ATE228003T1 - Verwendung von cntf (ciliary neurotrophic factor) rezeptoraktivatoren fur behandlung von fettleibigkeit - Google Patents
Verwendung von cntf (ciliary neurotrophic factor) rezeptoraktivatoren fur behandlung von fettleibigkeitInfo
- Publication number
- ATE228003T1 ATE228003T1 AT97946043T AT97946043T ATE228003T1 AT E228003 T1 ATE228003 T1 AT E228003T1 AT 97946043 T AT97946043 T AT 97946043T AT 97946043 T AT97946043 T AT 97946043T AT E228003 T1 ATE228003 T1 AT E228003T1
- Authority
- AT
- Austria
- Prior art keywords
- obesity
- cntf
- treatment
- neurotrophic factor
- ciliary neurotrophic
- Prior art date
Links
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 title 2
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 title 2
- 208000008589 Obesity Diseases 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
- 108091006084 receptor activators Proteins 0.000 title 1
- 239000000883 anti-obesity agent Substances 0.000 abstract 1
- 229940125710 antiobesity agent Drugs 0.000 abstract 1
- 230000001886 ciliary effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96RM000790A IT1288388B1 (it) | 1996-11-19 | 1996-11-19 | Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia |
| PCT/IT1997/000283 WO1998022128A1 (en) | 1996-11-19 | 1997-11-18 | Use of cntf (ciliary neurotrophic factor) receptor activators for the treatment of obesity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE228003T1 true ATE228003T1 (de) | 2002-12-15 |
Family
ID=11404538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97946043T ATE228003T1 (de) | 1996-11-19 | 1997-11-18 | Verwendung von cntf (ciliary neurotrophic factor) rezeptoraktivatoren fur behandlung von fettleibigkeit |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US6565869B1 (de) |
| EP (1) | EP0946189B1 (de) |
| JP (1) | JP4067127B2 (de) |
| CN (2) | CN102145163B (de) |
| AT (1) | ATE228003T1 (de) |
| AU (1) | AU727174B2 (de) |
| CA (1) | CA2271781C (de) |
| DE (1) | DE69717308T2 (de) |
| DK (1) | DK0946189T3 (de) |
| ES (1) | ES2187830T3 (de) |
| IL (2) | IL129968A0 (de) |
| IT (1) | IT1288388B1 (de) |
| PT (1) | PT946189E (de) |
| WO (1) | WO1998022128A1 (de) |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6472178B1 (en) | 1998-02-27 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof |
| IT1288388B1 (it) | 1996-11-19 | 1998-09-22 | Angeletti P Ist Richerche Bio | Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia |
| AU718500B2 (en) | 1997-01-23 | 2000-04-13 | Sumitomo Pharmaceuticals Company, Limited | Remedies for diabetes |
| IT1291114B1 (it) | 1997-03-20 | 1998-12-29 | Angeletti P Ist Richerche Bio | Varianti del fattore neurotrofico ciliare (cntf) con migliorata selettivita' al recettore, e metodo per la loro selezione |
| US6680291B1 (en) | 1998-02-27 | 2004-01-20 | Regeneron Pharmaceuticals, Inc. | Modified ciliary neurotrophic factor, method of making and methods of use thereof |
| CA2368431C (en) | 1999-03-29 | 2006-01-24 | The Procter & Gamble Company | Melanocortin receptor ligands |
| AU4651900A (en) * | 1999-04-20 | 2000-11-02 | Beth Israel Deaconess Medical Center | Methods and compositions for modulating ciliary neurotrophic factor activity |
| IL132312A0 (en) * | 1999-09-05 | 2001-03-19 | Yeda Res & Dev | Use of leptin in inhibition of endothelial cell proliferation |
| AU2001230587A1 (en) * | 2000-02-18 | 2001-08-27 | Sumitomo Pharmaceuticals Company, Limited | Drugs for ameliorating impaired glucose tolerance |
| US20030036512A1 (en) * | 2000-03-06 | 2003-02-20 | Tsutomu Nakagawa | Leptin-resistance amerliorating agents |
| EP1365785A2 (de) * | 2000-05-24 | 2003-12-03 | Regeneron Pharmaceuticals, Inc. | Verwendung von ciliary neurotrophic factor |
| AU2001267058A1 (en) * | 2000-06-09 | 2001-12-17 | University Of Florida Research Foundation, Inc. | Aav vector-based compositions and therapeutic uses thereof |
| JP2004529629A (ja) * | 2001-03-02 | 2004-09-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 低減された免疫原性を有する修飾された繊毛様神経栄養因子(cntf) |
| US7105526B2 (en) | 2002-06-28 | 2006-09-12 | Banyu Pharmaceuticals Co., Ltd. | Benzimidazole derivatives |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20050064555A1 (en) * | 2003-07-09 | 2005-03-24 | Xencor, Inc. | Ciliary neurotrophic factor variants |
| ATE547404T1 (de) | 2003-09-22 | 2012-03-15 | Msd Kk | Piperidinderivate |
| EP1734963A4 (de) | 2004-04-02 | 2008-06-18 | Merck & Co Inc | Verfahren zur behandlung von menschen mit metabolischen und anthropometrischen störungen |
| US7279282B2 (en) * | 2004-07-09 | 2007-10-09 | Scott Mellis | Methods for identifying a candidate for treatment of obesity |
| US8394765B2 (en) | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| CN101094689B (zh) † | 2004-11-01 | 2013-06-12 | 安米林药品有限责任公司 | 治疗肥胖以及肥胖相关疾病和病症的方法 |
| US7737155B2 (en) | 2005-05-17 | 2010-06-15 | Schering Corporation | Nitrogen-containing heterocyclic compounds and methods of use thereof |
| BRPI0610580B8 (pt) | 2005-05-30 | 2021-05-25 | Banyu Pharma Co Ltd | composto derivado de piperidina |
| JPWO2007018248A1 (ja) | 2005-08-10 | 2009-02-19 | 萬有製薬株式会社 | ピリドン化合物 |
| WO2007024004A1 (ja) | 2005-08-24 | 2007-03-01 | Banyu Pharmaceutical Co., Ltd. | フェニルピリドン誘導体 |
| WO2007029847A1 (ja) | 2005-09-07 | 2007-03-15 | Banyu Pharmaceutical Co., Ltd. | 二環性芳香族置換ピリドン誘導体 |
| EP1940842B1 (de) | 2005-09-29 | 2012-05-30 | Merck Sharp & Dohme Corp. | Acylierte spiropiperidinderivate als modulatoren des melanocortin-4-rezeptors |
| JP2009512715A (ja) | 2005-10-21 | 2009-03-26 | ノバルティス アクチエンゲゼルシャフト | レニン阻害剤と抗異脂肪血症剤および/または抗肥満症剤の組み合わせ |
| EP1944301A4 (de) | 2005-10-27 | 2012-01-04 | Msd Kk | Neue benzoxathiinderivate |
| ES2381205T3 (es) | 2005-11-10 | 2012-05-24 | Msd K.K. | Derivado espiro aza-sustituido |
| US8173629B2 (en) | 2006-09-22 | 2012-05-08 | Merck Sharp & Dohme Corp. | Method of treatment using fatty acid synthesis inhibitors |
| US20090247560A1 (en) | 2006-09-28 | 2009-10-01 | Banyu Pharmaceutical Co., Ltd. | Diaryl ketimine derivative |
| JP5319518B2 (ja) | 2007-04-02 | 2013-10-16 | Msd株式会社 | インドールジオン誘導体 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| EP2264026A4 (de) | 2008-03-06 | 2012-03-28 | Msd Kk | Alkylaminopyridinderivate |
| WO2009119726A1 (ja) | 2008-03-28 | 2009-10-01 | 萬有製薬株式会社 | メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体 |
| ES2522968T3 (es) | 2008-06-04 | 2014-11-19 | Synergy Pharmaceuticals Inc. | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| JPWO2009154132A1 (ja) | 2008-06-19 | 2011-12-01 | Msd株式会社 | スピロジアミン−ジアリールケトオキシム誘導体 |
| AU2009270833B2 (en) | 2008-07-16 | 2015-02-19 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| EP2319841A1 (de) | 2008-07-30 | 2011-05-11 | Msd K.K. | (5-gliedriges)-(5-gliedriges) oder (5-gliedriges)-(6-gliedriges) kondensiertes ringcycloalkylaminderivat |
| EP2348857B1 (de) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Neue cyclische benzimidazolderivate als antidiabetika |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2379547A1 (de) | 2008-12-16 | 2011-10-26 | Schering Corporation | Pyridopyrimidinderivate und verfahren zu deren anwendung |
| US20110243940A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Bicyclic pyranone derivatives and methods of use thereof |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| SG192941A1 (en) | 2011-02-25 | 2013-09-30 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| RU2015106909A (ru) | 2012-08-02 | 2016-09-27 | Мерк Шарп И Доум Корп. | Антидиабетические трициклические соединения |
| KR20150118158A (ko) | 2013-02-22 | 2015-10-21 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 비시클릭 화합물 |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| AU2014235215A1 (en) | 2013-03-15 | 2015-10-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| CN104558148B (zh) * | 2013-10-17 | 2018-11-06 | 北京生物制品研究所有限责任公司 | 睫状神经营养因子突变体及其修饰型突变体和用途 |
| KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
| CN107073077B (zh) * | 2014-11-07 | 2020-12-01 | 陕西麦科奥特科技有限公司 | 睫状神经营养因子鼻腔给药系统及其制备方法和应用 |
| CN106632650B (zh) * | 2015-10-30 | 2020-11-13 | 北京生物制品研究所有限责任公司 | 睫状神经营养因子突变体及其修饰型突变体和应用 |
| WO2018069532A1 (en) | 2016-10-14 | 2018-04-19 | Tes Pharma S.R.L. | Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase |
| US11072602B2 (en) | 2016-12-06 | 2021-07-27 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| EP3558298B1 (de) | 2016-12-20 | 2026-03-11 | Merck Sharp & Dohme LLC | Antidiabetische spirochromanverbindungen |
| WO2018128745A1 (en) * | 2017-01-06 | 2018-07-12 | The Board Of Trustees Of The Leland Stanford Junior University | Ciliary neurotrophic factor receptor ligands and methods of using the same |
| SG11202005146VA (en) * | 2017-12-18 | 2020-06-29 | Regeneron Pharma | Bispecific antigen binding molecules that bind leptin receptor and/or gp130, and methods of use thereof |
| PT3773713T (pt) | 2018-04-06 | 2025-07-29 | Regeneron Pharma | Anticorpo agonista do recetor de leptina para usar no aumento da massa óssea num sujeito que sofre de disfunção metabólica ou de hipoleptinemia |
| WO2019246141A1 (en) * | 2018-06-19 | 2019-12-26 | Cella Therapeutics, Llc | DRUG DELIVERY SYSTEMS COMPRISING A NEUROTROPHIC AGENT, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR (FAS) OR FAS LIGAND (FASL) INHIBITOR, A TUMOR NECROSIS FACTOR-α (TNF-α) OR TNF RECEPTOR INHIBITOR, A MITOCHONDRIAL PEPTIDE, AN OLIGONUCLEOTIDE, A CHEMOKINE INHIBITOR, OR A CYSTEINE-ASPARTIC PROTEASE |
| CN112566622A (zh) * | 2018-06-19 | 2021-03-26 | 细胞疗法有限责任公司 | 用于治疗青光眼或高眼压症的包含眼内压降低剂、cnp化合物、npr-b化合物、tie-2激动剂或神经营养剂的缓释药物递送系统 |
| WO2020023621A1 (en) * | 2018-07-24 | 2020-01-30 | Puneeth Iyengar | Improved weight loss therapy |
| AR117122A1 (es) | 2018-11-20 | 2021-07-14 | Tes Pharma S R L | INHIBIDORES DE LA ÁCIDO a-AMINO-b-CARBOXIMUCÓNICO SEMIALDEHÍDO DESCARBOXILASA |
| US20230094423A1 (en) * | 2019-12-18 | 2023-03-30 | Cella Therapeutics, Llc | Drug delivery systems comprising a neurotrophic agent, an apoptosis signaling fragment inhibitor (fas) or fas ligand (fasl) inhibitor, a tumor necrosis factor-alpha (tnf-alpha) or tnf receptor inhibitor, a mitochondrial peptide, an oligonucleotide, a chemokine inhibitor, or a cysteine-aspartic protease inhibitor |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166317A (en) | 1988-10-31 | 1992-11-24 | Houston Biotechnology Incorporated | Neurotrophic factor |
| US5011914A (en) | 1989-01-05 | 1991-04-30 | Collins Franklin D | Purified ciliary neurotrophic factor |
| US5141856A (en) | 1989-01-05 | 1992-08-25 | Synergen, Inc. | Expression of purified ciliary neurotrophic factor |
| US4997929A (en) | 1989-01-05 | 1991-03-05 | Synergen, Inc. | Purified ciliary neurotrophic factor |
| IE903130A1 (en) | 1989-09-15 | 1991-03-27 | Regeneron Pharma | Ciliary neurotrophic factor |
| US5426177A (en) | 1990-06-01 | 1995-06-20 | Regeneron Pharmaceuticals, Inc. | Ciliary neurotrophic factor receptor |
| CS156891A3 (en) | 1990-06-01 | 1992-04-15 | Regeneron Pharma | Receptor of a cilary neurotropic factor |
| CN1061623A (zh) | 1990-06-01 | 1992-06-03 | 里珍纳龙药品有限公司 | 睫状神经营养性因子受体 |
| US5691313A (en) | 1991-07-23 | 1997-11-25 | Amgen Inc. | Methods of treating impotency with ciliary neurotrophic factor |
| WO1993002206A1 (en) | 1991-07-23 | 1993-02-04 | Syntex-Synergen Neuroscience Joint Venture | Purification of recombinant ciliary neurotrophic factor and c-terminal truncated ciliary neurotrophic factor and methods for treating peripheral nerve damage |
| US5593857A (en) | 1991-08-23 | 1997-01-14 | Scios Inc. | Production of homogeneous truncated CNTF |
| EP0668911A1 (de) | 1991-11-11 | 1995-08-30 | FIDIA S.p.A. | Synthese und reinigung von unvollständigen und mutierten formen des humanen ciliaren neurotrophen faktors |
| US5955290A (en) | 1991-12-02 | 1999-09-21 | Regeneron Pharmaceuticals, Inc. | Assay systems using the CNTF signal transduction pathway |
| US5349056A (en) | 1992-10-09 | 1994-09-20 | Regeneron Pharmaceuticals | Modified ciliary neurotrophic factors |
| US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
| US6143714A (en) | 1994-10-24 | 2000-11-07 | Regeneron Pharmaceuticals, Inc. | Methods of using hepatocyte growth factor to promote survival, growth and differentiation of motor neurons |
| IT1284867B1 (it) * | 1996-07-10 | 1998-05-22 | Angeletti P Ist Richerche Bio | Varianti del fattore neurotrofico ciliare umano (hcntf) con uno spettro di azione differente dalla molecola di tipo selvatico |
| IT1288388B1 (it) | 1996-11-19 | 1998-09-22 | Angeletti P Ist Richerche Bio | Uso di sostanze che attivano il recettore del cntf ( fattore neurotrofico ciliare) per la preparazione di farmaci per la terapia |
-
1996
- 1996-11-19 IT IT96RM000790A patent/IT1288388B1/it active IP Right Grant
-
1997
- 1997-11-18 AU AU51344/98A patent/AU727174B2/en not_active Expired
- 1997-11-18 EP EP97946043A patent/EP0946189B1/de not_active Expired - Lifetime
- 1997-11-18 US US09/308,368 patent/US6565869B1/en not_active Expired - Lifetime
- 1997-11-18 CN CN201010282598XA patent/CN102145163B/zh not_active Expired - Lifetime
- 1997-11-18 ES ES97946043T patent/ES2187830T3/es not_active Expired - Lifetime
- 1997-11-18 WO PCT/IT1997/000283 patent/WO1998022128A1/en not_active Ceased
- 1997-11-18 JP JP52343398A patent/JP4067127B2/ja not_active Expired - Lifetime
- 1997-11-18 PT PT97946043T patent/PT946189E/pt unknown
- 1997-11-18 CN CN2009102210662A patent/CN101703761B/zh not_active Expired - Lifetime
- 1997-11-18 DK DK97946043T patent/DK0946189T3/da active
- 1997-11-18 AT AT97946043T patent/ATE228003T1/de active
- 1997-11-18 CA CA002271781A patent/CA2271781C/en not_active Expired - Lifetime
- 1997-11-18 DE DE69717308T patent/DE69717308T2/de not_active Expired - Lifetime
- 1997-11-18 IL IL12996897A patent/IL129968A0/xx unknown
-
2003
- 2003-01-31 US US10/356,191 patent/US6960558B2/en not_active Expired - Lifetime
-
2005
- 2005-07-26 IL IL12996805A patent/IL129968A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT946189E (pt) | 2003-02-28 |
| ITRM960790A0 (it) | 1996-11-19 |
| IL129968A (en) | 2005-11-20 |
| US6960558B2 (en) | 2005-11-01 |
| EP0946189A1 (de) | 1999-10-06 |
| US20030176346A1 (en) | 2003-09-18 |
| CN102145163A (zh) | 2011-08-10 |
| JP2000511561A (ja) | 2000-09-05 |
| WO1998022128A1 (en) | 1998-05-28 |
| CN102145163B (zh) | 2013-09-18 |
| ES2187830T3 (es) | 2003-06-16 |
| IT1288388B1 (it) | 1998-09-22 |
| EP0946189B1 (de) | 2002-11-20 |
| CN101703761B (zh) | 2013-11-20 |
| US6565869B1 (en) | 2003-05-20 |
| AU727174B2 (en) | 2000-12-07 |
| ITRM960790A1 (it) | 1998-05-19 |
| DK0946189T3 (da) | 2002-12-16 |
| CA2271781A1 (en) | 1998-05-28 |
| DE69717308D1 (de) | 2003-01-02 |
| DE69717308T2 (de) | 2003-07-10 |
| CN101703761A (zh) | 2010-05-12 |
| AU5134498A (en) | 1998-06-10 |
| CA2271781C (en) | 2002-11-12 |
| JP4067127B2 (ja) | 2008-03-26 |
| IL129968A0 (en) | 2000-02-29 |
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