
JP2004065243A (ja) 2004-03-04
DE69233724T2 (de) 2009-04-02
JP2007330258A (ja) 2007-12-27
DK0933082T3 (da) 2010-10-25

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