ATE227726T1 - Thienopyrimidinderivate als endothelin antagonisten - Google Patents

Thienopyrimidinderivate als endothelin antagonisten

Info

Publication number: ATE227726T1
Authority: AT; Austria
Prior art keywords: group; prophylactic; substituted; denotes; formula
Prior art date: 1995-08-17

Application number

AT96926638T

Other languages

English (en)

Inventor

Shuichi Furuya

Nobuo Choh

Toshifumi Watanabe

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-08-17

Filing date

1996-08-13

Publication date

2002-11-15

1996-08-13 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2002-11-15 Application granted granted Critical

2002-11-15 Publication of ATE227726T1 publication Critical patent/ATE227726T1/de

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
229940043274 prophylactic drug Drugs 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
206010002383 Angina Pectoris Diseases 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
210000000056 organ Anatomy 0.000 abstract 2
230000000069 prophylactic effect Effects 0.000 abstract 2
229940126585 therapeutic drug Drugs 0.000 abstract 2
230000002792 vascular Effects 0.000 abstract 2
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
208000009304 Acute Kidney Injury Diseases 0.000 abstract 1
201000001320 Atherosclerosis Diseases 0.000 abstract 1
125000005915 C6-C14 aryl group Chemical group 0.000 abstract 1
206010007558 Cardiac failure chronic Diseases 0.000 abstract 1
229940118365 Endothelin receptor antagonist Drugs 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
206010020772 Hypertension Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000003782 Raynaud disease Diseases 0.000 abstract 1
208000012322 Raynaud phenomenon Diseases 0.000 abstract 1
208000033626 Renal failure acute Diseases 0.000 abstract 1
208000032450 Surgical Shock Diseases 0.000 abstract 1
206010047139 Vasoconstriction Diseases 0.000 abstract 1
201000011040 acute kidney failure Diseases 0.000 abstract 1
208000012998 acute renal failure Diseases 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
208000006673 asthma Diseases 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
206010008118 cerebral infarction Diseases 0.000 abstract 1
208000026106 cerebrovascular disease Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000007887 coronary angioplasty Methods 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000002308 endothelin receptor antagonist Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
208000017169 kidney disease Diseases 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
208000010125 myocardial infarction Diseases 0.000 abstract 1
230000002685 pulmonary effect Effects 0.000 abstract 1
208000002815 pulmonary hypertension Diseases 0.000 abstract 1
208000037803 restenosis Diseases 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
206010040560 shock Diseases 0.000 abstract 1
125000006850 spacer group Chemical group 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
RBNBDIMXFJYDLQ-UHFFFAOYSA-N thieno[3,2-d]pyrimidine Chemical class C1=NC=C2SC=CC2=N1 RBNBDIMXFJYDLQ-UHFFFAOYSA-N 0.000 abstract 1
230000025033 vasoconstriction Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT96926638T 1995-08-17 1996-08-13 Thienopyrimidinderivate als endothelin antagonisten ATE227726T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP20949895		1995-08-17
PCT/JP1996/002290 WO1997007119A1 (en)	1994-08-26	1996-08-13	Thienopyrimidine derivatives, their production and use

Publications (1)

Publication Number	Publication Date
ATE227726T1 true ATE227726T1 (de)	2002-11-15

Family

ID=16573808

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96926638T ATE227726T1 (de)	1995-08-17	1996-08-13	Thienopyrimidinderivate als endothelin antagonisten

Country Status (6)

Country	Link
EP (1)	EP0846119B1 (de)
AT (1)	ATE227726T1 (de)
AU (1)	AU6670196A (de)
CA (1)	CA2227384A1 (de)
DE (1)	DE69624829T2 (de)
WO (1)	WO1997007119A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1280806B1 (de) *	2000-05-04	2004-08-04	AstraZeneca AB	THIENO[2,3-d]PYRIMIDINDIONE UND IHRE VERWENDUNG ALS PHARMAZEUTISCHE MITTEL
GB201105659D0 (en)	2011-04-01	2011-05-18	Xention Ltd	Compounds
RS57157B1 (sr)	2011-11-11	2018-07-31	Gilead Apollo Llc	Acc inhibitori i njihove primene
AR106472A1 (es)	2015-10-26	2018-01-17	Gilead Apollo Llc	Inhibidores de acc y usos de los mismos
PL3380479T3 (pl)	2015-11-25	2023-05-08	Gilead Apollo, Llc	Triazolowe inhibitory acc i ich zastosowania
AU2016361412A1 (en)	2015-11-25	2018-05-24	Gilead Apollo, Llc	Pyrazole ACC inhibitors and uses thereof
EA201890949A1 (ru)	2015-11-25	2018-12-28	Джилид Аполло, Ллс	СЛОЖНОЭФИРНЫЕ ИНГИБИТОРЫ АЦЕТИЛ-КоА-КАРБОКСИЛАЗЫ И ВАРИАНТЫ ИХ ПРИМЕНЕНИЯ
BR112018009212B1 (pt)	2015-11-25	2022-06-14	Gilead Apollo, Llc	Método para controlar patógenos fúngicos agrícolas
SG11201807077RA (en)	2016-03-02	2018-09-27	Gilead Apollo Llc	Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
SI4122464T1 (sl)	2017-03-28	2024-07-31	Gilead Sciences, Inc.	Terapevtske kombinacije za zdravljenje bolezni jeter

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUT67665A (en) *	1991-11-05	1995-04-28	Smithkline Beckman Corp	Indane and indene deriv.s as endothelin receptor antagonists, pharmaceutical compn.s contg. them and process for prepg. them
TW276256B (de) *	1993-08-26	1996-05-21	Takeda Pharm Industry Co Ltd

1996
- 1996-08-13 EP EP96926638A patent/EP0846119B1/de not_active Expired - Lifetime
- 1996-08-13 AU AU66701/96A patent/AU6670196A/en not_active Abandoned
- 1996-08-13 AT AT96926638T patent/ATE227726T1/de not_active IP Right Cessation
- 1996-08-13 WO PCT/JP1996/002290 patent/WO1997007119A1/en not_active Ceased
- 1996-08-13 DE DE69624829T patent/DE69624829T2/de not_active Expired - Fee Related
- 1996-08-13 CA CA002227384A patent/CA2227384A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO1997007119A1 (en)	1997-02-27
DE69624829T2 (de)	2003-07-31
EP0846119A1 (de)	1998-06-10
CA2227384A1 (en)	1997-02-27
AU6670196A (en)	1997-03-12
DE69624829D1 (de)	2002-12-19
EP0846119B1 (de)	2002-11-13

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Legal Events

Date	Code	Title	Description
2003-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties