ATE473754T1 - Verfahren zur manipulation der zelldifferenzierung - Google Patents

Verfahren zur manipulation der zelldifferenzierung

Info

Publication number
ATE473754T1
ATE473754T1 AT99101561T AT99101561T ATE473754T1 AT E473754 T1 ATE473754 T1 AT E473754T1 AT 99101561 T AT99101561 T AT 99101561T AT 99101561 T AT99101561 T AT 99101561T AT E473754 T1 ATE473754 T1 AT E473754T1
Authority
AT
Austria
Prior art keywords
manipulation
cell differentiation
toporythmic protein
fragment
cell
Prior art date
Application number
AT99101561T
Other languages
English (en)
Inventor
Spyridon Artavanis-Tsakonas
Original Assignee
Univ Yale
Indiana University Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE473754(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Yale, Indiana University Foundation filed Critical Univ Yale
Application granted granted Critical
Publication of ATE473754T1 publication Critical patent/ATE473754T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT99101561T 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung ATE473754T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US79192391A 1991-11-14 1991-11-14

Publications (1)

Publication Number Publication Date
ATE473754T1 true ATE473754T1 (de) 2010-07-15

Family

ID=27105529

Family Applications (4)

Application Number Title Priority Date Filing Date
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins
AT92911557T ATE226633T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen
AT99101561T ATE473754T1 (de) 1991-05-03 1992-05-01 Verfahren zur manipulation der zelldifferenzierung
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT99101563T ATE397661T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des delta-proteins
AT92911557T ATE226633T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen in notch- und delta-proteinen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99101562T ATE386116T1 (de) 1991-05-03 1992-05-01 Bindungsdomänen des serrate-proteins

Country Status (12)

Country Link
US (1) US5849869A (de)
EP (4) EP0576623B2 (de)
JP (7) JPH07503123A (de)
AT (4) ATE397661T1 (de)
AU (1) AU675203B2 (de)
CA (1) CA2102208C (de)
DE (4) DE69232832T3 (de)
DK (4) DK0930366T3 (de)
ES (4) ES2310933T3 (de)
IE (2) IE85350B1 (de)
IL (1) IL101728A (de)
WO (1) WO1992019734A1 (de)

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US6004924A (en) 1991-12-11 1999-12-21 Imperial Cancer Research Technology, Ltd. Protein sequences of serrate gene products
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US20050112121A1 (en) * 1992-04-30 2005-05-26 Yale University Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
US5750652A (en) * 1994-01-21 1998-05-12 Yale University Deltex proteins
DE69638023D1 (de) * 1995-06-28 2009-10-22 Univ Yale Nukleotid- und proteinsequenzen von delta-genen von vertebraten und darauf basierende methoden
US5780300A (en) * 1995-09-29 1998-07-14 Yale University Manipulation of non-terminally differentiated cells using the notch pathway
US20050158859A1 (en) * 1995-09-29 2005-07-21 Yale University Manipulation of non-terminally differentiated cells using the Notch pathway
US6337387B1 (en) 1995-11-17 2002-01-08 Asahi Kasei Kabushiki Kaisha Differentiation-suppressive polypeptide
EP0869802A4 (de) * 1995-11-22 2001-11-14 Univ Yale Deltex proteine, nukleinsäuren, und antikörper von vertebraten, sowie diesbezügliche verfahren und zusammensetzungen
AU720930B2 (en) 1996-07-16 2000-06-15 Asahi Kasei Kabushiki Kaisha Differentiation inhibitor
US6887475B1 (en) 1996-11-07 2005-05-03 Lorantis Limited Notch
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GB9623236D0 (en) * 1996-11-07 1997-01-08 Imperial College Notch
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US6664098B1 (en) 1997-05-14 2003-12-16 Asahi Kasei Kabushiki Kaisha Differentiation inhibitory agent
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US6436650B1 (en) 1997-07-23 2002-08-20 Yale University Activated forms of notch and methods based thereon
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US6808890B2 (en) 1999-07-28 2004-10-26 Nuvelo, Inc. Method of detecting a cancerous cell expressing EGFL6, and EGF mutif protein
CA2309897A1 (en) 1997-11-22 1999-06-03 Hyseq, Inc. A novel egf motif protein obtained from a cdna library of fetal liver-spleen
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US8084258B2 (en) 1999-07-12 2011-12-27 University Of Basel Manipulation of tissue of organ type using the notch pathway
GB9927328D0 (en) 1999-11-18 2000-01-12 Lorantis Ltd Immunotherapy
US6448197B1 (en) * 2000-07-13 2002-09-10 Exxonmobil Chemical Patents Inc. Method for making a metal containing small pore molecular sieve catalyst
US6984522B2 (en) * 2000-08-03 2006-01-10 Regents Of The University Of Michigan Isolation and use of solid tumor stem cells
US8044259B2 (en) * 2000-08-03 2011-10-25 The Regents Of The University Of Michigan Determining the capability of a test compound to affect solid tumor stem cells
US20020151487A1 (en) * 2000-08-31 2002-10-17 Loyola University Chicago Method and reagents for epithelial barrier formation and treatment of malignant and benign skin disorders by modulating the notch pathway
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AU2002364537A1 (en) * 2001-12-07 2003-06-23 Regents Of The University Of Michigan Prospective identification and characterization of breast cancer stem cells
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US20060252073A1 (en) * 2005-04-18 2006-11-09 Regents Of The University Of Michigan Compositions and methods for the treatment of cancer
AU2006259583A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US20070099209A1 (en) * 2005-06-13 2007-05-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2628255C (en) * 2005-10-31 2016-04-19 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
CA2628221A1 (en) 2005-10-31 2007-05-10 Oncomed Pharmaceuticals, Inc. Anti-frizzled receptor antibodies for treating cancer
ES2413087T3 (es) 2006-06-13 2013-07-15 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para el diagnóstico y tratamiento del cáncer
DK2066694T3 (en) 2006-09-29 2016-02-08 Oncomed Pharm Inc Compositions and Methods for Diagnosing and Treating Cancer
RU2448979C2 (ru) * 2006-12-14 2012-04-27 Ридженерон Фармасьютикалз, Инк. Антитела человека к дельта-подобному лиганду-4 человека
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WO2008092002A2 (en) * 2007-01-24 2008-07-31 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
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US8068607B2 (en) 2007-07-31 2011-11-29 Ricoh Company, Limited Information processing apparatus and information processing method
KR101323126B1 (ko) 2007-11-12 2013-10-30 가부시키가이샤 지에스 유아사 리튬 이차전지의 제조방법
CN102112490B (zh) 2008-07-08 2014-10-22 昂考梅德药品有限公司 Notch1受体结合剂和其使用方法
US9132189B2 (en) 2008-07-08 2015-09-15 Oncomed Pharmaceuticals, Inc. Notch1 binding agents and methods of use thereof
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HUE029661T2 (en) 2009-10-16 2017-03-28 Oncomed Pharm Inc A therapeutic combination and use of DLL4 antagonist antibodies and antihypertensive agents
TWI535445B (zh) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Ｗｎｔ拮抗劑及治療和篩選方法
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CA2795627C (en) 2010-04-09 2023-03-14 Fred Hutchinson Cancer Research Center Compositions and methods for providing hematopoietic function without hla matching
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
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US9599620B2 (en) 2012-10-31 2017-03-21 Oncomed Pharmaceuticals, Inc. Methods and monitoring of treatment with a DLL4 antagonist
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US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
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CN106459919B (zh) 2014-06-04 2021-03-23 弗莱德哈钦森癌症研究中心 使用notch 1和/或notch 2激动剂扩增和植入干细胞
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US5115096A (en) * 1988-04-15 1992-05-19 Oncogen Amphiregulin: a bifunctional growth modulating glycoprotein
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WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
IL101728A (en) * 1991-05-03 2007-08-19 Univ Yale Human Abandonment and Delta, Restrictive Areas of Effect in Tophoric Proteins, and Methods Based on Them
WO1993012141A1 (en) * 1991-12-11 1993-06-24 Yale University Nucleotide and protein sequences of the serrate gene and methods based thereon
JPH08509358A (ja) * 1992-12-11 1996-10-08 アメリカ合衆国 神経内分泌腫瘍で発現されるδ様遺伝子

Also Published As

Publication number Publication date
US5849869A (en) 1998-12-15
JP2007330259A (ja) 2007-12-27
AU1919792A (en) 1992-12-21
ES2181674T3 (es) 2003-03-01
DK0576623T4 (da) 2008-01-02
EP0576623A1 (de) 1994-01-05
DK0933082T3 (da) 2010-10-25
CA2102208A1 (en) 1992-11-12
JP4430891B2 (ja) 2010-03-10
ES2303363T3 (es) 2008-08-01
IL101728A0 (en) 1992-12-30
JP2011135886A (ja) 2011-07-14
IE85350B1 (en) 2009-10-14
EP0930365A2 (de) 1999-07-21
IE20030774A1 (en) 2003-12-10
ES2181674T5 (es) 2008-03-01
DK0930365T3 (da) 2008-06-02
EP0576623B1 (de) 2002-10-23
EP0930365B1 (de) 2008-02-13
EP0576623A4 (de) 1995-01-18
JP4604227B2 (ja) 2011-01-05
DE69233735D1 (de) 2008-07-17
ATE397661T1 (de) 2008-06-15
JP2004065243A (ja) 2004-03-04
EP0576623B2 (de) 2007-10-03
EP0930365A3 (de) 1999-07-28
DE69232832T2 (de) 2003-06-18
DK0576623T3 (da) 2003-02-24
EP0930366A3 (de) 1999-07-28
DK0930366T3 (da) 2008-10-13
JPH07503123A (ja) 1995-04-06
JP2007330258A (ja) 2007-12-27
DE69233724T2 (de) 2009-04-02
ES2348919T3 (es) 2010-12-16
WO1992019734A1 (en) 1992-11-12
JP4604228B2 (ja) 2011-01-05
DE69233724D1 (de) 2008-03-27
EP0933082A1 (de) 1999-08-04
ATE226633T1 (de) 2002-11-15
DE69232832D1 (de) 2002-11-28
IL101728A (en) 2007-08-19
DE69232832T3 (de) 2008-02-28
IE921367A1 (en) 1992-11-04
EP0930366A2 (de) 1999-07-21
EP0930366B1 (de) 2008-06-04
AU675203B2 (en) 1997-01-30
EP0933082B1 (de) 2010-07-14
JP2011155979A (ja) 2011-08-18
ES2310933T3 (es) 2009-01-16
DE69233791D1 (de) 2010-08-26
ATE386116T1 (de) 2008-03-15
JP2008005843A (ja) 2008-01-17
CA2102208C (en) 2003-04-29

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