ATE228837T1 - Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden - Google Patents

Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden

Info

Publication number: ATE228837T1
Authority: AT; Austria
Prior art keywords: group; cyclopropylpyrroloindole; oligopeptides; cancer agent; novel
Prior art date: 1995-01-31

Application number

AT96906176T

Other languages

English (en)

Inventor

J William Lown

Yuqiang Wang

Weide Luo

Original Assignee

Univ Alberta

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-31

Filing date

1996-01-31

Publication date

2002-12-15

1996-01-31 Application filed by Univ Alberta filed Critical Univ Alberta

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE228837T1 publication Critical patent/ATE228837T1/de

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
ANDCDPBTSFSYLB-UHFFFAOYSA-N 2-cyclopropylpyrrolo[2,3-e]indole Chemical compound C1CC1C(C=C1C=C2)=NC1=C1C2=NC=C1 ANDCDPBTSFSYLB-UHFFFAOYSA-N 0.000 title 1
102000015636 Oligopeptides Human genes 0.000 title 1
108010038807 Oligopeptides Proteins 0.000 title 1
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 2
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical class S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 abstract 1
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 abstract 1
150000001409 amidines Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
150000003865 secondary ammonium salts Chemical class 0.000 abstract 1
150000003866 tertiary ammonium salts Chemical class 0.000 abstract 1
229930192474 thiophene Natural products 0.000 abstract 1
150000003852 triazoles Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT96906176T 1995-01-31 1996-01-31 Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden ATE228837T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/381,355 US5502068A (en)	1995-01-31	1995-01-31	Cyclopropylpyrroloindole-oligopeptide anticancer agents
PCT/US1996/000727 WO1996023497A1 (en)	1995-01-31	1996-01-31	Cyclopropylpyrroloindole-oligopeptide anticancer agents

Publications (1)

Publication Number	Publication Date
ATE228837T1 true ATE228837T1 (de)	2002-12-15

Family

ID=23504694

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96906176T ATE228837T1 (de)	1995-01-31	1996-01-31	Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden

Country Status (8)

Country	Link
US (1)	US5502068A (de)
EP (1)	EP0800390B1 (de)
JP (1)	JPH11500427A (de)
AT (1)	ATE228837T1 (de)
AU (1)	AU698001B2 (de)
CA (1)	CA2210093A1 (de)
DE (1)	DE69625175T2 (de)
WO (1)	WO1996023497A1 (de)

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US6015895A (en) *	1995-12-22	2000-01-18	University Technologies International Inc.	Linker arm for solid support oligonucleotide synthesis and process for production thereof
US5659022A (en) *	1996-01-05	1997-08-19	Epoch Pharmaceuticals, Inc.	Oligonucleotide-cyclopropapyrroloindole conjugates as sequence specific hybridization and crosslinking agents for nucleic acids
US5843937A (en) *	1996-05-23	1998-12-01	Panorama Research, Inc.	DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
GB9818730D0 (en)	1998-08-27	1998-10-21	Univ Portsmouth	Collections of compounds
PT1109812E (pt)	1998-08-27	2005-09-30	Spirogen Ltd	Pirrolobenzodiazepinas
JP3649617B2 (ja) *	1999-03-26	2005-05-18	独立行政法人科学技術振興機構	２本鎖ｄｎａを切断できる化合物及びその使用方法
US6559125B1 (en)	2000-01-28	2003-05-06	California Institute Of Technology	Polyamide-alkylator conjugates and related products and method
US7078536B2 (en) *	2001-03-14	2006-07-18	Genesoft Pharmaceuticals, Inc.	Charged compounds comprising a nucleic acid binding moiety and uses therefor
KR20030043785A (ko)	2000-03-16	2003-06-02	젠소프트, 인크.	핵산 결합 부위를 포함하는 하전된 화합물 및 이의 용도
JP4061819B2 (ja) *	2000-05-12	2008-03-19	独立行政法人科学技術振興機構	インターストランドクロスリンク剤の合成方法
BR0112030A (pt) *	2000-06-27	2003-04-29	Genelabs Tech Inc	Novos compostos que possuem atividade antibacteriana, antifúngica ou antitumor
US7122626B2 (en) *	2001-04-26	2006-10-17	Genesoft Pharmceuticals, Inc.	Halogen-substitued thienyl compounds
US7064218B2 (en) *	2001-12-26	2006-06-20	Genelabs Technologies, Inc.	Aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity
AU2003258022A1 (en)	2002-08-02	2004-02-23	Genesoft Pharmaceuticals, Inc.	Biaryl compounds having anti-infective activity
WO2004039318A2 (en) *	2002-10-25	2004-05-13	Genesoft Pharmaceuticals, Inc.	Anti-infective biaryl compounds
GB0226593D0 (en)	2002-11-14	2002-12-24	Consultants Ltd	Compounds
CA2508769A1 (en)	2002-12-10	2004-06-24	Oscient Pharmaceuticals Corporation	Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif
WO2005012256A1 (en)	2003-07-22	2005-02-10	Astex Therapeutics Limited	3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators
GB0321295D0 (en)	2003-09-11	2003-10-15	Spirogen Ltd	Synthesis of protected pyrrolobenzodiazepines
AU2005221959C1 (en) *	2004-03-13	2010-06-17	Kyoto University	Novel indole derivative for alkylating specific base sequence of DNA and alkylating agent and drug each comprising the same
AR052559A1 (es) *	2005-01-21	2007-03-21	Astex Therapeutics Ltd	Derivados de pirazol para inhibir cdk's y gsk's
AR054425A1 (es) *	2005-01-21	2007-06-27	Astex Therapeutics Ltd	Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US8404718B2 (en)	2005-01-21	2013-03-26	Astex Therapeutics Limited	Combinations of pyrazole kinase inhibitors
US20080161251A1 (en) *	2005-01-21	2008-07-03	Astex Therapeutics Limited	Pharmaceutical Compounds
US20080161355A1 (en) *	2005-01-21	2008-07-03	Astex Therapeutics Limited	Combinations of Pyrazole Kinase Inhibitors and Further Antitumor Agents
US20080139620A1 (en) *	2005-01-21	2008-06-12	Astex Therapeutics Limited	Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's
CA2594477C (en) *	2005-01-21	2016-07-12	Astex Therapeutics Limited	Pharmaceutical compounds
WO2006093271A1 (ja) *	2005-03-03	2006-09-08	Mitsubishi Rayon Co., Ltd.	ポリマー粒子、これを含む樹脂組成物、成形体
EP2027109A1 (de) *	2006-05-05	2009-02-25	Astex Therapeutics Limited	4-(2,6-dichlorbenzoylamino)-1h-pyrazol-s-carbonsäure-(1-methansulfonylpiperidin-4-yl)amid zur behandlung von krebs
JP2009536186A (ja) *	2006-05-08	2009-10-08	アステックス・セラピューティクス・リミテッド	癌処置のためのジアゾール誘導体の医薬組合せ
EP2049516A2 (de) *	2006-07-14	2009-04-22	Astex Therapeutics Limited	Pharmazeutische verbindungen
US9901567B2 (en)	2007-08-01	2018-02-27	Syntarga B.V.	Substituted CC-1065 analogs and their conjugates
MX2011004625A (es) *	2008-11-03	2011-07-20	Syntarga Bv	Analogos cc-1065 novedosos y sus conjugados.
CA2956934C (en)	2010-04-21	2019-07-09	Syntarga B.V.	Novel conjugates of cc-1065 analogs and bifunctional linkers
MX368396B (es)	2014-01-10	2019-10-01	Synthon Biopharmaceuticals Bv	Conjugados de anticuerpo-farmaco (adc) de duocarmicina que muestran actividad antitumoral in vivo mejorada.
HRP20160797T1 (hr)	2014-01-10	2016-08-12	Synthon Biopharmaceuticals B.V.	Duokarmicin adsc, namijenjen upotrebi u liječenju raka endometrija
AU2015205574B2 (en)	2014-01-10	2019-08-15	Byondis B.V.	Method for purifying Cys-linked antibody-drug conjugates

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US4978757A (en) *	1984-02-21	1990-12-18	The Upjohn Company	1,2,8,8a-tetrahydrocyclopropa (C) pyrrolo [3,2-e)]-indol-4(5H)-ones and related compounds
CA1308516C (en) *	1987-07-06	1992-10-06	The Governors Of The University Of Alberta	Oligopeptide anticancer and antiviral agents
JP3380237B2 (ja) *	1988-09-12	2003-02-24	ファルマシア・アンド・アップジョン・カンパニー	２のｃｐｉサブユニットを有する新規ｃｃ―１０６５アナログ類

1995
- 1995-01-31 US US08/381,355 patent/US5502068A/en not_active Expired - Fee Related
1996
- 1996-01-31 AU AU49643/96A patent/AU698001B2/en not_active Ceased
- 1996-01-31 DE DE69625175T patent/DE69625175T2/de not_active Expired - Fee Related
- 1996-01-31 AT AT96906176T patent/ATE228837T1/de not_active IP Right Cessation
- 1996-01-31 JP JP8523576A patent/JPH11500427A/ja not_active Ceased
- 1996-01-31 EP EP96906176A patent/EP0800390B1/de not_active Expired - Lifetime
- 1996-01-31 WO PCT/US1996/000727 patent/WO1996023497A1/en not_active Ceased
- 1996-01-31 CA CA002210093A patent/CA2210093A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE69625175T2 (de)	2003-09-11
AU698001B2 (en)	1998-10-22
WO1996023497A1 (en)	1996-08-08
DE69625175D1 (de)	2003-01-16
CA2210093A1 (en)	1996-08-08
AU4964396A (en)	1996-08-21
EP0800390B1 (de)	2002-12-04
US5502068A (en)	1996-03-26
JPH11500427A (ja)	1999-01-12
EP0800390A4 (de)	1999-01-20
EP0800390A1 (de)	1997-10-15

Legal Events

Date	Code	Title	Description
2003-06-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69625175D1 (de)	2003-01-16	Krebsmittel auf basis von cyclopropylpyrroloindol-oligopeptiden
GB9902592D0 (en)	1999-03-24	Fungicides
IT1283588B1 (it)	1998-04-22	Miscela sinergica di agenti stabilizzanti
YU164791A (sh)	1994-04-05	Nezasićene hidroksialkilhinolin kiseline
DE69428125D1 (de)	2001-10-04	Fungizide tetrahydrofurane
ATE159722T1 (de)	1997-11-15	Dihalotriazolopyrimidinderivate als fugizide
SE8004783L (sv)	1981-02-26	Delta?722-1,2,4triazolin-5-on-derivat
IL132474A0 (en)	2001-03-19	Fungicides
IT1152287B (it)	1986-12-31	Pirrolidin-derivati
DK0687259T3 (da)	1997-05-26	Fremgangsmåde til fremstilling af taxoider
BR0004534A (pt)	2001-02-28	Composto, composição farmacêutica, agente contendo um composto, e uso de um composto.
IE873280L (en)	1988-06-03	Carbamoylimidazole derivatives, a process for their¹preparation, and their use as fungicides
AU6940491A (en)	1991-07-25	Stabilized aqueous alkyldiketene emulsions
EP0643966A4 (de)	1995-08-09	Wirkstoff zur verbesserung des empfindlichkeit für antineoplastische wirkstoffe.
KR960037677A (ko)	1996-11-19	4-인돌릴피페라지닐 유도체
EP0680960A4 (de)	1997-05-14	Imidazolverbindung.
KR900701762A (ko)	1990-12-04	테트라히드로피리미딘 유도체
SE8304410L (sv)	1983-08-15	Cyklohexylkarboxylsyraderivat och sett for deras framstellning
DE69629474D1 (de)	2003-09-18	Antifungale tetrahydrofurane
MX9101066A (es)	1993-01-01	Derivados fungicidas de acido 3,3,-bistioalquil-2-piridil-acrilico
ATE189886T1 (de)	2000-03-15	Synthese von carbonsäurederivaten
PL137023B1 (en)	1986-04-30	Detoxicant incorporating herbicide
AU7032594A (en)	1995-04-06	Azoxycyanobenzene derivatives
FR2737409B1 (fr)	1997-10-24	Nouvelles utilisations de diamines alticycliques
BR0206533A (pt)	2003-12-16	Composto, composição farmacêutica, e, uso de um composto