ATE227272T1 - Verfahren zur gewinnung von enantiomeren von cis- olirtin - Google Patents

Verfahren zur gewinnung von enantiomeren von cis- olirtin

Info

Publication number: ATE227272T1
Authority: AT; Austria
Prior art keywords: cis; olirtin; enantiomer; order; obtaining enantiomers
Prior art date: 1997-08-04

Application number

AT98935042T

Other languages

English (en)

Inventor

Antoni Torrens-Jover

Jordi Frigola-Constansa

Original Assignee

Esteve Labor Dr

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-04

Filing date

1998-07-31

Publication date

2002-11-15

1998-07-31 Application filed by Esteve Labor Dr filed Critical Esteve Labor Dr

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE227272T1 publication Critical patent/ATE227272T1/de

Links

238000000034 method Methods 0.000 title abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
150000002576 ketones Chemical class 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
WQMAANNAZKNUDL-UHFFFAOYSA-N 2-dimethylaminoethyl chloride Chemical compound CN(C)CCCl WQMAANNAZKNUDL-UHFFFAOYSA-N 0.000 abstract 1
ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
230000029936 alkylation Effects 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
229910052796 boron Inorganic materials 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

AT98935042T 1997-08-04 1998-07-31 Verfahren zur gewinnung von enantiomeren von cis- olirtin ATE227272T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ES009701728A ES2130083B1 (es)	1997-08-04	1997-08-04	Procedimiento para la obtencion de los enantiomeros de cizolirtina.
PCT/ES1998/000223 WO1999007684A1 (es)	1997-08-04	1998-07-31	Procedimiento para la obtencion de los enantiomeros de cizolirtina

Publications (1)

Publication Number	Publication Date
ATE227272T1 true ATE227272T1 (de)	2002-11-15

Family

ID=8300306

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98935042T ATE227272T1 (de)	1997-08-04	1998-07-31	Verfahren zur gewinnung von enantiomeren von cis- olirtin

Country Status (12)

Country	Link
US (1)	US6118009A (de)
EP (1)	EP1029852B1 (de)
JP (1)	JP2001512718A (de)
AT (1)	ATE227272T1 (de)
AU (1)	AU8442698A (de)
CA (1)	CA2299447C (de)
DE (1)	DE69809282T2 (de)
DK (1)	DK1029852T3 (de)
ES (2)	ES2130083B1 (de)
NO (1)	NO314499B1 (de)
PT (1)	PT1029852E (de)
WO (1)	WO1999007684A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20040142929A1 (en) *	2001-07-06	2004-07-22	Ramon Merce-Vidal	Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence
TW200533657A (en) *	2004-02-17	2005-10-16	Esteve Labor Dr	Substituted pyrazoline compounds, their preparation and use as medicaments
ES2244326B1 (es) *	2004-04-05	2007-02-16	Laboratorios Del Dr. Esteve, S.A.	Combinacion de substancias activas.
EP1584335A3 (de) *	2004-04-05	2006-02-22	Laboratorios Del Dr. Esteve, S.A.	Zusammensetzung aus Aktiva mit einer Carbinolverbindung und einem Opioid
EP1755678A2 (de) *	2004-04-05	2007-02-28	Laboratorios Del Dr. Esteve, S.A.	Zusammensetzung aus aktiva mit einer carbinolverbindung und einem opioid
US20060040924A1 (en) *	2004-06-22	2006-02-23	Laboratorios Dr. Esteve S.A.	Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic
EP1838678A1 (de) *	2004-12-17	2007-10-03	Laboratorios Del Dr. Esteve, S.A.	Verfahren zur gewinnung von cizolirtin und seinen enantiomeren
EP1671953A1 (de)	2004-12-17	2006-06-21	Laboratorios Del Dr. Esteve, S.A.	Verfahren zur Herstellung von Cizolirtine und dessen Enantiomeren
EP1671968A1 (de) *	2004-12-17	2006-06-21	Laboratorios Del Dr. Esteve, S.A.	Verfahren zur Herstellung von Enantiomeren von Thienylazolylalkoxyethanamines
EP1743890A1 (de) *	2005-07-15	2007-01-17	Laboratorios Del Dr. Esteve, S.A.	4,5-Dihydro-1H-Pyrazol-Derivative, Verfahren zur Herstellung und ihre Verwendung als Medikamente.
US7897589B2 (en) *	2005-07-15	2011-03-01	Laboratorios Del Dr. Esteve, S.A.	Substituted pyrazoline compounds, their preparation and use as medicaments
EP1757587A1 (de) *	2005-07-15	2007-02-28	Laboratorios Del Dr. Esteve, S.A.	Substituierte Pyrazolinderivate, ihre Herstellung und Verwendung als Arzneimittel
EP1743892A1 (de) *	2005-07-15	2007-01-17	Laboratorios del Dr. Esteve S.A.	Substituierte Pyrazolin Verbindungen, deren Herstellung und Verwendung als Medikament
EP1820502A1 (de)	2006-02-10	2007-08-22	Laboratorios Del Dr. Esteve, S.A.	Wirkstoffzusammensetzungen enthaltend Azolycarbinolderivate
EP2151234A1 (de) *	2008-07-28	2010-02-10	Laboratorios Del. Dr. Esteve, S.A.	Pharmazeutische Formulierung mit einer CB1-Rezeptorverbindung in einer festen Lösung und/oder festen Dispersion
WO2010123999A2 (en) *	2009-04-21	2010-10-28	Auspex Pharmaceuticals, Inc.	1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor
DE102010056283A1 (de)	2010-12-24	2012-06-28	Volkswagen Ag	Wärmeübertragungssystem
CN108558695A (zh) *	2018-05-15	2018-09-21	浙江华贝药业有限责任公司	2，2，2-三氟-n-[(1s，4s)-4-羟基四氢萘-1-基]-乙酰胺制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4943635A (en) *	1987-08-27	1990-07-24	President & Fellows Of Harvard College	Enantioselective reduction of ketones
DE69306945T2 (de) *	1992-05-14	1997-05-07	Pfizer	Enantioselektive katalysatoren aus oxazaborolidin
US5442118A (en) *	1994-04-22	1995-08-15	Sepracor, Inc.	Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones

1997
- 1997-08-04 ES ES009701728A patent/ES2130083B1/es not_active Expired - Fee Related
1998
- 1998-07-31 ES ES98935042T patent/ES2187044T3/es not_active Expired - Lifetime
- 1998-07-31 DE DE69809282T patent/DE69809282T2/de not_active Expired - Fee Related
- 1998-07-31 CA CA002299447A patent/CA2299447C/en not_active Expired - Fee Related
- 1998-07-31 DK DK98935042T patent/DK1029852T3/da active
- 1998-07-31 WO PCT/ES1998/000223 patent/WO1999007684A1/es not_active Ceased
- 1998-07-31 JP JP2000506188A patent/JP2001512718A/ja active Pending
- 1998-07-31 PT PT98935042T patent/PT1029852E/pt unknown
- 1998-07-31 AT AT98935042T patent/ATE227272T1/de not_active IP Right Cessation
- 1998-07-31 EP EP98935042A patent/EP1029852B1/de not_active Expired - Lifetime
- 1998-07-31 US US09/485,023 patent/US6118009A/en not_active Expired - Fee Related
- 1998-07-31 AU AU84426/98A patent/AU8442698A/en not_active Abandoned
2000
- 2000-02-03 NO NO20000560A patent/NO314499B1/no unknown

Also Published As

Publication number	Publication date
PT1029852E (pt)	2003-03-31
DK1029852T3 (da)	2003-02-24
US6118009A (en)	2000-09-12
ES2130083A1 (es)	1999-06-16
WO1999007684A1 (es)	1999-02-18
JP2001512718A (ja)	2001-08-28
CA2299447A1 (en)	1999-02-18
NO20000560L (no)	2000-03-29
NO20000560D0 (no)	2000-02-03
DE69809282D1 (de)	2002-12-12
CA2299447C (en)	2007-05-29
NO314499B1 (no)	2003-03-31
EP1029852A1 (de)	2000-08-23
ES2187044T3 (es)	2003-05-16
DE69809282T2 (de)	2003-09-11
AU8442698A (en)	1999-03-01
ES2130083B1 (es)	2000-01-16
EP1029852B1 (de)	2002-11-06

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2003-05-15

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