ATE227341T1 - Trimerisierende polypeptide, deren herstellung und verwendung - Google Patents

Trimerisierende polypeptide, deren herstellung und verwendung

Info

Publication number
ATE227341T1
ATE227341T1 AT95918689T AT95918689T ATE227341T1 AT E227341 T1 ATE227341 T1 AT E227341T1 AT 95918689 T AT95918689 T AT 95918689T AT 95918689 T AT95918689 T AT 95918689T AT E227341 T1 ATE227341 T1 AT E227341T1
Authority
AT
Austria
Prior art keywords
polypeptides
amino acid
amino acids
preparation
heterotrimerization
Prior art date
Application number
AT95918689T
Other languages
English (en)
Inventor
Hans-Juergen Hoppe
Kenneth Bannerman Reid
Original Assignee
Isis Innovation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovation filed Critical Isis Innovation
Application granted granted Critical
Publication of ATE227341T1 publication Critical patent/ATE227341T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT95918689T 1994-05-16 1995-05-16 Trimerisierende polypeptide, deren herstellung und verwendung ATE227341T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9409768A GB9409768D0 (en) 1994-05-16 1994-05-16 Trimerising polypeptides
PCT/GB1995/001104 WO1995031540A1 (en) 1994-05-16 1995-05-16 Trimerising polypeptides, their manufacture and use

Publications (1)

Publication Number Publication Date
ATE227341T1 true ATE227341T1 (de) 2002-11-15

Family

ID=10755201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95918689T ATE227341T1 (de) 1994-05-16 1995-05-16 Trimerisierende polypeptide, deren herstellung und verwendung

Country Status (12)

Country Link
US (1) US6190886B1 (de)
EP (1) EP0757720B1 (de)
JP (2) JPH10500298A (de)
AT (1) ATE227341T1 (de)
AU (1) AU2451995A (de)
CA (1) CA2190264A1 (de)
DE (1) DE69528761T2 (de)
DK (1) DK0757720T3 (de)
ES (1) ES2186718T3 (de)
GB (1) GB9409768D0 (de)
PT (1) PT757720E (de)
WO (1) WO1995031540A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
WO1998018943A1 (en) * 1996-10-28 1998-05-07 Novartis Ag Method for the oligomerisation of peptides
WO1998018918A1 (en) * 1996-10-29 1998-05-07 Commonwealth Scientific And Industrial Research Organisation Stable expression of triple helical proteins
EP1012280B1 (de) 1997-06-11 2004-11-10 Borean Pharma A/S Trimerisierendes modul
US7914814B2 (en) * 1997-09-17 2011-03-29 Strategic Science & Technologies, Llc Topical delivery of arginine of cause beneficial effects
EP1039931B1 (de) * 1997-12-01 2005-04-27 Fang Fang Multivalente rekombinante antikörper zur behandlung von hrv infektionen
US20030035798A1 (en) * 2000-08-16 2003-02-20 Fang Fang Humanized antibodies
US7300774B1 (en) 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
AU4770300A (en) * 1999-05-14 2000-12-05 Medical Research Council Protein scaffold and its use to multimerise monomeric polypeptides
JP4344136B2 (ja) 2000-11-10 2009-10-14 エフ・ホフマン−ラ・ロシュ・リミテッド アポリポタンパク質類似体
US20040115180A1 (en) * 2001-03-06 2004-06-17 Mustapha Abdelouahed Carrier chimeric proteins targeted carrier chimeric proteins and preparation thereof
WO2003062370A2 (en) 2001-07-19 2003-07-31 Perlan Therapeutics, Inc. Multimeric proteins and methods of making and using same
EP1440083B1 (de) 2001-10-25 2013-01-02 Medical Research Council Moleküle
PL208287B1 (pl) * 2001-12-21 2011-04-29 Immunex Corp Polipeptyd fuzyjny, sposób jego wytwarzania oraz kodujący go kwas nukleinowy, komórka gospodarza, rekombinowany wektor oraz sposób jego konstruowania
EP1558640B1 (de) 2002-10-29 2011-04-13 Anaphore, Inc. Trimer-proteine zur trimer-zytokine
WO2005037852A2 (en) * 2003-08-22 2005-04-28 Barnes-Jewish Hospital Trimerizing polypeptides and their uses
US7268116B2 (en) * 2003-10-02 2007-09-11 Genhunter Corp. Methods and compositions for producing secreted trimeric receptor analogs and biologically active fusion proteins
US8030448B2 (en) 2004-02-16 2011-10-04 Techno Network Shikoku Co., Ltd. Polypeptide having collagen-like structure
NZ555353A (en) 2004-11-22 2009-12-24 Anaphore Inc TNF antagonists
US7655439B2 (en) * 2005-09-09 2010-02-02 Zymogenetics, Inc. Trimerizing polypeptides
US10183986B2 (en) * 2005-12-15 2019-01-22 Industrial Technology Research Institute Trimeric collagen scaffold antibodies
US20070264687A1 (en) * 2005-12-15 2007-11-15 Min-Yuan Chou Recombinant triplex scaffold-based polypeptides
EP2674440B1 (de) 2005-12-16 2019-07-03 IBC Pharmaceuticals, Inc. Polyvalente bioaktive anordnungen auf immunglobulinbasis
CN103159857B (zh) * 2007-05-21 2014-11-05 财团法人工业技术研究院 以重组的三股螺旋支架为基础的复合物
ES2657801T3 (es) 2007-07-10 2018-03-06 Apogenix Ag Proteínas de fusión de colectina de la superfamilia de TNF
KR20100087344A (ko) 2007-10-29 2010-08-04 버지니아 테크 인터렉추얼 프라퍼티스, 인크. 돼지 ＤＣ-ＳＩＧＮ, ＩＣＡＭ－３ 및 ＬＳＥＣｔｉｎ 및 이의 용도
DK2294202T3 (en) 2008-07-08 2015-08-31 Medicago Inc SOLUBLE RECOMBINANT INFLUENZA ANTIGENES
WO2010042890A2 (en) 2008-10-10 2010-04-15 Anaphore, Inc. Polypeptides that bind trail-ri and trail-r2
CN106243229B (zh) * 2008-12-22 2019-09-06 国立大学法人北海道大学 具有三螺旋结构的蛋白质物质及其制造方法
ES2593049T3 (es) * 2009-01-09 2016-12-05 Apogenix Ag Proteínas de fusión que forman trímeros
WO2010122181A1 (es) * 2009-04-20 2010-10-28 Universidad Autónoma de Madrid Proteínas oligoméricas y sus aplicaciones
JP2013507124A (ja) * 2009-10-09 2013-03-04 アナフォア インコーポレイテッド Ｉｌ−２３ｒを結合するポリペプチド
US20110086806A1 (en) * 2009-10-09 2011-04-14 Anaphore, Inc. Polypeptides that Bind IL-23R
PL2970427T3 (pl) 2013-03-15 2020-06-01 Geoffrey W. STONE Kompozycja składająca się z antygenu związanego z ligandem z nadrodziny TNF
JP2014218510A (ja) * 2014-08-11 2014-11-20 アポゲニクスゲゼルシャフト ミット ベシュレンクテルハフツングＡｐｏｇｅｎｉｘ ＧｍｂＨ 三量体形成融合タンパク質
CN108431027B (zh) 2015-11-13 2022-07-22 思百博技术股份公司 电荷逆转的n端蜘蛛丝蛋白结构域及其用途
GB201522610D0 (en) * 2015-12-22 2016-02-03 Univ Southampton Protein
JP2016210791A (ja) * 2016-08-03 2016-12-15 アポゲニクス アーゲー 三量体形成融合タンパク質
US11377490B2 (en) 2017-05-31 2022-07-05 Sichuan Clover Biopharmaceuticals, Inc Method for treating cancer using disulfide-linked trimeric 4-1BBL
WO2021249116A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Coronavirus vaccine compositions, methods, and uses thereof
WO2021249011A1 (en) 2020-06-10 2021-12-16 Sichuan Clover Biopharmaceuticals, Inc. Hiv vaccine compositions, methods, and uses thereof
WO2022041760A1 (en) 2020-08-31 2022-03-03 Sichuan Clover Biopharmaceuticals, Inc. Methods and compositions for purification of trimeric fusion proteins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins

Also Published As

Publication number Publication date
JP3836865B2 (ja) 2006-10-25
PT757720E (pt) 2003-03-31
EP0757720B1 (de) 2002-11-06
GB9409768D0 (en) 1994-07-06
DK0757720T3 (da) 2003-03-17
ES2186718T3 (es) 2003-05-16
DE69528761T2 (de) 2003-07-17
JPH10500298A (ja) 1998-01-13
JP2005328851A (ja) 2005-12-02
US6190886B1 (en) 2001-02-20
WO1995031540A1 (en) 1995-11-23
DE69528761D1 (de) 2002-12-12
CA2190264A1 (en) 1995-11-23
AU2451995A (en) 1995-12-05
EP0757720A1 (de) 1997-02-12

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